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Taysha Gene Therapies, Inc.

TSHA
Exchange
Nasdaq
Industry
Biological Products, (No Diagnostic Substances)
SEC CIK
0001806310

In the last 90 days, Taysha Gene Therapies, Inc. insiders filed 0 open-market purchases and 1 sale; 208 institutions reported holding it in 13F filings for Q2 2026, worth $2.03B in total; no superinvestor holds it.

13F holders, Q4 2021

Institutional positions in Taysha Gene Therapies, Inc. as of Dec 31, 2021. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
65
+17 vs. Q3 2021
Shares held
18.5M
−933.4K (−4.8%) vs. Q3 2021
Total value
$215.6M
−$146.3M (−40.4%) vs. Q3 2021
New holders
22
23 more added
Sold out
5
8 more reduced

Compare with Q3 2021: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting TSHA on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ4 2021: 65 institutions
Q1 2021: 46 institutionsQ2 2021: 49 institutionsQ3 2021: 48 institutionsQ4 2021: 65 institutionsQ1 2022: 71 institutionsQ2 2022: 59 institutionsQ3 2022: 54 institutionsQ4 2022: 52 institutionsQ1 2023: 44 institutionsQ2 2023: 39 institutionsQ3 2023: 63 institutionsQ4 2023: 87 institutionsQ1 2024: 109 institutionsQ2 2024: 107 institutionsQ3 2024: 119 institutionsQ4 2024: 131 institutionsQ1 2025: 127 institutionsQ2 2025: 150 institutionsQ3 2025: 155 institutionsQ4 2025: 195 institutionsQ1 2026: 191 institutionsQ2 2026: 208 institutions
Value heldQ4 2021: $215.6M
Q1 2021: $358.5MQ2 2021: $388.6MQ3 2021: $361.9MQ4 2021: $215.6MQ1 2022: $110.9MQ2 2022: $54.7MQ3 2022: $27.0MQ4 2022: $43.8MQ1 2023: $13.3MQ2 2023: $9.05MQ3 2023: $410.6MQ4 2023: $230.3MQ1 2024: $402.2MQ2 2024: $354.3MQ3 2024: $315.5MQ4 2024: $289.8MQ1 2025: $232.0MQ2 2025: $595.4MQ3 2025: $865.6MQ4 2025: $1.48BQ1 2026: $1.18BQ2 2026: $2.03B
Institutions holding TSHA and their total value by quarter
QuarterHoldersValue
Q2 2026208$2.03B
Q1 2026191$1.18B
Q4 2025195$1.48B
Q3 2025155$865.6M
Q2 2025150$595.4M
Q1 2025127$232.0M
Q4 2024131$289.8M
Q3 2024119$315.5M
Q2 2024107$354.3M
Q1 2024109$402.2M
Q4 202387$230.3M
Q3 202363$410.6M
Q2 202339$9.05M
Q1 202344$13.3M
Q4 202252$43.8M
Q3 202254$27.0M
Q2 202259$54.7M
Q1 202271$110.9M
Q4 202165$215.6M
Q3 202148$361.9M
Q2 202149$388.6M
Q1 202146$358.5M

Institutions, Q4 2021

Shares, value and share of portfolio for each institution holding Taysha Gene Therapies, Inc.; share changes are against Q3 2021.

