Rhythm Pharmaceuticals, Inc.
RYTM- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001649904
In the last 90 days, Rhythm Pharmaceuticals, Inc. insiders filed 0 open-market purchases and 6 sales; 304 institutions reported holding it in 13F filings for Q2 2026, worth $8.55B in total; Duquesne Family Office is the only superinvestor holding it.
13F holders, Q4 2025
Institutional positions in Rhythm Pharmaceuticals, Inc. as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 281
- +19 vs. Q3 2025
- Shares held
- 72.9M
- +2.01M (+2.8%) vs. Q3 2025
- Total value
- $7.80B
- +$602.5M (+8.4%) vs. Q3 2025
- New holders
- 58
- 107 more added
- Sold out
- 39
- 89 more reduced
2 institutions that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting RYTM on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 304 | $8.55B |
| Q1 2026 | 285 | $6.42B |
| Q4 2025 | 281 | $7.80B |
| Q3 2025 | 264 | $7.20B |
| Q2 2025 | 227 | $4.20B |
| Q1 2025 | 228 | $3.44B |
| Q4 2024 | 203 | $3.63B |
| Q3 2024 | 176 | $3.55B |
| Q2 2024 | 165 | $2.85B |
| Q1 2024 | 167 | $2.95B |
| Q4 2023 | 169 | $3.07B |
| Q3 2023 | 144 | $1.56B |
| Q2 2023 | 116 | $1.09B |
| Q1 2023 | 126 | $1.08B |
| Q4 2022 | 115 | $1.81B |
| Q3 2022 | 101 | $1.45B |
| Q2 2022 | 90 | $190.8M |
| Q1 2022 | 111 | $562.7M |
| Q4 2021 | 98 | $483.6M |
| Q3 2021 | 97 | $626.3M |
| Q2 2021 | 105 | $905.6M |
| Q1 2021 | 124 | $1.01B |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Rhythm Pharmaceuticals, Inc.; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| NEXTBio Capital Management LP | 67,586 | $7.23M | 4.24% | +67,586 | New |
| AQR Capital Management LLC | 70,046 | $7.50M | 0.00% | −9,734−12.2% | Reduced |
| Rhumbline Advisers | 71,212 | $7.62M | 0.01% | −10,856−13.2% | Reduced |
| Balyasny Asset Management LLC | 72,282 | $7.74M | 0.01% | −277,726−79.3% | Reduced |
| Wells Fargo & Company | 72,617 | $7.77M | 0.00% | +25,483+54.1% | Added |
| Neuberger Berman Group LLC | 73,572 | $7.88M | 0.01% | −11,545−13.6% | Reduced |
| ExodusPoint Capital Management, LP | 75,141 | $8.04M | 0.09% | +75,141 | New |
| SummitTX Capital, L.P. | 80,729 | $8.64M | 0.26% | +68,860+580.2% | Added |
| Zweig-DiMenna Associates LLC | 81,600 | $8.73M | 0.62% | +81,600 | New |
| Axiom Investors LLC | 83,554 | $8.94M | 0.08% | +523+0.6% | Added |
| Algert Global LLC | 88,250 | $9.45M | 0.15% | −52,034−37.1% | Reduced |
| First Trust Advisors LP | 88,505 | $9.47M | 0.01% | +7,602+9.4% | Added |
| New York State Common Retirement Fund | 93,677 | $10.0M | 0.01% | +18,546+24.7% | Added |
| Swiss National Bank | 111,300 | $11.9M | 0.01% | +9,000+8.8% | Added |
| Capital World Investors | 115,693 | $12.4M | 0.00% | +115,693 | New |
| Nuveen, LLC | 115,934 | $12.4M | 0.00% | −2,030−1.7% | Reduced |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 123,537 | $13.2M | 0.02% | +22,165+21.9% | Added |
| Deutsche Bank AG | 129,123 | $13.8M | 0.00% | +12,381+10.6% | Added |
| Barclays PLC | 131,436 | $14.1M | 0.01% | −10,949−7.7% | Reduced |
| Russell Investments Group, Ltd. | 134,180 | $14.4M | 0.02% | −23,498−14.9% | Reduced |
| Silverarc Capital Management, LLC | 135,950 | $14.6M | 2.11% | −234,046−63.3% | Reduced |
