Prime Medicine, Inc.
PRME- Exchange
- Nasdaq
- Industry
- Biological Products, (No Diagnostic Substances)
- SEC CIK
- 0001894562
No open-market purchases or sales by Prime Medicine, Inc. insiders were filed in the last 90 days; 187 institutions reported holding it in 13F filings for Q2 2026, worth $393.5M in total; ARK Invest is the only superinvestor holding it.
13F holders, Q1 2025
Institutional positions in Prime Medicine, Inc. as of Mar 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 125
- −6 vs. Q4 2024
- Shares held
- 60.4M
- −3.56M (−5.6%) vs. Q4 2024
- Total value
- $120.4M
- −$66.4M (−35.6%) vs. Q4 2024
- New holders
- 23
- 41 more added
- Sold out
- 29
- 35 more reduced
1 institution that held it in Q4 2024 haven't filed for Q1 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q4 2024: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting PRME on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 187 | $393.5M |
| Q1 2026 | 192 | $342.6M |
| Q4 2025 | 183 | $336.5M |
| Q3 2025 | 167 | $511.5M |
| Q2 2025 | 121 | $145.0M |
| Q1 2025 | 125 | $120.4M |
| Q4 2024 | 132 | $188.0M |
| Q3 2024 | 116 | $265.9M |
| Q2 2024 | 122 | $354.0M |
| Q1 2024 | 115 | $466.6M |
| Q4 2023 | 105 | $431.4M |
| Q3 2023 | 83 | $472.3M |
| Q2 2023 | 79 | $675.7M |
| Q1 2023 | 76 | $512.1M |
| Q4 2022 | 66 | $767.8M |
| Q3 2022 | 0 | $0 |
| Q2 2022 | 0 | $0 |
| Q1 2022 | 0 | $0 |
| Q4 2021 | 0 | $0 |
| Q3 2021 | 0 | $0 |
| Q2 2021 | 0 | $0 |
| Q1 2021 | 0 | $0 |
Institutions, Q1 2025
Shares, value and share of portfolio for each institution holding Prime Medicine, Inc.; share changes are against Q4 2024.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Alphabet Inc. | 15,062,498 | $30.0M | 1.90% | 00.0% | Unchanged |
| BlackRock, Inc. | 4,306,211 | $8.57M | 0.00% | −218,573−4.8% | Reduced |
| T. Rowe Price Investment Management, Inc. | 4,143,096 | $8.24M | 0.01% | +165,268+4.2% | Added |
| FMR LLC | 3,747,235 | $7.46M | 0.00% | −54,793−1.4% | Reduced |
| Vanguard Group Inc | 3,641,348 | $7.25M | 0.00% | −13,969−0.4% | Reduced |
| ARK Investment Management LLCSuperinvestorARK Invest | 3,095,172 | $6.16M | 0.06% | −2,055,061−39.9% | Reduced |
| Sumitomo Mitsui Trust Holdings, Inc. | 2,926,023 | $5.82M | 0.00% | −164,157−5.3% | Reduced |
| Nikko Asset Management Americas, Inc. | 2,926,023 | $5.82M | 0.08% | −164,157−5.3% | Reduced |
| Redmile Group, LLC | 2,074,350 | $4.13M | 0.39% | 00.0% | Unchanged |
| MWG Management Limited | 1,792,210 | $3.57M | 6.08% | 00.0% | Unchanged |
| Millennium Management LLC | 1,779,945 | $3.54M | 0.00% | −94,626−5.0% | Reduced |
| Price T Rowe Associates Inc | 1,567,192 | $3.12M | 0.00% | −17,284−1.1% | Reduced |
| Geode Capital Management, LLC | 1,526,530 | $3.04M | 0.00% | +58,924+4.0% | Added |
| State Street Corp | 1,145,305 | $2.28M | 0.00% | −8,876−0.8% | Reduced |
| Baker Bros. Advisors LP | 1,028,466 | $2.05M | 0.02% | 00.0% | Unchanged |
| Greenwich Wealth Management LLC | 819,001 | $1.63M | 0.12% | +45,000+5.8% | Added |
| Farallon Capital Management, L.L.C. | 750,000 | $1.49M | 0.01% | 00.0% | Unchanged |
| EcoR1 Capital, LLC | 700,000 | $1.39M | 0.08% | 00.0% | Unchanged |
