Taysha Gene Therapies, Inc.
TSHA- Exchange
- Nasdaq
- Industry
- Biological Products, (No Diagnostic Substances)
- SEC CIK
- 0001806310
In the last 90 days, Taysha Gene Therapies, Inc. insiders filed 0 open-market purchases and 1 sale; 208 institutions reported holding it in 13F filings for Q2 2026, worth $2.03B in total; no superinvestor holds it.
13F holders, Q4 2025
Institutional positions in Taysha Gene Therapies, Inc. as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 195
- +42 vs. Q3 2025
- Shares held
- 269.0M
- +8.09M (+3.1%) vs. Q3 2025
- Total value
- $1.48B
- +$625.8M (+73.3%) vs. Q3 2025
- New holders
- 64
- 62 more added
- Sold out
- 22
- 46 more reduced
2 institutions that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting TSHA on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 208 | $2.03B |
| Q1 2026 | 191 | $1.18B |
| Q4 2025 | 195 | $1.48B |
| Q3 2025 | 155 | $865.6M |
| Q2 2025 | 150 | $595.4M |
| Q1 2025 | 127 | $232.0M |
| Q4 2024 | 131 | $289.8M |
| Q3 2024 | 119 | $315.5M |
| Q2 2024 | 107 | $354.3M |
| Q1 2024 | 109 | $402.2M |
| Q4 2023 | 87 | $230.3M |
| Q3 2023 | 63 | $410.6M |
| Q2 2023 | 39 | $9.05M |
| Q1 2023 | 44 | $13.3M |
| Q4 2022 | 52 | $43.8M |
| Q3 2022 | 54 | $27.0M |
| Q2 2022 | 59 | $54.7M |
| Q1 2022 | 71 | $110.9M |
| Q4 2021 | 65 | $215.6M |
| Q3 2021 | 48 | $361.9M |
| Q2 2021 | 49 | $388.6M |
| Q1 2021 | 46 | $358.5M |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Taysha Gene Therapies, Inc.; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Ra Capital Management, L.P. | 23,555,648 | $129.6M | 1.33% | 00.0% | Unchanged |
| Avoro Capital Advisors LLC | 21,700,000 | $119.3M | 1.17% | 00.0% | Unchanged |
| BlackRock, Inc. | 18,643,129 | $102.5M | 0.00% | +2,278,268+13.9% | Added |
| Morgan Stanley | 18,078,518 | $99.4M | 0.01% | −1,229,085−6.4% | Reduced |
| RTW Investments, LP | 16,398,297 | $90.2M | 0.90% | −7,955,994−32.7% | Reduced |
| Vestal Point Capital, LP | 13,750,000 | $75.6M | 2.77% | +8,250,000+150.0% | Added |
| Goldman Sachs Group Inc | 13,692,739 | $75.3M | 0.01% | +309,031+2.3% | Added |
| FMR LLC | 13,528,366 | $74.4M | 0.00% | −1,065,046−7.3% | Reduced |
| Vanguard Group Inc | 13,267,805 | $73.0M | 0.00% | +418,192+3.3% | Added |
| State Street Corp | 10,790,084 | $59.3M | 0.00% | +3,553,619+49.1% | Added |
| Siren, L.L.C. | 10,129,913 | $55.7M | 1.66% | −884,824−8.0% | Reduced |
| Octagon Capital Advisors LP | 8,859,911 | $48.7M | 6.10% | −207,589−2.3% | Reduced |
| Polar Capital Holdings Plc | 7,931,403 | $43.6M | 0.20% | +2,637,524+49.8% | Added |
| Barclays PLC | 5,539,001 | $30.5M | 0.01% | +390,889+7.6% | Added |
| Geode Capital Management, LLC | 5,387,026 | $29.6M | 0.00% | +212,510+4.1% | Added |
| D. E. Shaw & Co., Inc. | 4,013,635 | $22.1M | 0.02% | +1,307,201+48.3% | Added |
| Baker Bros. Advisors LP | 4,004,756 | $22.0M | 0.13% | 00.0% | Unchanged |
| Point72 Asset Management, L.P. | 3,868,682 | $21.3M | 0.03% | −3,462,788−47.2% | Reduced |
| Healthcare of Ontario Pension Plan Trust Fund | 3,722,000 | $20.5M | 0.03% | +3,722,000 | New |
| Affinity Asset Advisors, LLC | 3,300,000 | $18.1M | 1.30% | +300,000+10.0% | Added |
| Millennium Management LLC | 3,178,863 | $17.5M | 0.01% | −847,259−21.0% | Reduced |
