Prime Medicine, Inc.
PRME- Exchange
- Nasdaq
- Industry
- Biological Products, (No Diagnostic Substances)
- SEC CIK
- 0001894562
No open-market purchases or sales by Prime Medicine, Inc. insiders were filed in the last 90 days; 187 institutions reported holding it in 13F filings for Q2 2026, worth $393.5M in total; ARK Invest is the only superinvestor holding it.
13F holders, Q3 2025
Institutional positions in Prime Medicine, Inc. as of Sep 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 167
- +46 vs. Q2 2025
- Shares held
- 92.3M
- +33.7M (+57.4%) vs. Q2 2025
- Total value
- $511.5M
- +$366.5M (+252.7%) vs. Q2 2025
- New holders
- 53
- 63 more added
- Sold out
- 7
- 31 more reduced
Compare with Q2 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting PRME on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 187 | $393.5M |
| Q1 2026 | 192 | $342.6M |
| Q4 2025 | 183 | $336.5M |
| Q3 2025 | 167 | $511.5M |
| Q2 2025 | 121 | $145.0M |
| Q1 2025 | 125 | $120.4M |
| Q4 2024 | 132 | $188.0M |
| Q3 2024 | 116 | $265.9M |
| Q2 2024 | 122 | $354.0M |
| Q1 2024 | 115 | $466.6M |
| Q4 2023 | 105 | $431.4M |
| Q3 2023 | 83 | $472.3M |
| Q2 2023 | 79 | $675.7M |
| Q1 2023 | 76 | $512.1M |
| Q4 2022 | 66 | $767.8M |
| Q3 2022 | 0 | $0 |
| Q2 2022 | 0 | $0 |
| Q1 2022 | 0 | $0 |
| Q4 2021 | 0 | $0 |
| Q3 2021 | 0 | $0 |
| Q2 2021 | 0 | $0 |
| Q1 2021 | 0 | $0 |
Institutions, Q3 2025
Shares, value and share of portfolio for each institution holding Prime Medicine, Inc.; share changes are against Q2 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Alphabet Inc. | 16,562,498 | $91.8M | 3.81% | +1,500,000+10.0% | Added |
| T. Rowe Price Investment Management, Inc. | 9,217,097 | $51.1M | 0.03% | +2,732,310+42.1% | Added |
| BlackRock, Inc. | 5,650,859 | $31.3M | 0.00% | +1,165,031+26.0% | Added |
| ARK Investment Management LLCSuperinvestorARK Invest | 5,477,851 | $30.3M | 0.18% | +3,155,182+135.8% | Added |
| Vanguard Group Inc | 4,921,865 | $27.3M | 0.00% | +1,294,355+35.7% | Added |
| Farallon Capital Management, L.L.C. | 4,750,000 | $26.3M | 0.15% | +4,000,000+533.3% | Added |
| Sumitomo Mitsui Trust Holdings, Inc. | 3,629,924 | $20.1M | 0.01% | +2,035,406+127.7% | Added |
| Nikko Asset Management Americas, Inc. | 3,629,924 | $20.0M | 0.19% | +2,040,807+128.4% | Added |
| Casdin Capital, LLC | 3,167,175 | $17.5M | 1.46% | +1,600,000+102.1% | Added |
| Woodline Partners LP | 3,002,482 | $16.6M | 0.08% | +3,002,482 | New |
| Ra Capital Management, L.P. | 3,000,000 | $16.6M | 0.20% | +3,000,000 | New |
| FMR LLC | 2,813,075 | $15.6M | 0.00% | −931,352−24.9% | Reduced |
| D. E. Shaw & Co., Inc. | 2,215,852 | $12.3M | 0.01% | +2,215,852 | New |
| MWG Management Limited | 1,792,210 | $9.93M | 12.21% | 00.0% | Unchanged |
| Geode Capital Management, LLC | 1,766,896 | $9.79M | 0.00% | +256,147+17.0% | Added |
| EcoR1 Capital, LLC | 1,543,326 | $8.55M | 0.41% | +1,543,326 | New |
| Millennium Management LLC | 1,418,463 | $7.86M | 0.01% | +1,270,467+858.4% | Added |
| State Street Corp | 1,296,626 | $7.18M | 0.00% | +57,289+4.6% | Added |
| Renaissance Technologies LLC | 1,134,670 | $6.29M | 0.01% | +911,270+407.9% | Added |
