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Lexicon Pharmaceuticals, Inc.

LXRX
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
SEC CIK
0001062822

No open-market purchases or sales by Lexicon Pharmaceuticals, Inc. insiders were filed in the last 90 days; 149 institutions reported holding it in 13F filings for Q2 2026, worth $875.1M in total; no superinvestor holds it.

13F holders, Q1 2022

Institutional positions in Lexicon Pharmaceuticals, Inc. as of Mar 31, 2022. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
101
−9 vs. Q4 2021
Shares held
120.2M
−1.37M (−1.1%) vs. Q4 2021
Total value
$251.3M
−$227.6M (−47.5%) vs. Q4 2021
New holders
7
33 more added
Sold out
16
39 more reduced

Compare with Q4 2021: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting LXRX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ1 2022: 101 institutions
Q1 2021: 107 institutionsQ2 2021: 107 institutionsQ3 2021: 96 institutionsQ4 2021: 110 institutionsQ1 2022: 101 institutionsQ2 2022: 86 institutionsQ3 2022: 98 institutionsQ4 2022: 105 institutionsQ1 2023: 104 institutionsQ2 2023: 123 institutionsQ3 2023: 112 institutionsQ4 2023: 106 institutionsQ1 2024: 118 institutionsQ2 2024: 127 institutionsQ3 2024: 137 institutionsQ4 2024: 127 institutionsQ1 2025: 127 institutionsQ2 2025: 123 institutionsQ3 2025: 124 institutionsQ4 2025: 126 institutionsQ1 2026: 137 institutionsQ2 2026: 149 institutions
Value heldQ1 2022: $251.3M
Q1 2021: $711.5MQ2 2021: $540.2MQ3 2021: $583.0MQ4 2021: $478.9MQ1 2022: $251.3MQ2 2022: $221.0MQ3 2022: $357.3MQ4 2022: $280.5MQ1 2023: $353.8MQ2 2023: $438.2MQ3 2023: $205.8MQ4 2023: $279.8MQ1 2024: $417.8MQ2 2024: $471.0MQ3 2024: $453.1MQ4 2024: $220.1MQ1 2025: $122.5MQ2 2025: $242.9MQ3 2025: $344.4MQ4 2025: $299.5MQ1 2026: $504.5MQ2 2026: $875.1M
Institutions holding LXRX and their total value by quarter
QuarterHoldersValue
Q2 2026149$875.1M
Q1 2026137$504.5M
Q4 2025126$299.5M
Q3 2025124$344.4M
Q2 2025123$242.9M
Q1 2025127$122.5M
Q4 2024127$220.1M
Q3 2024137$453.1M
Q2 2024127$471.0M
Q1 2024118$417.8M
Q4 2023106$279.8M
Q3 2023112$205.8M
Q2 2023123$438.2M
Q1 2023104$353.8M
Q4 2022105$280.5M
Q3 202298$357.3M
Q2 202286$221.0M
Q1 2022101$251.3M
Q4 2021110$478.9M
Q3 202196$583.0M
Q2 2021107$540.2M
Q1 2021107$711.5M

Institutions, Q1 2022

Shares, value and share of portfolio for each institution holding Lexicon Pharmaceuticals, Inc.; share changes are against Q4 2021.