| Deerfield Management Company, L.P. (Series C) | 2,722,165 | $15.0M | 0.19% | −2,663,835−49.5% | Reduced |
| ADAR1 Capital Management, LLC | 2,495,809 | $13.7M | 1.03% | −339,871−12.0% | Reduced |
| Charles Schwab Investment Management Inc | 1,902,978 | $10.5M | 0.00% | +56,468+3.1% | Added |
| Citadel Advisors LLC | 1,854,855 | $10.2M | 0.01% | +1,487,546+405.0% | Added |
| Norges Bank | 1,837,800 | $10.1M | 0.00% | +1,837,800 | New |
| B Group, Inc. | 1,800,556 | $9.90M | 7.34% | 00.0% | Unchanged |
| Casdin Capital, LLC | 1,500,000 | $8.25M | 0.51% | +1,500,000 | New |
| Invesco Ltd. | 1,332,780 | $7.33M | 0.00% | +1,052,987+376.3% | Added |
| GordonMD Global Investments LP | 1,330,901 | $7.32M | 5.25% | +1,330,901 | New |
| Adage Capital Partners GP, L.L.C. | 1,328,000 | $7.30M | 0.01% | −2,000,000−60.1% | Reduced |
| Rice Hall James & Associates, LLC | 1,270,645 | $6.99M | 0.38% | +692,527+119.8% | Added |
| Northern Trust Corp | 1,237,987 | $6.81M | 0.00% | −479,191−27.9% | Reduced |
| Palo Alto Investors LP | 1,183,195 | $6.51M | 0.91% | −62,838−5.0% | Reduced |
| Bank of America Corp | 1,152,680 | $6.34M | 0.00% | −154,607−11.8% | Reduced |
| Standard Life Aberdeen plc | 1,021,063 | $5.62M | 0.01% | +1,021,063 | New |
| Superstring Capital Management LP | 980,768 | $5.39M | 2.89% | +980,768 | New |
| EAM Investors, LLC | 823,758 | $4.53M | 0.50% | +823,758 | New |
| Quantum Private Wealth, LLC | 819,715 | $4.51M | 1.32% | −2,361−0.3% | Reduced |
| SG Americas Securities, LLC | 781,474 | $4.30M | 0.01% | +748,525+2,271.8% | Added |
| JPMorgan Chase & Co | 774,412 | $4.26M | 0.00% | +478,168+161.4% | Added |
| Sands Capital Ventures, LLC | 724,873 | $3.99M | 0.77% | 00.0% | Unchanged |
| Wellington Management Group LLP | 711,235 | $3.91M | 0.00% | +143,229+25.2% | Added |
| Granahan Investment Management Inc | 703,971 | $3.87M | 0.17% | −412,658−37.0% | Reduced |
| Bank of New York Mellon Corp | 624,367 | $3.43M | 0.00% | −472−0.1% | Reduced |
| Nuveen, LLC | 545,286 | $3.00M | 0.00% | +38,076+7.5% | Added |
| Woodline Partners LP | 500,000 | $2.75M | 0.01% | 00.0% | Unchanged |
| Dimensional Fund Advisors LP | 490,472 | $2.70M | 0.00% | +145,309+42.1% | Added |
| Squarepoint Ops LLC | 471,577 | $2.59M | 0.01% | +273,225+137.7% | Added |
| Ally Bridge Group (NY) LLC | 457,132 | $2.51M | 3.99% | −1,440,980−75.9% | Reduced |
| Acuta Capital Partners, LLC | 454,827 | $2.50M | 1.70% | 00.0% | Unchanged |
| HRT Financial LP | 409,254 | $2.25M | 0.01% | +409,254 | New |
| UBS Group AG | 383,043 | $2.11M | 0.00% | −256,313−40.1% | Reduced |
| Sphera Funds Management Ltd. | 368,146 | $2.02M | 0.42% | −40,000−9.8% | Reduced |
| Two Sigma Investments, LP | 351,126 | $1.93M | 0.00% | +285,021+431.2% | Added |
| Rafferty Asset Management, LLC | 344,784 | $1.90M | 0.01% | +104,999+43.8% | Added |
| Boothbay Fund Management, LLC | 309,481 | $1.70M | 0.04% | −106,126−25.5% | Reduced |
| Hennion & Walsh Asset Management, Inc. | 308,457 | $1.70M | 0.06% | +308,457 | New |
| Wells Fargo & Company | 305,086 | $1.68M | 0.00% | +159,988+110.3% | Added |
| Capricorn Fund Managers Ltd | 300,000 | $1.65M | 0.40% | +300,000 | New |
