Prime Medicine, Inc.
PRME- Exchange
- Nasdaq
- Industry
- Biological Products, (No Diagnostic Substances)
- SEC CIK
- 0001894562
No open-market purchases or sales by Prime Medicine, Inc. insiders were filed in the last 90 days; 187 institutions reported holding it in 13F filings for Q2 2026, worth $393.5M in total; ARK Invest is the only superinvestor holding it.
13F holders, Q4 2025
Institutional positions in Prime Medicine, Inc. as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 183
- +18 vs. Q3 2025
- Shares held
- 97.0M
- +6.43M (+7.1%) vs. Q3 2025
- Total value
- $336.5M
- −$165.1M (−32.9%) vs. Q3 2025
- New holders
- 44
- 66 more added
- Sold out
- 26
- 40 more reduced
2 institutions that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting PRME on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 187 | $393.5M |
| Q1 2026 | 192 | $342.6M |
| Q4 2025 | 183 | $336.5M |
| Q3 2025 | 167 | $511.5M |
| Q2 2025 | 121 | $145.0M |
| Q1 2025 | 125 | $120.4M |
| Q4 2024 | 132 | $188.0M |
| Q3 2024 | 116 | $265.9M |
| Q2 2024 | 122 | $354.0M |
| Q1 2024 | 115 | $466.6M |
| Q4 2023 | 105 | $431.4M |
| Q3 2023 | 83 | $472.3M |
| Q2 2023 | 79 | $675.7M |
| Q1 2023 | 76 | $512.1M |
| Q4 2022 | 66 | $767.8M |
| Q3 2022 | 0 | $0 |
| Q2 2022 | 0 | $0 |
| Q1 2022 | 0 | $0 |
| Q4 2021 | 0 | $0 |
| Q3 2021 | 0 | $0 |
| Q2 2021 | 0 | $0 |
| Q1 2021 | 0 | $0 |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Prime Medicine, Inc.; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Crestwood Advisors Group LLC | 31,973 | $110.9K | 0.00% | +286+0.9% | Added |
| Manufacturers Life Insurance Company, The | 31,602 | $109.7K | 0.00% | +4,470+16.5% | Added |
| SG Americas Securities, LLC | 30,954 | $107.0K | 0.00% | +30,954 | New |
| China Universal Asset Management Co., Ltd. | 29,414 | $102.1K | 0.01% | −1,236−4.0% | Reduced |
| Wealth Enhancement Advisory Services, LLC | 26,098 | $96.6K | 0.00% | −680−2.5% | Reduced |
| Raymond James Financial Inc | 27,044 | $93.8K | 0.00% | −4,763−15.0% | Reduced |
| Transcend Wealth Collective, LLC | 26,500 | $92.0K | 0.01% | +26,500 | New |
| ProShare Advisors LLC | 26,158 | $90.8K | 0.00% | +7,059+37.0% | Added |
| CWM, LLC | 25,427 | $88.0K | 0.00% | +75+0.3% | Added |
| Abacus Planning Group, Inc. | 25,188 | $87.4K | 0.01% | 00.0% | Unchanged |
| Nomura Holdings Inc | 24,789 | $86.0K | 0.00% | −126−0.5% | Reduced |
| Arizona State Retirement System | 24,085 | $83.6K | 0.00% | +24,085 | New |
| JustInvest LLC | 23,651 | $82.1K | 0.00% | −333−1.4% | Reduced |
| Voloridge Investment Management, LLC | 23,121 | $80.2K | 0.00% | −146,900−86.4% | Reduced |
| Thompson Davis & Co., Inc. | 22,740 | $78.9K | 0.05% | −4,833−17.5% | Reduced |
| Scientech Research LLC | 22,393 | $77.7K | 0.05% | +22,393 | New |
| Police & Firemen's Retirement System of New Jersey | 21,166 | $73.4K | 0.00% | 00.0% | Unchanged |
| Shelton Wealth Management, LLC | 20,066 | $69.6K | 0.03% | +2,734+15.8% | Added |
| KLP Kapitalforvaltning AS | 18,500 | $64.2K | 0.00% | +18,500 | New |