Institutions holding LXRX in Q1 2022
InstitutionSharesValue% of portfolioChange in sharesAction
Northwestern Mutual Wealth Management Co500$1.00K0.00%00.0%Unchanged
Daiwa Securities Group Inc.434$1.00K0.00%00.0%Unchanged
Costello Asset Management, INC500$1.00K0.00%00.0%Unchanged
Avion Wealth407$1.00K0.00%00.0%Unchanged
Farmers & Merchants Investments Inc1,000$2.00K0.00%00.0%Unchanged
Hall Laurie J Trustee1,650$3.00K0.00%00.0%Unchanged
Advisor Group Holdings, Inc.2,482$4.00K0.00%−77−3.0%Reduced
Quantbot Technologies LP3,625$7.00K0.00%00.0%Unchanged
Compagnie Lombard Odier SCmA4,000$8.00K0.00%00.0%Unchanged
Point72 Hong Kong Ltd3,603$8.00K0.00%+3,603New
Royal Bank of Canada4,811$10.0K0.00%−8,975−65.1%Reduced
Great West Life Assurance Co4,635$10.0K0.00%00.0%Unchanged
Ameritas Investment Partners, Inc.5,367$11.0K0.00%00.0%Unchanged
Citigroup Inc8,676$18.0K0.00%−14,931−63.2%Reduced
Amalgamated Bank9,621$20.0K0.00%−683−6.6%Reduced
Amalgamated Financial Corp.9,621$20.0K0.00%+9,621New
Estabrook Capital Management10,000$20.9K0.00%00.0%Unchanged
Simplex Trading, LLC10,178$21.0K0.00%−36,967−78.4%Reduced
Victory Capital Management Inc11,583$21.0K0.00%−16,368−58.6%Reduced
Pegasus Asset Management, Inc.10,000$21.0K0.01%00.0%Unchanged
Cubist Systematic Strategies, LLC10,816$23.0K0.00%−55,992−83.8%Reduced
LPL Financial LLC11,000$23.0K0.00%+11,000New
Berger Financial Group, Inc10,929$23.0K0.00%+10,929New
Janus Henderson Group PLC11,815$25.0K0.00%+29+0.2%Added
Teacher Retirement System of Texas12,393$26.0K0.00%+1,492+13.7%Added
Bank of Montreal12,000$26.0K0.00%+12,000New
Zurcher Kantonalbank (Zurich Cantonalbank)12,688$27.0K0.00%00.0%Unchanged
Commonwealth Equity Services, LLC14,276$29.0K0.00%00.0%Unchanged
ExodusPoint Capital Management, LP16,301$34.0K0.00%−17,600−51.9%Reduced
Arizona State Retirement System16,100$34.0K0.00%+546+3.5%Added
Tower Research Capital LLC (TRC)16,265$34.0K0.00%+8,584+111.8%Added
Legal & General Group Plc17,566$37.0K0.00%00.0%Unchanged
Parallax Volatility Advisers, L.P.19,265$40.0K0.00%−16,272−45.8%Reduced
Jane Street Group, LLC19,723$41.0K0.00%−18,744−48.7%Reduced
AXA S.A.20,900$43.7K0.00%−54,300−72.2%Reduced
Squarepoint Ops LLC26,189$55.0K0.00%−12,576−32.4%Reduced
ProShare Advisors LLC28,535$60.0K0.00%−7,722−21.3%Reduced
State Board of Administration of Florida Retirement System29,390$61.0K0.00%00.0%Unchanged
Invesco Ltd.29,849$62.0K0.00%+1,071+3.7%Added
Voya Investment Management LLC30,980$65.0K0.00%+1,804+6.2%Added
New York State Common Retirement Fund33,499$70.0K0.00%+52+0.2%Added
SG Americas Securities, LLC33,720$70.0K0.00%+13,876+69.9%Added
Manufacturers Life Insurance Company, The33,729$70.5K0.00%−5,611−14.3%Reduced
American International Group, Inc.34,757$73.0K0.00%−2,445−6.6%Reduced
University of Texas/Texas Am Investment Managment Co35,714$75.0K0.04%00.0%Unchanged
Deutsche Bank AG37,895$80.0K0.00%−4,516−10.6%Reduced
Virtus ETF Advisers LLC39,262$82.0K0.04%−2,322−5.6%Reduced
Susquehanna Fundamental Investments, LLC42,424$89.0K0.00%−37,431−46.9%Reduced
Credit Suisse AG43,150$90.0K0.00%+406+0.9%Added
Bank of America Corp46,716$97.0K0.00%−229,807−83.1%Reduced
