Definium Therapeutics, Inc.
DFTX- Exchange
- Nasdaq
- Industry
- Medicinal Chemicals & Botanical Products
- SEC CIK
- 0001813814
In the last 90 days, Definium Therapeutics, Inc. insiders filed 0 open-market purchases and 1 sale; 362 institutions reported holding it in 13F filings for Q2 2026, worth $5.35B in total; Duquesne Family Office is the only superinvestor holding it.
13F holders, Q4 2021
Institutional positions in Definium Therapeutics, Inc. as of Dec 31, 2021. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 176
- +7 vs. Q3 2021
- Shares held
- 51.9M
- +7.33M (+16.4%) vs. Q3 2021
- Total value
- $72.0M
- −$32.6M (−31.1%) vs. Q3 2021
- New holders
- 37
- 54 more added
- Sold out
- 30
- 35 more reduced
6 institutions that held it in Q3 2021 haven't filed for Q4 2021 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2021: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting DFTX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 362 | $5.35B |
| Q1 2026 | 248 | $1.47B |
| Q4 2025 | 209 | $908.7M |
| Q3 2025 | 196 | $468.6M |
| Q2 2025 | 183 | $271.0M |
| Q1 2025 | 191 | $240.5M |
| Q4 2024 | 174 | $288.9M |
| Q3 2024 | 158 | $281.6M |
| Q2 2024 | 152 | $299.3M |
| Q1 2024 | 135 | $327.2M |
| Q4 2023 | 104 | $17.9M |
| Q3 2023 | 93 | $12.1M |
| Q2 2023 | 84 | $13.9M |
| Q1 2023 | 89 | $12.6M |
| Q4 2022 | 104 | $11.1M |
| Q3 2022 | 101 | $20.5M |
| Q2 2022 | 156 | $15.1M |
| Q1 2022 | 159 | $53.6M |
| Q4 2021 | 176 | $72.0M |
| Q3 2021 | 175 | $104.8M |
| Q2 2021 | 156 | $131.0M |
| Q1 2021 | 8 | $932.0K |
Institutions, Q4 2021
Shares, value and share of portfolio for each institution holding Definium Therapeutics, Inc.; share changes are against Q3 2021.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Wolverine Trading, LLC | 33,479 | $48.0K | 0.00% | +6,085+22.2% | Added |
| Squarepoint Ops LLC | 34,795 | $48.0K | 0.00% | +23,379+204.8% | Added |
| Wedbush Securities Inc | 36,000 | $50.0K | 0.00% | +13,500+60.0% | Added |
| Two Sigma Securities, LLC | 36,347 | $50.0K | 0.01% | +36,347 | New |
| Jaffetilchin Investment Partners, LLC | 36,855 | $51.0K | 0.00% | 00.0% | Unchanged |
| First Republic Investment Management, Inc. | 37,500 | $52.0K | 0.00% | −4,837−11.4% | Reduced |
| Shell Asset Management Co | 37,982 | $52.0K | 0.00% | +9,169+31.8% | Added |
| Toronto Dominion Bank | 40,923 | $56.0K | 0.00% | +1,100+2.8% | Added |
| Stifel Financial Corp | 46,240 | $64.0K | 0.00% | +1,260+2.8% | Added |
| State Board of Administration of Florida Retirement System | 48,230 | $66.0K | 0.00% | +100+0.2% | Added |
| Parallax Volatility Advisers, L.P. | 53,563 | $74.0K | 0.00% | +53,563 | New |
| Legal & General Group Plc | 54,490 | $78.0K | 0.00% | +802+1.5% | Added |
| Two Sigma Advisers, LP | 56,400 | $78.0K | 0.00% | +56,400 | New |
| XTX Topco Ltd | 57,608 | $79.0K | 0.04% | +57,608 | New |
| Creative Planning | 58,080 | $80.0K | 0.00% | −18,152−23.8% | Reduced |
| HighTower Advisors, LLC | 59,228 | $81.0K | 0.00% | −52,975−47.2% | Reduced |
| Principal Financial Group Inc | 59,189 | $82.0K | 0.00% | −13,812−18.9% | Reduced |
| Alpine Global Management, LLC | 59,690 | $82.0K | 0.01% | +59,690 | New |
