Spero Therapeutics, Inc.
SPRO- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001701108
No open-market purchases or sales by Spero Therapeutics, Inc. insiders were filed in the last 90 days; 59 institutions reported holding it in 13F filings for Q2 2026, worth $47.5M in total; no superinvestor holds it.
13F holders, Q1 2025
Institutional positions in Spero Therapeutics, Inc. as of Mar 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 38
- −11 vs. Q4 2024
- Shares held
- 15.1M
- −569.4K (−3.6%) vs. Q4 2024
- Total value
- $10.9M
- −$5.27M (−32.6%) vs. Q4 2024
- New holders
- 1
- 9 more added
- Sold out
- 12
- 10 more reduced
1 institution that held it in Q4 2024 haven't filed for Q1 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q4 2024: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SPRO on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 59 | $47.5M |
| Q1 2026 | 50 | $48.3M |
| Q4 2025 | 56 | $49.2M |
| Q3 2025 | 47 | $21.3M |
| Q2 2025 | 44 | $32.1M |
| Q1 2025 | 38 | $10.9M |
| Q4 2024 | 50 | $16.1M |
| Q3 2024 | 46 | $16.5M |
| Q2 2024 | 48 | $18.0M |
| Q1 2024 | 54 | $23.7M |
| Q4 2023 | 50 | $19.6M |
| Q3 2023 | 54 | $17.2M |
| Q2 2023 | 56 | $20.8M |
| Q1 2023 | 48 | $20.6M |
| Q4 2022 | 60 | $24.6M |
| Q3 2022 | 69 | $39.7M |
| Q2 2022 | 79 | $15.5M |
| Q1 2022 | 100 | $176.1M |
| Q4 2021 | 84 | $316.7M |
| Q3 2021 | 88 | $338.3M |
| Q2 2021 | 89 | $244.2M |
| Q1 2021 | 95 | $273.1M |
Institutions, Q1 2025
Shares, value and share of portfolio for each institution holding Spero Therapeutics, Inc.; share changes are against Q4 2024.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| BNP Paribas Arbitrage, SA | 12 | $9 | 0.00% | 00.0% | Unchanged |
| CoreCap Advisors, LLC | 50 | $36 | 0.00% | 00.0% | Unchanged |
| SBI Securities Co., Ltd. | 60 | $43 | 0.00% | −153−71.8% | Reduced |
| GWM Advisors LLC | 100 | $72 | 0.00% | 00.0% | Unchanged |
| US Bancorp | 151 | $109 | 0.00% | −5,000−97.1% | Reduced |
| Wells Fargo & Company | 200 | $144 | 0.00% | 00.0% | Unchanged |
| Cullen/Frost Bankers, Inc. | 2,000 | $1.44K | 0.00% | 00.0% | Unchanged |
| UBS Group AG | 2,826 | $2.04K | 0.00% | +2,685+1,904.3% | Added |
| Simplex Trading, LLC | 5,098 | $3.00K | 0.00% | −12−0.2% | Reduced |
| FMR LLC | 5,056 | $3.64K | 0.00% | +767+17.9% | Added |
| Bank of America Corp | 5,565 | $4.01K | 0.00% | +18+0.3% | Added |
| Morgan Stanley | 6,971 | $5.02K | 0.00% | 00.0% | Unchanged |
| Texas Yale Capital Corp. | 10,000 | $7.20K | 0.00% | 00.0% | Unchanged |
| EP Wealth Advisors, LLC | 16,500 | $11.9K | 0.00% | +16,500 | New |
| Charles Schwab Investment Management Inc | 28,565 | $20.6K | 0.00% | 00.0% | Unchanged |
| DLK Investment Management, LLC | 29,825 | $21.5K | 0.01% | +870+3.0% | Added |
| Three Seasons Wealth, LLC | 30,000 | $21.6K | 0.01% | 00.0% | Unchanged |
| Prudential Financial Inc | 56,000 | $40.3K | 0.00% | +6,800+13.8% | Added |
| JPMorgan Chase & Co | 60,817 | $43.8K | 0.00% | −807−1.3% | Reduced |
| Citadel Advisors LLC | 61,316 | $44.1K | 0.00% | −111,556−64.5% | Reduced |
| Squarepoint Ops LLC | 92,939 | $66.9K | 0.00% | +37,888+68.8% | Added |
| Northern Trust Corp | 100,924 | $72.7K | 0.00% | +14,477+16.7% | Added |
| DAFNA Capital Management LLC | 125,000 | $90.0K | 0.03% | 00.0% | Unchanged |
| State Street Corp | 148,911 | $107.2K | 0.00% | 00.0% | Unchanged |
| Bridgeway Capital Management, LLC | 154,800 | $111.5K | 0.00% | −30,000−16.2% | Reduced |
| Mackenzie Financial Corp | 209,031 | $150.5K | 0.00% | +21,472+11.4% | Added |
| Atlas Venture Life Science Advisors, LLC | 305,255 | $219.8K | 0.04% | 00.0% | Unchanged |
| Monimus Capital Management, LP | 310,908 | $223.9K | 0.19% | 00.0% | Unchanged |
| BlackRock, Inc. | 482,082 | $347.1K | 0.00% | −3,270−0.7% | Reduced |
| Geode Capital Management, LLC | 524,869 | $378.0K | 0.00% | +43,741+9.1% | Added |
| ADAR1 Capital Management, LLC | 801,277 | $576.9K | 0.11% | 00.0% | Unchanged |
| Acadian Asset Management LLC | 871,212 | $626.0K | 0.00% | −168,710−16.2% | Reduced |
| Murchinson Ltd. | 873,910 | $629.2K | 0.11% | 00.0% | Unchanged |
| Alphabet Inc. | 889,979 | $640.8K | 0.04% | 00.0% | Unchanged |
| Renaissance Technologies LLC | 970,907 | $699.1K | 0.00% | −134,684−12.2% | Reduced |
| Vanguard Group Inc | 1,763,620 | $1.27M | 0.00% | 00.0% | Unchanged |
| Pfizer Inc | 2,362,348 | $1.70M | 0.34% | 00.0% | Unchanged |
| Anson Funds Management LP | 3,798,932 | $2.74M | 0.66% | −40,954−1.1% | Reduced |
| Jane Street Group, LLC | 0 | $0 | 0.00% | −52,869−100.0% | Sold out |
| Virtu Financial LLC | 0 | $0 | 0.00% | −46,046−100.0% | Sold out |
| XTX Topco Ltd | 0 | $0 | 0.00% | −30,138−100.0% | Sold out |
| Susquehanna International Group, LLP | 0 | $0 | 0.00% | −29,755−100.0% | Sold out |
| PFG Investments, LLC | 0 | $0 | 0.00% | −24,534−100.0% | Sold out |
| HRT Financial LP | 0 | $0 | 0.00% | −14,692−100.0% | Sold out |
| Dimensional Fund Advisors LP | 0 | $0 | 0.00% | −10,003−100.0% | Sold out |
| National Bank of Canada | 0 | $0 | 0.00% | −10,000−100.0% | Sold out |
| Tower Research Capital LLC (TRC) | 0 | $0 | 0.00% | −929−100.0% | Sold out |
| Advisor Group Holdings, Inc. | 0 | $0 | 0.00% | −295−100.0% | Sold out |
| Richards, Merrill & Peterson, Inc. | 0 | $0 | 0.00% | −150−100.0% | Sold out |
| Federation des caisses Desjardins du Quebec | 0 | $0 | 0.00% | −30−100.0% | Sold out |
| WR Wealth Planners, LLC | – | – | – | – | Not filed |