| M&G Plc | 137,074 | $14.7M | 0.08% | +137,074 | New |
| First Turn Management, LLC | 146,303 | $15.7M | 1.79% | +146,303 | New |
| Connor, Clark & Lunn Investment Management Ltd. | 149,373 | $16.0M | 0.04% | +28,113+23.2% | Added |
| Citadel Advisors LLC | 153,322 | $16.4M | 0.01% | +20,696+15.6% | Added |
| BNP Paribas Arbitrage, SA | 164,563 | $17.6M | 0.01% | −59,118−26.4% | Reduced |
| Millennium Management LLC | 186,709 | $20.0M | 0.01% | +53,548+40.2% | Added |
| Logos Global Management LP | 190,000 | $20.3M | 1.36% | −10,000−5.0% | Reduced |
| Bank of America Corp | 224,484 | $24.0M | 0.00% | −8,666−3.7% | Reduced |
| Hood River Capital Management LLC | 237,043 | $25.4M | 0.28% | +1,207+0.5% | Added |
| OrbiMed Advisors LLC | 239,800 | $25.7M | 0.53% | +24,648+11.5% | Added |
| Voya Investment Management LLC | 249,874 | $26.7M | 0.03% | +28,281+12.8% | Added |
| Wellington Management Group LLP | 250,156 | $26.8M | 0.00% | +225,679+922.0% | Added |
| Ameriprise Financial Inc | 261,160 | $28.0M | 0.01% | +123,193+89.3% | Added |
| Artisan Partners Limited Partnership | 263,591 | $28.2M | 0.04% | +26,750+11.3% | Added |
| Sofinnova Investments, Inc. | 271,394 | $29.1M | 1.25% | +24,428+9.9% | Added |
| Candriam Luxembourg S.C.A. | 287,907 | $30.8M | 0.15% | +66,044+29.8% | Added |
| Invesco Ltd. | 291,150 | $31.2M | 0.00% | +147,595+102.8% | Added |
| First Light Asset Management, LLC | 295,844 | $31.7M | 2.42% | +115,360+63.9% | Added |
| Bank of New York Mellon Corp | 301,080 | $32.2M | 0.01% | +118,715+65.1% | Added |
| Qube Research & Technologies Ltd | 310,919 | $33.3M | 0.05% | +72,100+30.2% | Added |
| Opaleye Management Inc. | 330,000 | $35.3M | 4.66% | −131,700−28.5% | Reduced |
| Renaissance Technologies LLC | 341,193 | $36.5M | 0.06% | −205,400−37.6% | Reduced |
| UBS Group AG | 427,236 | $45.7M | 0.01% | +6,900+1.6% | Added |
| Point72 Asset Management, L.P. | 429,420 | $46.0M | 0.07% | +429,420 | New |
| Integral Health Asset Management, LLC | 475,000 | $50.8M | 2.58% | +255,000+115.9% | Added |
| Northern Trust Corp | 488,216 | $52.3M | 0.01% | −22,690−4.4% | Reduced |
| Siren, L.L.C. | 499,975 | $53.5M | 1.60% | 00.0% | Unchanged |
| Loomis Sayles & Co L P | 503,901 | $53.9M | 0.07% | −23,538−4.5% | Reduced |
| Clearbridge Investments, LLC | 506,109 | $54.2M | 0.04% | +21,377+4.4% | Added |
| Charles Schwab Investment Management Inc | 532,447 | $57.0M | 0.01% | +4,525+0.9% | Added |
| UBS Asset Management Americas Inc | 549,020 | $58.8M | 0.01% | +111,548+25.5% | Added |
| Pictet Asset Management Holding SA | 614,663 | $66.2M | 0.06% | −68,354−10.0% | Reduced |
| Lord, Abbett & Co. LLC | 619,542 | $66.3M | 0.20% | +43,558+7.6% | Added |
| Adage Capital Partners GP, L.L.C. | 621,585 | $66.5M | 0.10% | +77,585+14.3% | Added |
| Morgan Stanley | 651,402 | $69.7M | 0.00% | +186,212+40.0% | Added |
| Woodline Partners LP | 688,779 | $73.7M | 0.29% | +108,596+18.7% | Added |
| Rock Springs Capital Management LP | 695,010 | $74.4M | 3.82% | −22,092−3.1% | Reduced |
| Franklin Resources Inc | 695,735 | $74.5M | 0.02% | +127,953+22.5% | Added |
| Jennison Associates LLC | 918,567 | $98.3M | 0.06% | +507,017+123.2% | Added |
