Prime Medicine, Inc.
PRME- Exchange
- Nasdaq
- Industry
- Biological Products, (No Diagnostic Substances)
- SEC CIK
- 0001894562
No open-market purchases or sales by Prime Medicine, Inc. insiders were filed in the last 90 days; 187 institutions reported holding it in 13F filings for Q2 2026, worth $393.5M in total; ARK Invest is the only superinvestor holding it.
13F holders, Q4 2025
Institutional positions in Prime Medicine, Inc. as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 183
- +18 vs. Q3 2025
- Shares held
- 97.0M
- +6.43M (+7.1%) vs. Q3 2025
- Total value
- $336.5M
- −$165.1M (−32.9%) vs. Q3 2025
- New holders
- 44
- 66 more added
- Sold out
- 26
- 40 more reduced
2 institutions that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting PRME on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 187 | $393.5M |
| Q1 2026 | 192 | $342.6M |
| Q4 2025 | 183 | $340.4M |
| Q3 2025 | 167 | $512.0M |
| Q2 2025 | 121 | $145.0M |
| Q1 2025 | 125 | $120.5M |
| Q4 2024 | 132 | $188.0M |
| Q3 2024 | 116 | $266.0M |
| Q2 2024 | 122 | $354.2M |
| Q1 2024 | 115 | $469.7M |
| Q4 2023 | 105 | $433.7M |
| Q3 2023 | 83 | $472.3M |
| Q2 2023 | 79 | $675.7M |
| Q1 2023 | 76 | $616.9M |
| Q4 2022 | 66 | $767.8M |
| Q3 2022 | 0 | $0 |
| Q2 2022 | 0 | $0 |
| Q1 2022 | 0 | $0 |
| Q4 2021 | 0 | $0 |
| Q3 2021 | 0 | $0 |
| Q2 2021 | 0 | $0 |
| Q1 2021 | 0 | $0 |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Prime Medicine, Inc.; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Alphabet Inc. | 16,562,498 | $57.5M | 2.23% | 00.0% | Unchanged |
| BlackRock, Inc. | 8,268,843 | $28.7M | 0.00% | +2,617,984+46.3% | Added |
| Vanguard Group Inc | 6,467,872 | $22.4M | 0.00% | +1,546,007+31.4% | Added |
| T. Rowe Price Investment Management, Inc. | 5,995,183 | $20.8M | 0.01% | −3,221,914−35.0% | Reduced |
| ARK Investment Management LLCSuperinvestorARK Invest | 5,368,526 | $18.6M | 0.12% | −109,325−2.0% | Reduced |
| State Street Corp | 5,095,510 | $17.7M | 0.00% | +3,798,884+293.0% | Added |
| Sumitomo Mitsui Trust Holdings, Inc. | 3,245,506 | $11.3M | 0.01% | −384,418−10.6% | Reduced |
| Nikko Asset Management Americas, Inc. | 3,245,506 | $11.2M | 0.13% | −384,418−10.6% | Reduced |
| Casdin Capital, LLC | 3,167,175 | $11.0M | 0.68% | 00.0% | Unchanged |
| Balyasny Asset Management LLC | 3,124,362 | $10.8M | 0.02% | +3,076,489+6,426.4% | Added |
| Woodline Partners LP | 3,002,844 | $10.4M | 0.04% | +3620.0% | Added |
| Geode Capital Management, LLC | 2,628,429 | $9.12M | 0.00% | +861,533+48.8% | Added |
| UBS Group AG | 2,440,583 | $8.47M | 0.00% | +2,135,810+700.8% | Added |
| FMR LLC | 2,176,646 | $7.55M | 0.00% | −636,429−22.6% | Reduced |
| MWG Caph Ltd | 1,792,210 | $6.22M | 8.59% | +1,792,210 | New |
| Goldman Sachs Group Inc | 1,755,768 | $6.09M | 0.00% | +1,345,032+327.5% | Added |
| Two Sigma Investments, LP | 1,629,324 | $5.65M | 0.01% | +1,181,657+264.0% | Added |
| D. E. Shaw & Co., Inc. | 1,551,369 | $5.38M | 0.00% | −664,483−30.0% | Reduced |
| Farallon Capital Management, L.L.C. | 1,240,843 | $4.31M | 0.02% | −3,509,157−73.9% | Reduced |
| Susquehanna International Group, LLP | 1,176,727 | $4.08M | 0.01% | +592,303+101.3% | Added |
