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Prime Medicine, Inc.

PRME
Exchange
Nasdaq
Industry
Biological Products, (No Diagnostic Substances)
SEC CIK
0001894562

No open-market purchases or sales by Prime Medicine, Inc. insiders were filed in the last 90 days; 187 institutions reported holding it in 13F filings for Q2 2026, worth $393.5M in total; ARK Invest is the only superinvestor holding it.

Q4 2025 vs. Q3 2025

How the institutions holding Prime Medicine, Inc. changed between Q3 2025 and Q4 2025.

All holders in Q4 2025All holders in Q3 2025

13F holders of PRME: Q3 2025 compared with Q4 2025
MeasureQ3 2025Of which not filed for Q4 2025Q4 2025Change
Holders1672183+18
Shares92.3M1.79M97.0M+6.43M (+7.1%)
Value$511.5M$9.94M$336.5M−$165.1M (−32.9%)

2 institutions that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so the changes leave them out.

New holders (44)

Institutions that held Prime Medicine, Inc. at the end of Q4 2025 but not at the end of Q3 2025.

Institutions new to PRME in Q4 2025
InstitutionSharesValue% of portfolio
MWG Caph Ltd1,792,210$6.22M8.59%
Point72 Asset Management, L.P.551,030$1.91M0.00%
Two Sigma Advisers, LP383,500$1.33M0.00%
Verition Fund Management LLC290,983$1.01M0.01%
Dark Forest Capital Management LP225,859$783.7K0.04%
Rafferty Asset Management, LLC187,711$651.4K0.00%
Jump Financial, LLC171,931$596.6K0.01%
Swiss National Bank170,100$590.2K0.00%
Graham Capital Management, L.P.114,680$397.9K0.01%
Group One Trading, L.P.103,213$358.1K0.01%
UBS Asset Management Americas Inc99,100$343.9K0.00%
Qube Research & Technologies Ltd94,670$328.5K0.00%
Dimensional Fund Advisors LP84,054$291.7K0.00%
Profund Advisors LLC69,605$241.5K0.01%
Virtus Investment Advisers, Inc.64,886$225.2K0.06%
Janus Henderson Group PLC60,900$210.4K0.00%
Toroso Investments, LLC50,244$174.3K0.00%
Walleye Capital LLC46,139$160.1K0.00%
Elevate Capital Advisors, LLC42,666$148.1K0.10%
Caitong International Asset Management Co., Ltd38,696$134.3K0.03%
Gsa Capital Partners LLP38,510$134.0K0.01%
Central Trust Co34,995$121.4K0.00%
Envestnet Asset Management Inc32,576$113.0K0.00%
SG Americas Securities, LLC30,954$107.0K0.00%
Transcend Wealth Collective, LLC26,500$92.0K0.01%
Arizona State Retirement System24,085$83.6K0.00%
Scientech Research LLC22,393$77.7K0.05%
KLP Kapitalforvaltning AS18,500$64.2K0.00%
Martingale Asset Management L P14,808$51.4K0.00%
Oppenheimer & Co Inc12,433$43.1K0.00%
Teacher Retirement System of Texas12,235$42.5K0.00%
Integrity Advisory Solutions, LLC11,689$40.6K0.01%
Callan Family Office, LLC11,292$39.2K0.00%
Neuberger Berman Group LLC10,915$37.9K0.00%
Lazard Asset Management LLC10,844$37.6K0.00%
Rhodes Investment Advisors Inc10,750$37.3K0.03%
Forum Financial Management, LP10,000$34.7K0.00%
Glen Eagle Advisors, LLC10,000$34.7K0.00%
Zurcher Kantonalbank (Zurich Cantonalbank)8,814$30.6K0.00%
MTM Investment Management, LLC3,090$10.7K0.00%
Basecamp Wealth Advisors LLC287$9960.00%
CIBC Private Wealth Group, LLC267$9260.00%
Global Retirement Partners, LLC146$5070.00%
GAMMA Investing LLC111$3850.00%

Sold out (26)

Institutions that held Prime Medicine, Inc. at the end of Q3 2025 and filed for Q4 2025 without it.

Institutions that sold out of PRME in Q4 2025
InstitutionShares, Q3 2025Value, Q3 2025
Ra Capital Management, L.P.3,000,000$16.6M
EcoR1 Capital, LLC1,543,326$8.55M
Adage Capital Partners GP, L.L.C.771,361$4.27M
Schonfeld Strategic Advisors LLC593,039$3.29M
Man Group plc189,588$1.05M
JBF Capital, Inc.188,900$1.05M
DnB Asset Management AS182,133$1.01M
Simplex Trading, LLC157,897$874.0K
Ikarian Capital, LLC150,000$831.0K
Fred Alger Management, LLC122,654$679.5K
Redmile Group, LLC87,118$482.6K
Jane Street Group, LLC85,892$475.8K
Diametric Capital, LP81,271$450.2K
Tudor Investment Corp Et Al62,981$348.9K
Boothbay Fund Management, LLC55,050$305.0K
Jain Global LLC44,849$248.5K
PEAK6 LLC35,063$194.2K
ExodusPoint Capital Management, LP33,494$185.6K
Bank of Nova Scotia25,500$141.3K
Turtle Creek Wealth Advisors, LLC25,000$138.5K
Owen LaRue, LLC19,032$105.4K
Hudson Bay Capital Management LP13,025$72.2K
SRS Capital Advisors, Inc.5,406$29.9K
National Bank of Canada4,500$24.9K
Principal Securities, Inc.200$1.11K
Larson Financial Group LLC6$33

Not filed for Q4 2025 yet (2)

Institutions that held Prime Medicine, Inc. at the end of Q3 2025 and haven't filed a 13F for Q4 2025. Not filing isn't selling, so they aren't counted as sold out.

Institutions holding PRME in Q3 2025 that haven't filed for Q4 2025
InstitutionShares, Q3 2025Value, Q3 2025
MWG Management Limited1,792,210$9.93M
FSA Wealth Management LLC1,500$8.31K