| Alliancebernstein L.P. | 930,233 | $99.6M | 0.03% | −49,449−5.0% | Reduced |
| Capital Research Global Investors | 985,086 | $105.4M | 0.02% | +386,839+64.7% | Added |
| Checkpoint Capital L.P. | 992,200 | $106.2M | 33.65% | +228,493+29.9% | Added |
| Janus Henderson Group PLC | 1,126,125 | $120.6M | 0.05% | −34,762−3.0% | Reduced |
| Polar Capital Holdings Plc | 1,185,392 | $126.9M | 0.58% | −59,540−4.8% | Reduced |
| Westfield Capital Management Co LP | 1,267,158 | $135.6M | 0.57% | +198,154+18.5% | Added |
| Driehaus Capital Management LLC | 1,285,222 | $137.6M | 0.93% | −98,553−7.1% | Reduced |
| Geode Capital Management, LLC | 1,375,729 | $147.3M | 0.01% | +12,900+0.9% | Added |
| JPMorgan Chase & Co | 1,423,989 | $152.4M | 0.01% | +235,920+19.9% | Added |
| Price T Rowe Associates Inc | 1,560,847 | $167.1M | 0.02% | +160,950+11.5% | Added |
| Federated Hermes, Inc. | 1,623,841 | $173.8M | 0.29% | −104,044−6.0% | Reduced |
| FMR LLC | 1,706,317 | $182.6M | 0.01% | −438,866−20.5% | Reduced |
| Goldman Sachs Group Inc | 1,830,866 | $196.0M | 0.03% | −62,797−3.3% | Reduced |
| State Street Corp | 2,198,615 | $235.3M | 0.01% | +169,964+8.4% | Added |
| Perceptive Advisors LLC | 2,546,391 | $272.6M | 4.99% | +107,422+4.4% | Added |
| NEA Management Company, LLC | 2,909,956 | $311.5M | 15.88% | 00.0% | Unchanged |
| Primecap Management Co | 3,478,669 | $372.4M | 0.28% | −784,190−18.4% | Reduced |
| Baker Bros. Advisors LP | 5,604,483 | $599.9M | 3.51% | 00.0% | Unchanged |
| Vanguard Group Inc | 6,210,916 | $664.8M | 0.01% | +1,214,489+24.3% | Added |
| BlackRock, Inc. | 6,297,334 | $674.1M | 0.01% | −4,881−0.1% | Reduced |
| Ra Capital Management, L.P. | 6,666,837 | $713.6M | 7.31% | +985,478+17.3% | Added |
| Alkeon Capital Management LLC | 0 | $0 | 0.00% | −1,017,700−100.0% | Sold out |
| Assenagon Asset Management S.A. | 0 | $0 | 0.00% | −224,128−100.0% | Sold out |
| Marshall Wace, LLP | 0 | $0 | 0.00% | −171,834−100.0% | Sold out |
| Panagora Asset Management Inc | 0 | $0 | 0.00% | −64,614−100.0% | Sold out |
| Walleye Capital LLC | 0 | $0 | 0.00% | −50,181−100.0% | Sold out |
| Aquatic Capital Management LLC | 0 | $0 | 0.00% | −42,490−100.0% | Sold out |
| Trexquant Investment LP | 0 | $0 | 0.00% | −37,161−100.0% | Sold out |
| Canada Pension Plan Investment Board | 0 | $0 | 0.00% | −37,000−100.0% | Sold out |
| Jain Global LLC | 0 | $0 | 0.00% | −35,110−100.0% | Sold out |
| Alps Advisors Inc | 0 | $0 | 0.00% | −33,000−100.0% | Sold out |
| Samsara BioCapital, LLC | 0 | $0 | 0.00% | −30,285−100.0% | Sold out |
| Dark Forest Capital Management LP | 0 | $0 | 0.00% | −28,639−100.0% | Sold out |
| Standard Life Aberdeen plc | 0 | $0 | 0.00% | −26,740−100.0% | Sold out |
| Burkehill Global Management, LP | 0 | $0 | 0.00% | −20,000−100.0% | Sold out |
| Schroder Investment Management Group | 0 | $0 | 0.00% | −18,042−100.0% | Sold out |
| Engineers Gate Manager LP | 0 | $0 | 0.00% | −13,775−100.0% | Sold out |
| Fiduciary Trust Co | 0 | $0 | 0.00% | −10,000−100.0% | Sold out |
| Readystate Asset Management LP | 0 | $0 | 0.00% | −8,365−100.0% | Sold out |
| Aigen Investment Management, LP | 0 | $0 | 0.00% | −8,225−100.0% | Sold out |