Prime Medicine, Inc.
PRME- Exchange
- Nasdaq
- Industry
- Biological Products, (No Diagnostic Substances)
- SEC CIK
- 0001894562
No open-market purchases or sales by Prime Medicine, Inc. insiders were filed in the last 90 days; 187 institutions reported holding it in 13F filings for Q2 2026, worth $393.5M in total; ARK Invest is the only superinvestor holding it.
13F holders, Q4 2024
Institutional positions in Prime Medicine, Inc. as of Dec 31, 2024. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 132
- +18 vs. Q3 2024
- Shares held
- 64.3M
- −4.33M (−6.3%) vs. Q3 2024
- Total value
- $188.0M
- −$77.7M (−29.2%) vs. Q3 2024
- New holders
- 35
- 39 more added
- Sold out
- 17
- 32 more reduced
2 institutions that held it in Q3 2024 haven't filed for Q4 2024 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2024: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting PRME on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 187 | $393.5M |
| Q1 2026 | 192 | $342.6M |
| Q4 2025 | 183 | $336.5M |
| Q3 2025 | 167 | $511.5M |
| Q2 2025 | 121 | $145.0M |
| Q1 2025 | 125 | $120.4M |
| Q4 2024 | 132 | $188.0M |
| Q3 2024 | 116 | $265.9M |
| Q2 2024 | 122 | $354.0M |
| Q1 2024 | 115 | $466.6M |
| Q4 2023 | 105 | $431.4M |
| Q3 2023 | 83 | $472.3M |
| Q2 2023 | 79 | $675.7M |
| Q1 2023 | 76 | $512.1M |
| Q4 2022 | 66 | $767.8M |
| Q3 2022 | 0 | $0 |
| Q2 2022 | 0 | $0 |
| Q1 2022 | 0 | $0 |
| Q4 2021 | 0 | $0 |
| Q3 2021 | 0 | $0 |
| Q2 2021 | 0 | $0 |
| Q1 2021 | 0 | $0 |
Institutions, Q4 2024
Shares, value and share of portfolio for each institution holding Prime Medicine, Inc.; share changes are against Q3 2024.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| R Squared Ltd | 2,230 | $6.51K | 0.01% | +2,230 | New |
| Skopos Labs, Inc. | 1,894 | $5.53K | 0.00% | +1,894 | New |
| Signaturefd, LLC | 1,653 | $4.83K | 0.00% | +243+17.2% | Added |
| Tower Research Capital LLC (TRC) | 1,397 | $4.08K | 0.00% | −6,652−82.6% | Reduced |
| Amalgamated Bank | 1,347 | $4.00K | 0.00% | 00.0% | Unchanged |
| Simplex Trading, LLC | 1,458 | $4.00K | 0.00% | +1,458 | New |
| SBI Securities Co., Ltd. | 1,205 | $3.52K | 0.00% | +1,205 | New |
| First Horizon Advisors, Inc. | 1,109 | $3.24K | 0.00% | 00.0% | Unchanged |
| Comerica Bank | 1,073 | $3.13K | 0.00% | +758+240.6% | Added |
| Royal Bank of Canada | 1,162 | $3.00K | 0.00% | −9,523−89.1% | Reduced |
| Quadrant Capital Group LLC | 833 | $2.43K | 0.00% | −133−13.8% | Reduced |
| Fairman Group, LLC | 500 | $1.46K | 0.00% | 00.0% | Unchanged |
| National Bank of Canada | 400 | $1.17K | 0.00% | −4,122−91.2% | Reduced |
| Russell Investments Group, Ltd. | 388 | $1.13K | 0.00% | +336+646.2% | Added |
| Advisor Group Holdings, Inc. | 388 | $1.13K | 0.00% | −9,513−96.1% | Reduced |
| Daiwa Securities Group Inc. | 398 | $1.00K | 0.00% | 00.0% | Unchanged |
| Point72 (DIFC) Ltd | 309 | $902 | 0.00% | +309 | New |
| Principal Securities, Inc. | 280 | $818 | 0.00% | 00.0% | Unchanged |
| Rothschild Investment LLC | 280 | $818 | 0.00% | +280 | New |
| Raffa Wealth Management, LLC | 250 | $730 | 0.00% | +250 | New |
| US Bancorp | 202 | $590 | 0.00% | +202 | New |
| Allworth Financial LP | 141 | $449 | 0.00% | +141 | New |
| The PNC Financial Services Group, Inc. | 146 | $426 | 0.00% | +118+421.4% | Added |
| Massmutual Trust Co FSB | 104 | $304 | 0.00% | +104 | New |
| Catherine Avery Investment Management LLC | 67 | $196 | 0.00% | +67 | New |
| Sterling Capital Management LLC | 58 | $169 | 0.00% | 00.0% | Unchanged |
| Farther Finance Advisors, LLC | 26 | $76 | 0.00% | 00.0% | Unchanged |
| IFP Advisors, Inc | 24 | $70 | 0.00% | +24 | New |
| EverSource Wealth Advisors, LLC | 6 | $18 | 0.00% | −100−94.3% | Reduced |
| Federated Hermes, Inc. | 6 | $18 | 0.00% | +2+50.0% | Added |
| Lazard Asset Management LLC | 26 | $0 | 0.00% | 00.0% | Unchanged |
| Covestor Ltd | 14 | $0 | 0.00% | +1+7.7% | Added |
| Vestal Point Capital, LP | 0 | $0 | 0.00% | −1,070,000−100.0% | Sold out |
| Deerfield Management Company, L.P. (Series C) | 0 | $0 | 0.00% | −896,960−100.0% | Sold out |
| Avidity Partners Management LP | 0 | $0 | 0.00% | −694,000−100.0% | Sold out |
| Trexquant Investment LP | 0 | $0 | 0.00% | −242,160−100.0% | Sold out |
| D. E. Shaw & Co., Inc. | 0 | $0 | 0.00% | −139,451−100.0% | Sold out |
| Squarepoint Ops LLC | 0 | $0 | 0.00% | −124,369−100.0% | Sold out |
| Sphera Funds Management Ltd. | 0 | $0 | 0.00% | −76,456−100.0% | Sold out |
| Citadel Advisors LLC | 0 | $0 | 0.00% | −50,995−100.0% | Sold out |
| Ameriprise Financial Inc | 0 | $0 | 0.00% | −28,801−100.0% | Sold out |
| Voloridge Investment Management, LLC | 0 | $0 | 0.00% | −27,119−100.0% | Sold out |
| Renaissance Technologies LLC | 0 | $0 | 0.00% | −20,000−100.0% | Sold out |
| Corsair Capital Management, L.P. | 0 | $0 | 0.00% | −20,000−100.0% | Sold out |
| Paloma Partners Management Co | 0 | $0 | 0.00% | −11,587−100.0% | Sold out |
| Acadian Asset Management LLC | 0 | $0 | 0.00% | −10,886−100.0% | Sold out |
| Brown Brothers Harriman & Co | 0 | $0 | 0.00% | −10,065−100.0% | Sold out |
| GAMMA Investing LLC | 0 | $0 | 0.00% | −654−100.0% | Sold out |
| SRS Capital Advisors, Inc. | 0 | $0 | 0.00% | −139−100.0% | Sold out |
| PEAK6 Investments LLC | – | – | – | – | Not filed |
| Abich Financial Wealth Management LLC | – | – | – | – | Not filed |