Taysha Gene Therapies, Inc.
TSHA- Exchange
- Nasdaq
- Industry
- Biological Products, (No Diagnostic Substances)
- SEC CIK
- 0001806310
In the last 90 days, Taysha Gene Therapies, Inc. insiders filed 0 open-market purchases and 1 sale; 208 institutions reported holding it in 13F filings for Q2 2026, worth $2.03B in total; no superinvestor holds it.
13F holders, Q3 2025
Institutional positions in Taysha Gene Therapies, Inc. as of Sep 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 155
- +8 vs. Q2 2025
- Shares held
- 264.6M
- +6.95M (+2.7%) vs. Q2 2025
- Total value
- $865.6M
- +$270.3M (+45.4%) vs. Q2 2025
- New holders
- 28
- 61 more added
- Sold out
- 20
- 34 more reduced
3 institutions that held it in Q2 2025 haven't filed for Q3 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q2 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting TSHA on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 208 | $2.03B |
| Q1 2026 | 191 | $1.18B |
| Q4 2025 | 195 | $1.48B |
| Q3 2025 | 155 | $865.6M |
| Q2 2025 | 150 | $595.4M |
| Q1 2025 | 127 | $232.0M |
| Q4 2024 | 131 | $289.8M |
| Q3 2024 | 119 | $315.5M |
| Q2 2024 | 107 | $354.3M |
| Q1 2024 | 109 | $402.2M |
| Q4 2023 | 87 | $230.3M |
| Q3 2023 | 63 | $410.6M |
| Q2 2023 | 39 | $9.05M |
| Q1 2023 | 44 | $13.3M |
| Q4 2022 | 52 | $43.8M |
| Q3 2022 | 54 | $27.0M |
| Q2 2022 | 59 | $54.7M |
| Q1 2022 | 71 | $110.9M |
| Q4 2021 | 65 | $215.6M |
| Q3 2021 | 48 | $361.9M |
| Q2 2021 | 49 | $388.6M |
| Q1 2021 | 46 | $358.5M |
Institutions, Q3 2025
Shares, value and share of portfolio for each institution holding Taysha Gene Therapies, Inc.; share changes are against Q2 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| RTW Investments, LP | 24,354,291 | $79.6M | 0.98% | −667,293−2.7% | Reduced |
| Ra Capital Management, L.P. | 23,555,648 | $77.0M | 0.95% | 00.0% | Unchanged |
| Avoro Capital Advisors LLC | 21,700,000 | $71.0M | 0.92% | 00.0% | Unchanged |
| Morgan Stanley | 19,307,603 | $63.1M | 0.00% | +2,442,521+14.5% | Added |
| BlackRock, Inc. | 16,364,861 | $53.5M | 0.00% | +3,061,086+23.0% | Added |
| FMR LLC | 14,593,412 | $47.7M | 0.00% | −1,034,410−6.6% | Reduced |
| Goldman Sachs Group Inc | 13,383,708 | $43.8M | 0.01% | +796,008+6.3% | Added |
| Vanguard Group Inc | 12,849,613 | $42.0M | 0.00% | +1,955,486+17.9% | Added |
| Siren, L.L.C. | 11,014,737 | $36.0M | 1.41% | 00.0% | Unchanged |
| Octagon Capital Advisors LP | 9,067,500 | $29.7M | 4.63% | −3,525,000−28.0% | Reduced |
| Point72 Asset Management, L.P. | 7,331,470 | $24.0M | 0.05% | +13,856+0.2% | Added |
| State Street Corp | 7,236,465 | $23.7M | 0.00% | +2,098,155+40.8% | Added |
| Vestal Point Capital, LP | 5,500,000 | $18.0M | 0.82% | +2,500,000+83.3% | Added |
| Deerfield Management Company, L.P. (Series C) | 5,386,000 | $17.6M | 0.27% | 00.0% | Unchanged |
| Polar Capital Holdings Plc | 5,293,879 | $17.3M | 0.08% | +293,879+5.9% | Added |
| Geode Capital Management, LLC | 5,174,516 | $16.9M | 0.00% | +1,380,944+36.4% | Added |
| Barclays PLC | 5,148,112 | $16.8M | 0.01% | +4,697,611+1,042.8% | Added |
| Millennium Management LLC | 4,026,122 | $13.2M | 0.01% | +1,090,394+37.1% | Added |
| Baker Bros. Advisors LP | 4,004,756 | $13.1M | 0.09% | 00.0% | Unchanged |
