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Amylyx Pharmaceuticals, Inc.

AMLX
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
SEC CIK
0001658551

In the last 90 days, Amylyx Pharmaceuticals, Inc. insiders filed 0 open-market purchases and 6 sales; 206 institutions reported holding it in 13F filings for Q2 2026, worth $2.07B in total; no superinvestor holds it.

13F holders, Q4 2023

Institutional positions in Amylyx Pharmaceuticals, Inc. as of Dec 31, 2023. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
178
+9 vs. Q3 2023
Shares held
60.3M
+1.65M (+2.8%) vs. Q3 2023
Total value
$887.4M
−$186.2M (−17.3%) vs. Q3 2023
New holders
37
78 more added
Sold out
28
46 more reduced

1 institution that held it in Q3 2023 haven't filed for Q4 2023 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.

Compare with Q3 2023: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting AMLX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ4 2023: 178 institutions
Q1 2021: 0 institutionsQ2 2021: 0 institutionsQ3 2021: 0 institutionsQ4 2021: 0 institutionsQ1 2022: 72 institutionsQ2 2022: 78 institutionsQ3 2022: 95 institutionsQ4 2022: 133 institutionsQ1 2023: 147 institutionsQ2 2023: 154 institutionsQ3 2023: 170 institutionsQ4 2023: 178 institutionsQ1 2024: 143 institutionsQ2 2024: 119 institutionsQ3 2024: 110 institutionsQ4 2024: 122 institutionsQ1 2025: 136 institutionsQ2 2025: 131 institutionsQ3 2025: 169 institutionsQ4 2025: 180 institutionsQ1 2026: 171 institutionsQ2 2026: 206 institutions
Value heldQ4 2023: $887.4M
Q1 2021: $0Q2 2021: $0Q3 2021: $0Q4 2021: $0Q1 2022: $299.9MQ2 2022: $512.9MQ3 2022: $1.05BQ4 2022: $1.79BQ1 2023: $1.51BQ2 2023: $1.18BQ3 2023: $1.08BQ4 2023: $887.4MQ1 2024: $141.5MQ2 2024: $82.9MQ3 2024: $140.8MQ4 2024: $188.3MQ1 2025: $261.6MQ2 2025: $523.6MQ3 2025: $1.49BQ4 2025: $1.36BQ1 2026: $1.59BQ2 2026: $2.07B
Institutions holding AMLX and their total value by quarter
QuarterHoldersValue
Q2 2026206$2.07B
Q1 2026171$1.59B
Q4 2025180$1.36B
Q3 2025169$1.49B
Q2 2025131$523.6M
Q1 2025136$261.6M
Q4 2024122$188.3M
Q3 2024110$140.8M
Q2 2024119$82.9M
Q1 2024143$141.5M
Q4 2023178$887.4M
Q3 2023170$1.08B
Q2 2023154$1.18B
Q1 2023147$1.51B
Q4 2022133$1.79B
Q3 202295$1.05B
Q2 202278$512.9M
Q1 202272$299.9M
Q4 20210$0
Q3 20210$0
Q2 20210$0
Q1 20210$0

Institutions, Q4 2023

Shares, value and share of portfolio for each institution holding Amylyx Pharmaceuticals, Inc.; share changes are against Q3 2023.