| Northern Trust Corp | 527,309 | $1.05M | 0.00% | −17,628−3.2% | Reduced |
| Charles Schwab Investment Management Inc | 503,697 | $1.00M | 0.00% | +19,106+3.9% | Added |
| Moore Capital Management, LP | 500,000 | $995.0K | 0.03% | 00.0% | Unchanged |
| Renaissance Technologies LLC | 447,600 | $890.7K | 0.00% | +447,600 | New |
| Samsara BioCapital, LLC | 405,228 | $806.4K | 0.14% | 00.0% | Unchanged |
| Casdin Capital, LLC | 367,175 | $730.7K | 0.06% | 00.0% | Unchanged |
| Bollard Group LLC | 361,136 | $719.0K | 0.02% | 00.0% | Unchanged |
| Morgan Stanley | 355,176 | $706.8K | 0.00% | +43,900+14.1% | Added |
| Two Sigma Investments, LP | 258,770 | $515.0K | 0.00% | +92,571+55.7% | Added |
| Goldman Sachs Group Inc | 251,399 | $500.3K | 0.00% | −170,499−40.4% | Reduced |
| AQR Capital Management LLC | 243,795 | $485.2K | 0.00% | +227,749+1,419.4% | Added |
| Chelsea Counsel Co | 208,210 | $414.3K | 0.23% | +21,430+11.5% | Added |
| Nuveen, LLC | 59,402 | $373.7K | 0.00% | +59,402 | New |
| Bank of New York Mellon Corp | 155,992 | $310.4K | 0.00% | +26,478+20.4% | Added |
| Gsa Capital Partners LLP | 153,273 | $305.0K | 0.03% | +137,962+901.1% | Added |
| Susquehanna International Group, LLP | 142,619 | $283.8K | 0.00% | +105,567+284.9% | Added |
| Deutsche Bank AG | 126,846 | $252.4K | 0.00% | +46,011+56.9% | Added |
| FIL Ltd | 121,017 | $240.8K | 0.00% | 00.0% | Unchanged |
| UBS Group AG | 117,680 | $234.2K | 0.00% | −100,506−46.1% | Reduced |
| Bank of America Corp | 112,926 | $224.7K | 0.00% | −317,687−73.8% | Reduced |
| Palumbo Wealth Management LLC | 95,462 | $190.0K | 0.06% | +95,462 | New |
| Wells Fargo & Company | 90,819 | $180.7K | 0.00% | −5,362−5.6% | Reduced |
| Davy Global Fund Management Ltd | 89,870 | $178.8K | 0.02% | +29,185+48.1% | Added |
| Green Alpha Advisors, LLC | 83,467 | $166.1K | 0.18% | +19,061+29.6% | Added |
| Rhumbline Advisers | 81,900 | $163.0K | 0.00% | +9,944+13.8% | Added |
| Vestmark Advisory Solutions, Inc. | 78,599 | $156.4K | 0.00% | −32,866−29.5% | Reduced |
| Alliancebernstein L.P. | 76,000 | $151.2K | 0.00% | 00.0% | Unchanged |
| Barclays PLC | 71,424 | $142.1K | 0.00% | −26,197−26.8% | Reduced |
| Tudor Investment Corp Et Al | 60,368 | $120.1K | 0.00% | +60,368 | New |
| Intech Investment Management LLC | 54,946 | $109.3K | 0.00% | +24,542+80.7% | Added |
| Virtus Investment Advisers, Inc. | 54,535 | $108.5K | 0.03% | +54,535 | New |
| Two Sigma Advisers, LP | 53,900 | $107.3K | 0.00% | +10,700+24.8% | Added |
| SG Americas Securities, LLC | 51,456 | $102.0K | 0.00% | −8,773−14.6% | Reduced |
| Jacobs Levy Equity Management, Inc | 50,514 | $100.5K | 0.00% | +50,514 | New |
| TD Asset Management Inc | 46,434 | $92.4K | 0.00% | 00.0% | Unchanged |
| Citigroup Inc | 42,302 | $84.2K | 0.00% | −5,129−10.8% | Reduced |
| Skopos Labs, Inc. | 39,967 | $79.5K | 0.02% | +38,073+2,010.2% | Added |
| Verition Fund Management LLC | 38,255 | $76.1K | 0.00% | −65,290−63.1% | Reduced |
| JPMorgan Chase & Co | 35,663 | $71.0K | 0.00% | +23+0.1% | Added |
| Levin Capital Strategies, L.P. | 35,000 | $69.7K | 0.01% | −40,000−53.3% | Reduced |
| Ieq Capital, LLC | 34,882 | $69.4K | 0.00% | +34,882 | New |
| Mirae Asset Global ETFs Holdings Ltd. | 33,918 | $67.5K | 0.00% | +1,419+4.4% | Added |