| Colony Group, LLC | 295,516 | $1.63M | 0.00% | +295,516 | New |
| American Century Companies Inc | 288,535 | $1.59M | 0.00% | +249,979+648.4% | Added |
| Ensign Peak Advisors, Inc | 275,111 | $1.51M | 0.00% | +275,111 | New |
| Swiss National Bank | 268,800 | $1.48M | 0.00% | +268,800 | New |
| Oracle Investment Management Inc | 265,000 | $1.46M | 0.96% | +265,000 | New |
| Nomura Holdings Inc | 259,339 | $1.43M | 0.00% | +259,339 | New |
| Rhumbline Advisers | 257,440 | $1.42M | 0.00% | −31,419−10.9% | Reduced |
| Alps Advisors Inc | 224,920 | $1.24M | 0.01% | +224,920 | New |
| Voya Investment Management LLC | 218,185 | $1.20M | 0.00% | +181,685+497.8% | Added |
| Gsa Capital Partners LLP | 208,016 | $1.14M | 0.10% | −269,733−56.5% | Reduced |
| Victory Capital Management Inc | 195,764 | $1.08M | 0.00% | +170,164+664.7% | Added |
| StemPoint Capital LP | 182,130 | $1.00M | 0.17% | −657,539−78.3% | Reduced |
| Wexford Capital LP | 180,853 | $994.7K | 0.26% | +177,353+5,067.2% | Added |
| Alliancebernstein L.P. | 179,640 | $988.0K | 0.00% | 00.0% | Unchanged |
| Palumbo Wealth Management LLC | 178,007 | $979.0K | 0.24% | +20,654+13.1% | Added |
| BNP Paribas Arbitrage, SA | 172,482 | $948.7K | 0.00% | +126,448+274.7% | Added |
| Renaissance Technologies LLC | 171,100 | $941.0K | 0.00% | +171,100 | New |
| AQR Capital Management LLC | 168,862 | $928.7K | 0.00% | +17,862+11.8% | Added |
| UBS Asset Management Americas Inc | 167,500 | $921.3K | 0.00% | +167,500 | New |
| Seven Fleet Capital Management LP | 167,223 | $919.7K | 0.62% | +167,223 | New |
| Privium Fund Management B.V. | 164,900 | $907.0K | 0.17% | +30,000+22.2% | Added |
| Jane Street Group, LLC | 163,146 | $897.3K | 0.00% | −393,639−70.7% | Reduced |
| Deutsche Bank AG | 160,779 | $884.3K | 0.00% | +37,980+30.9% | Added |
| Polen Capital Management LLC | 156,586 | $861.2K | 0.00% | +156,586 | New |
| Chicago Partners Investment Group LLC | 166,541 | $776.1K | 0.02% | +2,504+1.5% | Added |
| Two Sigma Advisers, LP | 139,581 | $767.7K | 0.00% | +139,581 | New |
| California State Teachers Retirement System | 138,580 | $762.2K | 0.00% | +128,207+1,236.0% | Added |
| Legal & General Group Plc | 133,146 | $732.3K | 0.00% | +109,997+475.2% | Added |
| Profund Advisors LLC | 128,590 | $707.2K | 0.02% | +75,224+141.0% | Added |
| Susquehanna International Group, LLP | 124,975 | $687.4K | 0.00% | +103,233+474.8% | Added |
| Mirae Asset Global ETFs Holdings Ltd. | 122,639 | $677.7K | 0.00% | +11,615+10.5% | Added |
| Price T Rowe Associates Inc | 121,814 | $670.0K | 0.00% | +7,979+7.0% | Added |
| MetLife Investment Management | 113,266 | $623.0K | 0.00% | −13,778−10.8% | Reduced |
| State of Wisconsin Investment Board | 113,178 | $622.5K | 0.00% | +70,229+163.5% | Added |
| Franklin Resources Inc | 108,399 | $596.2K | 0.00% | 00.0% | Unchanged |
| Prudential Financial Inc | 86,730 | $477.0K | 0.00% | +58,385+206.0% | Added |
| Intech Investment Management LLC | 71,069 | $390.9K | 0.00% | +2,443+3.6% | Added |
| Canada Pension Plan Investment Board | 68,900 | $378.9K | 0.00% | +68,900 | New |
| Janus Henderson Group PLC | 69,000 | $378.5K | 0.00% | +69,000 | New |
| New York State Common Retirement Fund | 67,500 | $371.3K | 0.00% | −100−0.1% | Reduced |