| SG Americas Securities, LLC | 62,146 | $86.0K | 0.00% | −78,877−55.9% | Reduced |
| Ground Swell Capital, LLC | 63,698 | $88.0K | 0.51% | +63,698 | New |
| HSBC Holdings PLC | 38,229 | $93.0K | 0.00% | +10,114+36.0% | Added |
| Gofen & Glossberg LLC | 72,500 | $100.0K | 0.00% | 00.0% | Unchanged |
| ProShare Advisors LLC | 76,012 | $105.0K | 0.00% | +31,421+70.5% | Added |
| Metropolitan Life Insurance Co | 77,352 | $106.7K | 0.00% | +6,407+9.0% | Added |
| Audent Global Asset Management, LLC | 78,000 | $108.0K | 0.05% | +78,000 | New |
| STRS Ohio | 79,800 | $110.0K | 0.00% | 00.0% | Unchanged |
| Scotia Capital Inc. | 87,608 | $120.0K | 0.00% | +4,461+5.4% | Added |
| Citigroup Inc | 94,316 | $129.0K | 0.00% | +53,789+132.7% | Added |
| Ergoteles LLC | 98,829 | $136.0K | 0.01% | +50,721+105.4% | Added |
| Ikarian Capital, LLC | 100,000 | $138.0K | 0.04% | +100,000 | New |
| UBS Group AG | 106,831 | $147.0K | 0.00% | +105,784+10,103.5% | Added |
| Man Group plc | 109,400 | $151.0K | 0.00% | +109,400 | New |
| Voya Investment Management LLC | 134,563 | $186.0K | 0.00% | +171+0.1% | Added |
| MetLife Investment Management | 138,319 | $190.9K | 0.00% | +46,054+49.9% | Added |
| BIT Capital GmbH | 140,000 | $193.2K | 0.01% | 00.0% | Unchanged |
| Royal Bank of Canada | 143,677 | $199.0K | 0.00% | +47,664+49.6% | Added |
| Invesco Ltd. | 146,994 | $203.0K | 0.00% | −52,638−26.4% | Reduced |
| Bank of America Corp | 155,458 | $214.0K | 0.00% | +118,264+318.0% | Added |
| Bank of Montreal | 146,730 | $216.0K | 0.00% | −22,882−13.5% | Reduced |
| Commonwealth Equity Services, LLC | 166,202 | $229.0K | 0.00% | +16,240+10.8% | Added |
| D. E. Shaw & Co., Inc. | 167,211 | $231.0K | 0.00% | −3,311−1.9% | Reduced |
| tru Independence LLC | 167,293 | $232.0K | 0.06% | 00.0% | Unchanged |
| Jane Street Group, LLC | 175,205 | $241.0K | 0.00% | +124,170+243.3% | Added |
| National Bank of Canada | 177,053 | $244.0K | 0.00% | +177,053 | New |
| Manufacturers Life Insurance Company, The | 177,756 | $245.0K | 0.00% | +1,710+1.0% | Added |
| American International Group, Inc. | 184,914 | $255.0K | 0.00% | −5,531−2.9% | Reduced |
| California State Teachers Retirement System | 188,069 | $260.0K | 0.00% | −626−0.3% | Reduced |
| Cresset Asset Management, LLC | 201,100 | $278.0K | 0.00% | +201,100 | New |
| Wells Fargo & Company | 201,729 | $279.0K | 0.00% | +175,536+670.2% | Added |
| New York State Common Retirement Fund | 206,258 | $285.0K | 0.00% | −665−0.3% | Reduced |
| Parametric Portfolio Associates LLC | 214,152 | $296.0K | 0.00% | +88,272+70.1% | Added |
| Credit Suisse AG | 215,090 | $297.0K | 0.00% | −22,241−9.4% | Reduced |
| Goldman Sachs Group Inc | 228,702 | $316.0K | 0.00% | −787,312−77.5% | Reduced |
| Penserra Capital Management LLC | 242,116 | $334.0K | 0.01% | +46,096+23.5% | Added |
| Alliancebernstein L.P. | 290,700 | $401.0K | 0.00% | −45,200−13.5% | Reduced |
| Rhumbline Advisers | 309,943 | $428.0K | 0.00% | +2,739+0.9% | Added |
| Deutsche Bank AG | 331,718 | $458.0K | 0.00% | +17,089+5.4% | Added |
| LPL Financial LLC | 387,205 | $534.0K | 0.00% | +343,320+782.3% | Added |
| AdvisorShares Investments LLC | 417,522 | $576.0K | 0.07% | +265,004+173.8% | Added |
