Definium Therapeutics, Inc.
DFTX- Exchange
- Nasdaq
- Industry
- Medicinal Chemicals & Botanical Products
- SEC CIK
- 0001813814
In the last 90 days, Definium Therapeutics, Inc. insiders filed 0 open-market purchases and 1 sale; 362 institutions reported holding it in 13F filings for Q2 2026, worth $5.35B in total; Duquesne Family Office is the only superinvestor holding it.
13F holders, Q4 2025
Institutional positions in Definium Therapeutics, Inc. as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 209
- +20 vs. Q3 2025
- Shares held
- 67.9M
- +28.3M (+71.7%) vs. Q3 2025
- Total value
- $908.7M
- +$442.6M (+95.0%) vs. Q3 2025
- New holders
- 50
- 92 more added
- Sold out
- 30
- 31 more reduced
7 institutions that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting DFTX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 362 | $5.35B |
| Q1 2026 | 248 | $1.47B |
| Q4 2025 | 209 | $908.7M |
| Q3 2025 | 196 | $468.6M |
| Q2 2025 | 183 | $271.0M |
| Q1 2025 | 191 | $240.5M |
| Q4 2024 | 174 | $288.9M |
| Q3 2024 | 158 | $281.6M |
| Q2 2024 | 152 | $299.3M |
| Q1 2024 | 135 | $327.2M |
| Q4 2023 | 104 | $17.9M |
| Q3 2023 | 93 | $12.1M |
| Q2 2023 | 84 | $13.9M |
| Q1 2023 | 89 | $12.6M |
| Q4 2022 | 104 | $11.1M |
| Q3 2022 | 101 | $20.5M |
| Q2 2022 | 156 | $15.1M |
| Q1 2022 | 159 | $53.6M |
| Q4 2021 | 176 | $72.0M |
| Q3 2021 | 175 | $104.8M |
| Q2 2021 | 156 | $131.0M |
| Q1 2021 | 8 | $932.0K |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Definium Therapeutics, Inc.; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Geode Capital Management, LLC | 2,332,938 | $31.2M | 0.00% | +508,237+27.9% | Added |
| State Street Corp | 2,368,066 | $31.7M | 0.00% | +443,173+23.0% | Added |
| Janus Henderson Group PLC | 2,411,696 | $32.3M | 0.01% | +2,383,696+8,513.2% | Added |
| Trails Edge Capital Partners, LP | 2,568,110 | $34.4M | 8.50% | +2,568,110 | New |
| Vanguard Group Inc | 2,591,901 | $34.7M | 0.00% | +579,027+28.8% | Added |
| Marshall Wace, LLP | 2,975,702 | $39.8M | 0.04% | +593,722+24.9% | Added |
| Avoro Capital Advisors LLC | 5,000,000 | $67.0M | 0.66% | +5,000,000 | New |
| Driehaus Capital Management LLC | 6,537,202 | $87.5M | 0.59% | +3,427,291+110.2% | Added |
| BlackRock, Inc. | 8,273,276 | $110.8M | 0.00% | +2,337,719+39.4% | Added |
| Tang Capital Management LLC | 0 | $0 | 0.00% | −600,200−100.0% | Sold out |
| Ally Bridge Group (NY) LLC | 0 | $0 | 0.00% | −361,444−100.0% | Sold out |
| Diadema Partners LP | 0 | $0 | 0.00% | −105,891−100.0% | Sold out |
| StemPoint Capital LP | 0 | $0 | 0.00% | −76,875−100.0% | Sold out |
| PFM Health Sciences, LP | 0 | $0 | 0.00% | −75,138−100.0% | Sold out |
| Boothbay Fund Management, LLC | 0 | $0 | 0.00% | −67,984−100.0% | Sold out |
| Cerity Partners LLC | 0 | $0 | 0.00% | −49,650−100.0% | Sold out |
| Virtu Financial LLC | 0 | $0 | 0.00% | −32,184−100.0% | Sold out |
| Blair William & Co | 0 | $0 | 0.00% | −31,905−100.0% | Sold out |
| DRW Securities, LLC | 0 | $0 | 0.00% | −30,727−100.0% | Sold out |
| Sender Co & Partners, Inc. | 0 | $0 | 0.00% | −25,906−100.0% | Sold out |
| Persistent Asset Partners Ltd | 0 | $0 | 0.00% | −24,282−100.0% | Sold out |
| Omers Administration Corp | 0 | $0 | 0.00% | −16,600−100.0% | Sold out |
| Axq Capital, LP | 0 | $0 | 0.00% | −15,585−100.0% | Sold out |
| HighTower Advisors, LLC | 0 | $0 | 0.00% | −12,643−100.0% | Sold out |
| Creative Planning | 0 | $0 | 0.00% | −11,909−100.0% | Sold out |
| Stoneridge Investment Partners LLC | 0 | $0 | 0.00% | −11,563−100.0% | Sold out |
| FNY Investment Advisers, LLC | 0 | $0 | 0.00% | −9,094−100.0% | Sold out |
| Walleye Capital LLC | 0 | $0 | 0.00% | −5,737−100.0% | Sold out |
| Ameritas Advisory Services, LLC | 0 | $0 | 0.00% | −3,250−100.0% | Sold out |
| Mirae Asset Global Investments Co., Ltd. | 0 | $0 | 0.00% | −2,942−100.0% | Sold out |
| BIT Capital GmbH | 0 | $0 | 0.00% | −2,245−100.0% | Sold out |
| Advisory Services Network, LLC | 0 | $0 | 0.00% | −656−100.0% | Sold out |
| Harbour Investments, Inc. | 0 | $0 | 0.00% | −556−100.0% | Sold out |
| Tortoise Investment Management, LLC | 0 | $0 | 0.00% | −400−100.0% | Sold out |
| Principal Securities, Inc. | 0 | $0 | 0.00% | −58−100.0% | Sold out |
| Louisbourg Investments Inc. | 0 | $0 | 0.00% | −52−100.0% | Sold out |
| Anfield Capital Management, LLC | 0 | $0 | 0.00% | −36−100.0% | Sold out |
| Strategic Investment Solutions, Inc. | 0 | $0 | 0.00% | −6−100.0% | Sold out |
| Grey Fox Wealth Advisors, LLC | 0 | $0 | 0.00% | −6−100.0% | Sold out |
| Cubist Systematic Strategies, LLC | – | – | – | – | Not filed |
| Wolverine Trading, LLC | – | – | – | – | Not filed |
| Moloney Securities Asset Management, LLC | – | – | – | – | Not filed |
| Point72 Asia (Singapore) Pte. Ltd. | – | – | – | – | Not filed |
| Point72 (DIFC) Ltd | – | – | – | – | Not filed |
| Point72 Europe (London) LLP | – | – | – | – | Not filed |
| Guerra Advisors Inc | – | – | – | – | Not filed |