| Crestwood Advisors Group LLC | 31,687 | $63.1K | 0.00% | 00.0% | Unchanged |
| Cerity Partners LLC | 31,387 | $62.5K | 0.00% | +31,387 | New |
| BNP Paribas Arbitrage, SA | 31,322 | $62.3K | 0.00% | +11,226+55.9% | Added |
| Brevan Howard Capital Management LP | 28,478 | $56.7K | 0.00% | +28,478 | New |
| Corebridge Financial, Inc. | 27,785 | $55.3K | 0.00% | −412−1.5% | Reduced |
| China Universal Asset Management Co., Ltd. | 26,309 | $52.4K | 0.00% | −1,502−5.4% | Reduced |
| Quadrature Capital Ltd | 24,802 | $49.6K | 0.00% | +24,802 | New |
| Manufacturers Life Insurance Company, The | 24,924 | $49.6K | 0.00% | +1,332+5.6% | Added |
| Prime Capital Investment Advisors, LLC | 24,261 | $48.3K | 0.00% | +306+1.3% | Added |
| Sanctuary Advisors, LLC | 23,822 | $47.4K | 0.00% | +23,822 | New |
| Envestnet Asset Management Inc | 23,515 | $46.8K | 0.00% | +1,958+9.1% | Added |
| HighTower Advisors, LLC | 21,646 | $43.1K | 0.00% | +56+0.3% | Added |
| Avanza Fonder AB | 23,918 | $42.8K | 0.00% | +1,438+6.4% | Added |
| Benjamin Edwards Inc | 21,101 | $42.0K | 0.00% | −820−3.7% | Reduced |
| CWM, LLC | 20,466 | $41.0K | 0.00% | +18,034+741.5% | Added |
| ProShare Advisors LLC | 18,194 | $36.2K | 0.00% | −3,992−18.0% | Reduced |
| Voya Investment Management LLC | 17,222 | $34.3K | 0.00% | −951−5.2% | Reduced |
| Police & Firemen's Retirement System of New Jersey | 17,092 | $34.0K | 0.00% | 00.0% | Unchanged |
| CIBC World Markets Inc. | 17,015 | $33.9K | 0.00% | −2,008−10.6% | Reduced |
| Clarius Group, LLC | 16,080 | $32.0K | 0.00% | 00.0% | Unchanged |
| JustInvest LLC | 15,237 | $30.3K | 0.00% | +2,859+23.1% | Added |
| Invesco Ltd. | 14,836 | $29.5K | 0.00% | −235−1.6% | Reduced |
| CIBC World Markets Corp | 12,585 | $25.0K | 0.00% | +12,585 | New |
| Wealth Enhancement Advisory Services, LLC | 12,230 | $24.3K | 0.00% | +12,230 | New |
| American Century Companies Inc | 11,426 | $22.7K | 0.00% | 00.0% | Unchanged |
| State Board of Administration of Florida Retirement System | 11,420 | $22.7K | 0.00% | 00.0% | Unchanged |
| Pathstone Holdings, LLC | 11,250 | $22.4K | 0.00% | −61−0.5% | Reduced |
| Tower Research Capital LLC (TRC) | 9,909 | $19.7K | 0.00% | +8,512+609.3% | Added |
| Farther Finance Advisors, LLC | 10,763 | $19.2K | 0.00% | +10,737+41,296.2% | Added |
| New York State Common Retirement Fund | 8,434 | $16.8K | 0.00% | 00.0% | Unchanged |
| Simplex Trading, LLC | 8,376 | $16.0K | 0.00% | +6,918+474.5% | Added |
| Legal & General Group Plc | 5,915 | $11.8K | 0.00% | −364−5.8% | Reduced |
| Mirae Asset Global Investments Co., Ltd. | 4,389 | $8.73K | 0.00% | +18+0.4% | Added |
| California State Teachers Retirement System | 4,110 | $8.18K | 0.00% | 00.0% | Unchanged |
| Ameritas Investment Partners, Inc. | 3,901 | $7.76K | 0.00% | 00.0% | Unchanged |
| GF Fund Management Co. Ltd. | 3,358 | $6.68K | 0.00% | +658+24.4% | Added |
| Signaturefd, LLC | 2,649 | $5.27K | 0.00% | +996+60.3% | Added |
| Amalgamated Bank | 1,957 | $4.00K | 0.00% | +610+45.3% | Added |
| Quadrant Capital Group LLC | 1,842 | $3.67K | 0.00% | +1,009+121.1% | Added |
| Royal Bank of Canada | 1,640 | $3.00K | 0.00% | +478+41.1% | Added |