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Taysha Gene Therapies, Inc.

TSHA
Exchange
Nasdaq
Industry
Biological Products, (No Diagnostic Substances)
SEC CIK
0001806310

In the last 90 days, Taysha Gene Therapies, Inc. insiders filed 0 open-market purchases and 1 sale; 208 institutions reported holding it in 13F filings for Q2 2026, worth $2.03B in total; no superinvestor holds it.

13F holders, Q1 2022

Institutional positions in Taysha Gene Therapies, Inc. as of Mar 31, 2022. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
71
+6 vs. Q4 2021
Shares held
17.0M
−1.49M (−8.0%) vs. Q4 2021
Total value
$110.9M
−$104.7M (−48.6%) vs. Q4 2021
New holders
15
27 more added
Sold out
9
15 more reduced

Compare with Q4 2021: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting TSHA on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ1 2022: 71 institutions
Q1 2021: 46 institutionsQ2 2021: 49 institutionsQ3 2021: 48 institutionsQ4 2021: 65 institutionsQ1 2022: 71 institutionsQ2 2022: 59 institutionsQ3 2022: 54 institutionsQ4 2022: 52 institutionsQ1 2023: 44 institutionsQ2 2023: 39 institutionsQ3 2023: 63 institutionsQ4 2023: 87 institutionsQ1 2024: 109 institutionsQ2 2024: 107 institutionsQ3 2024: 119 institutionsQ4 2024: 131 institutionsQ1 2025: 127 institutionsQ2 2025: 150 institutionsQ3 2025: 155 institutionsQ4 2025: 195 institutionsQ1 2026: 191 institutionsQ2 2026: 208 institutions
Value heldQ1 2022: $110.9M
Q1 2021: $358.5MQ2 2021: $388.6MQ3 2021: $361.9MQ4 2021: $215.6MQ1 2022: $110.9MQ2 2022: $54.7MQ3 2022: $27.0MQ4 2022: $43.8MQ1 2023: $13.3MQ2 2023: $9.05MQ3 2023: $410.6MQ4 2023: $230.3MQ1 2024: $402.2MQ2 2024: $354.3MQ3 2024: $315.5MQ4 2024: $289.8MQ1 2025: $232.0MQ2 2025: $595.4MQ3 2025: $865.6MQ4 2025: $1.48BQ1 2026: $1.18BQ2 2026: $2.03B
Institutions holding TSHA and their total value by quarter
QuarterHoldersValue
Q2 2026208$2.03B
Q1 2026191$1.18B
Q4 2025195$1.48B
Q3 2025155$865.6M
Q2 2025150$595.4M
Q1 2025127$232.0M
Q4 2024131$289.8M
Q3 2024119$315.5M
Q2 2024107$354.3M
Q1 2024109$402.2M
Q4 202387$230.3M
Q3 202363$410.6M
Q2 202339$9.05M
Q1 202344$13.3M
Q4 202252$43.8M
Q3 202254$27.0M
Q2 202259$54.7M
Q1 202271$110.9M
Q4 202165$215.6M
Q3 202148$361.9M
Q2 202149$388.6M
Q1 202146$358.5M

Institutions, Q1 2022

Shares, value and share of portfolio for each institution holding Taysha Gene Therapies, Inc.; share changes are against Q4 2021.

