Prime Medicine, Inc.
PRME- Exchange
- Nasdaq
- Industry
- Biological Products, (No Diagnostic Substances)
- SEC CIK
- 0001894562
No open-market purchases or sales by Prime Medicine, Inc. insiders were filed in the last 90 days; 187 institutions reported holding it in 13F filings for Q2 2026, worth $393.5M in total; ARK Invest is the only superinvestor holding it.
13F holders, Q4 2024
Institutional positions in Prime Medicine, Inc. as of Dec 31, 2024. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 132
- +18 vs. Q3 2024
- Shares held
- 64.3M
- −4.33M (−6.3%) vs. Q3 2024
- Total value
- $188.0M
- −$77.7M (−29.2%) vs. Q3 2024
- New holders
- 35
- 39 more added
- Sold out
- 17
- 32 more reduced
2 institutions that held it in Q3 2024 haven't filed for Q4 2024 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2024: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting PRME on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 187 | $393.5M |
| Q1 2026 | 192 | $342.6M |
| Q4 2025 | 183 | $340.4M |
| Q3 2025 | 167 | $512.0M |
| Q2 2025 | 121 | $145.0M |
| Q1 2025 | 125 | $120.5M |
| Q4 2024 | 132 | $188.0M |
| Q3 2024 | 116 | $266.0M |
| Q2 2024 | 122 | $354.2M |
| Q1 2024 | 115 | $469.7M |
| Q4 2023 | 105 | $433.7M |
| Q3 2023 | 83 | $472.3M |
| Q2 2023 | 79 | $675.7M |
| Q1 2023 | 76 | $616.9M |
| Q4 2022 | 66 | $767.8M |
| Q3 2022 | 0 | $0 |
| Q2 2022 | 0 | $0 |
| Q1 2022 | 0 | $0 |
| Q4 2021 | 0 | $0 |
| Q3 2021 | 0 | $0 |
| Q2 2021 | 0 | $0 |
| Q1 2021 | 0 | $0 |
Institutions, Q4 2024
Shares, value and share of portfolio for each institution holding Prime Medicine, Inc.; share changes are against Q3 2024.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Alphabet Inc. | 15,062,498 | $44.0M | 2.56% | 00.0% | Unchanged |
| ARK Investment Management LLCSuperinvestorARK Invest | 5,150,233 | $15.0M | 0.13% | −510,486−9.0% | Reduced |
| BlackRock, Inc. | 4,524,784 | $13.2M | 0.00% | −741,991−14.1% | Reduced |
| T. Rowe Price Investment Management, Inc. | 3,977,828 | $11.6M | 0.01% | +170,541+4.5% | Added |
| FMR LLC | 3,802,028 | $11.1M | 0.00% | +58,716+1.6% | Added |
| Vanguard Group Inc | 3,655,317 | $10.7M | 0.00% | −1,234,996−25.3% | Reduced |
| Sumitomo Mitsui Trust Holdings, Inc. | 3,090,180 | $9.02M | 0.01% | −100,275−3.1% | Reduced |
| Nikko Asset Management Americas, Inc. | 3,090,180 | $9.02M | 0.10% | −92,275−2.9% | Reduced |
| Redmile Group, LLC | 2,074,350 | $6.06M | 0.42% | 00.0% | Unchanged |
| Millennium Management LLC | 1,874,571 | $5.47M | 0.00% | −323,669−14.7% | Reduced |
| MWG Management Limited | 1,792,210 | $5.23M | 7.04% | 00.0% | Unchanged |
| Price T Rowe Associates Inc | 1,584,476 | $4.63M | 0.00% | +38,515+2.5% | Added |
| Geode Capital Management, LLC | 1,467,606 | $4.29M | 0.00% | +107,627+7.9% | Added |
| State Street Corp | 1,154,181 | $3.37M | 0.00% | +7,232+0.6% | Added |
| Baker Bros. Advisors LP | 1,028,466 | $3.00M | 0.03% | 00.0% | Unchanged |
| Westwood Holdings Group Inc. | 883,129 | $2.58M | 0.02% | +433,653+96.5% | Added |
| Greenwich Wealth Management LLC | 774,001 | $2.26M | 0.16% | +41,000+5.6% | Added |
| Farallon Capital Management, L.L.C. | 750,000 | $2.19M | 0.01% | 00.0% | Unchanged |
