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Spero Therapeutics, Inc.

SPRO
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
SEC CIK
0001701108

No open-market purchases or sales by Spero Therapeutics, Inc. insiders were filed in the last 90 days; 59 institutions reported holding it in 13F filings for Q2 2026, worth $47.5M in total; no superinvestor holds it.

13F holders, Q3 2025

Institutional positions in Spero Therapeutics, Inc. as of Sep 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
47
+3 vs. Q2 2025
Shares held
11.3M
+232.8K (+2.1%) vs. Q2 2025
Total value
$21.3M
−$10.9M (−33.8%) vs. Q2 2025
New holders
14
12 more added
Sold out
11
6 more reduced

Compare with Q2 2025: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting SPRO on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ3 2025: 47 institutions
Q1 2021: 95 institutionsQ2 2021: 89 institutionsQ3 2021: 88 institutionsQ4 2021: 84 institutionsQ1 2022: 100 institutionsQ2 2022: 79 institutionsQ3 2022: 69 institutionsQ4 2022: 60 institutionsQ1 2023: 48 institutionsQ2 2023: 56 institutionsQ3 2023: 54 institutionsQ4 2023: 50 institutionsQ1 2024: 54 institutionsQ2 2024: 48 institutionsQ3 2024: 46 institutionsQ4 2024: 50 institutionsQ1 2025: 38 institutionsQ2 2025: 44 institutionsQ3 2025: 47 institutionsQ4 2025: 56 institutionsQ1 2026: 50 institutionsQ2 2026: 59 institutions
Value heldQ3 2025: $21.3M
Q1 2021: $273.1MQ2 2021: $244.2MQ3 2021: $338.3MQ4 2021: $316.7MQ1 2022: $176.1MQ2 2022: $15.5MQ3 2022: $39.7MQ4 2022: $24.6MQ1 2023: $20.6MQ2 2023: $20.8MQ3 2023: $17.2MQ4 2023: $19.6MQ1 2024: $23.7MQ2 2024: $18.0MQ3 2024: $16.5MQ4 2024: $16.1MQ1 2025: $10.9MQ2 2025: $32.1MQ3 2025: $21.3MQ4 2025: $49.2MQ1 2026: $48.3MQ2 2026: $47.5M
Institutions holding SPRO and their total value by quarter
QuarterHoldersValue
Q2 202659$47.5M
Q1 202650$48.3M
Q4 202556$49.2M
Q3 202547$21.3M
Q2 202544$32.1M
Q1 202538$10.9M
Q4 202450$16.1M
Q3 202446$16.5M
Q2 202448$18.0M
Q1 202454$23.7M
Q4 202350$19.6M
Q3 202354$17.2M
Q2 202356$20.8M
Q1 202348$20.6M
Q4 202260$24.6M
Q3 202269$39.7M
Q2 202279$15.5M
Q1 2022100$176.1M
Q4 202184$316.7M
Q3 202188$338.3M
Q2 202189$244.2M
Q1 202195$273.1M

Institutions, Q3 2025

Shares, value and share of portfolio for each institution holding Spero Therapeutics, Inc.; share changes are against Q2 2025.

