Prime Medicine, Inc.
PRME- Exchange
- Nasdaq
- Industry
- Biological Products, (No Diagnostic Substances)
- SEC CIK
- 0001894562
No open-market purchases or sales by Prime Medicine, Inc. insiders were filed in the last 90 days; 187 institutions reported holding it in 13F filings for Q2 2026, worth $393.5M in total; ARK Invest is the only superinvestor holding it.
13F holders, Q1 2024
Institutional positions in Prime Medicine, Inc. as of Mar 31, 2024. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 115
- +10 vs. Q4 2023
- Shares held
- 66.7M
- +18.0M (+36.9%) vs. Q4 2023
- Total value
- $466.6M
- +$35.1M (+8.1%) vs. Q4 2023
- New holders
- 23
- 39 more added
- Sold out
- 13
- 35 more reduced
Compare with Q4 2023: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting PRME on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 187 | $393.5M |
| Q1 2026 | 192 | $342.6M |
| Q4 2025 | 183 | $336.5M |
| Q3 2025 | 167 | $511.5M |
| Q2 2025 | 121 | $145.0M |
| Q1 2025 | 125 | $120.4M |
| Q4 2024 | 132 | $188.0M |
| Q3 2024 | 116 | $265.9M |
| Q2 2024 | 122 | $354.0M |
| Q1 2024 | 115 | $466.6M |
| Q4 2023 | 105 | $431.4M |
| Q3 2023 | 83 | $472.3M |
| Q2 2023 | 79 | $675.7M |
| Q1 2023 | 76 | $512.1M |
| Q4 2022 | 66 | $767.8M |
| Q3 2022 | 0 | $0 |
| Q2 2022 | 0 | $0 |
| Q1 2022 | 0 | $0 |
| Q4 2021 | 0 | $0 |
| Q3 2021 | 0 | $0 |
| Q2 2021 | 0 | $0 |
| Q1 2021 | 0 | $0 |
Institutions, Q1 2024
Shares, value and share of portfolio for each institution holding Prime Medicine, Inc.; share changes are against Q4 2023.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Alphabet Inc. | 15,062,498 | $105.4M | 4.19% | +3,200,000+27.0% | Added |
| ARK Investment Management LLCSuperinvestorARK Invest | 5,993,354 | $42.0M | 0.29% | +2,855,084+91.0% | Added |
| Vanguard Group Inc | 5,801,445 | $40.6M | 0.00% | +1,746,534+43.1% | Added |
| FMR LLC | 3,924,370 | $27.5M | 0.00% | −9760.0% | Reduced |
| BlackRock Inc. | 3,756,210 | $26.3M | 0.00% | −22,408−0.6% | Reduced |
| Sumitomo Mitsui Trust Holdings, Inc. | 3,364,663 | $23.6M | 0.02% | −154,366−4.4% | Reduced |
| Nikko Asset Management Americas, Inc. | 3,364,663 | $23.5M | 0.23% | −154,366−4.4% | Reduced |
| T. Rowe Price Investment Management, Inc. | 3,090,083 | $21.6M | 0.01% | +3,090,083 | New |
| Price T Rowe Associates Inc | 2,522,590 | $17.7M | 0.00% | +301,431+13.6% | Added |
| Redmile Group, LLC | 2,074,350 | $14.5M | 0.53% | +750,000+56.6% | Added |
| Avidity Partners Management LP | 1,990,000 | $13.9M | 0.50% | +1,990,000 | New |
| MWG Management Limited | 1,792,210 | $12.5M | 9.29% | 00.0% | Unchanged |
| Baker Bros. Advisors LP | 1,028,466 | $7.20M | 0.09% | 00.0% | Unchanged |
| Geode Capital Management, LLC | 916,861 | $6.42M | 0.00% | +29,358+3.3% | Added |
| Deerfield Management Company, L.P. (Series C) | 885,314 | $6.20M | 0.11% | 00.0% | Unchanged |
| State Street Corp | 778,782 | $5.45M | 0.00% | +19,024+2.5% | Added |
| Farallon Capital Management, L.L.C. | 750,000 | $5.25M | 0.03% | +750,000 | New |
| EcoR1 Capital, LLC | 700,000 | $4.90M | 0.12% | +700,000 | New |
| Greenwich Wealth Management LLC | 578,001 | $4.05M | 0.32% | +65,000+12.7% | Added |
