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Rhythm Pharmaceuticals, Inc.

RYTM
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
SEC CIK
0001649904

In the last 90 days, Rhythm Pharmaceuticals, Inc. insiders filed 0 open-market purchases and 6 sales; 305 institutions reported holding it in 13F filings for Q2 2026, worth $8.55B in total; Duquesne Family Office is the only superinvestor holding it.

13F holders, Q4 2023

Institutional positions in Rhythm Pharmaceuticals, Inc. as of Dec 31, 2023. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
169
+25 vs. Q3 2023
Shares held
66.7M
−1.44M (−2.1%) vs. Q3 2023
Total value
$3.07B
+$1.50B (+96.3%) vs. Q3 2023
New holders
45
41 more added
Sold out
20
64 more reduced

Compare with Q3 2023: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting RYTM on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ4 2023: 169 institutions
Q1 2021: 124 institutionsQ2 2021: 105 institutionsQ3 2021: 97 institutionsQ4 2021: 98 institutionsQ1 2022: 111 institutionsQ2 2022: 90 institutionsQ3 2022: 101 institutionsQ4 2022: 115 institutionsQ1 2023: 126 institutionsQ2 2023: 116 institutionsQ3 2023: 144 institutionsQ4 2023: 169 institutionsQ1 2024: 167 institutionsQ2 2024: 165 institutionsQ3 2024: 176 institutionsQ4 2024: 203 institutionsQ1 2025: 228 institutionsQ2 2025: 227 institutionsQ3 2025: 264 institutionsQ4 2025: 281 institutionsQ1 2026: 285 institutionsQ2 2026: 305 institutions
Value heldQ4 2023: $3.07B
Q1 2021: $1.01BQ2 2021: $905.6MQ3 2021: $626.3MQ4 2021: $483.6MQ1 2022: $562.7MQ2 2022: $190.8MQ3 2022: $1.45BQ4 2022: $1.81BQ1 2023: $1.08BQ2 2023: $1.09BQ3 2023: $1.56BQ4 2023: $3.07BQ1 2024: $2.95BQ2 2024: $2.85BQ3 2024: $3.55BQ4 2024: $3.63BQ1 2025: $3.44BQ2 2025: $4.20BQ3 2025: $7.20BQ4 2025: $7.80BQ1 2026: $6.42BQ2 2026: $8.55B
Institutions holding RYTM and their total value by quarter
QuarterHoldersValue
Q2 2026305$8.55B
Q1 2026285$6.42B
Q4 2025281$7.80B
Q3 2025264$7.20B
Q2 2025227$4.20B
Q1 2025228$3.44B
Q4 2024203$3.63B
Q3 2024176$3.55B
Q2 2024165$2.85B
Q1 2024167$2.95B
Q4 2023169$3.07B
Q3 2023144$1.56B
Q2 2023116$1.09B
Q1 2023126$1.08B
Q4 2022115$1.81B
Q3 2022101$1.45B
Q2 202290$190.8M
Q1 2022111$562.7M
Q4 202198$483.6M
Q3 202197$626.3M
Q2 2021105$905.6M
Q1 2021124$1.01B

Institutions, Q4 2023

Shares, value and share of portfolio for each institution holding Rhythm Pharmaceuticals, Inc.; share changes are against Q3 2023.