| Creative Planning | 17,892 | $62.1K | 0.00% | −5,190−22.5% | Reduced |
| Voya Investment Management LLC | 17,491 | $60.7K | 0.00% | +4,642+36.1% | Added |
| Clarius Group, LLC | 16,080 | $55.8K | 0.00% | 00.0% | Unchanged |
| Kingsview Wealth Management, LLC | 15,000 | $52.0K | 0.00% | −9,750−39.4% | Reduced |
| Levin Capital Strategies, L.P. | 15,000 | $52.0K | 0.00% | 00.0% | Unchanged |
| Martingale Asset Management L P | 14,808 | $51.4K | 0.00% | +14,808 | New |
| Sanctuary Advisors, LLC | 14,659 | $50.9K | 0.00% | +336+2.3% | Added |
| Prime Capital Investment Advisors, LLC | 14,055 | $48.8K | 0.00% | −324−2.3% | Reduced |
| Sterling Investment Advisors, Ltd. | 13,400 | $46.5K | 0.01% | +3,400+34.0% | Added |
| JTC Employer Solutions Trusteee Ltd | 13,249 | $46.0K | 0.00% | 00.0% | Unchanged |
| Oppenheimer & Co Inc | 12,433 | $43.1K | 0.00% | +12,433 | New |
| Teacher Retirement System of Texas | 12,235 | $42.5K | 0.00% | +12,235 | New |
| Federation des caisses Desjardins du Quebec | 12,000 | $41.6K | 0.00% | −3,900−24.5% | Reduced |
| Integrity Advisory Solutions, LLC | 11,689 | $40.6K | 0.01% | +11,689 | New |
| Callan Family Office, LLC | 11,292 | $39.2K | 0.00% | +11,292 | New |
| Neuberger Berman Group LLC | 10,915 | $37.9K | 0.00% | +10,915 | New |
| Lazard Asset Management LLC | 10,844 | $37.6K | 0.00% | +10,844 | New |
| Victory Capital Management Inc | 10,801 | $37.5K | 0.00% | +611+6.0% | Added |
| Rhodes Investment Advisors Inc | 10,750 | $37.3K | 0.03% | +10,750 | New |
| Prelude Capital Management, LLC | 10,200 | $35.4K | 0.00% | −12,283−54.6% | Reduced |
| Forum Financial Management, LP | 10,000 | $34.7K | 0.00% | +10,000 | New |
| Glen Eagle Advisors, LLC | 10,000 | $34.7K | 0.00% | +10,000 | New |
| BNP Paribas Arbitrage, SA | 9,823 | $34.1K | 0.00% | −9,833−50.0% | Reduced |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 8,814 | $30.6K | 0.00% | +8,814 | New |
| Mirae Asset Global Investments Co., Ltd. | 8,772 | $30.4K | 0.00% | +2,012+29.8% | Added |
| New York State Common Retirement Fund | 8,434 | $29.3K | 0.00% | 00.0% | Unchanged |
| Advisor Group Holdings, Inc. | 8,428 | $29.2K | 0.00% | +1,478+21.3% | Added |
| Russell Investments Group, Ltd. | 6,827 | $23.7K | 0.00% | 00.0% | Unchanged |
| Ameritas Investment Partners, Inc. | 5,901 | $20.5K | 0.00% | 00.0% | Unchanged |
| Sterling Capital Management LLC | 5,736 | $19.9K | 0.00% | +542+10.4% | Added |
| NBC Securities, Inc. | 5,000 | $17.4K | 0.00% | −2,500−33.3% | Reduced |
| Signaturefd, LLC | 5,000 | $17.4K | 0.00% | 00.0% | Unchanged |
| Royal Bank of Canada | 4,889 | $17.0K | 0.00% | +3,046+165.3% | Added |
| Nisa Investment Advisors, LLC | 4,546 | $15.8K | 0.00% | −55,900−92.5% | Reduced |
| GF Fund Management Co. Ltd. | 3,547 | $12.3K | 0.00% | −215−5.7% | Reduced |
| Financial Connections Group, Inc. | 3,712 | $12.0K | 0.00% | 00.0% | Unchanged |
| Amalgamated Bank | 3,126 | $11.0K | 0.00% | +1,169+59.7% | Added |
| Allworth Financial LP | 3,115 | $10.8K | 0.00% | +2,109+209.6% | Added |
