Taysha Gene Therapies, Inc.
TSHA- Exchange
- Nasdaq
- Industry
- Biological Products, (No Diagnostic Substances)
- SEC CIK
- 0001806310
In the last 90 days, Taysha Gene Therapies, Inc. insiders filed 0 open-market purchases and 1 sale; 208 institutions reported holding it in 13F filings for Q2 2026, worth $2.03B in total; no superinvestor holds it.
13F holders, Q2 2025
Institutional positions in Taysha Gene Therapies, Inc. as of Jun 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 150
- +24 vs. Q1 2025
- Shares held
- 257.7M
- +90.9M (+54.5%) vs. Q1 2025
- Total value
- $595.4M
- +$363.4M (+156.7%) vs. Q1 2025
- New holders
- 44
- 48 more added
- Sold out
- 20
- 34 more reduced
1 institution that held it in Q1 2025 haven't filed for Q2 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q1 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting TSHA on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 208 | $2.03B |
| Q1 2026 | 191 | $1.18B |
| Q4 2025 | 195 | $1.48B |
| Q3 2025 | 155 | $865.6M |
| Q2 2025 | 150 | $595.4M |
| Q1 2025 | 127 | $232.0M |
| Q4 2024 | 131 | $289.8M |
| Q3 2024 | 119 | $315.5M |
| Q2 2024 | 107 | $354.3M |
| Q1 2024 | 109 | $402.2M |
| Q4 2023 | 87 | $230.3M |
| Q3 2023 | 63 | $410.6M |
| Q2 2023 | 39 | $9.05M |
| Q1 2023 | 44 | $13.3M |
| Q4 2022 | 52 | $43.8M |
| Q3 2022 | 54 | $27.0M |
| Q2 2022 | 59 | $54.7M |
| Q1 2022 | 71 | $110.9M |
| Q4 2021 | 65 | $215.6M |
| Q3 2021 | 48 | $361.9M |
| Q2 2021 | 49 | $388.6M |
| Q1 2021 | 46 | $358.5M |
Institutions, Q2 2025
Shares, value and share of portfolio for each institution holding Taysha Gene Therapies, Inc.; share changes are against Q1 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| RTW Investments, LP | 25,021,584 | $57.8M | 0.82% | +6,233,718+33.2% | Added |
| Ra Capital Management, L.P. | 23,555,648 | $54.4M | 0.92% | +12,683,145+116.7% | Added |
| Avoro Capital Advisors LLC | 21,700,000 | $50.1M | 0.88% | +1,700,001+8.5% | Added |
| Morgan Stanley | 16,865,082 | $39.0M | 0.00% | +18,708+0.1% | Added |
| FMR LLC | 15,627,822 | $36.1M | 0.00% | −4,1320.0% | Reduced |
| BlackRock, Inc. | 13,303,775 | $30.7M | 0.00% | −285,403−2.1% | Reduced |
| Octagon Capital Advisors LP | 12,592,500 | $29.1M | 6.39% | +1,892,500+17.7% | Added |
| Goldman Sachs Group Inc | 12,587,700 | $29.1M | 0.00% | +12,228,693+3,406.3% | Added |
| Siren, L.L.C. | 11,014,737 | $25.4M | 1.32% | +4,500,000+69.1% | Added |
| Vanguard Group Inc | 10,894,127 | $25.2M | 0.00% | +2,123,206+24.2% | Added |
| Jefferies Financial Group Inc. | 10,313,733 | $23.8M | 0.39% | +10,068,479+4,105.3% | Added |
| Point72 Asset Management, L.P. | 7,317,614 | $16.9M | 0.04% | +2,747,936+60.1% | Added |
| Deerfield Management Company, L.P. (Series C) | 5,386,000 | $12.4M | 0.23% | +5,386,000 | New |
| State Street Corp | 5,138,310 | $11.9M | 0.00% | +1,904,798+58.9% | Added |
| Polar Capital Holdings Plc | 5,000,000 | $11.6M | 0.06% | +2,000,000+66.7% | Added |
| Adage Capital Partners GP, L.L.C. | 4,839,000 | $11.2M | 0.02% | +4,839,000 | New |
| Toronto Dominion Bank | 4,728,806 | $10.9M | 0.02% | +4,728,806 | New |
| Tybourne Capital Management (HK) Ltd | 4,095,000 | $9.46M | 27.39% | +395,000+10.7% | Added |