| Samsara BioCapital, LLC | 540,304 | $3.78M | 0.59% | +70,000+14.9% | Added |
| Two Sigma Investments, LP | 508,078 | $3.56M | 0.01% | +239,716+89.3% | Added |
| Moore Capital Management, LP | 500,000 | $3.50M | 0.07% | +500,000 | New |
| Millennium Management LLC | 435,317 | $3.05M | 0.00% | +300,773+223.5% | Added |
| Bank of America Corp | 421,420 | $2.95M | 0.00% | −49,176−10.4% | Reduced |
| Casdin Capital, LLC | 367,175 | $2.57M | 0.19% | 00.0% | Unchanged |
| Renaissance Technologies LLC | 362,400 | $2.54M | 0.00% | +309,108+580.0% | Added |
| Bollard Group LLC | 361,136 | $2.53M | 0.08% | 00.0% | Unchanged |
| Vestal Point Capital, LP | 360,000 | $2.52M | 0.21% | +339,694+1,672.9% | Added |
| Northern Trust Corp | 339,998 | $2.38M | 0.00% | −4,929−1.4% | Reduced |
| Schonfeld Strategic Advisors LLC | 330,500 | $2.31M | 0.02% | +330,500 | New |
| Deep Track Capital, LP | 303,716 | $2.13M | 0.06% | +303,716 | New |
| Charles Schwab Investment Management Inc | 297,823 | $2.08M | 0.00% | +1,635+0.6% | Added |
| Sphera Funds Management Ltd. | 205,242 | $1.44M | 0.23% | +131,262+177.4% | Added |
| Morgan Stanley | 198,466 | $1.39M | 0.00% | −13,268−6.3% | Reduced |
| Two Sigma Advisers, LP | 164,000 | $1.15M | 0.00% | +118,000+256.5% | Added |
| Westwood Holdings Group Inc. | 159,351 | $1.11M | 0.01% | +159,351 | New |
| Nuveen Asset Management, LLC | 150,373 | $1.05M | 0.00% | +42,280+39.1% | Added |
| Ensign Peak Advisors, Inc | 150,000 | $1.05M | 0.00% | 00.0% | Unchanged |
| Vestmark Advisory Solutions, Inc. | 147,484 | $1.03M | 0.04% | +3,196+2.2% | Added |
| FIL Ltd | 138,276 | $967.9K | 0.00% | −8,666−5.9% | Reduced |
| TD Asset Management Inc | 129,022 | $903.2K | 0.00% | +76,280+144.6% | Added |
| Susquehanna Portfolio Strategies, LLC | 116,887 | $818.2K | 0.02% | 00.0% | Unchanged |
| Citadel Advisors LLC | 108,198 | $757.4K | 0.00% | +108,198 | New |
| Bank of New York Mellon Corp | 105,963 | $741.7K | 0.00% | −8,283−7.3% | Reduced |
| TrueMark Investments, LLC | 85,183 | $596.3K | 0.55% | +10,153+13.5% | Added |
| Manufacturers Life Insurance Company, The | 74,928 | $524.5K | 0.00% | +10,381+16.1% | Added |
| Tudor Investment Corp Et Al | 61,295 | $429.1K | 0.01% | +61,295 | New |
| Squarepoint Ops LLC | 59,566 | $417.0K | 0.00% | −11,957−16.7% | Reduced |
| Rhumbline Advisers | 52,512 | $367.6K | 0.00% | +1,654+3.3% | Added |
| Bank of Montreal | 46,637 | $327.4K | 0.00% | +1,637+3.6% | Added |
| Royce & Associates LP | 46,214 | $323.5K | 0.00% | +6,377+16.0% | Added |
| Citigroup Inc | 43,970 | $307.8K | 0.00% | +33,035+302.1% | Added |
| UBS Group AG | 42,523 | $297.7K | 0.00% | +11,111+35.4% | Added |
| JPMorgan Chase & Co | 42,081 | $294.6K | 0.00% | −3,438−7.6% | Reduced |
| HRT Financial LP | 41,000 | $287.0K | 0.00% | −18,116−30.6% | Reduced |
| Goldman Sachs Group Inc | 38,180 | $267.3K | 0.00% | −12,969−25.4% | Reduced |
| Alliancebernstein L.P. | 37,950 | $265.6K | 0.00% | +590+1.6% | Added |
| STRS Ohio | 34,000 | $238.0K | 0.00% | +16,900+98.8% | Added |
| Green Alpha Advisors, LLC | 33,738 | $236.2K | 0.17% | +4,200+14.2% | Added |
| Cinctive Capital Management LP | 33,033 | $231.2K | 0.01% | +33,033 | New |