| Morgan Stanley | 1,169,898 | $4.06M | 0.00% | +438,894+60.0% | Added |
| Renaissance Technologies LLC | 1,149,159 | $3.99M | 0.01% | +14,489+1.3% | Added |
| Charles Schwab Investment Management Inc | 936,815 | $3.25M | 0.00% | +363,657+63.4% | Added |
| Northern Trust Corp | 842,153 | $2.92M | 0.00% | +234,164+38.5% | Added |
| Greenwich Wealth Management LLC | 740,001 | $2.57M | 0.11% | +20,000+2.8% | Added |
| HRT Financial LP | 655,351 | $2.27M | 0.01% | +433,887+195.9% | Added |
| Bank of America Corp | 648,012 | $2.25M | 0.00% | +537,170+484.6% | Added |
| Point72 Asset Management, L.P. | 551,030 | $1.91M | 0.00% | +551,030 | New |
| Moore Capital Management, LP | 500,000 | $1.74M | 0.04% | 00.0% | Unchanged |
| JPMorgan Chase & Co | 435,710 | $1.51M | 0.00% | +392,321+904.2% | Added |
| AQR Capital Management LLC | 415,821 | $1.44M | 0.00% | +1,610+0.4% | Added |
| HighTower Advisors, LLC | 400,110 | $1.39M | 0.00% | +66,355+19.9% | Added |
| Two Sigma Advisers, LP | 383,500 | $1.33M | 0.00% | +383,500 | New |
| Barclays PLC | 363,826 | $1.26M | 0.00% | +247,926+213.9% | Added |
| Bollard Group LLC | 361,136 | $1.25M | 0.03% | 00.0% | Unchanged |
| Wells Fargo & Company | 294,496 | $1.02M | 0.00% | +97,482+49.5% | Added |
| Verition Fund Management LLC | 290,983 | $1.01M | 0.01% | +290,983 | New |
| Nuveen, LLC | 251,636 | $873.2K | 0.00% | +25,793+11.4% | Added |
| Wellington Management Group LLP | 248,227 | $861.3K | 0.00% | +42,902+20.9% | Added |
| Bank of New York Mellon Corp | 246,770 | $856.3K | 0.00% | +49,041+24.8% | Added |
| Chelsea Counsel Co | 227,000 | $787.7K | 0.34% | +18,790+9.0% | Added |
| Dark Forest Capital Management LP | 225,859 | $783.7K | 0.04% | +225,859 | New |
| Squarepoint Ops LLC | 218,042 | $756.6K | 0.00% | +178,441+450.6% | Added |
| Green Alpha Advisors, LLC | 190,883 | $662.4K | 0.61% | +530+0.3% | Added |
| Rafferty Asset Management, LLC | 187,711 | $651.4K | 0.00% | +187,711 | New |
| Davy Global Fund Management Ltd | 178,519 | $619.5K | 0.04% | +57,746+47.8% | Added |
| Jump Financial, LLC | 171,931 | $596.6K | 0.01% | +171,931 | New |
| Swiss National Bank | 170,100 | $590.2K | 0.00% | +170,100 | New |
| Deutsche Bank AG | 147,943 | $513.4K | 0.00% | +15,174+11.4% | Added |
| Bridgeway Capital Management, LLC | 134,800 | $467.8K | 0.01% | −30,000−18.2% | Reduced |
| Keystone Financial Group | 129,665 | $449.9K | 0.03% | +58,810+83.0% | Added |
| Rockefeller Capital Management L.P. | 121,391 | $421.2K | 0.00% | +120,252+10,557.7% | Added |
| Steward Partners Investment Advisory, LLC | 118,406 | $410.9K | 0.00% | −7,981−6.3% | Reduced |
| FIL Ltd | 115,602 | $401.1K | 0.00% | −727−0.6% | Reduced |
| Mirae Asset Global ETFs Holdings Ltd. | 115,060 | $398.9K | 0.00% | −5,363−4.5% | Reduced |
| Graham Capital Management, L.P. | 114,680 | $397.9K | 0.01% | +114,680 | New |
| Citadel Advisors LLC | 112,870 | $391.7K | 0.00% | −787,272−87.5% | Reduced |
| Alliancebernstein L.P. | 108,690 | $377.2K | 0.00% | 00.0% | Unchanged |
| Rhumbline Advisers | 108,409 | $376.2K | 0.00% | −1,378−1.3% | Reduced |
| Price T Rowe Associates Inc | 104,553 | $363.0K | 0.00% | +30,051+40.3% | Added |