Institutions holding TSHA in Q4 2021
InstitutionSharesValue% of portfolioChange in sharesAction
FMR LLC4,280,494$49.9M0.00%−1,478,180−25.7%Reduced
BlackRock Inc.3,032,963$35.3M0.00%+10,994+0.4%Added
Nantahala Capital Management, LLC1,456,147$17.0M1.06%+206,838+16.6%Added
Franklin Resources Inc1,308,533$15.2M0.01%−1,677−0.1%Reduced
University of Texas/Texas Am Investment Managment Co1,147,040$13.4M6.07%00.0%Unchanged
Artal Group S.A.1,040,882$12.1M0.36%00.0%Unchanged
Vanguard Group Inc883,647$10.3M0.00%+77,929+9.7%Added
Sands Capital Ventures, LLC724,873$8.45M1.25%00.0%Unchanged
TimesSquare Capital Management, LLC659,100$7.68M0.07%+8,500+1.3%Added
Alphabet Inc.640,882$7.47M0.18%00.0%Unchanged
Tybourne Capital Management (HK) Ltd500,000$5.83M0.17%00.0%Unchanged
State Street Corp464,169$5.41M0.00%+111,983+31.8%Added
Geode Capital Management, LLC390,851$4.55M0.00%+27,835+7.7%Added
JPMorgan Chase & Co237,559$2.77M0.00%−182,803−43.5%Reduced
Northern Trust Corp214,970$2.50M0.00%+3,042+1.4%Added
Charles Schwab Investment Management Inc162,560$1.89M0.00%+4,153+2.6%Added
Quantum Private Wealth, LLC145,718$1.70M0.64%+145,718New
Morgan Stanley142,345$1.66M0.00%+17,251+13.8%Added
Nuveen Asset Management, LLC102,568$1.20M0.00%+10,194+11.0%Added
Bank of New York Mellon Corp76,170$887.0K0.00%+2,425+3.3%Added
Two Sigma Investments, LP69,229$807.0K0.00%+69,229New
Bank of America Corp61,646$718.0K0.00%+28,969+88.7%Added
Millennium Management LLC60,049$700.0K0.00%+60,049New
Marshall Wace, LLP58,358$679.0K0.00%+58,358New
Goldman Sachs Group Inc53,048$618.0K0.00%+40,949+338.4%Added
UBS Group AG51,036$594.0K0.00%+17,653+52.9%Added
Gsa Capital Partners LLP40,885$476.0K0.06%+40,885New
Swiss National Bank37,500$437.0K0.00%00.0%Unchanged
Citadel Advisors LLC36,337$423.0K0.00%+36,337New
Two Sigma Advisers, LP34,100$397.0K0.00%+34,100New
Trexquant Investment LP29,631$345.0K0.02%+29,631New
Squarepoint Ops LLC29,210$340.0K0.00%+29,210New
State of Wisconsin Investment Board28,800$336.0K0.00%00.0%Unchanged
Davenport & Co LLC27,670$322.0K0.00%−55,100−66.6%Reduced
California State Teachers Retirement System26,690$311.0K0.00%+736+2.8%Added
Mitsubishi UFJ Kokusai Asset Management Co., Ltd.21,834$259.0K0.00%+21,834New
Jump Financial, LLC20,700$241.0K0.02%+20,700New
Rhumbline Advisers19,770$230.0K0.00%−361−1.8%Reduced
Cubist Systematic Strategies, LLC19,635$229.0K0.00%+19,635New
Legal & General Group Plc16,100$187.0K0.00%+8,993+126.5%Added
Credit Suisse AG14,756$172.0K0.00%+1,304+9.7%Added
New York State Common Retirement Fund14,287$166.0K0.00%−40−0.3%Reduced
Deutsche Bank AG13,824$161.0K0.00%+716+5.5%Added
Manufacturers Life Insurance Company, The12,964$151.0K0.00%+650+5.3%Added
American International Group, Inc.12,035$140.0K0.00%−149−1.2%Reduced
Virtus ETF Advisers LLC11,519$134.0K0.05%+3,251+39.3%Added
Citigroup Inc10,607$124.0K0.00%+7,286+219.4%Added
ProShare Advisors LLC10,368$121.0K0.00%+10,368New
683 Capital Management, LLC10,000$117.0K0.01%+10,000New
MetLife Investment Management9,509$110.8K0.00%00.0%Unchanged
Wells Fargo & Company9,459$110.0K0.00%+9,459New
Metropolitan Life Insurance Co7,280$84.8K0.00%00.0%Unchanged
Royal Bank of Canada4,615$53.0K0.00%+2,598+128.8%Added
Ameritas Investment Partners, Inc.1,745$20.0K0.00%00.0%Unchanged
Ensign Peak Advisors, Inc1,410$16.0K0.00%+1,410New
Tower Research Capital LLC (TRC)1,180$14.0K0.00%+390+49.4%Added
Captrust Financial Advisors1,021$12.0K0.00%00.0%Unchanged
Macquarie Group Ltd867$10.0K0.00%−1,343−60.8%Reduced
Simplex Trading, LLC902$10.0K0.00%+902New
US Bancorp524$6.00K0.00%+524New
Quantbot Technologies LP514$5.00K0.00%+514New
Advisor Group Holdings, Inc.241$3.00K0.00%00.0%Unchanged
Daiwa Securities Group Inc.112$1.00K0.00%+112New
Parallel Advisors, LLC45$1.00K0.00%+45New
CWM, LLC25$00.00%+25New
Perceptive Advisors LLC0$00.00%−320,440−100.0%Sold out
Granite Point Capital Management, L.P.0$00.00%−40,000−100.0%Sold out
Gilder Gagnon Howe & Co LLC0$00.00%−37,578−100.0%Sold out
SG Americas Securities, LLC0$00.00%−9,168−100.0%Sold out
Brewin Dolphin Ltd0$00.00%−250−100.0%Sold out