| Brandywine Managers, LLC | 32,977 | $230.8K | 0.23% | 00.0% | Unchanged |
| Verition Fund Management LLC | 29,515 | $206.6K | 0.00% | +29,515 | New |
| Cornercap Investment Counsel Inc | 29,241 | $204.7K | 0.03% | +29,241 | New |
| Barclays PLC | 27,590 | $193.1K | 0.00% | −26,645−49.1% | Reduced |
| Jane Street Group, LLC | 27,468 | $192.3K | 0.00% | −27,751−50.3% | Reduced |
| D. E. Shaw & Co., Inc. | 26,668 | $186.7K | 0.00% | +26,668 | New |
| Levin Capital Strategies, L.P. | 26,500 | $185.5K | 0.02% | +6,500+32.5% | Added |
| Envestnet Asset Management Inc | 22,880 | $160.2K | 0.00% | +510+2.3% | Added |
| China Universal Asset Management Co., Ltd. | 22,378 | $156.6K | 0.02% | +11,120+98.8% | Added |
| HighTower Advisors, LLC | 22,286 | $153.0K | 0.00% | +1,169+5.5% | Added |
| Susquehanna International Group, LLP | 21,312 | $149.2K | 0.00% | −25,273−54.3% | Reduced |
| MetLife Investment Management | 21,262 | $148.8K | 0.00% | 00.0% | Unchanged |
| Susquehanna Fundamental Investments, LLC | 21,175 | $148.2K | 0.01% | +21,175 | New |
| Deutsche Bank AG | 20,715 | $145.0K | 0.00% | +614+3.1% | Added |
| Oppenheimer & Co Inc | 20,176 | $141.2K | 0.00% | −422−2.0% | Reduced |
| American International Group, Inc. | 19,496 | $136.5K | 0.00% | −167−0.8% | Reduced |
| Principal Financial Group Inc | 17,633 | $123.4K | 0.00% | −257−1.4% | Reduced |
| PEAK6 Investments LLC | 17,000 | $119.0K | 0.01% | −5,000−22.7% | Reduced |
| Clarius Group, LLC | 16,080 | $112.6K | 0.01% | 00.0% | Unchanged |
| ProShare Advisors LLC | 15,276 | $106.9K | 0.00% | +2,520+19.8% | Added |
| Red Lighthouse Investment Management, LLC | 14,950 | $104.7K | 0.04% | 00.0% | Unchanged |
| Voya Investment Management LLC | 12,906 | $90.3K | 0.00% | −3,254−20.1% | Reduced |
| CIBC World Markets Inc. | 12,047 | $84.0K | 0.00% | −214−1.7% | Reduced |
| Wells Fargo & Company | 11,810 | $82.7K | 0.00% | +1,581+15.5% | Added |
| Advisor Group Holdings, Inc. | 11,609 | $81.3K | 0.00% | −1,961−14.5% | Reduced |
| Invesco Ltd. | 10,611 | $74.3K | 0.00% | +10,611 | New |
| Walleye Capital LLC | 10,443 | $73.1K | 0.00% | −57,863−84.7% | Reduced |
| Brown Brothers Harriman & Co | 10,065 | $70.5K | 0.00% | 00.0% | Unchanged |
| New York State Common Retirement Fund | 8,423 | $59.0K | 0.00% | −17−0.2% | Reduced |
| EntryPoint Capital, LLC | 7,997 | $56.0K | 0.05% | −27,238−77.3% | Reduced |
| Tower Research Capital LLC (TRC) | 7,063 | $49.4K | 0.00% | −13,948−66.4% | Reduced |
| Chelsea Counsel Co | 5,000 | $35.0K | 0.02% | 00.0% | Unchanged |
| Simplex Trading, LLC | 4,837 | $33.0K | 0.00% | +4,837 | New |
| Legal & General Group Plc | 4,336 | $30.3K | 0.00% | 00.0% | Unchanged |
| California State Teachers Retirement System | 3,978 | $27.8K | 0.00% | −2,533−38.9% | Reduced |
| Ameritas Investment Partners, Inc. | 3,901 | $27.3K | 0.00% | 00.0% | Unchanged |
| Federated Hermes, Inc. | 3,576 | $25.0K | 0.00% | +3,576 | New |
| Metropolitan Life Insurance Co | 2,203 | $15.4K | 0.00% | 00.0% | Unchanged |
| Royal Bank of Canada | 1,689 | $12.0K | 0.00% | −10,484−86.1% | Reduced |
| Amalgamated Bank | 1,347 | $9.00K | 0.00% | −4,266−76.0% | Reduced |