| EcoR1 Capital, LLC | 700,000 | $2.04M | 0.08% | 00.0% | Unchanged |
| Northern Trust Corp | 544,937 | $1.59M | 0.00% | +20,389+3.9% | Added |
| Moore Capital Management, LP | 500,000 | $1.46M | 0.03% | 00.0% | Unchanged |
| Charles Schwab Investment Management Inc | 484,591 | $1.42M | 0.00% | +20,614+4.4% | Added |
| Bank of America Corp | 430,613 | $1.26M | 0.00% | −54,512−11.2% | Reduced |
| Goldman Sachs Group Inc | 421,898 | $1.23M | 0.00% | +201,754+91.6% | Added |
| Samsara BioCapital, LLC | 405,228 | $1.18M | 0.16% | −135,076−25.0% | Reduced |
| Walleye Capital LLC | 403,739 | $1.18M | 0.01% | +295,365+272.5% | Added |
| Nuveen Asset Management, LLC | 392,443 | $1.15M | 0.00% | 00.0% | Unchanged |
| Casdin Capital, LLC | 367,175 | $1.07M | 0.07% | 00.0% | Unchanged |
| Bollard Group LLC | 361,136 | $1.05M | 0.03% | 00.0% | Unchanged |
| Morgan Stanley | 311,276 | $908.9K | 0.00% | +10,885+3.6% | Added |
| UBS Group AG | 218,186 | $637.1K | 0.00% | +183,165+523.0% | Added |
| Chelsea Counsel Co | 186,780 | $545.4K | 0.28% | +108,090+137.4% | Added |
| Two Sigma Investments, LP | 166,199 | $485.3K | 0.00% | −152,374−47.8% | Reduced |
| Vestmark Advisory Solutions, Inc. | 111,465 | $459.7K | 0.02% | +21,429+23.8% | Added |
| Susquehanna Fundamental Investments, LLC | 144,719 | $422.6K | 0.01% | +144,719 | New |
| ExodusPoint Capital Management, LP | 131,732 | $385.0K | 0.00% | +131,732 | New |
| Bank of New York Mellon Corp | 129,514 | $378.2K | 0.00% | −200−0.2% | Reduced |
| FIL Ltd | 121,017 | $353.4K | 0.00% | −8,844−6.8% | Reduced |
| Verition Fund Management LLC | 103,545 | $302.4K | 0.00% | +65,000+168.6% | Added |
| Jane Street Group, LLC | 101,758 | $297.1K | 0.00% | +44,210+76.8% | Added |
| Barclays PLC | 97,621 | $285.1K | 0.00% | +12,924+15.3% | Added |
| Wells Fargo & Company | 96,181 | $280.8K | 0.00% | −75,287−43.9% | Reduced |
| Deutsche Bank AG | 80,835 | $236.0K | 0.00% | −34,072−29.7% | Reduced |
| Alliancebernstein L.P. | 76,000 | $221.9K | 0.00% | 00.0% | Unchanged |
| Levin Capital Strategies, L.P. | 75,000 | $219.0K | 0.02% | +45,000+150.0% | Added |
| Rhumbline Advisers | 71,956 | $210.1K | 0.00% | +1,909+2.7% | Added |
| Aristides Capital LLC | 70,500 | $205.9K | 0.06% | +70,500 | New |
| Point72 Asset Management, L.P. | 68,528 | $200.1K | 0.00% | +68,528 | New |
| Green Alpha Advisors, LLC | 64,406 | $188.1K | 0.15% | +64,406 | New |
| Davy Global Fund Management Ltd | 60,685 | $177.2K | 0.02% | +32,572+115.9% | Added |
| SG Americas Securities, LLC | 60,229 | $176.0K | 0.00% | +13,247+28.2% | Added |
| Sculptor Capital LP | 50,700 | $148.0K | 0.00% | +50,700 | New |
| Citigroup Inc | 47,431 | $138.5K | 0.00% | −640−1.3% | Reduced |
| TD Asset Management Inc | 46,434 | $135.6K | 0.00% | 00.0% | Unchanged |
| Two Sigma Advisers, LP | 43,200 | $126.1K | 0.00% | −76,700−64.0% | Reduced |
| Susquehanna International Group, LLP | 37,052 | $108.2K | 0.00% | −78,002−67.8% | Reduced |
| JPMorgan Chase & Co | 35,640 | $104.1K | 0.00% | −1,742−4.7% | Reduced |
| Mirae Asset Global ETFs Holdings Ltd. | 32,499 | $94.9K | 0.00% | +1,372+4.4% | Added |
| Crestwood Advisors Group LLC | 31,687 | $92.5K | 0.00% | +31,687 | New |
