Rhythm Pharmaceuticals, Inc.
RYTM- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001649904
In the last 90 days, Rhythm Pharmaceuticals, Inc. insiders filed 0 open-market purchases and 6 sales; 304 institutions reported holding it in 13F filings for Q2 2026, worth $8.55B in total; Duquesne Family Office is the only superinvestor holding it.
13F holders, Q1 2026
Institutional positions in Rhythm Pharmaceuticals, Inc. as of Mar 31, 2026. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 285
- +10 vs. Q4 2025
- Shares held
- 73.6M
- +6.99M (+10.5%) vs. Q4 2025
- Total value
- $6.42B
- −$704.3M (−9.9%) vs. Q4 2025
- New holders
- 63
- 102 more added
- Sold out
- 53
- 89 more reduced
6 institutions that held it in Q4 2025 haven't filed for Q1 2026 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q4 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting RYTM on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 304 | $8.55B |
| Q1 2026 | 285 | $6.42B |
| Q4 2025 | 281 | $7.80B |
| Q3 2025 | 264 | $7.20B |
| Q2 2025 | 227 | $4.20B |
| Q1 2025 | 228 | $3.44B |
| Q4 2024 | 203 | $3.63B |
| Q3 2024 | 176 | $3.55B |
| Q2 2024 | 165 | $2.85B |
| Q1 2024 | 167 | $2.95B |
| Q4 2023 | 169 | $3.07B |
| Q3 2023 | 144 | $1.56B |
| Q2 2023 | 116 | $1.09B |
| Q1 2023 | 126 | $1.08B |
| Q4 2022 | 115 | $1.81B |
| Q3 2022 | 101 | $1.45B |
| Q2 2022 | 90 | $190.8M |
| Q1 2022 | 111 | $562.7M |
| Q4 2021 | 98 | $483.6M |
| Q3 2021 | 97 | $626.3M |
| Q2 2021 | 105 | $905.6M |
| Q1 2021 | 124 | $1.01B |
Institutions, Q1 2026
Shares, value and share of portfolio for each institution holding Rhythm Pharmaceuticals, Inc.; share changes are against Q4 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| XTX Topco Ltd | 59,502 | $5.17M | 0.09% | +49,069+470.3% | Added |
| Blue Owl Capital Holdings LP | 61,455 | $5.34M | 1.44% | +61,455 | New |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 62,936 | $5.47M | 0.01% | −60,601−49.1% | Reduced |
| California State Teachers Retirement System | 65,806 | $5.72M | 0.01% | +12,269+22.9% | Added |
| Kennedy Capital Management, Inc. | 65,818 | $5.72M | 0.12% | +25,931+65.0% | Added |
| Rhumbline Advisers | 69,858 | $6.08M | 0.01% | −1,354−1.9% | Reduced |
| WCM Investment Management, LLC | 80,620 | $6.23M | 0.01% | +35,815+79.9% | Added |
| Neuberger Berman Group LLC | 73,434 | $6.39M | 0.00% | −138−0.2% | Reduced |
| Granahan Investment Management Inc | 77,709 | $6.76M | 0.33% | +24,257+45.4% | Added |
| Standard Life Aberdeen plc | 79,357 | $6.90M | 0.01% | +79,357 | New |
| First Trust Advisors LP | 85,506 | $7.44M | 0.01% | −2,999−3.4% | Reduced |
| First Light Asset Management, LLC | 87,181 | $7.58M | 0.68% | −208,663−70.5% | Reduced |
| Axiom Investors LLC | 91,749 | $7.98M | 0.09% | +8,195+9.8% | Added |
| Swiss National Bank | 112,200 | $9.76M | 0.01% | +900+0.8% | Added |
| Capital World Investors | 115,693 | $10.1M | 0.00% | 00.0% | Unchanged |
| Russell Investments Group, Ltd. | 115,712 | $10.1M | 0.01% | −18,468−13.8% | Reduced |
| Schroder Investment Management Group | 131,674 | $10.2M | 0.01% | +131,674 | New |
| Nuveen, LLC | 117,376 | $10.2M | 0.00% | +1,442+1.2% | Added |
| New York State Common Retirement Fund | 125,207 | $10.9M | 0.02% | +31,530+33.7% | Added |