| Group One Trading, L.P. | 475,859 | $657.0K | 0.01% | +328,202+222.3% | Added |
| Charles Schwab Investment Management Inc | 749,388 | $1.03M | 0.00% | +12,328+1.7% | Added |
| Swiss National Bank | 772,800 | $1.05M | 0.00% | +56,300+7.9% | Added |
| Bank of New York Mellon Corp | 919,642 | $1.27M | 0.00% | +33,807+3.8% | Added |
| Susquehanna International Group, LLP | 1,053,838 | $1.45M | 0.00% | −7,348−0.7% | Reduced |
| Millennium Management LLC | 1,076,153 | $1.49M | 0.00% | −316,206−22.7% | Reduced |
| Two Sigma Investments, LP | 1,123,766 | $1.55M | 0.00% | +790,860+237.6% | Added |
| Busey Wealth Management | 1,248,201 | $1.72M | 0.07% | +431,267+52.8% | Added |
| Citadel Advisors LLC | 1,660,750 | $2.29M | 0.00% | +1,390,655+514.9% | Added |
| Data Collective IV GP, LLC | 1,505,248 | $2.60M | 0.35% | +1,505,248 | New |
| Vanguard Group Inc | 1,974,999 | $2.73M | 0.00% | +99,591+5.3% | Added |
| Morgan Stanley | 2,399,883 | $3.31M | 0.00% | +2,205,055+1,131.8% | Added |
| Northern Trust Corp | 2,539,207 | $3.50M | 0.00% | −50,110−1.9% | Reduced |
| Geode Capital Management, LLC | 2,908,735 | $4.01M | 0.00% | −4,298−0.1% | Reduced |
| State Street Corp | 5,728,738 | $7.91M | 0.00% | +94,650+1.7% | Added |
| BlackRock Inc. | 17,065,574 | $23.6M | 0.00% | +383,577+2.3% | Added |
| JPMorgan Chase & Co | 134,644 | – | – | +5,966+4.6% | Added |
| MMCAP International Inc. SPC | 0 | $0 | 0.00% | −325,804−100.0% | Sold out |
| Shay Capital LLC | 0 | $0 | 0.00% | −141,250−100.0% | Sold out |
| Stokes Family Office, LLC | 0 | $0 | 0.00% | −46,095−100.0% | Sold out |
| Envestnet Asset Management Inc | 0 | $0 | 0.00% | −44,030−100.0% | Sold out |
| Virtu Financial LLC | 0 | $0 | 0.00% | −37,355−100.0% | Sold out |
| Intersect Capital LLC | 0 | $0 | 0.00% | −32,500−100.0% | Sold out |
| Koshinski Asset Management, Inc. | 0 | $0 | 0.00% | −32,272−100.0% | Sold out |
| Arete Wealth Advisors, LLC | 0 | $0 | 0.00% | −32,052−100.0% | Sold out |
| Cubist Systematic Strategies, LLC | 0 | $0 | 0.00% | −30,600−100.0% | Sold out |
| Accurate Wealth Management, LLC | 0 | $0 | 0.00% | −26,440−100.0% | Sold out |
| Texas Yale Capital Corp. | 0 | $0 | 0.00% | −17,300−100.0% | Sold out |
| Sara-Bay Financial | 0 | $0 | 0.00% | −16,204−100.0% | Sold out |
| Invst, LLC | 0 | $0 | 0.00% | −16,058−100.0% | Sold out |
| Cambridge Investment Research Advisors, Inc. | 0 | $0 | 0.00% | −14,430−100.0% | Sold out |
| Blair William & Co | 0 | $0 | 0.00% | −13,270−100.0% | Sold out |
| Truist Financial Corp | 0 | $0 | 0.00% | −11,468−100.0% | Sold out |
| Cetera Advisors LLC | 0 | $0 | 0.00% | −11,300−100.0% | Sold out |
| IPG Investment Advisors LLC | 0 | $0 | 0.00% | −11,027−100.0% | Sold out |
| Ameriprise Financial Inc | 0 | $0 | 0.00% | −10,400−100.0% | Sold out |
| Investment Advisory Services Inc | 0 | $0 | 0.00% | −10,000−100.0% | Sold out |
| Visionary Wealth Advisors | 0 | $0 | 0.00% | −10,500−100.0% | Sold out |
| Atlas Private Wealth Advisors | 0 | $0 | 0.00% | −6,000−100.0% | Sold out |
| Pacitti Group Inc. | 0 | $0 | 0.00% | −5,100−100.0% | Sold out |
| FNY Investment Advisers, LLC | 0 | $0 | 0.00% | −4,000−100.0% | Sold out |