Spero Therapeutics, Inc.
SPRO- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001701108
No open-market purchases or sales by Spero Therapeutics, Inc. insiders were filed in the last 90 days; 59 institutions reported holding it in 13F filings for Q2 2026, worth $47.5M in total; no superinvestor holds it.
Q3 2025 vs. Q2 2025
How the institutions holding Spero Therapeutics, Inc. changed between Q2 2025 and Q3 2025.
All holders in Q3 2025All holders in Q2 2025
| Measure | Q2 2025 | Q3 2025 | Change |
|---|---|---|---|
| Holders | 44 | 47 | +3 |
| Shares | 11.1M | 11.3M | +232.8K (+2.1%) |
| Value | $32.1M | $21.3M | −$10.9M (−33.8%) |
New holders (14)
Institutions that held Spero Therapeutics, Inc. at the end of Q3 2025 but not at the end of Q2 2025.
| Institution | Shares | Value | % of portfolio |
|---|---|---|---|
| Arrowstreet Capital, Limited Partnership | 150,516 | $283.0K | 0.00% |
| Intrepid Family Office LLC | 110,000 | $206.8K | 0.19% |
| Gsa Capital Partners LLP | 106,894 | $201.0K | 0.02% |
| Shay Capital LLC | 63,667 | $119.7K | 0.02% |
| Two Sigma Investments, LP | 49,399 | $92.9K | 0.00% |
| Jane Street Group, LLC | 42,988 | $80.8K | 0.00% |
| American Century Companies Inc | 40,219 | $75.6K | 0.00% |
| Assenagon Asset Management S.A. | 36,993 | $69.5K | 0.00% |
| Rangeley Capital, LLC | 30,000 | $56.4K | 0.05% |
| Dimensional Fund Advisors LP | 28,994 | $54.9K | 0.00% |
| Torrey Growth & Income Advisors | 15,775 | $29.7K | 0.01% |
| FNY Investment Advisers, LLC | 5,300 | $9.00K | 0.00% |
| FMR LLC | 550 | $1.03K | 0.00% |
| Rockefeller Capital Management L.P. | 200 | $376 | 0.00% |
Sold out (11)
Institutions that held Spero Therapeutics, Inc. at the end of Q2 2025 and filed for Q3 2025 without it.
| Institution | Shares, Q2 2025 | Value, Q2 2025 |
|---|---|---|
| Schonfeld Strategic Advisors LLC | 510,834 | $1.48M |
| Monimus Capital Management, LP | 310,908 | $901.6K |
| Stonepine Capital Management, LLC | 156,888 | $455.0K |
| Acadian Asset Management LLC | 112,889 | $327.0K |
| Citadel Advisors LLC | 103,786 | $301.0K |
| Susquehanna International Group, LLP | 69,814 | $202.5K |
| Quadrature Capital Ltd | 31,205 | $90.5K |
| Royal Bank of Canada | 5,739 | $17.0K |
| Raymond James Financial Inc | 3,082 | $8.94K |
| Cullen/Frost Bankers, Inc. | 2,000 | $5.80K |
| Tower Research Capital LLC (TRC) | 603 | $1.75K |