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Taysha Gene Therapies, Inc.

TSHA
Exchange
Nasdaq
Industry
Biological Products, (No Diagnostic Substances)
SEC CIK
0001806310

In the last 90 days, Taysha Gene Therapies, Inc. insiders filed 0 open-market purchases and 1 sale; 208 institutions reported holding it in 13F filings for Q2 2026, worth $2.03B in total; no superinvestor holds it.

13F holders, Q3 2025

Institutional positions in Taysha Gene Therapies, Inc. as of Sep 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
155
+8 vs. Q2 2025
Shares held
264.6M
+6.95M (+2.7%) vs. Q2 2025
Total value
$865.6M
+$270.3M (+45.4%) vs. Q2 2025
New holders
28
61 more added
Sold out
20
34 more reduced

3 institutions that held it in Q2 2025 haven't filed for Q3 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.

Compare with Q2 2025: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting TSHA on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ3 2025: 155 institutions
Q1 2021: 46 institutionsQ2 2021: 49 institutionsQ3 2021: 48 institutionsQ4 2021: 65 institutionsQ1 2022: 71 institutionsQ2 2022: 59 institutionsQ3 2022: 54 institutionsQ4 2022: 52 institutionsQ1 2023: 44 institutionsQ2 2023: 39 institutionsQ3 2023: 63 institutionsQ4 2023: 87 institutionsQ1 2024: 109 institutionsQ2 2024: 107 institutionsQ3 2024: 119 institutionsQ4 2024: 131 institutionsQ1 2025: 127 institutionsQ2 2025: 150 institutionsQ3 2025: 155 institutionsQ4 2025: 195 institutionsQ1 2026: 191 institutionsQ2 2026: 208 institutions
Value heldQ3 2025: $865.6M
Q1 2021: $358.5MQ2 2021: $388.6MQ3 2021: $361.9MQ4 2021: $215.6MQ1 2022: $110.9MQ2 2022: $54.7MQ3 2022: $27.0MQ4 2022: $43.8MQ1 2023: $13.3MQ2 2023: $9.05MQ3 2023: $410.6MQ4 2023: $230.3MQ1 2024: $402.2MQ2 2024: $354.3MQ3 2024: $315.5MQ4 2024: $289.8MQ1 2025: $232.0MQ2 2025: $595.4MQ3 2025: $865.6MQ4 2025: $1.48BQ1 2026: $1.18BQ2 2026: $2.03B
Institutions holding TSHA and their total value by quarter
QuarterHoldersValue
Q2 2026208$2.03B
Q1 2026191$1.18B
Q4 2025195$1.48B
Q3 2025155$865.6M
Q2 2025150$595.4M
Q1 2025127$232.0M
Q4 2024131$289.8M
Q3 2024119$315.5M
Q2 2024107$354.3M
Q1 2024109$402.2M
Q4 202387$230.3M
Q3 202363$410.6M
Q2 202339$9.05M
Q1 202344$13.3M
Q4 202252$43.8M
Q3 202254$27.0M
Q2 202259$54.7M
Q1 202271$110.9M
Q4 202165$215.6M
Q3 202148$361.9M
Q2 202149$388.6M
Q1 202146$358.5M

Institutions, Q3 2025

Shares, value and share of portfolio for each institution holding Taysha Gene Therapies, Inc.; share changes are against Q2 2025.

