Prime Medicine, Inc.
PRME- Exchange
- Nasdaq
- Industry
- Biological Products, (No Diagnostic Substances)
- SEC CIK
- 0001894562
No open-market purchases or sales by Prime Medicine, Inc. insiders were filed in the last 90 days; 187 institutions reported holding it in 13F filings for Q2 2026, worth $393.5M in total; ARK Invest is the only superinvestor holding it.
13F holders, Q1 2026
Institutional positions in Prime Medicine, Inc. as of Mar 31, 2026. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 192
- +14 vs. Q4 2025
- Shares held
- 98.6M
- +9.86M (+11.1%) vs. Q4 2025
- Total value
- $342.6M
- +$34.8M (+11.3%) vs. Q4 2025
- New holders
- 39
- 74 more added
- Sold out
- 25
- 49 more reduced
5 institutions that held it in Q4 2025 haven't filed for Q1 2026 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q4 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting PRME on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 187 | $393.5M |
| Q1 2026 | 192 | $342.6M |
| Q4 2025 | 183 | $336.5M |
| Q3 2025 | 167 | $511.5M |
| Q2 2025 | 121 | $145.0M |
| Q1 2025 | 125 | $120.4M |
| Q4 2024 | 132 | $188.0M |
| Q3 2024 | 116 | $265.9M |
| Q2 2024 | 122 | $354.0M |
| Q1 2024 | 115 | $466.6M |
| Q4 2023 | 105 | $431.4M |
| Q3 2023 | 83 | $472.3M |
| Q2 2023 | 79 | $675.7M |
| Q1 2023 | 76 | $512.1M |
| Q4 2022 | 66 | $767.8M |
| Q3 2022 | 0 | $0 |
| Q2 2022 | 0 | $0 |
| Q1 2022 | 0 | $0 |
| Q4 2021 | 0 | $0 |
| Q3 2021 | 0 | $0 |
| Q2 2021 | 0 | $0 |
| Q1 2021 | 0 | $0 |
Institutions, Q1 2026
Shares, value and share of portfolio for each institution holding Prime Medicine, Inc.; share changes are against Q4 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Alphabet Inc. | 16,562,498 | $57.6M | 1.44% | 00.0% | Unchanged |
| BlackRock, Inc. | 8,501,708 | $29.6M | 0.00% | +232,865+2.8% | Added |
| State Street Corp | 6,345,125 | $22.1M | 0.00% | +1,249,615+24.5% | Added |
| ARK Investment Management LLCSuperinvestorARK Invest | 6,246,827 | $21.7M | 0.17% | +878,301+16.4% | Added |
| T. Rowe Price Investment Management, Inc. | 5,481,893 | $19.1M | 0.01% | −513,290−8.6% | Reduced |
| Vanguard Capital Management LLC | 4,474,162 | $15.6M | 0.00% | +4,474,162 | New |
| Balyasny Asset Management LLC | 4,123,365 | $14.3M | 0.03% | +999,003+32.0% | Added |
| Casdin Capital, LLC | 3,167,175 | $11.0M | 0.83% | 00.0% | Unchanged |
| Woodline Partners LP | 3,003,313 | $10.5M | 0.04% | +4690.0% | Added |
| Sumitomo Mitsui Trust Holdings, Inc. | 2,940,793 | $10.2M | 0.01% | −304,713−9.4% | Reduced |
| Nikko Asset Management Americas, Inc. | 2,940,793 | $10.2M | 0.14% | −304,713−9.4% | Reduced |
| UBS Group AG | 2,888,418 | $10.1M | 0.00% | +447,835+18.3% | Added |
| Geode Capital Management, LLC | 2,743,700 | $9.55M | 0.00% | +115,271+4.4% | Added |
| ADAR1 Capital Management, LLC | 1,973,282 | $6.87M | 0.41% | +1,973,282 | New |
| FMR LLC | 1,769,476 | $6.16M | 0.00% | −407,170−18.7% | Reduced |
| Redmile Group, LLC | 1,590,832 | $5.54M | 0.37% | +1,590,832 | New |
| Two Sigma Investments, LP | 1,572,811 | $5.47M | 0.00% | −56,513−3.5% | Reduced |
| D. E. Shaw & Co., Inc. | 1,393,621 | $4.85M | 0.00% | −157,748−10.2% | Reduced |
| Farallon Capital Management, L.L.C. | 1,240,843 | $4.32M | 0.03% | 00.0% | Unchanged |