| Citadel Advisors LLC | 900,142 | $4.99M | 0.00% | +378,634+72.6% | Added |
| Adage Capital Partners GP, L.L.C. | 771,361 | $4.27M | 0.01% | +771,361 | New |
| Invesco Ltd. | 762,078 | $4.22M | 0.00% | +748,416+5,478.1% | Added |
| Morgan Stanley | 731,004 | $4.05M | 0.00% | +143,328+24.4% | Added |
| Greenwich Wealth Management LLC | 720,001 | $3.99M | 0.20% | −126,200−14.9% | Reduced |
| Northern Trust Corp | 607,989 | $3.37M | 0.00% | +95,755+18.7% | Added |
| Schonfeld Strategic Advisors LLC | 593,039 | $3.29M | 0.02% | −225,479−27.5% | Reduced |
| Susquehanna International Group, LLP | 584,424 | $3.24M | 0.00% | +101,696+21.1% | Added |
| Charles Schwab Investment Management Inc | 573,158 | $3.18M | 0.00% | +54,530+10.5% | Added |
| Moore Capital Management, LP | 500,000 | $2.77M | 0.06% | 00.0% | Unchanged |
| Two Sigma Investments, LP | 447,667 | $2.48M | 0.00% | +189,244+73.2% | Added |
| AQR Capital Management LLC | 414,211 | $2.29M | 0.00% | −10,144−2.4% | Reduced |
| Goldman Sachs Group Inc | 410,736 | $2.28M | 0.00% | +203,728+98.4% | Added |
| Bollard Group LLC | 361,136 | $2.00M | 0.05% | 00.0% | Unchanged |
| HighTower Advisors, LLC | 333,755 | $1.85M | 0.00% | +312,401+1,463.0% | Added |
| UBS Group AG | 304,773 | $1.69M | 0.00% | +109,446+56.0% | Added |
| Nuveen, LLC | 225,843 | $1.25M | 0.00% | +17,949+8.6% | Added |
| HRT Financial LP | 221,464 | $1.23M | 0.00% | +157,297+245.1% | Added |
| Chelsea Counsel Co | 208,210 | $1.15M | 0.51% | 00.0% | Unchanged |
| Wellington Management Group LLP | 205,325 | $1.14M | 0.00% | +205,325 | New |
| Bank of New York Mellon Corp | 197,729 | $1.10M | 0.00% | +35,677+22.0% | Added |
| Wells Fargo & Company | 197,014 | $1.09M | 0.00% | +95,863+94.8% | Added |
| Green Alpha Advisors, LLC | 190,353 | $1.05M | 1.02% | +111,359+141.0% | Added |
| Man Group plc | 189,588 | $1.05M | 0.00% | +189,588 | New |
| JBF Capital, Inc. | 188,900 | $1.05M | 0.15% | +188,900 | New |
| DnB Asset Management AS | 182,133 | $1.01M | 0.00% | +182,133 | New |
| TD Asset Management Inc | 181,048 | $1.00M | 0.00% | +158,138+690.3% | Added |
| Voloridge Investment Management, LLC | 170,021 | $941.9K | 0.00% | +170,021 | New |
| Bridgeway Capital Management, LLC | 164,800 | $913.0K | 0.02% | −50,000−23.3% | Reduced |
| Simplex Trading, LLC | 157,897 | $874.0K | 0.02% | −35,718−18.4% | Reduced |
| Ikarian Capital, LLC | 150,000 | $831.0K | 0.19% | +150,000 | New |
| Deutsche Bank AG | 132,769 | $735.5K | 0.00% | +7,324+5.8% | Added |
| Steward Partners Investment Advisory, LLC | 126,387 | $700.2K | 0.00% | +126,387 | New |
| Fred Alger Management, LLC | 122,654 | $679.5K | 0.00% | −260,540−68.0% | Reduced |
| Davy Global Fund Management Ltd | 120,773 | $669.1K | 0.05% | +87,113+258.8% | Added |
| Mirae Asset Global ETFs Holdings Ltd. | 120,423 | $667.1K | 0.00% | +567+0.5% | Added |
| FIL Ltd | 116,329 | $644.5K | 0.00% | −941−0.8% | Reduced |
| Barclays PLC | 115,900 | $642.1K | 0.00% | +1,098+1.0% | Added |
| Bank of America Corp | 110,842 | $614.1K | 0.00% | −33,669−23.3% | Reduced |
| Rhumbline Advisers | 109,787 | $608.2K | 0.00% | +11,815+12.1% | Added |
