Prime Medicine, Inc.
PRME- Exchange
- Nasdaq
- Industry
- Biological Products, (No Diagnostic Substances)
- SEC CIK
- 0001894562
No open-market purchases or sales by Prime Medicine, Inc. insiders were filed in the last 90 days; 187 institutions reported holding it in 13F filings for Q2 2026, worth $393.5M in total; ARK Invest is the only superinvestor holding it.
13F holders, Q1 2023
Institutional positions in Prime Medicine, Inc. as of Mar 31, 2023. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 76
- +11 vs. Q4 2022
- Shares held
- 41.7M
- +420.4K (+1.0%) vs. Q4 2022
- Total value
- $512.1M
- −$255.6M (−33.3%) vs. Q4 2022
- New holders
- 18
- 29 more added
- Sold out
- 7
- 6 more reduced
1 institution that held it in Q4 2022 haven't filed for Q1 2023 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q4 2022: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting PRME on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 187 | $393.5M |
| Q1 2026 | 192 | $342.6M |
| Q4 2025 | 183 | $336.5M |
| Q3 2025 | 167 | $511.5M |
| Q2 2025 | 121 | $145.0M |
| Q1 2025 | 125 | $120.4M |
| Q4 2024 | 132 | $188.0M |
| Q3 2024 | 116 | $265.9M |
| Q2 2024 | 122 | $354.0M |
| Q1 2024 | 115 | $466.6M |
| Q4 2023 | 105 | $431.4M |
| Q3 2023 | 83 | $472.3M |
| Q2 2023 | 79 | $675.7M |
| Q1 2023 | 76 | $512.1M |
| Q4 2022 | 66 | $767.8M |
| Q3 2022 | 0 | $0 |
| Q2 2022 | 0 | $0 |
| Q1 2022 | 0 | $0 |
| Q4 2021 | 0 | $0 |
| Q3 2021 | 0 | $0 |
| Q2 2021 | 0 | $0 |
| Q1 2021 | 0 | $0 |
Institutions, Q1 2023
Shares, value and share of portfolio for each institution holding Prime Medicine, Inc.; share changes are against Q4 2022.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Alphabet Inc. | 13,284,688 | $163.4M | 9.06% | 00.0% | Unchanged |
| FMR LLC | 8,517,129 | $104.8M | 0.01% | +54,083+0.6% | Added |
| Redmile Group, LLC | 1,992,843 | $24.5M | 1.06% | −216,507−9.8% | Reduced |
| ARK Investment Management LLCSuperinvestorARK Invest | 1,922,277 | $23.6M | 0.16% | +282,293+17.2% | Added |
| MWG Management Limited | 1,835,876 | $22.6M | 15.90% | 00.0% | Unchanged |
| FIL Ltd | 1,805,558 | $22.2M | 0.03% | 00.0% | Unchanged |
| BlackRock Inc. | 1,514,123 | $18.6M | 0.00% | +26,277+1.8% | Added |
| Baker Bros. Advisors LP | 1,028,466 | $12.7M | 0.07% | 00.0% | Unchanged |
| Sumitomo Mitsui Trust Holdings, Inc. | 997,572 | $12.3M | 0.01% | +509,346+104.3% | Added |
| Price T Rowe Associates Inc | 903,741 | $11.1M | 0.00% | −1,474,841−62.0% | Reduced |
| Nikko Asset Management Americas, Inc. | 999,333 | $11.0M | 0.13% | +511,107+104.7% | Added |
| Deerfield Management Company, L.P. (Series C) | 885,314 | $10.9M | 0.24% | 00.0% | Unchanged |
| Vanguard Group Inc | 884,446 | $10.9M | 0.00% | +11,923+1.4% | Added |
| Cormorant Asset Management, LP | 734,350 | $9.03M | 0.59% | 00.0% | Unchanged |
| Casdin Capital, LLC | 734,350 | $9.03M | 0.75% | 00.0% | Unchanged |
| EcoR1 Capital, LLC | 600,000 | $7.38M | 0.24% | 00.0% | Unchanged |
| Moore Capital Management, LP | 500,000 | $6.15M | 0.19% | 00.0% | Unchanged |
| Samsara BioCapital, LLC | 470,304 | $5.78M | 1.20% | 00.0% | Unchanged |
| Greenwich Wealth Management LLC | 349,000 | $4.29M | 0.47% | +349,000 | New |
| Geode Capital Management, LLC | 240,345 | $2.96M | 0.00% | +6,050+2.6% | Added |
| State Street Corp | 189,428 | $2.33M | 0.00% | +74,582+64.9% | Added |
| Wexford Capital LP | 153,705 | $1.89M | 0.39% | +153,705 | New |
| Bank of America Corp | 150,267 | $1.85M | 0.00% | +102,908+217.3% | Added |
| Ensign Peak Advisors, Inc | 150,000 | $1.84M | 0.00% | 00.0% | Unchanged |
| OUP Management Co., LLC | 121,255 | $1.49M | 2.98% | 00.0% | Unchanged |
| Northern Trust Corp | 90,079 | $1.11M | 0.00% | +6,533+7.8% | Added |
| Charles Schwab Investment Management Inc | 73,427 | $903.2K | 0.00% | +2,243+3.2% | Added |
| Laurion Capital Management LP | 60,000 | $738.0K | 0.03% | 00.0% | Unchanged |
| Manufacturers Life Insurance Company, The | 45,631 | $561.3K | 0.00% | +642+1.4% | Added |