| Tybourne Capital Management (HK) Ltd | 3,700,000 | $12.1M | 39.11% | −395,000−9.6% | Reduced |
| Adage Capital Partners GP, L.L.C. | 3,328,000 | $10.9M | 0.02% | −1,511,000−31.2% | Reduced |
| Affinity Asset Advisors, LLC | 3,000,000 | $9.81M | 0.91% | +2,800,000+1,400.0% | Added |
| ADAR1 Capital Management, LLC | 2,835,680 | $9.27M | 0.92% | −174,190−5.8% | Reduced |
| D. E. Shaw & Co., Inc. | 2,706,434 | $8.85M | 0.01% | +2,304,925+574.1% | Added |
| Jefferies Financial Group Inc. | 2,156,642 | $7.05M | 0.06% | −8,157,091−79.1% | Reduced |
| Toronto Dominion Bank | 1,923,962 | $6.29M | 0.01% | −2,804,844−59.3% | Reduced |
| Ally Bridge Group (NY) LLC | 1,898,112 | $6.21M | 5.20% | +1,898,112 | New |
| Charles Schwab Investment Management Inc | 1,846,510 | $6.04M | 0.00% | +1,354,801+275.5% | Added |
| B Group, Inc. | 1,800,556 | $5.89M | 5.63% | 00.0% | Unchanged |
| Northern Trust Corp | 1,717,178 | $5.62M | 0.00% | +388,437+29.2% | Added |
| Great Point Partners LLC | 1,500,000 | $4.91M | 2.05% | 00.0% | Unchanged |
| Bank of America Corp | 1,307,287 | $4.27M | 0.00% | +576,559+78.9% | Added |
| Palo Alto Investors LP | 1,246,033 | $4.07M | 0.75% | 00.0% | Unchanged |
| Granahan Investment Management Inc | 1,116,629 | $3.65M | 0.15% | +158,136+16.5% | Added |
| Tang Capital Management LLC | 900,000 | $2.94M | 0.11% | 00.0% | Unchanged |
| StemPoint Capital LP | 839,669 | $2.75M | 0.55% | −364,272−30.3% | Reduced |
| Quantum Private Wealth, LLC | 822,076 | $2.69M | 0.79% | +6,100+0.7% | Added |
| Sands Capital Ventures, LLC | 724,873 | $2.37M | 0.52% | 00.0% | Unchanged |
| Alphabet Inc. | 640,882 | $2.10M | 0.09% | 00.0% | Unchanged |
| UBS Group AG | 639,356 | $2.09M | 0.00% | +378,117+144.7% | Added |
| Bank of New York Mellon Corp | 624,839 | $2.04M | 0.00% | +166,180+36.2% | Added |
| Anson Funds Management LP | 603,500 | $1.97M | 0.22% | −200,000−24.9% | Reduced |
| Royal Bank of Canada | 583,375 | $1.91M | 0.00% | +88,064+17.8% | Added |
| Rice Hall James & Associates, LLC | 578,118 | $1.89M | 0.10% | +578,118 | New |
| Wellington Management Group LLP | 568,006 | $1.86M | 0.00% | −67,962−10.7% | Reduced |
| Jane Street Group, LLC | 556,785 | $1.82M | 0.00% | +419,791+306.4% | Added |
| Nuveen, LLC | 507,210 | $1.66M | 0.00% | +42,066+9.0% | Added |
| Woodline Partners LP | 500,000 | $1.64M | 0.01% | −500,254−50.0% | Reduced |
| Gsa Capital Partners LLP | 477,749 | $1.56M | 0.13% | +433,059+969.0% | Added |
| Marshall Wace, LLP | 476,865 | $1.56M | 0.00% | +397,367+499.8% | Added |
| Acuta Capital Partners, LLC | 454,827 | $1.49M | 1.54% | −30,842−6.4% | Reduced |
| Boothbay Fund Management, LLC | 415,607 | $1.36M | 0.04% | +415,607 | New |
| Sphera Funds Management Ltd. | 408,146 | $1.33M | 0.32% | −11,854−2.8% | Reduced |
| Citadel Advisors LLC | 367,309 | $1.20M | 0.00% | −161,684−30.6% | Reduced |
| Dimensional Fund Advisors LP | 345,163 | $1.13M | 0.00% | +345,163 | New |
| Kovitz Investment Group Partners, LLC | 298,667 | $976.6K | 0.00% | 00.0% | Unchanged |
| JPMorgan Chase & Co | 296,244 | $968.7K | 0.00% | +73,595+33.1% | Added |
| Rhumbline Advisers | 288,859 | $944.6K | 0.00% | +55,603+23.8% | Added |
| Invesco Ltd. | 279,793 | $914.9K | 0.00% | +76,122+37.4% | Added |
| Chicago Partners Investment Group LLC | 164,037 | $818.5K | 0.02% | +271+0.2% | Added |