| Group One Trading, L.P. | 103,213 | $358.1K | 0.01% | +103,213 | New |
| UBS Asset Management Americas Inc | 99,100 | $343.9K | 0.00% | +99,100 | New |
| Virtu Financial LLC | 94,778 | $329.0K | 0.01% | +82,948+701.2% | Added |
| Qube Research & Technologies Ltd | 94,670 | $328.5K | 0.00% | +94,670 | New |
| TD Asset Management Inc | 94,148 | $326.7K | 0.00% | −86,900−48.0% | Reduced |
| California State Teachers Retirement System | 86,929 | $301.6K | 0.00% | +83,275+2,279.0% | Added |
| Palumbo Wealth Management LLC | 85,539 | $296.8K | 0.07% | −6,996−7.6% | Reduced |
| Dimensional Fund Advisors LP | 84,054 | $291.7K | 0.00% | +84,054 | New |
| Legal & General Group Plc | 80,749 | $280.2K | 0.00% | +73,998+1,096.1% | Added |
| XTX Topco Ltd | 72,935 | $253.1K | 0.01% | +24,710+51.2% | Added |
| Profund Advisors LLC | 69,605 | $241.5K | 0.01% | +69,605 | New |
| Virtus Investment Advisers, Inc. | 64,886 | $225.2K | 0.06% | +64,886 | New |
| Janus Henderson Group PLC | 60,900 | $210.4K | 0.00% | +60,900 | New |
| Engineers Gate Manager LP | 60,490 | $209.9K | 0.00% | +4,893+8.8% | Added |
| Wiley Bros.-Aintree Capital, LLC | 60,352 | $209.4K | 0.00% | +48,504+409.4% | Added |
| MetLife Investment Management | 57,570 | $199.8K | 0.00% | +14,573+33.9% | Added |
| Invesco Ltd. | 56,779 | $197.0K | 0.00% | −705,299−92.5% | Reduced |
| Brevan Howard Capital Management LP | 56,088 | $194.6K | 0.00% | −6,154−9.9% | Reduced |
| Ameriprise Financial Inc | 54,082 | $187.7K | 0.00% | −7,490−12.2% | Reduced |
| Quadrature Capital Ltd | 52,866 | $183.4K | 0.00% | +42,684+419.2% | Added |
| Millennium Management LLC | 51,335 | $178.1K | 0.00% | −1,367,128−96.4% | Reduced |
| Citigroup Inc | 51,229 | $177.8K | 0.00% | +46,078+894.5% | Added |
| Toroso Investments, LLC | 50,244 | $174.3K | 0.00% | +50,244 | New |
| Walleye Capital LLC | 46,139 | $160.1K | 0.00% | +46,139 | New |
| Mutual Advisors, LLC | 45,200 | $156.8K | 0.00% | 00.0% | Unchanged |
| Elevate Capital Advisors, LLC | 42,666 | $148.1K | 0.10% | +42,666 | New |
| IvyRock Asset Management (HK) Ltd | 41,800 | $145.0K | 0.08% | 00.0% | Unchanged |
| Jones Financial Companies LLLP | 40,403 | $140.2K | 0.00% | +30,828+322.0% | Added |
| CI Private Wealth, LLC | 38,777 | $134.6K | 0.00% | 00.0% | Unchanged |
| Caitong International Asset Management Co., Ltd | 38,696 | $134.3K | 0.03% | +38,696 | New |
| Gsa Capital Partners LLP | 38,510 | $134.0K | 0.01% | +38,510 | New |
| Ieq Capital, LLC | 37,136 | $128.9K | 0.00% | +469+1.3% | Added |
| Mariner, LLC | 36,290 | $125.9K | 0.00% | +18,071+99.2% | Added |
| Polymer Capital Management (US) LLC | 35,981 | $124.9K | 0.02% | +15,190+73.1% | Added |
| Intech Investment Management LLC | 35,036 | $121.6K | 0.00% | +11,808+50.8% | Added |
| Central Trust Co | 34,995 | $121.4K | 0.00% | +34,995 | New |
| Commonwealth Equity Services, LLC | 34,399 | $119.4K | 0.00% | −28,769−45.5% | Reduced |
| Axq Capital, LP | 33,405 | $115.9K | 0.03% | −11,413−25.5% | Reduced |
| LPL Financial LLC | 32,924 | $114.2K | 0.00% | +1,885+6.1% | Added |
| Envestnet Asset Management Inc | 32,576 | $113.0K | 0.00% | +32,576 | New |