| Goldman Sachs Group Inc | 970,425 | $3.38M | 0.00% | −785,343−44.7% | Reduced |
| Charles Schwab Investment Management Inc | 917,212 | $3.19M | 0.00% | −19,603−2.1% | Reduced |
| Northern Trust Corp | 886,716 | $3.09M | 0.00% | +44,563+5.3% | Added |
| Vanguard Portfolio Management LLC | 862,204 | $3.00M | 0.00% | +862,204 | New |
| JPMorgan Chase & Co | 844,154 | $2.66M | 0.00% | +408,444+93.7% | Added |
| Greenwich Wealth Management LLC | 750,001 | $2.61M | 0.11% | +10,000+1.4% | Added |
| Renaissance Technologies LLC | 741,039 | $2.58M | 0.00% | −408,120−35.5% | Reduced |
| Vanguard Fiduciary Trust Co | 717,002 | $2.50M | 0.00% | +717,002 | New |
| Susquehanna International Group, LLP | 715,829 | $2.49M | 0.00% | −460,898−39.2% | Reduced |
| Morgan Stanley | 639,457 | $2.23M | 0.00% | −530,441−45.3% | Reduced |
| HRT Financial LP | 612,769 | $2.13M | 0.01% | −42,582−6.5% | Reduced |
| Bank of America Corp | 577,004 | $2.01M | 0.00% | −71,008−11.0% | Reduced |
| AQR Capital Management LLC | 554,935 | $1.93M | 0.00% | +139,114+33.5% | Added |
| Moore Capital Management, LP | 500,000 | $1.74M | 0.06% | 00.0% | Unchanged |
| Chelsea Counsel Co | 462,340 | $1.61M | 0.72% | +235,340+103.7% | Added |
| Alessandra Capital Management, LLC | 425,510 | $1.48M | 1.26% | +425,510 | New |
| Bollard Group LLC | 361,136 | $1.26M | 0.04% | 00.0% | Unchanged |
| HighTower Advisors, LLC | 340,255 | $1.18M | 0.00% | −59,855−15.0% | Reduced |
| Citadel Advisors LLC | 336,358 | $1.17M | 0.00% | +223,488+198.0% | Added |
| Wells Fargo & Company | 319,550 | $1.11M | 0.00% | +25,054+8.5% | Added |
| Dimensional Fund Advisors LP | 304,522 | $1.06M | 0.00% | +220,468+262.3% | Added |
| Wellington Management Group LLP | 278,120 | $967.9K | 0.00% | +29,893+12.0% | Added |
| Nuveen, LLC | 275,931 | $960.2K | 0.00% | +24,295+9.7% | Added |
| Bank of New York Mellon Corp | 267,219 | $929.9K | 0.00% | +20,449+8.3% | Added |
| Rafferty Asset Management, LLC | 215,582 | $750.2K | 0.00% | +27,871+14.8% | Added |
| Davy Global Fund Management Ltd | 205,389 | $714.8K | 0.05% | +26,870+15.1% | Added |
| Green Alpha Advisors, LLC | 191,171 | $665.3K | 0.66% | +288+0.2% | Added |
| Swiss National Bank | 178,600 | $621.5K | 0.00% | +8,500+5.0% | Added |
| Keystone Financial Group | 166,010 | $577.7K | 0.04% | +36,345+28.0% | Added |
| Deutsche Bank AG | 157,440 | $547.9K | 0.00% | +9,497+6.4% | Added |
| XTX Topco Ltd | 157,282 | $547.3K | 0.01% | +84,347+115.6% | Added |
| Elevate Capital Advisors, LLC | 151,069 | $525.7K | 0.34% | +108,403+254.1% | Added |
| Marshall Wace, LLP | 141,957 | $494.0K | 0.00% | +141,957 | New |
| Bridgeway Capital Management, LLC | 134,800 | $469.1K | 0.01% | 00.0% | Unchanged |
| Price T Rowe Associates Inc | 133,755 | $466.0K | 0.00% | +29,202+27.9% | Added |
| Alliancebernstein L.P. | 122,460 | $424.9K | 0.00% | +13,770+12.7% | Added |
| Mirae Asset Global ETFs Holdings Ltd. | 122,463 | $421.2K | 0.00% | +7,403+6.4% | Added |
| Steward Partners Investment Advisory, LLC | 117,456 | $408.7K | 0.00% | −950−0.8% | Reduced |
| FIL Ltd | 115,206 | $400.9K | 0.00% | −396−0.3% | Reduced |
| Rhumbline Advisers | 114,269 | $397.6K | 0.00% | +5,860+5.4% | Added |