Institutions holding TSHA in Q3 2025
InstitutionSharesValue% of portfolioChange in sharesAction
Capital Advisors, Ltd. LLC79$00.00%00.0%Unchanged
IFP Advisors, Inc14$460.00%00.0%Unchanged
SBI Securities Co., Ltd.16$520.00%−64−80.0%Reduced
True Wealth Design, LLC30$990.00%00.0%Unchanged
Farther Finance Advisors, LLC55$1800.00%+55New
EverSource Wealth Advisors, LLC91$2980.00%−114−55.6%Reduced
Advisor Group Holdings, Inc.134$4260.00%00.0%Unchanged
Allworth Financial LP215$7040.00%+215New
Morton Brown Family Wealth, LLC260$8500.00%00.0%Unchanged
Parallel Advisors, LLC280$9160.00%00.0%Unchanged
Essential Partners LLC327$1.07K0.00%00.0%Unchanged
Sterling Capital Management LLC515$1.68K0.00%+107+26.2%Added
Clearstead Advisors, LLC690$2.26K0.00%00.0%Unchanged
US Bancorp912$2.98K0.00%−63−6.5%Reduced
Aster Capital Management (DIFC) Ltd1,280$4.19K0.00%+1,280New
The PNC Financial Services Group, Inc.1,308$4.28K0.00%+308+30.8%Added
Group One Trading, L.P.1,754$5.74K0.00%+1,754New
Optiver Holding B.V.2,269$7.42K0.00%+204+9.9%Added
Simplex Trading, LLC2,722$8.00K0.00%−541−16.6%Reduced
Caitong International Asset Management Co., Ltd3,204$10.5K0.01%+1,057+49.2%Added
Wexford Capital LP3,500$11.4K0.00%+3,500New
FNY Investment Advisers, LLC4,289$14.0K0.00%+4,289New
Rockefeller Capital Management L.P.5,000$16.4K0.00%+5,000New
Amalgamated Bank5,534$18.0K0.00%00.0%Unchanged
GF Fund Management Co. Ltd.5,869$19.2K0.00%+621+11.8%Added
Nisa Investment Advisors, LLC5,872$19.2K0.00%+2,125+56.7%Added
Tower Research Capital LLC (TRC)6,607$21.6K0.00%−10,999−62.5%Reduced
St Germain D J Co Inc9,633$31.5K0.00%+4,333+81.8%Added
Capital Investment Advisors, LLC10,000$32.7K0.00%00.0%Unchanged
Aigen Investment Management, LP10,367$33.9K0.01%+10,367New
California State Teachers Retirement System10,373$33.9K0.00%−2,262−17.9%Reduced
Mirae Asset Global Investments Co., Ltd.10,546$34.5K0.00%+443+4.4%Added
Mackenzie Financial Corp11,214$36.7K0.00%00.0%Unchanged
Arrowpoint Investment Partners (Singapore) Pte. Ltd.12,200$39.9K0.06%+12,200New
CWM, LLC12,885$42.0K0.00%−61−0.5%Reduced
Bank of Montreal13,668$44.7K0.00%+13,668New
Allegheny Financial Group LTD15,000$49.0K0.01%+15,000New
Ameritas Investment Partners, Inc.15,672$51.2K0.00%00.0%Unchanged
R Squared Ltd16,094$52.6K0.02%+16,094New
Cetera Investment Advisers16,162$52.9K0.00%+16,162New
Principal Financial Group Inc16,251$53.1K0.00%+4,091+33.6%Added
DRW Securities, LLC16,389$53.3K0.00%+16,389New
Xponance, Inc.16,575$54.2K0.00%+3,738+29.1%Added
Russell Investments Group, Ltd.18,165$59.4K0.00%+18,165New
Lee Financial Co20,000$65.4K0.01%00.0%Unchanged
Daiwa Securities Group Inc.21,820$71.0K0.00%−2,021−8.5%Reduced
Susquehanna International Group, LLP21,742$71.1K0.00%−190,830−89.8%Reduced
CIBC Bancorp USA Inc.22,643$74.0K0.00%+22,643New
Legal & General Group Plc23,149$75.7K0.00%+4,754+25.8%Added
Cambridge Investment Research Advisors, Inc.23,690$77.0K0.00%00.0%Unchanged
Victory Capital Management Inc25,600$83.7K0.00%+108+0.4%Added