| NEXTBio Capital Management LP | 126,078 | $11.0M | 5.09% | +58,492+86.5% | Added |
| PFM Health Sciences, LP | 136,621 | $11.9M | 1.25% | +96,411+239.8% | Added |
| M&G Plc | 138,567 | $12.1M | 0.06% | +1,493+1.1% | Added |
| Deutsche Bank AG | 141,601 | $12.3M | 0.00% | +12,478+9.7% | Added |
| Connor, Clark & Lunn Investment Management Ltd. | 151,842 | $13.2M | 0.03% | +2,469+1.7% | Added |
| SummitTX Capital, L.P. | 165,599 | $14.4M | 0.46% | +84,870+105.1% | Added |
| ADAR1 Capital Management, LLC | 211,450 | $18.4M | 1.11% | +160,101+311.8% | Added |
| UBS Group AG | 231,650 | $20.1M | 0.00% | −195,586−45.8% | Reduced |
| Voya Investment Management LLC | 233,810 | $20.3M | 0.02% | −16,064−6.4% | Reduced |
| Hood River Capital Management LLC | 239,912 | $20.9M | 0.21% | +2,869+1.2% | Added |
| BNP Paribas Arbitrage, SA | 247,876 | $21.6M | 0.01% | +83,313+50.6% | Added |
| Renaissance Technologies LLC | 258,011 | $22.4M | 0.04% | −83,182−24.4% | Reduced |
| Squarepoint Ops LLC | 262,968 | $22.9M | 0.05% | +230,139+701.0% | Added |
| Wellington Management Group LLP | 273,757 | $23.8M | 0.00% | +23,601+9.4% | Added |
| Qube Research & Technologies Ltd | 277,943 | $24.2M | 0.03% | −32,976−10.6% | Reduced |
| Bank of New York Mellon Corp | 293,298 | $25.5M | 0.00% | −7,782−2.6% | Reduced |
| Silverarc Capital Management, LLC | 306,000 | $26.6M | 3.14% | +170,050+125.1% | Added |
| Braidwell LP | 310,628 | $27.0M | 0.90% | +310,628 | New |
| OrbiMed Advisors LLC | 314,100 | $27.3M | 0.62% | +74,300+31.0% | Added |
| Lord, Abbett & Co. LLC | 348,953 | $30.3M | 0.10% | −270,589−43.7% | Reduced |
| Invesco Ltd. | 364,306 | $31.7M | 0.00% | +73,156+25.1% | Added |
| Ameriprise Financial Inc | 383,957 | $33.4M | 0.01% | +122,797+47.0% | Added |
| Artisan Partners Limited Partnership | 390,669 | $34.0M | 0.06% | +127,078+48.2% | Added |
| Opaleye Management Inc. | 123,000 | $35.3M | 4.65% | −207,000−62.7% | Reduced |
| Vanguard Fiduciary Trust Co | 421,911 | $36.7M | 0.01% | +421,911 | New |
| Driehaus Capital Management LLC | 436,546 | $38.0M | 0.28% | −848,676−66.0% | Reduced |
| Logos Global Management LP | 450,000 | $39.1M | 2.02% | +260,000+136.8% | Added |
| Sofinnova Investments, Inc. | 450,096 | $39.1M | 1.96% | +178,702+65.8% | Added |
| Millennium Management LLC | 451,825 | $39.3M | 0.03% | +265,116+142.0% | Added |
| Candriam Luxembourg S.C.A. | 464,340 | $40.4M | 0.21% | +176,433+61.3% | Added |
| Loomis Sayles & Co L P | 465,102 | $40.4M | 0.05% | −38,799−7.7% | Reduced |
| Northern Trust Corp | 498,514 | $43.4M | 0.01% | +10,298+2.1% | Added |
| Charles Schwab Investment Management Inc | 526,459 | $45.8M | 0.01% | −5,988−1.1% | Reduced |
| UBS Asset Management Americas Inc | 541,450 | $47.1M | 0.01% | −7,570−1.4% | Reduced |
| Integral Health Asset Management, LLC | 600,000 | $52.2M | 2.76% | +125,000+26.3% | Added |
| Clearbridge Investments, LLC | 609,437 | $53.0M | 0.05% | +103,328+20.4% | Added |
| Franklin Resources Inc | 626,845 | $54.5M | 0.01% | −68,890−9.9% | Reduced |
| Bank of America Corp | 628,667 | $54.7M | 0.00% | +404,183+180.0% | Added |
| Pictet Asset Management Holding SA | 667,046 | $57.3M | 0.06% | +52,383+8.5% | Added |
| Rock Springs Capital Management LP | 689,748 | $60.0M | 3.54% | −5,262−0.8% | Reduced |