| Engineers Gate Manager LP | 110,348 | $384.0K | 0.00% | +49,858+82.4% | Added |
| Palumbo Wealth Management LLC | 102,246 | $355.8K | 0.09% | +16,707+19.5% | Added |
| Invesco Ltd. | 96,875 | $337.1K | 0.00% | +40,096+70.6% | Added |
| Profund Advisors LLC | 95,806 | $333.4K | 0.01% | +26,201+37.6% | Added |
| TD Asset Management Inc | 94,148 | $327.6K | 0.00% | 00.0% | Unchanged |
| Squarepoint Ops LLC | 94,066 | $327.4K | 0.00% | −123,976−56.9% | Reduced |
| Rockefeller Capital Management L.P. | 91,401 | $318.1K | 0.00% | −29,990−24.7% | Reduced |
| California State Teachers Retirement System | 86,473 | $300.9K | 0.00% | −456−0.5% | Reduced |
| UBS Asset Management Americas Inc | 85,300 | $296.8K | 0.00% | −13,800−13.9% | Reduced |
| Mariner, LLC | 78,398 | $272.7K | 0.00% | +42,108+116.0% | Added |
| Concurrent Investment Advisors, LLC | 74,177 | $258.1K | 0.00% | +74,177 | New |
| Ieq Capital, LLC | 74,013 | $257.6K | 0.00% | +36,877+99.3% | Added |
| Virtus Investment Advisers, Inc. | 66,508 | $231.4K | 0.06% | +1,622+2.5% | Added |
| LPL Financial LLC | 66,424 | $231.2K | 0.00% | +33,500+101.7% | Added |
| Legal & General Group Plc | 66,444 | $230.9K | 0.00% | −14,305−17.7% | Reduced |
| Russell Investments Group, Ltd. | 64,273 | $223.7K | 0.00% | +57,446+841.5% | Added |
| Barclays PLC | 63,773 | $221.9K | 0.00% | −300,053−82.5% | Reduced |
| Tudor Investment Corp Et Al | 61,546 | $214.2K | 0.00% | +61,546 | New |
| Janus Henderson Group PLC | 60,900 | $211.6K | 0.00% | 00.0% | Unchanged |
| Wiley Bros.-Aintree Capital, LLC | 59,470 | $207.0K | 0.00% | −882−1.5% | Reduced |
| Vanguard Asset Management, Ltd | 59,021 | $205.4K | 0.00% | +59,021 | New |
| Aquatic Capital Management LLC | 54,230 | $188.7K | 0.01% | +54,230 | New |
| Los Angeles Capital Management LLC | 52,615 | $183.1K | 0.00% | +52,615 | New |
| Ameriprise Financial Inc | 49,584 | $172.6K | 0.00% | −4,498−8.3% | Reduced |
| Citigroup Inc | 47,232 | $164.4K | 0.00% | −3,997−7.8% | Reduced |
| Quadrature Capital Ltd | 46,893 | $163.2K | 0.00% | −5,973−11.3% | Reduced |
| Mutual Advisors, LLC | 45,200 | $157.3K | 0.00% | 00.0% | Unchanged |
| Vanguard Global Advisers, LLC | 44,269 | $154.1K | 0.00% | +44,269 | New |
| MetLife Investment Management | 44,208 | $153.8K | 0.00% | −13,362−23.2% | Reduced |
| VARCOV Co. | 41,964 | $146.0K | 0.05% | +41,964 | New |
| IvyRock Asset Management (HK) Ltd | 41,800 | $145.5K | 0.08% | 00.0% | Unchanged |
| DRW Securities, LLC | 40,964 | $142.6K | 0.01% | +40,964 | New |
| Jones Financial Companies LLLP | 40,307 | $136.2K | 0.00% | −96−0.2% | Reduced |
| Axq Capital, LP | 36,742 | $127.9K | 0.02% | +3,337+10.0% | Added |
| Wealth Enhancement Advisory Services, LLC | 37,681 | $125.1K | 0.00% | +11,583+44.4% | Added |
| Kingsview Wealth Management, LLC | 35,000 | $121.8K | 0.00% | +20,000+133.3% | Added |
| BNP Paribas Arbitrage, SA | 34,413 | $119.8K | 0.00% | +24,590+250.3% | Added |
| CWM, LLC | 33,811 | $117.7K | 0.00% | +8,384+33.0% | Added |
| Oppenheimer & Co Inc | 33,656 | $117.1K | 0.00% | +21,223+170.7% | Added |
| Crestwood Advisors Group LLC | 32,374 | $112.7K | 0.00% | +401+1.3% | Added |
| China Universal Asset Management Co., Ltd. | 32,033 | $111.5K | 0.01% | +2,619+8.9% | Added |