| Baker Bros. Advisors LP | 4,004,756 | $9.25M | 0.09% | 00.0% | Unchanged |
| Geode Capital Management, LLC | 3,793,572 | $8.77M | 0.00% | +128,840+3.5% | Added |
| Suvretta Capital Management, LLC | 3,217,449 | $7.43M | 0.28% | +3,217,449 | New |
| ADAR1 Capital Management, LLC | 3,009,870 | $6.95M | 1.13% | +1,943,561+182.3% | Added |
| Vestal Point Capital, LP | 3,000,000 | $6.93M | 0.36% | +3,000,000 | New |
| MPM Oncology Impact Management LP | 2,953,562 | $6.82M | 1.18% | +2,953,562 | New |
| Millennium Management LLC | 2,935,728 | $6.78M | 0.01% | +1,163,074+65.6% | Added |
| B Group, Inc. | 1,800,556 | $4.16M | 3.59% | +545,000+43.4% | Added |
| Great Point Partners LLC | 1,500,000 | $3.46M | 2.25% | +1,500,000 | New |
| Northern Trust Corp | 1,328,741 | $3.07M | 0.00% | −102,925−7.2% | Reduced |
| Palo Alto Investors LP | 1,246,033 | $2.88M | 0.61% | −173,435−12.2% | Reduced |
| StemPoint Capital LP | 1,203,941 | $2.78M | 0.90% | +1,203,941 | New |
| Woodline Partners LP | 1,000,254 | $2.31M | 0.01% | +142,000+16.5% | Added |
| Granahan Investment Management Inc | 958,493 | $2.21M | 0.09% | −682,300−41.6% | Reduced |
| Tang Capital Management LLC | 900,000 | $2.08M | 0.11% | +900,000 | New |
| Quantum Private Wealth, LLC | 815,976 | $1.88M | 0.61% | +24,500+3.1% | Added |
| Anson Funds Management LP | 803,500 | $1.86M | 0.34% | +803,500 | New |
| Bank of America Corp | 730,728 | $1.69M | 0.00% | +93,886+14.7% | Added |
| Sands Capital Ventures, LLC | 724,873 | $1.67M | 0.33% | 00.0% | Unchanged |
| Alphabet Inc. | 640,882 | $1.48M | 0.07% | 00.0% | Unchanged |
| Wellington Management Group LLP | 635,968 | $1.47M | 0.00% | +10,770+1.7% | Added |
| Citadel Advisors LLC | 528,993 | $1.22M | 0.00% | +312,382+144.2% | Added |
| Royal Bank of Canada | 495,311 | $1.15M | 0.00% | +493,849+33,779.0% | Added |
| SG Americas Securities, LLC | 493,301 | $1.14M | 0.01% | +493,301 | New |
| Charles Schwab Investment Management Inc | 491,709 | $1.14M | 0.00% | −55,419−10.1% | Reduced |
| Acuta Capital Partners, LLC | 485,669 | $1.12M | 1.57% | +485,669 | New |
| Nuveen, LLC | 465,144 | $1.07M | 0.00% | −81,270−14.9% | Reduced |
| Bank of New York Mellon Corp | 458,659 | $1.06M | 0.00% | +5,239+1.2% | Added |
| Barclays PLC | 450,501 | $1.04M | 0.00% | −258,465−36.5% | Reduced |
| Sphera Funds Management Ltd. | 420,000 | $970.2K | 0.25% | +420,000 | New |
| D. E. Shaw & Co., Inc. | 401,509 | $927.5K | 0.00% | +401,509 | New |
| XTX Topco Ltd | 320,737 | $740.9K | 0.03% | +117,608+57.9% | Added |
| Kovitz Investment Group Partners, LLC | 298,667 | $689.9K | 0.00% | +5,889+2.0% | Added |
| UBS Group AG | 261,239 | $603.5K | 0.00% | −156,893−37.5% | Reduced |
| Rhumbline Advisers | 233,256 | $538.8K | 0.00% | +27,794+13.5% | Added |
| JPMorgan Chase & Co | 222,649 | $514.3K | 0.00% | −780,418−77.8% | Reduced |
| Susquehanna International Group, LLP | 212,572 | $491.0K | 0.00% | −14,900−6.6% | Reduced |
| Invesco Ltd. | 203,671 | $470.5K | 0.00% | +43,772+27.4% | Added |
| Affinity Asset Advisors, LLC | 200,000 | $462.0K | 0.07% | +200,000 | New |
| Chicago Partners Investment Group LLC | 163,766 | $440.5K | 0.01% | +47,201+40.5% | Added |
| Alliancebernstein L.P. | 179,620 | $414.9K | 0.00% | +71,370+65.9% | Added |