| Alliancebernstein L.P. | 108,690 | $602.1K | 0.00% | −58,730−35.1% | Reduced |
| Palumbo Wealth Management LLC | 92,535 | $512.6K | 0.16% | −90,823−49.5% | Reduced |
| Redmile Group, LLC | 87,118 | $482.6K | 0.05% | −1,987,232−95.8% | Reduced |
| Jane Street Group, LLC | 85,892 | $475.8K | 0.00% | +58,747+216.4% | Added |
| Diametric Capital, LP | 81,271 | $450.2K | 0.17% | −24,259−23.0% | Reduced |
| Price T Rowe Associates Inc | 74,502 | $413.0K | 0.00% | +9,182+14.1% | Added |
| Keystone Financial Group | 70,855 | $392.5K | 0.03% | +70,855 | New |
| Commonwealth Equity Services, LLC | 63,168 | $350.0K | 0.00% | +48,226+322.8% | Added |
| Tudor Investment Corp Et Al | 62,981 | $348.9K | 0.00% | +62,981 | New |
| Brevan Howard Capital Management LP | 62,242 | $344.8K | 0.00% | +62,242 | New |
| Ameriprise Financial Inc | 61,572 | $341.1K | 0.00% | +61,572 | New |
| Nisa Investment Advisors, LLC | 60,446 | $334.9K | 0.00% | +56,210+1,327.0% | Added |
| Engineers Gate Manager LP | 55,597 | $308.0K | 0.00% | +55,597 | New |
| Boothbay Fund Management, LLC | 55,050 | $305.0K | 0.01% | +55,050 | New |
| XTX Topco Ltd | 48,225 | $267.2K | 0.01% | −85,265−63.9% | Reduced |
| Balyasny Asset Management LLC | 47,873 | $265.2K | 0.00% | +47,873 | New |
| Jain Global LLC | 44,849 | $248.5K | 0.00% | +44,849 | New |
| Axq Capital, LP | 44,818 | $248.3K | 0.10% | +7,231+19.2% | Added |
| Mutual Advisors, LLC | 45,200 | $243.2K | 0.01% | 00.0% | Unchanged |
| JPMorgan Chase & Co | 43,389 | $240.4K | 0.00% | +10,354+31.3% | Added |
| MetLife Investment Management | 42,997 | $238.2K | 0.00% | +3,983+10.2% | Added |
| IvyRock Asset Management (HK) Ltd | 41,800 | $231.6K | 0.10% | +41,800 | New |
| Squarepoint Ops LLC | 39,601 | $219.4K | 0.00% | +3,775+10.5% | Added |
| CI Private Wealth, LLC | 38,777 | $214.8K | 0.00% | +38,777 | New |
| Ieq Capital, LLC | 36,667 | $203.1K | 0.00% | +837+2.3% | Added |
| PEAK6 LLC | 35,063 | $194.2K | 0.00% | +35,063 | New |
| ExodusPoint Capital Management, LP | 33,494 | $185.6K | 0.00% | +33,494 | New |
| Raymond James Financial Inc | 31,807 | $176.2K | 0.00% | +30,243+1,933.7% | Added |
| Crestwood Advisors Group LLC | 31,687 | $175.5K | 0.00% | 00.0% | Unchanged |
| LPL Financial LLC | 31,039 | $172.0K | 0.00% | +31,039 | New |
| China Universal Asset Management Co., Ltd. | 30,650 | $169.8K | 0.01% | +4,280+16.2% | Added |
| Wealth Enhancement Advisory Services, LLC | 26,778 | $157.2K | 0.00% | +771+3.0% | Added |
| Thompson Davis & Co., Inc. | 27,573 | $152.8K | 0.09% | +27,573 | New |
| Manufacturers Life Insurance Company, The | 27,132 | $150.3K | 0.00% | +6,153+29.3% | Added |
| Bank of Nova Scotia | 25,500 | $141.3K | 0.00% | +25,500 | New |
| CWM, LLC | 25,352 | $140.0K | 0.00% | −10,409−29.1% | Reduced |
| Abacus Planning Group, Inc. | 25,188 | $139.5K | 0.02% | +25,188 | New |
| Turtle Creek Wealth Advisors, LLC | 25,000 | $138.5K | 0.01% | +25,000 | New |
| Nomura Holdings Inc | 24,915 | $138.0K | 0.00% | +24,915 | New |
| Kingsview Wealth Management, LLC | 24,750 | $137.1K | 0.00% | −250−1.0% | Reduced |
| JustInvest LLC | 23,984 | $132.9K | 0.00% | +793+3.4% | Added |