Institutions holding TSHA in Q1 2022
InstitutionSharesValue% of portfolioChange in sharesAction
FMR LLC3,294,821$21.5M0.00%−985,673−23.0%Reduced
BlackRock Inc.2,193,703$14.3M0.00%−839,260−27.7%Reduced
Nantahala Capital Management, LLC1,333,947$8.70M0.60%−122,200−8.4%Reduced
Franklin Resources Inc1,300,668$8.48M0.00%−7,865−0.6%Reduced
Artal Group S.A.1,040,882$6.79M0.29%00.0%Unchanged
Vanguard Group Inc1,012,164$6.60M0.00%+128,517+14.5%Added
Sands Capital Ventures, LLC724,873$4.73M0.99%00.0%Unchanged
TimesSquare Capital Management, LLC665,900$4.34M0.05%+6,800+1.0%Added
Alphabet Inc.640,882$4.18M0.14%00.0%Unchanged
Tybourne Capital Management (HK) Ltd500,000$3.26M0.19%00.0%Unchanged
State Street Corp499,214$3.25M0.00%+35,045+7.6%Added
JPMorgan Chase & Co439,804$2.87M0.00%+202,245+85.1%Added
Geode Capital Management, LLC409,570$2.67M0.00%+18,719+4.8%Added
Renaissance Technologies LLC250,500$1.63M0.00%+250,500New
Citadel Advisors LLC208,749$1.36M0.00%+172,412+474.5%Added
Northern Trust Corp205,625$1.34M0.00%−9,345−4.3%Reduced
Two Sigma Investments, LP181,908$1.19M0.00%+112,679+162.8%Added
Morgan Stanley175,755$1.15M0.00%+33,410+23.5%Added
Charles Schwab Investment Management Inc165,345$1.08M0.00%+2,785+1.7%Added
Quantum Private Wealth, LLC151,974$990.0K0.43%+6,256+4.3%Added
Marshall Wace, LLP139,386$909.0K0.00%+81,028+138.8%Added
Two Sigma Advisers, LP136,300$889.0K0.00%+102,200+299.7%Added
Gsa Capital Partners LLP117,109$764.0K0.10%+76,224+186.4%Added
State of Wisconsin Investment Board103,100$672.0K0.00%+74,300+258.0%Added
Nuveen Asset Management, LLC105,426$665.0K0.00%+2,858+2.8%Added
Goldman Sachs Group Inc89,039$580.0K0.00%+35,991+67.8%Added
Bank of New York Mellon Corp78,237$510.0K0.00%+2,067+2.7%Added
D. E. Shaw & Co., Inc.74,734$487.0K0.00%+74,734New
Trexquant Investment LP71,483$466.0K0.02%+41,852+141.2%Added
Bank of America Corp71,358$465.0K0.00%+9,712+15.8%Added
UBS Group AG67,980$443.0K0.00%+16,944+33.2%Added
1623 Capital LLC46,763$305.0K0.16%+46,763New
Thompson Siegel & Walmsley LLC42,100$274.0K0.00%+42,100New
Barclays PLC44,387$273.0K0.00%+44,387New
Swiss National Bank41,000$267.0K0.00%+3,500+9.3%Added
Cubist Systematic Strategies, LLC33,694$220.0K0.00%+14,059+71.6%Added
Davenport & Co LLC27,670$180.0K0.00%00.0%Unchanged
Occudo Quantitative Strategies LP26,328$172.0K0.01%+26,328New
California State Teachers Retirement System24,435$159.0K0.00%−2,255−8.4%Reduced
Rhumbline Advisers22,389$146.0K0.00%+2,619+13.2%Added
Mitsubishi UFJ Kokusai Asset Management Co., Ltd.21,834$142.0K0.00%00.0%Unchanged
Schonfeld Strategic Advisors LLC20,000$131.0K0.00%+20,000New
Nisa Investment Advisors, LLC19,800$129.0K0.00%+19,800New
Parametric Portfolio Associates LLC18,928$123.0K0.00%+18,928New
Caption Management, LLC18,191$119.0K0.01%+18,191New
Legal & General Group Plc16,100$104.0K0.00%00.0%Unchanged
Credit Suisse AG15,201$99.0K0.00%+445+3.0%Added
New York State Common Retirement Fund14,291$93.0K0.00%+40.0%Added
Jump Financial, LLC13,700$89.0K0.00%−7,000−33.8%Reduced
Deutsche Bank AG12,366$81.0K0.00%−1,458−10.5%Reduced
Manufacturers Life Insurance Company, The11,233$73.2K0.00%−1,731−13.4%Reduced
American International Group, Inc.11,244$73.0K0.00%−791−6.6%Reduced
Virtus ETF Advisers LLC10,878$71.0K0.03%−641−5.6%Reduced
Sargent Investment Group, LLC10,656$69.0K0.02%+10,656New
Citigroup Inc10,316$67.0K0.00%−291−2.7%Reduced
683 Capital Management, LLC10,000$65.0K0.00%00.0%Unchanged
Amalgamated Bank3,535$23.0K0.00%+3,535New
Amalgamated Financial Corp.3,535$23.0K0.00%+3,535New
Quantbot Technologies LP2,929$19.0K0.00%+2,415+469.8%Added
Royal Bank of Canada2,411$16.0K0.00%−2,204−47.8%Reduced
Ameritas Investment Partners, Inc.1,745$11.0K0.00%00.0%Unchanged
Tower Research Capital LLC (TRC)1,600$10.0K0.00%+420+35.6%Added
Wells Fargo & Company1,445$9.00K0.00%−8,014−84.7%Reduced
Ensign Peak Advisors, Inc1,410$9.00K0.00%00.0%Unchanged
Captrust Financial Advisors1,021$7.00K0.00%00.0%Unchanged
Macquarie Group Ltd867$6.00K0.00%00.0%Unchanged
Simplex Trading, LLC320$2.00K0.00%−582−64.5%Reduced
Advisor Group Holdings, Inc.241$2.00K0.00%00.0%Unchanged
Daiwa Securities Group Inc.112$1.00K0.00%00.0%Unchanged
Signaturefd, LLC165$1.00K0.00%+165New
Tarbox Family Office, Inc.175$1.00K0.00%+175New
University of Texas/Texas Am Investment Managment Co0$00.00%−1,147,040−100.0%Sold out
Millennium Management LLC0$00.00%−60,049−100.0%Sold out
Squarepoint Ops LLC0$00.00%−29,210−100.0%Sold out
ProShare Advisors LLC0$00.00%−10,368−100.0%Sold out
MetLife Investment Management0$00.00%−9,509−100.0%Sold out
Metropolitan Life Insurance Co0$00.00%−7,280−100.0%Sold out
US Bancorp0$00.00%−524−100.0%Sold out
Parallel Advisors, LLC0$00.00%−45−100.0%Sold out
CWM, LLC0$00.00%−25−100.0%Sold out