Institutions holding AMLX in Q4 2023
InstitutionSharesValue% of portfolioChange in sharesAction
Walleye Trading LLC35,774$526.6K0.01%+35,774New
Wells Fargo & Company34,265$504.4K0.00%−11,076−24.4%Reduced
Landscape Capital Management, L.L.C.33,689$495.9K0.04%+33,689New
Tudor Investment Corp Et Al33,652$495.4K0.01%+6,293+23.0%Added
Squarepoint Ops LLC33,450$492.4K0.00%−6,550−16.4%Reduced
Dynamic Technology Lab Private Ltd31,342$461.0K0.05%−6,152−16.4%Reduced
Engineers Gate Manager LP29,205$429.9K0.01%+14,889+104.0%Added
State of Wisconsin Investment Board28,454$418.8K0.00%+2,759+10.7%Added
Virtu Financial LLC27,715$408.0K0.03%+27,715New
MetLife Investment Management26,712$393.2K0.00%00.0%Unchanged
HighVista Strategies LLC26,349$387.9K0.14%00.0%Unchanged
GTS Securities LLC26,311$387.3K0.01%+26,311New
American International Group, Inc.25,246$371.6K0.00%−102−0.4%Reduced
Profund Advisors LLC24,607$362.2K0.02%+5,239+27.0%Added
Mirae Asset Global Investments Co., Ltd.24,357$358.5K0.00%+103+0.4%Added
Invesco Ltd.23,895$351.7K0.00%−5,940−19.9%Reduced
New York State Common Retirement Fund23,754$349.7K0.00%+2,519+11.9%Added
AQR Capital Management LLC23,344$343.6K0.00%−295−1.2%Reduced
Virtus ETF Advisers LLC22,130$325.8K0.21%+9,907+81.1%Added
Fox Run Management, L.L.C.22,007$323.9K0.08%+5,022+29.6%Added
Parsons Capital Management Inc21,945$323.0K0.02%00.0%Unchanged
Premier Path Wealth Partners, LLC20,265$298.3K0.07%+20,265New
Voya Investment Management LLC20,175$297.0K0.00%−1,125,613−98.2%Reduced
Capstone Investment Advisors, LLC20,000$294.4K0.01%−2,829−12.4%Reduced
UBS Asset Management Americas Inc19,700$290.0K0.00%−8,100−29.1%Reduced
Balyasny Asset Management LLC19,698$290.0K0.00%−677,183−97.2%Reduced
Captrust Financial Advisors19,561$287.9K0.00%−13,469−40.8%Reduced
Centiva Capital, LP19,188$282.4K0.02%+19,188New
J. Goldman & Co LP19,029$280.1K0.02%−165,878−89.7%Reduced
XTX Topco Ltd18,913$278.4K0.06%+8,814+87.3%Added
Rafferty Asset Management, LLC18,320$269.7K0.00%+7,028+62.2%Added
STRS Ohio17,500$257.0K0.00%+17,500New
Greenwood Capital Associates LLC17,395$256.1K0.03%+43+0.2%Added
First Trust Advisors LP17,380$255.8K0.00%+17,380New
Royal Bank of Canada16,155$237.0K0.00%+8,060+99.6%Added
Guggenheim Capital LLC14,946$220.0K0.00%+14,946New
Janus Henderson Group PLC14,753$217.1K0.00%−10.0%Reduced
Teza Capital Management LLC14,660$215.8K0.04%+2,863+24.3%Added
State Board of Administration of Florida Retirement System14,580$214.6K0.00%00.0%Unchanged
Principal Financial Group Inc14,472$213.0K0.00%+126+0.9%Added
Lion Point Capital, LP14,000$206.1K0.18%+14,000New
Brown Advisory Inc13,461$198.1K0.00%00.0%Unchanged
Jump Financial, LLC13,343$196.4K0.01%−9,497−41.6%Reduced
Belvedere Trading LLC13,213$194.5K0.02%+13,213New
CWM, LLC13,203$194.0K0.00%+34+0.3%Added
ProShare Advisors LLC12,721$187.3K0.00%+1,715+15.6%Added
Tower Research Capital LLC (TRC)12,314$181.3K0.00%+8,343+210.1%Added
Handelsbanken Fonder AB11,900$175.0K0.00%+11,900New
Arizona State Retirement System11,302$166.4K0.00%+11,302New