Institutions holding SPRO in Q3 2025
InstitutionSharesValue% of portfolioChange in sharesAction
SBI Securities Co., Ltd.10$190.00%−52−83.9%Reduced
BNP Paribas Arbitrage, SA40$750.00%00.0%Unchanged
GWM Advisors LLC100$1880.00%00.0%Unchanged
US Bancorp151$2840.00%00.0%Unchanged
Wells Fargo & Company200$3760.00%00.0%Unchanged
Rockefeller Capital Management L.P.200$3760.00%+200New
JPMorgan Chase & Co236$4440.00%00.0%Unchanged
Advisor Group Holdings, Inc.290$5450.00%00.0%Unchanged
FMR LLC550$1.03K0.00%+550New
Bank of America Corp733$1.38K0.00%−4,900−87.0%Reduced
FNY Investment Advisers, LLC5,300$9.00K0.00%+5,300New
Simplex Trading, LLC7,618$14.0K0.00%−22,704−74.9%Reduced
Texas Yale Capital Corp.10,000$18.8K0.00%00.0%Unchanged
Torrey Growth & Income Advisors15,775$29.7K0.01%+15,775New
Group One Trading, L.P.16,879$31.7K0.00%+8,640+104.9%Added
Invesco Ltd.22,100$41.5K0.00%+7,132+47.6%Added
UBS Group AG27,101$51.0K0.00%+18,907+230.7%Added
Charles Schwab Investment Management Inc28,565$53.7K0.00%00.0%Unchanged
Dimensional Fund Advisors LP28,994$54.9K0.00%+28,994New
Three Seasons Wealth, LLC30,000$56.4K0.01%00.0%Unchanged
Rangeley Capital, LLC30,000$56.4K0.05%+30,000New
Capital Asset Advisory Services LLC32,548$61.2K0.00%00.0%Unchanged
Axxcess Wealth Management, LLC32,548$61.2K0.00%00.0%Unchanged
XTX Topco Ltd33,801$63.5K0.00%−750−2.2%Reduced
Assenagon Asset Management S.A.36,993$69.5K0.00%+36,993New
American Century Companies Inc40,219$75.6K0.00%+40,219New
Cubist Systematic Strategies, LLC40,845$76.8K0.00%+13,705+50.5%Added
Jane Street Group, LLC42,988$80.8K0.00%+42,988New
Morgan Stanley43,378$81.5K0.00%+34,157+370.4%Added
Two Sigma Investments, LP49,399$92.9K0.00%+49,399New
Shay Capital LLC63,667$119.7K0.02%+63,667New
Gsa Capital Partners LLP106,894$201.0K0.02%+106,894New
Intrepid Family Office LLC110,000$206.8K0.19%+110,000New
Bridgeway Capital Management, LLC114,800$215.8K0.00%00.0%Unchanged
ADAR1 Capital Management, LLC115,539$217.2K0.02%−28,378−19.7%Reduced
Northern Trust Corp129,643$243.7K0.00%+28,812+28.6%Added
Arrowstreet Capital, Limited Partnership150,516$283.0K0.00%+150,516New
State Street Corp190,951$359.0K0.00%+37,500+24.4%Added
Ionic Capital Management LLC208,725$392.4K0.44%+58,725+39.2%Added
EAM Investors, LLC282,445$531.0K0.06%+43,305+18.1%Added
BlackRock, Inc.434,768$817.4K0.00%00.0%Unchanged
Geode Capital Management, LLC527,477$991.9K0.00%+16,778+3.3%Added
Alphabet Inc.889,979$1.67M0.07%00.0%Unchanged
Renaissance Technologies LLC1,452,765$2.73M0.00%+620,600+74.6%Added
Anson Funds Management LP1,603,569$3.01M0.34%−11,900−0.7%Reduced
Vanguard Group Inc1,989,855$3.74M0.00%+39,474+2.0%Added
Pfizer Inc2,362,348$4.44M1.02%00.0%Unchanged
Schonfeld Strategic Advisors LLC0$00.00%−510,834−100.0%Sold out
Monimus Capital Management, LP0$00.00%−310,908−100.0%Sold out
Stonepine Capital Management, LLC0$00.00%−156,888−100.0%Sold out
Acadian Asset Management LLC0$00.00%−112,889−100.0%Sold out
Citadel Advisors LLC0$00.00%−103,786−100.0%Sold out
Susquehanna International Group, LLP0$00.00%−69,814−100.0%Sold out
Quadrature Capital Ltd0$00.00%−31,205−100.0%Sold out
Royal Bank of Canada0$00.00%−5,739−100.0%Sold out
Raymond James Financial Inc0$00.00%−3,082−100.0%Sold out
Cullen/Frost Bankers, Inc.0$00.00%−2,000−100.0%Sold out
Tower Research Capital LLC (TRC)0$00.00%−603−100.0%Sold out