| Intech Investment Management LLC | 30,404 | $88.8K | 0.00% | +16,302+115.6% | Added |
| PEAK6 LLC | 30,013 | $87.6K | 0.00% | +30,013 | New |
| Corebridge Financial, Inc. | 28,197 | $82.3K | 0.00% | −2,128−7.0% | Reduced |
| China Universal Asset Management Co., Ltd. | 27,811 | $81.2K | 0.01% | +4,725+20.5% | Added |
| Creative Planning | 27,623 | $80.7K | 0.00% | +27,623 | New |
| MetLife Investment Management | 25,031 | $73.1K | 0.00% | −9,097−26.7% | Reduced |
| Prime Capital Investment Advisors, LLC | 23,955 | $69.9K | 0.00% | +23,955 | New |
| Virtus ETF Advisers LLC | 23,618 | $69.0K | 0.03% | +11,948+102.4% | Added |
| Manufacturers Life Insurance Company, The | 23,592 | $68.9K | 0.00% | +197+0.8% | Added |
| Avanza Fonder AB | 22,480 | $65.6K | 0.00% | +22,480 | New |
| ProShare Advisors LLC | 22,186 | $64.8K | 0.00% | +4,375+24.6% | Added |
| Benjamin Edwards Inc | 21,921 | $63.9K | 0.00% | −1,275−5.5% | Reduced |
| HighTower Advisors, LLC | 21,590 | $63.0K | 0.00% | −85−0.4% | Reduced |
| HRT Financial LP | 21,695 | $63.0K | 0.00% | +21,695 | New |
| Envestnet Asset Management Inc | 21,557 | $62.9K | 0.00% | −6,798−24.0% | Reduced |
| Sherbrooke Park Advisers LLC | 20,441 | $59.7K | 0.02% | +20,441 | New |
| BNP Paribas Arbitrage, SA | 20,096 | $58.7K | 0.00% | +20,096 | New |
| CIBC World Markets Inc. | 19,023 | $56.0K | 0.00% | +8,801+86.1% | Added |
| Voya Investment Management LLC | 18,173 | $53.1K | 0.00% | −1,011−5.3% | Reduced |
| Impact Partnership Wealth, LLC | 17,274 | $50.4K | 0.01% | +17,274 | New |
| Police & Firemen's Retirement System of New Jersey | 17,092 | $49.9K | 0.00% | +17,092 | New |
| Balyasny Asset Management LLC | 16,342 | $47.7K | 0.00% | +16,342 | New |
| Clarius Group, LLC | 16,080 | $47.0K | 0.00% | 00.0% | Unchanged |
| AQR Capital Management LLC | 16,046 | $46.9K | 0.00% | +16,046 | New |
| Gsa Capital Partners LLP | 15,311 | $45.0K | 0.00% | −83,749−84.5% | Reduced |
| Axq Capital, LP | 15,363 | $44.9K | 0.02% | +15,363 | New |
| Invesco Ltd. | 15,071 | $44.0K | 0.00% | +1,048+7.5% | Added |
| XTX Topco Ltd | 14,466 | $42.2K | 0.00% | +14,466 | New |
| Nisa Investment Advisors, LLC | 12,616 | $36.8K | 0.00% | +12,507+11,474.3% | Added |
| JustInvest LLC | 12,378 | $36.1K | 0.00% | +12,378 | New |
| Oppenheimer & Co Inc | 12,106 | $35.4K | 0.00% | −5,765−32.3% | Reduced |
| American Century Companies Inc | 11,426 | $33.4K | 0.00% | +11,426 | New |
| State Board of Administration of Florida Retirement System | 11,420 | $33.3K | 0.00% | 00.0% | Unchanged |
| Pathstone Holdings, LLC | 11,311 | $33.0K | 0.00% | −3,059−21.3% | Reduced |
| New York State Common Retirement Fund | 8,434 | $24.6K | 0.00% | 00.0% | Unchanged |
| Legal & General Group Plc | 6,279 | $18.4K | 0.00% | 00.0% | Unchanged |
| Mirae Asset Global Investments Co., Ltd. | 4,371 | $12.7K | 0.00% | +30+0.7% | Added |
| California State Teachers Retirement System | 4,110 | $12.0K | 0.00% | 00.0% | Unchanged |
| Ameritas Investment Partners, Inc. | 3,901 | $11.4K | 0.00% | 00.0% | Unchanged |
| GF Fund Management Co. Ltd. | 2,700 | $7.88K | 0.00% | +2,700 | New |
| CWM, LLC | 2,432 | $7.00K | 0.00% | +2,410+10,954.5% | Added |