| Quadrature Capital Ltd | 161,940 | $373.3K | 0.01% | +161,940 | New |
| ExodusPoint Capital Management, LP | 148,357 | $343.0K | 0.00% | +148,357 | New |
| Jane Street Group, LLC | 136,994 | $316.5K | 0.00% | +136,994 | New |
| Privium Fund Management B.V. | 134,900 | $315.7K | 0.07% | 00.0% | Unchanged |
| AQR Capital Management LLC | 135,766 | $313.6K | 0.00% | +27,867+25.8% | Added |
| Citigroup Inc | 130,317 | $301.0K | 0.00% | −2,877−2.2% | Reduced |
| Rafferty Asset Management, LLC | 118,683 | $274.2K | 0.00% | +118,683 | New |
| Los Angeles Capital Management LLC | 117,740 | $272.0K | 0.00% | −25,070−17.6% | Reduced |
| Franklin Resources Inc | 108,399 | $250.4K | 0.00% | −7,839−6.7% | Reduced |
| MetLife Investment Management | 108,078 | $249.7K | 0.00% | +367+0.3% | Added |
| Deutsche Bank AG | 107,716 | $248.8K | 0.00% | −26,702−19.9% | Reduced |
| Wells Fargo & Company | 107,234 | $247.7K | 0.00% | −1,814−1.7% | Reduced |
| Squarepoint Ops LLC | 100,226 | $231.5K | 0.00% | +100,226 | New |
| Mirae Asset Global ETFs Holdings Ltd. | 96,543 | $223.4K | 0.00% | −6,531−6.3% | Reduced |
| Price T Rowe Associates Inc | 84,603 | $196.0K | 0.00% | +10,578+14.3% | Added |
| Intech Investment Management LLC | 82,195 | $189.9K | 0.00% | −17,717−17.7% | Reduced |
| Mitsubishi UFJ Kokusai Asset Management Co., Ltd. | 80,571 | $186.1K | 0.00% | +80,571 | New |
| Marshall Wace, LLP | 79,498 | $183.6K | 0.00% | +79,498 | New |
| Omers Administration Corp | 72,900 | $168.4K | 0.00% | +72,900 | New |
| EntryPoint Capital, LLC | 69,109 | $159.6K | 0.08% | −66,788−49.1% | Reduced |
| Militia Capital Partners, LP | 66,800 | $154.3K | 0.07% | +66,800 | New |
| Engineers Gate Manager LP | 64,617 | $149.3K | 0.00% | +64,617 | New |
| Manufacturers Life Insurance Company, The | 61,005 | $140.9K | 0.00% | −2,792−4.4% | Reduced |
| Commonwealth Equity Services, LLC | 60,036 | $139.0K | 0.00% | −33−0.1% | Reduced |
| Axq Capital, LP | 57,000 | $131.7K | 0.04% | +57,000 | New |
| Renaissance Technologies LLC | 54,900 | $126.8K | 0.00% | +54,900 | New |
| China Universal Asset Management Co., Ltd. | 52,527 | $121.3K | 0.01% | +11,407+27.7% | Added |
| Creative Planning | 51,981 | $120.1K | 0.00% | −26,354−33.6% | Reduced |
| Voya Investment Management LLC | 47,169 | $109.0K | 0.00% | −1,447−3.0% | Reduced |
| Police & Firemen's Retirement System of New Jersey | 45,678 | $105.5K | 0.00% | 00.0% | Unchanged |
| Williams & Novak, LLC | 45,000 | $104.0K | 0.09% | 00.0% | Unchanged |
| Gsa Capital Partners LLP | 44,690 | $103.0K | 0.01% | +44,690 | New |
| ProShare Advisors LLC | 43,746 | $101.1K | 0.00% | −3,449−7.3% | Reduced |
| Virtus Investment Advisers, Inc. | 35,484 | $82.0K | 0.03% | −37,473−51.4% | Reduced |
| Two Sigma Investments, LP | 32,682 | $75.5K | 0.00% | +32,682 | New |
| Ethic Inc. | 27,975 | $66.6K | 0.00% | +27,975 | New |
| First Manhattan Co | 28,500 | $65.8K | 0.00% | 00.0% | Unchanged |
| Leonteq Securities AG | 27,999 | $64.7K | 0.00% | −52,000−65.0% | Reduced |
| Profund Advisors LLC | 26,599 | $61.4K | 0.00% | +26,599 | New |
| Victory Capital Management Inc | 25,492 | $58.9K | 0.00% | +6,475+34.0% | Added |
| Point72 Asia (Singapore) Pte. Ltd. | 25,252 | $58.3K | 0.01% | +25,252 | New |