| Swiss National Bank | 41,900 | $515.4K | 0.00% | +41,900 | New |
| Morgan Stanley | 33,385 | $410.6K | 0.00% | +12,996+63.7% | Added |
| Brandywine Managers, LLC | 32,977 | $405.6K | 0.29% | 00.0% | Unchanged |
| Jump Financial, LLC | 32,500 | $399.8K | 0.02% | +32,500 | New |
| Panagora Asset Management Inc | 32,197 | $396.0K | 0.00% | +32,197 | New |
| Bank of New York Mellon Corp | 30,068 | $369.8K | 0.00% | +1,052+3.6% | Added |
| TD Asset Management Inc | 23,922 | $294.2K | 0.00% | 00.0% | Unchanged |
| California State Teachers Retirement System | 20,967 | $257.9K | 0.00% | +16,823+406.0% | Added |
| Cubist Systematic Strategies, LLC | 19,663 | $241.9K | 0.00% | +18,539+1,649.4% | Added |
| State of Wisconsin Investment Board | 17,999 | $221.4K | 0.00% | +17,999 | New |
| Clarius Group, LLC | 16,080 | $197.8K | 0.02% | 00.0% | Unchanged |
| Oppenheimer & Co Inc | 15,118 | $186.0K | 0.00% | +1,106+7.9% | Added |
| Red Lighthouse Investment Management, LLC | 14,950 | $183.9K | 0.09% | +14,950 | New |
| Credit Suisse AG | 14,705 | $180.9K | 0.00% | +13,905+1,738.1% | Added |
| Capstone Investment Advisors, LLC | 14,551 | $179.0K | 0.01% | +14,551 | New |
| Nuveen Asset Management, LLC | 14,128 | $174.0K | 0.00% | 00.0% | Unchanged |
| Janus Henderson Group PLC | 14,091 | $173.1K | 0.00% | +14,091 | New |
| JPMorgan Chase & Co | 12,897 | $159.0K | 0.00% | +3,023+30.6% | Added |
| Deutsche Bank AG | 10,860 | $133.6K | 0.00% | +6,387+142.8% | Added |
| Millennium Management LLC | 10,759 | $132.0K | 0.00% | +10,759 | New |
| Sandia Investment Management LP | 10,000 | $123.0K | 0.02% | 00.0% | Unchanged |
| Citigroup Inc | 8,859 | $109.0K | 0.00% | +5,272+147.0% | Added |
| New York State Common Retirement Fund | 7,793 | $95.9K | 0.00% | +2,793+55.9% | Added |
| Penserra Capital Management LLC | 7,000 | $86.0K | 0.00% | −570−7.5% | Reduced |
| Advisor Group Holdings, Inc. | 6,431 | $79.1K | 0.00% | +402+6.7% | Added |
| MetLife Investment Management | 6,091 | $74.9K | 0.00% | 00.0% | Unchanged |
| Barclays PLC | 5,336 | $65.6K | 0.00% | +2,549+91.5% | Added |
| American International Group, Inc. | 5,087 | $62.6K | 0.00% | +178+3.6% | Added |
| UBS Group AG | 4,935 | $60.7K | 0.00% | +3,726+308.2% | Added |
| Legal & General Group Plc | 3,427 | $42.2K | 0.00% | +2,502+270.5% | Added |
| Tower Research Capital LLC (TRC) | 3,225 | $40.0K | 0.00% | +2,852+764.6% | Added |
| STRS Ohio | 2,400 | $29.0K | 0.00% | 00.0% | Unchanged |
| Wells Fargo & Company | 1,936 | $23.8K | 0.00% | +1,936 | New |
| First Horizon Advisors, Inc. | 1,698 | $20.9K | 0.00% | −115−6.3% | Reduced |
| Lazard Asset Management LLC | 1,547 | $18.0K | 0.00% | +1,547 | New |
| Amalgamated Bank | 1,264 | $16.0K | 0.00% | −303−19.3% | Reduced |
| Allspring Global Investments Holdings, LLC | 1,151 | $14.2K | 0.00% | +1,151 | New |
| Ameritas Investment Partners, Inc. | 831 | $10.2K | 0.00% | 00.0% | Unchanged |
| Metropolitan Life Insurance Co | 718 | $8.83K | 0.00% | 00.0% | Unchanged |
| Chelsea Counsel Co | 600 | $7.38K | 0.00% | 00.0% | Unchanged |
| Royal Bank of Canada | 590 | $7.00K | 0.00% | −957−61.9% | Reduced |
| TCI Wealth Advisors, Inc. | 231 | $2.84K | 0.00% | +231 | New |
| Benjamin Edwards Inc | 182 | $2.00K | 0.00% | +35+23.8% | Added |
| Federated Hermes, Inc. | 45 | $554 | 0.00% | +45 | New |
| Endurance Wealth Management, Inc. | 500 | $0 | 0.00% | +500 | New |
| CWM, LLC | 15 | $0 | 0.00% | +15 | New |
| Covestor Ltd | 9 | $0 | 0.00% | +9 | New |
| Caas Capital Management LP | 0 | $0 | 0.00% | −89,331−100.0% | Sold out |
| Ghisallo Capital Management LLC | 0 | $0 | 0.00% | −70,000−100.0% | Sold out |
| Point72 Middle East FZE | 0 | $0 | 0.00% | −37,609−100.0% | Sold out |
| Walleye Capital LLC | 0 | $0 | 0.00% | −30,000−100.0% | Sold out |
| LMR Partners LLP | 0 | $0 | 0.00% | −17,760−100.0% | Sold out |
| Levin Capital Strategies, L.P. | 0 | $0 | 0.00% | −10,585−100.0% | Sold out |
| Leonteq Securities AG | 0 | $0 | 0.00% | −200−100.0% | Sold out |
| Alpha Paradigm Partners, LLC | – | – | – | – | Not filed |