AQR Capital Management LLC47,677$100.0K0.00%−71,597−60.0%Reduced
Alliancebernstein L.P.50,411$105.0K0.00%+300+0.6%Added
Parametric Portfolio Associates LLC51,724$108.0K0.00%−32,611−38.7%Reduced
Principal Financial Group Inc51,855$108.0K0.00%−18,934−26.7%Reduced
Panagora Asset Management Inc53,152$111.0K0.00%−236,327−81.6%Reduced
Salem Investment Counselors Inc73,000$153.0K0.01%00.0%Unchanged
California State Teachers Retirement System78,726$165.0K0.00%−7,162−8.3%Reduced
Group One Trading, L.P.79,963$167.0K0.00%−54,715−40.6%Reduced
Rhumbline Advisers79,934$167.0K0.00%−6,726−7.8%Reduced
Barclays PLC83,237$175.0K0.00%−1,733−2.0%Reduced
UBS Asset Management Americas Inc83,874$175.3K0.00%00.0%Unchanged
State of Wisconsin Investment Board87,800$183.0K0.00%−69,700−44.3%Reduced
Renaissance Technologies LLC88,776$186.0K0.00%+88,776New
BNP Paribas Arbitrage, SA106,564$222.7K0.00%+3,220+3.1%Added
Susquehanna International Group, LLP115,907$242.0K0.00%−19,869−14.6%Reduced
Stifel Financial Corp133,049$278.0K0.00%+27,630+26.2%Added
Tudor Investment Corp Et Al139,601$292.0K0.01%−11,347−7.5%Reduced
Swiss National Bank140,800$294.0K0.00%+13,500+10.6%Added
Los Angeles Capital Management LLC142,547$298.0K0.00%+23,680+19.9%Added
Price T Rowe Associates Inc153,932$322.0K0.00%+10,300+7.2%Added
Prudential Financial Inc169,008$353.0K0.00%−80,700−32.3%Reduced
Wells Fargo & Company179,952$376.0K0.00%−312,779−63.5%Reduced
Goldman Sachs Group Inc182,671$381.0K0.00%+25,189+16.0%Added
Morgan Stanley186,582$390.0K0.00%+78,114+72.0%Added
Walleye Capital LLC200,968$420.0K0.01%+200,968New
Allspring Global Investments Holdings, LLC203,754$425.0K0.00%−369,745−64.5%Reduced
UBS Group AG212,066$443.0K0.00%+116,066+120.9%Added
Wellington Management Group LLP217,197$454.0K0.00%+1,656+0.8%Added
Gsa Capital Partners LLP230,503$482.0K0.06%+198,941+630.3%Added
HRT Financial LP242,211$506.0K0.00%+140,650+138.5%Added
Russell Investments Group, Ltd.250,317$522.0K0.00%00.0%Unchanged
Nuveen Asset Management, LLC243,880$530.0K0.00%+1,527+0.6%Added
Bank of New York Mellon Corp284,610$595.0K0.00%+362+0.1%Added
Millennium Management LLC368,654$770.0K0.00%+113,516+44.5%Added
Fisher Asset Management, LLC368,194$770.0K0.00%+197,424+115.6%Added
Citadel Advisors LLC451,812$945.0K0.00%+418,766+1,267.2%Added
Charles Schwab Investment Management Inc501,128$1.05M0.00%+12,710+2.6%Added
Northern Trust Corp660,406$1.38M0.00%−27,970−4.1%Reduced
Nomura Holdings Inc633,638$1.41M0.01%+55,258+9.6%Added
Dimensional Fund Advisors LP869,611$1.82M0.00%+96,633+12.5%Added
JPMorgan Chase & Co1,129,321$2.36M0.00%−18,769−1.6%Reduced
Geode Capital Management, LLC1,257,864$2.63M0.00%+60,125+5.0%Added
State Street Corp1,324,385$2.77M0.00%+109,367+9.0%Added
Pinnacle Associates Ltd2,094,294$4.38M0.08%−33,368−1.6%Reduced
NEA Management Company, LLC2,382,286$4.98M0.16%00.0%Unchanged
D. E. Shaw & Co., Inc.3,228,704$6.75M0.01%+420,276+15.0%Added
Vanguard Group Inc4,156,236$8.69M0.00%+4,484+0.1%Added
BlackRock Inc.4,445,752$9.29M0.00%−102,172−2.2%Reduced
FMR LLC5,290,549$11.1M0.00%−377,589−6.7%Reduced
BVF Inc14,356,589$30.0M1.20%−3,4110.0%Reduced