| Morgan Stanley | 703,978 | $61.2M | 0.00% | +52,576+8.1% | Added |
| Siren, L.L.C. | 725,511 | $63.1M | 1.75% | +225,536+45.1% | Added |
| Adage Capital Partners GP, L.L.C. | 725,744 | $63.1M | 0.10% | +104,159+16.8% | Added |
| Woodline Partners LP | 758,891 | $66.0M | 0.25% | +70,112+10.2% | Added |
| Point72 Asset Management, L.P. | 846,801 | $73.6M | 0.13% | +417,381+97.2% | Added |
| Janus Henderson Group PLC | 918,153 | $79.9M | 0.04% | −207,972−18.5% | Reduced |
| Capital Research Global Investors | 1,115,460 | $97.0M | 0.02% | +130,374+13.2% | Added |
| Alliancebernstein L.P. | 910,413 | $97.5M | 0.03% | −19,820−2.1% | Reduced |
| Checkpoint Capital L.P. | 1,227,200 | $106.7M | 38.30% | +235,000+23.7% | Added |
| Federated Hermes, Inc. | 1,286,303 | $111.9M | 0.18% | −337,538−20.8% | Reduced |
| JPMorgan Chase & Co | 1,553,644 | $120.0M | 0.01% | +129,655+9.1% | Added |
| Geode Capital Management, LLC | 1,416,269 | $123.2M | 0.01% | +40,540+2.9% | Added |
| Citadel Advisors LLC | 1,418,619 | $123.4M | 0.09% | +1,265,297+825.3% | Added |
| Polar Capital Holdings Plc | 1,615,586 | $140.5M | 0.61% | +430,194+36.3% | Added |
| Price T Rowe Associates Inc | 1,654,876 | $143.9M | 0.02% | +94,029+6.0% | Added |
| FMR LLC | 1,689,671 | $147.0M | 0.01% | −16,646−1.0% | Reduced |
| Westfield Capital Management Co LP | 1,929,123 | $167.8M | 0.70% | +661,965+52.2% | Added |
| Goldman Sachs Group Inc | 1,965,432 | $170.9M | 0.02% | +134,566+7.3% | Added |
| State Street Corp | 2,271,851 | $197.6M | 0.01% | +73,236+3.3% | Added |
| Perceptive Advisors LLC | 2,373,795 | $206.4M | 4.08% | −172,596−6.8% | Reduced |
| Vanguard Capital Management LLC | 2,967,825 | $258.1M | 0.01% | +2,967,825 | New |
| Vanguard Portfolio Management LLC | 3,040,718 | $264.5M | 0.01% | +3,040,718 | New |
| Primecap Management Co | 3,417,509 | $297.2M | 0.23% | −61,160−1.8% | Reduced |
| Baker Bros. Advisors LP | 5,604,483 | $487.4M | 2.80% | 00.0% | Unchanged |
| BlackRock, Inc. | 6,237,151 | $542.4M | 0.01% | −60,183−1.0% | Reduced |
| Ra Capital Management, L.P. | 6,666,837 | $579.8M | 6.14% | 00.0% | Unchanged |
| NEA Management Company, LLC | 0 | $0 | 0.00% | −2,909,956−100.0% | Sold out |
| Jennison Associates LLC | 0 | $0 | 0.00% | −918,567−100.0% | Sold out |
| First Turn Management, LLC | 0 | $0 | 0.00% | −146,303−100.0% | Sold out |
| Zweig-DiMenna Associates LLC | 0 | $0 | 0.00% | −81,600−100.0% | Sold out |
| Voloridge Investment Management, LLC | 0 | $0 | 0.00% | −60,575−100.0% | Sold out |
| StemPoint Capital LP | 0 | $0 | 0.00% | −58,915−100.0% | Sold out |
| EAM Investors, LLC | 0 | $0 | 0.00% | −57,327−100.0% | Sold out |
| Rhenman & Partners Asset Management AB | 0 | $0 | 0.00% | −35,000−100.0% | Sold out |
| Nicholas Investment Partners, LP | 0 | $0 | 0.00% | −34,710−100.0% | Sold out |
| Magnetar Financial LLC | 0 | $0 | 0.00% | −29,598−100.0% | Sold out |
| Penserra Capital Management LLC | 0 | $0 | 0.00% | −21,514−100.0% | Sold out |
| Hennion & Walsh Asset Management, Inc. | 0 | $0 | 0.00% | −10,908−100.0% | Sold out |
| Fred Alger Management, LLC | 0 | $0 | 0.00% | −9,301−100.0% | Sold out |
| Virginia Retirement Systems Et Al | 0 | $0 | 0.00% | −9,200−100.0% | Sold out |
| Headlands Technologies LLC | 0 | $0 | 0.00% | −8,632−100.0% | Sold out |