| Rafferty Asset Management, LLC | 239,785 | $784.1K | 0.00% | +121,102+102.0% | Added |
| Squarepoint Ops LLC | 198,352 | $648.6K | 0.00% | +98,126+97.9% | Added |
| Alliancebernstein L.P. | 179,640 | $587.4K | 0.00% | +200.0% | Added |
| Readystate Asset Management LP | 161,972 | $529.6K | 0.03% | +161,972 | New |
| Palumbo Wealth Management LLC | 157,353 | $514.5K | 0.16% | +157,353 | New |
| AQR Capital Management LLC | 151,000 | $493.8K | 0.00% | +15,234+11.2% | Added |
| Wells Fargo & Company | 145,098 | $474.5K | 0.00% | +37,864+35.3% | Added |
| Privium Fund Management B.V. | 134,900 | $441.1K | 0.08% | 00.0% | Unchanged |
| MetLife Investment Management | 127,044 | $415.4K | 0.00% | +18,966+17.5% | Added |
| Deutsche Bank AG | 122,799 | $401.6K | 0.00% | +15,083+14.0% | Added |
| Price T Rowe Associates Inc | 113,835 | $373.0K | 0.00% | +29,232+34.6% | Added |
| Mirae Asset Global ETFs Holdings Ltd. | 111,024 | $361.7K | 0.00% | +14,481+15.0% | Added |
| Franklin Resources Inc | 108,399 | $354.5K | 0.00% | 00.0% | Unchanged |
| Mitsubishi UFJ Kokusai Asset Management Co., Ltd. | 80,732 | $264.0K | 0.00% | +161+0.2% | Added |
| Manufacturers Life Insurance Company, The | 69,857 | $228.4K | 0.00% | +8,852+14.5% | Added |
| Intech Investment Management LLC | 68,626 | $224.4K | 0.00% | −13,569−16.5% | Reduced |
| New York State Common Retirement Fund | 67,600 | $221.1K | 0.00% | +46,500+220.4% | Added |
| Militia Capital Partners, LP | 66,800 | $218.4K | 0.10% | 00.0% | Unchanged |
| Two Sigma Investments, LP | 66,105 | $216.2K | 0.00% | +33,423+102.3% | Added |
| Commonwealth Equity Services, LLC | 58,257 | $191.0K | 0.00% | −1,779−3.0% | Reduced |
| Police & Firemen's Retirement System of New Jersey | 57,168 | $186.9K | 0.00% | +11,490+25.2% | Added |
| Engineers Gate Manager LP | 53,483 | $174.9K | 0.00% | −11,134−17.2% | Reduced |
| Profund Advisors LLC | 53,366 | $174.5K | 0.01% | +26,767+100.6% | Added |
| Jain Global LLC | 52,608 | $172.0K | 0.00% | +52,608 | New |
| Creative Planning | 52,226 | $170.8K | 0.00% | +245+0.5% | Added |
| Axq Capital, LP | 49,677 | $162.4K | 0.06% | −7,323−12.8% | Reduced |
| Virtu Financial LLC | 48,123 | $157.0K | 0.01% | +48,123 | New |
| China Universal Asset Management Co., Ltd. | 47,817 | $156.4K | 0.01% | −4,710−9.0% | Reduced |
| Quadrature Capital Ltd | 47,328 | $154.3K | 0.00% | −114,612−70.8% | Reduced |
| Brevan Howard Capital Management LP | 46,643 | $152.5K | 0.00% | +46,643 | New |
| ProShare Advisors LLC | 46,039 | $150.5K | 0.00% | +2,293+5.2% | Added |
| BNP Paribas Arbitrage, SA | 46,034 | $150.5K | 0.00% | +27,443+147.6% | Added |
| Williams & Novak, LLC | 45,000 | $147.2K | 0.11% | 00.0% | Unchanged |
| State of Wisconsin Investment Board | 42,949 | $140.4K | 0.00% | +42,949 | New |
| Virtus Investment Advisers, Inc. | 42,938 | $140.4K | 0.04% | +7,454+21.0% | Added |
| American Century Companies Inc | 38,556 | $126.1K | 0.00% | +38,556 | New |
| Voya Investment Management LLC | 36,500 | $119.4K | 0.00% | −10,669−22.6% | Reduced |
| Citigroup Inc | 33,495 | $109.5K | 0.00% | −96,822−74.3% | Reduced |
| SG Americas Securities, LLC | 32,949 | $108.0K | 0.00% | −460,352−93.3% | Reduced |
| First Manhattan Co | 28,500 | $93.2K | 0.00% | 00.0% | Unchanged |