| MTM Investment Management, LLC | 3,090 | $10.7K | 0.00% | +3,090 | New |
| EverSource Wealth Advisors, LLC | 1,762 | $6.11K | 0.00% | 00.0% | Unchanged |
| Scarborough Advisors, LLC | 1,257 | $4.36K | 0.00% | +752+148.9% | Added |
| GWM Advisors LLC | 1,000 | $3.47K | 0.00% | 00.0% | Unchanged |
| Corsicana & Co. | 1,000 | $3.47K | 0.00% | 00.0% | Unchanged |
| Leonteq Securities AG | 915 | $3.17K | 0.00% | 00.0% | Unchanged |
| Tower Research Capital LLC (TRC) | 807 | $2.80K | 0.00% | −3,085−79.3% | Reduced |
| Fairman Group, LLC | 500 | $1.74K | 0.00% | 00.0% | Unchanged |
| Rothschild Investment LLC | 345 | $1.20K | 0.00% | 00.0% | Unchanged |
| The PNC Financial Services Group, Inc. | 319 | $1.11K | 0.00% | 00.0% | Unchanged |
| SBI Securities Co., Ltd. | 303 | $1.05K | 0.00% | −697−69.7% | Reduced |
| Fortitude Family Office, LLC | 296 | $1.03K | 0.00% | 00.0% | Unchanged |
| Daiwa Securities Group Inc. | 398 | $1.00K | 0.00% | 00.0% | Unchanged |
| Basecamp Wealth Advisors LLC | 287 | $996 | 0.00% | +287 | New |
| Parkside Financial Bank & Trust | 285 | $989 | 0.00% | 00.0% | Unchanged |
| MAI Capital Management | 274 | $951 | 0.00% | 00.0% | Unchanged |
| CIBC Private Wealth Group, LLC | 267 | $926 | 0.00% | +267 | New |
| Essential Partners LLC | 221 | $767 | 0.00% | +11+5.2% | Added |
| Optiver Holding B.V. | 160 | $555 | 0.00% | −738−82.2% | Reduced |
| Global Retirement Partners, LLC | 146 | $507 | 0.00% | +146 | New |
| True Wealth Design, LLC | 115 | $400 | 0.00% | 00.0% | Unchanged |
| GAMMA Investing LLC | 111 | $385 | 0.00% | +111 | New |
| Sunbelt Securities, Inc. | 80 | $278 | 0.00% | 00.0% | Unchanged |
| Farther Finance Advisors, LLC | 71 | $246 | 0.00% | 00.0% | Unchanged |
| IFP Advisors, Inc | 10 | $35 | 0.00% | +1+11.1% | Added |
| Covestor Ltd | 31 | $0 | 0.00% | 00.0% | Unchanged |
| Ra Capital Management, L.P. | 0 | $0 | 0.00% | −3,000,000−100.0% | Sold out |
| EcoR1 Capital, LLC | 0 | $0 | 0.00% | −1,543,326−100.0% | Sold out |
| Adage Capital Partners GP, L.L.C. | 0 | $0 | 0.00% | −771,361−100.0% | Sold out |
| Schonfeld Strategic Advisors LLC | 0 | $0 | 0.00% | −593,039−100.0% | Sold out |
| Man Group plc | 0 | $0 | 0.00% | −189,588−100.0% | Sold out |
| JBF Capital, Inc. | 0 | $0 | 0.00% | −188,900−100.0% | Sold out |
| DnB Asset Management AS | 0 | $0 | 0.00% | −182,133−100.0% | Sold out |
| Simplex Trading, LLC | 0 | $0 | 0.00% | −157,897−100.0% | Sold out |
| Ikarian Capital, LLC | 0 | $0 | 0.00% | −150,000−100.0% | Sold out |
| Fred Alger Management, LLC | 0 | $0 | 0.00% | −122,654−100.0% | Sold out |
| Redmile Group, LLC | 0 | $0 | 0.00% | −87,118−100.0% | Sold out |
| Jane Street Group, LLC | 0 | $0 | 0.00% | −85,892−100.0% | Sold out |
| Diametric Capital, LP | 0 | $0 | 0.00% | −81,271−100.0% | Sold out |
| Tudor Investment Corp Et Al | 0 | $0 | 0.00% | −62,981−100.0% | Sold out |
| Boothbay Fund Management, LLC | 0 | $0 | 0.00% | −55,050−100.0% | Sold out |
| Jain Global LLC | 0 | $0 | 0.00% | −44,849−100.0% | Sold out |
| PEAK6 LLC | 0 | $0 | 0.00% | −35,063−100.0% | Sold out |