Ethic Inc.25,784$84.3K0.00%−2,191−7.8%Reduced
Sender Co & Partners, Inc.27,121$88.7K0.03%+27,121New
Leonteq Securities AG27,999$91.6K0.00%00.0%Unchanged
Prudential Financial Inc28,345$92.7K0.00%+5,555+24.4%Added
First Manhattan Co28,500$93.2K0.00%00.0%Unchanged
SG Americas Securities, LLC32,949$108.0K0.00%−460,352−93.3%Reduced
Citigroup Inc33,495$109.5K0.00%−96,822−74.3%Reduced
Voya Investment Management LLC36,500$119.4K0.00%−10,669−22.6%Reduced
American Century Companies Inc38,556$126.1K0.00%+38,556New
Virtus Investment Advisers, Inc.42,938$140.4K0.04%+7,454+21.0%Added
State of Wisconsin Investment Board42,949$140.4K0.00%+42,949New
Williams & Novak, LLC45,000$147.2K0.11%00.0%Unchanged
BNP Paribas Arbitrage, SA46,034$150.5K0.00%+27,443+147.6%Added
ProShare Advisors LLC46,039$150.5K0.00%+2,293+5.2%Added
Brevan Howard Capital Management LP46,643$152.5K0.00%+46,643New
Quadrature Capital Ltd47,328$154.3K0.00%−114,612−70.8%Reduced
China Universal Asset Management Co., Ltd.47,817$156.4K0.01%−4,710−9.0%Reduced
Virtu Financial LLC48,123$157.0K0.01%+48,123New
Axq Capital, LP49,677$162.4K0.06%−7,323−12.8%Reduced
Creative Planning52,226$170.8K0.00%+245+0.5%Added
Jain Global LLC52,608$172.0K0.00%+52,608New
Profund Advisors LLC53,366$174.5K0.01%+26,767+100.6%Added
Engineers Gate Manager LP53,483$174.9K0.00%−11,134−17.2%Reduced
Police & Firemen's Retirement System of New Jersey57,168$186.9K0.00%+11,490+25.2%Added
Commonwealth Equity Services, LLC58,257$191.0K0.00%−1,779−3.0%Reduced
Two Sigma Investments, LP66,105$216.2K0.00%+33,423+102.3%Added
Militia Capital Partners, LP66,800$218.4K0.10%00.0%Unchanged
New York State Common Retirement Fund67,600$221.1K0.00%+46,500+220.4%Added
Intech Investment Management LLC68,626$224.4K0.00%−13,569−16.5%Reduced
Manufacturers Life Insurance Company, The69,857$228.4K0.00%+8,852+14.5%Added
Mitsubishi UFJ Kokusai Asset Management Co., Ltd.80,732$264.0K0.00%+161+0.2%Added
Franklin Resources Inc108,399$354.5K0.00%00.0%Unchanged
Mirae Asset Global ETFs Holdings Ltd.111,024$361.7K0.00%+14,481+15.0%Added
Price T Rowe Associates Inc113,835$373.0K0.00%+29,232+34.6%Added
Deutsche Bank AG122,799$401.6K0.00%+15,083+14.0%Added
MetLife Investment Management127,044$415.4K0.00%+18,966+17.5%Added
Privium Fund Management B.V.134,900$441.1K0.08%00.0%Unchanged
Wells Fargo & Company145,098$474.5K0.00%+37,864+35.3%Added
AQR Capital Management LLC151,000$493.8K0.00%+15,234+11.2%Added
Palumbo Wealth Management LLC157,353$514.5K0.16%+157,353New
Readystate Asset Management LP161,972$529.6K0.03%+161,972New
Alliancebernstein L.P.179,640$587.4K0.00%+200.0%Added
Squarepoint Ops LLC198,352$648.6K0.00%+98,126+97.9%Added
Rafferty Asset Management, LLC239,785$784.1K0.00%+121,102+102.0%Added
Chicago Partners Investment Group LLC164,037$818.5K0.02%+271+0.2%Added
Invesco Ltd.279,793$914.9K0.00%+76,122+37.4%Added
Rhumbline Advisers288,859$944.6K0.00%+55,603+23.8%Added
JPMorgan Chase & Co296,244$968.7K0.00%+73,595+33.1%Added
Kovitz Investment Group Partners, LLC298,667$976.6K0.00%00.0%Unchanged