Institutions holding RYTM in Q4 2023
InstitutionSharesValue% of portfolioChange in sharesAction
Citigroup Inc54,300$2.50M0.00%−14,844−21.5%Reduced
Alliancebernstein L.P.54,390$2.50M0.00%00.0%Unchanged
HRT Financial LP54,534$2.51M0.02%+3,982+7.9%Added
Zimmer Partners, LP61,800$2.84M0.10%−20,700−25.1%Reduced
BNP Paribas Arbitrage, SA63,085$2.90M0.01%+7,842+14.2%Added
Voya Investment Management LLC64,991$2.99M0.00%−19,268−22.9%Reduced
Connor, Clark & Lunn Investment Management Ltd.65,544$3.01M0.01%−66,118−50.2%Reduced
Hennion & Walsh Asset Management, Inc.66,708$3.07M0.18%+26,562+66.2%Added
Bank of America Corp69,870$3.21M0.00%−40,373−36.6%Reduced
Exome Asset Management LLC72,203$3.32M3.28%+72,203New
Rhumbline Advisers73,172$3.36M0.00%−287−0.4%Reduced
Woodline Partners LP74,850$3.44M0.04%+74,850New
Wedge Capital Management L L P76,507$3.52M0.06%−28,213−26.9%Reduced
JPMorgan Chase & Co77,599$3.57M0.00%+5,188+7.2%Added
Natixis80,500$3.70M0.03%+80,500New
Jefferies Financial Group Inc.82,061$3.77M0.06%−41,599−33.6%Reduced
UBS Group AG85,955$3.95M0.00%+59,304+222.5%Added
Rice Hall James & Associates, LLC89,605$4.12M0.24%−67,821−43.1%Reduced
Swiss National Bank89,700$4.12M0.00%−10,200−10.2%Reduced
Clearbridge Investments, LLC91,158$4.19M0.00%−91,667−50.1%Reduced
Dimensional Fund Advisors LP96,948$4.46M0.00%00.0%Unchanged
Citadel Advisors LLC113,915$5.24M0.01%−141,518−55.4%Reduced
Rafferty Asset Management, LLC121,654$5.59M0.02%−41,150−25.3%Reduced
D. E. Shaw & Co., Inc.128,492$5.91M0.01%+128,492New
Invesco Ltd.135,731$6.24M0.00%+107,357+378.4%Added
Wellington Management Group LLP139,802$6.43M0.00%+2,359+1.7%Added
Nuveen Asset Management, LLC143,669$6.60M0.00%+2,084+1.5%Added
Healthcare of Ontario Pension Plan Trust Fund151,843$6.98M0.02%−25,157−14.2%Reduced
Samsara BioCapital, LLC172,647$7.94M1.23%−172,646−50.0%Reduced
Silverarc Capital Management, LLC174,248$8.01M2.47%−86,289−33.1%Reduced
Bank of New York Mellon Corp180,222$8.28M0.00%+2,846+1.6%Added
Victory Capital Management Inc182,297$8.38M0.01%+162,247+809.2%Added
Jane Street Group, LLC184,359$8.47M0.01%+40,357+28.0%Added
UBS Asset Management Americas Inc209,938$9.65M0.00%−127,326−37.8%Reduced
Morgan Stanley231,656$10.6M0.00%−204,752−46.9%Reduced
National Bank of Canada239,000$10.8M0.02%+108,000+82.4%Added
Barclays PLC251,415$11.6M0.01%+10,154+4.2%Added
Canada Pension Plan Investment Board267,000$12.3M0.02%+267,000New
Artisan Partners Limited Partnership271,421$12.5M0.02%+271,421New
Lord, Abbett & Co. LLC283,518$13.0M0.05%+283,518New
Assenagon Asset Management S.A.301,636$13.9M0.04%−105,654−25.9%Reduced
Voloridge Investment Management, LLC362,717$16.7M0.07%+342,350+1,680.9%Added
Charles Schwab Investment Management Inc397,685$18.3M0.00%+12,937+3.4%Added
VR Adviser, LLC495,983$22.8M1.56%−594,017−54.5%Reduced
Northern Trust Corp501,094$23.0M0.00%−2,928−0.6%Reduced
FMR LLC529,130$24.3M0.00%−339,344−39.1%Reduced
OrbiMed Advisors LLC536,642$24.7M0.49%−47,000−8.1%Reduced
Cormorant Asset Management, LP550,000$25.3M1.21%−300,000−35.3%Reduced
Price T Rowe Associates Inc572,297$26.3M0.00%+361,945+172.1%Added
Driehaus Capital Management LLC598,905$27.5M0.33%+324,381+118.2%Added
Opaleye Management Inc.610,000$28.0M7.53%−43,000−6.6%Reduced
Janus Henderson Group PLC621,892$28.6M0.02%−443,853−41.6%Reduced
Checkpoint Capital L.P.730,000$33.6M23.42%+730,000New
Geode Capital Management, LLC1,119,129$51.5M0.01%+74,072+7.1%Added
Pictet Asset Management Holding SA1,163,961$53.5M0.06%+1,163,961New
Rock Springs Capital Management LP1,522,893$70.0M1.73%−74,230−4.6%Reduced
Commodore Capital LP1,550,000$71.3M6.23%−525,000−25.3%Reduced
Polar Capital Holdings Plc1,750,000$80.4M0.56%−750,000−30.0%Reduced
Perceptive Advisors LLC2,154,110$99.0M2.21%+1,773,282+465.6%Added
State Street Corp2,206,018$101.4M0.00%−159,838−6.8%Reduced
Federated Hermes, Inc.2,310,955$106.2M0.26%−30,380−1.3%Reduced
Frazier Life Sciences Management, L.P.2,371,304$109.0M5.83%00.0%Unchanged
NEA Management Company, LLC2,909,956$133.8M8.92%00.0%Unchanged
Vanguard Group Inc3,226,938$148.3M0.00%+212,370+7.0%Added
Goldman Sachs Group Inc5,047,934$232.1M0.05%−112,607−2.2%Reduced
Ra Capital Management, L.P.5,330,412$245.0M3.83%−345,655−6.1%Reduced
BlackRock Inc.6,351,750$292.0M0.01%+151,868+2.4%Added
Baker Bros. Advisors LP6,398,365$294.1M3.35%−303,984−4.5%Reduced
Primecap Management Co8,052,648$370.2M0.29%−214,773−2.6%Reduced
Alkeon Capital Management LLC0$00.00%−1,725,167−100.0%Sold out
Logos Global Management LP0$00.00%−400,000−100.0%Sold out
Hudson Bay Capital Management LP0$00.00%−207,500−100.0%Sold out
Cubist Systematic Strategies, LLC0$00.00%−80,102−100.0%Sold out
First Trust Advisors LP0$00.00%−75,315−100.0%Sold out
Adage Capital Partners GP, L.L.C.0$00.00%−43,815−100.0%Sold out
Marshall Wace, LLP0$00.00%−34,494−100.0%Sold out
Point72 Middle East FZE0$00.00%−31,181−100.0%Sold out
UBS Oconnor LLC0$00.00%−30,000−100.0%Sold out
Trexquant Investment LP0$00.00%−24,514−100.0%Sold out
Fox Run Management, L.L.C.0$00.00%−17,186−100.0%Sold out
Gsa Capital Partners LLP0$00.00%−16,465−100.0%Sold out
Engineers Gate Manager LP0$00.00%−13,071−100.0%Sold out
Man Group plc0$00.00%–Sold out
Point72 Asset Management, L.P.0$00.00%−4,146−100.0%Sold out
Aquatic Capital Management LLC0$00.00%−3,100−100.0%Sold out
Allspring Global Investments Holdings, LLC0$00.00%−2,260−100.0%Sold out
Headinvest, LLC0$00.00%−110−100.0%Sold out
Newbridge Financial Services Group, Inc.0$00.00%−65−100.0%Sold out
Allworth Financial LP0$00.00%−5−100.0%Sold out