Integrated Wealth Concepts LLC10,641$156.6K0.00%+285+2.8%Added
Zurcher Kantonalbank (Zurich Cantonalbank)10,389$152.9K0.00%+4,255+69.4%Added
Point72 Middle East FZE9,141$134.6K0.01%−14,233−60.9%Reduced
Advisors Asset Management, Inc.8,623$126.9K0.00%−20−0.2%Reduced
China Universal Asset Management Co., Ltd.7,815$115.0K0.02%+6,085+351.7%Added
Amalgamated Bank7,204$106.0K0.00%−513−6.6%Reduced
Quest Partners LLC6,035$88.8K0.02%+6,035New
Point72 Hong Kong Ltd5,100$75.1K0.00%+5,100New
Ameritas Investment Partners, Inc.5,046$74.3K0.00%00.0%Unchanged
Covestor Ltd3,726$55.0K0.04%+3,722+93,050.0%Added
Advisor Group Holdings, Inc.3,150$46.4K0.00%−22,514−87.7%Reduced
Metropolitan Life Insurance Co2,899$42.7K0.00%00.0%Unchanged
Russell Investments Group, Ltd.2,837$41.8K0.00%−1,646−36.7%Reduced
Steward Partners Investment Advisory, LLC2,000$29.4K0.00%−200−9.1%Reduced
Loring Wolcott & Coolidge Fiduciary Advisors LLP1,803$28.8K0.00%00.0%Unchanged
Cutler Group LP900$13.0K0.00%+850+1,700.0%Added
Quarry LP750$11.0K0.01%−4,250−85.0%Reduced
Daiwa Securities Group Inc.266$4.00K0.00%00.0%Unchanged
Capital Advisors, Ltd. LLC290$4.00K0.00%00.0%Unchanged
Global Retirement Partners, LLC200$3.10K0.00%+200New
The PNC Financial Services Group, Inc.196$2.88K0.00%+196New
Colonial Trust Co86$1.27K0.00%00.0%Unchanged
Psagot Value Holdings Ltd. / (Israel)95$1.00K0.00%−22−18.8%Reduced
Salem Investment Counselors Inc55$8100.00%+55New
GAMMA Investing LLC35$5600.00%+35New
Nisa Investment Advisors, LLC34$5000.00%+18+112.5%Added
Kelly Financial Services LLC33$4860.00%00.0%Unchanged
Allspring Global Investments Holdings, LLC29$4260.00%−14,158−99.8%Reduced
Farther Finance Advisors, LLC27$3970.00%+27New
Boxer Capital, LLC0$00.00%−2,084,000−100.0%Sold out
Adage Capital Partners GP, L.L.C.0$00.00%−1,700,200−100.0%Sold out
Deep Track Capital, LP0$00.00%−1,259,335−100.0%Sold out
Samlyn Capital, LLC0$00.00%−1,164,897−100.0%Sold out
Octagon Capital Advisors LP0$00.00%−695,000−100.0%Sold out
Gilder Gagnon Howe & Co LLC0$00.00%−688,438−100.0%Sold out
Tri Locum Partners LP0$00.00%−282,862−100.0%Sold out
Verition Fund Management LLC0$00.00%−267,694−100.0%Sold out
Ghost Tree Capital, LLC0$00.00%−215,000−100.0%Sold out
Oberweis Asset Management Inc0$00.00%−170,000−100.0%Sold out
Schonfeld Strategic Advisors LLC0$00.00%−137,523−100.0%Sold out
Ameriprise Financial Inc0$00.00%−129,918−100.0%Sold out
Alyeska Investment Group, L.P.0$00.00%−120,157−100.0%Sold out
Aigen Investment Management, LP0$00.00%−65,863−100.0%Sold out
Graham Capital Management, L.P.0$00.00%−56,241−100.0%Sold out
Moore Capital Management, LP0$00.00%−47,078−100.0%Sold out
Putnam Investments LLC0$00.00%−46,460−100.0%Sold out
UBS Oconnor LLC0$00.00%−35,000−100.0%Sold out
Jackson Creek Investment Advisors LLC0$00.00%−27,193−100.0%Sold out
Axxcess Wealth Management, LLC0$00.00%−26,151−100.0%Sold out
Knoll Capital Management, LLC0$00.00%−24,772−100.0%Sold out
Millrace Asset Group, Inc.0$00.00%−19,496−100.0%Sold out