Prime Medicine, Inc.
PRME- Exchange
- Nasdaq
- Industry
- Biological Products, (No Diagnostic Substances)
- SEC CIK
- 0001894562
No open-market purchases or sales by Prime Medicine, Inc. insiders were filed in the last 90 days; 187 institutions reported holding it in 13F filings for Q2 2026, worth $393.5M in total; ARK Invest is the only superinvestor holding it.
13F holders, Q1 2026
Institutional positions in Prime Medicine, Inc. as of Mar 31, 2026. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 192
- +14 vs. Q4 2025
- Shares held
- 98.6M
- +9.86M (+11.1%) vs. Q4 2025
- Total value
- $342.6M
- +$34.8M (+11.3%) vs. Q4 2025
- New holders
- 39
- 74 more added
- Sold out
- 25
- 49 more reduced
5 institutions that held it in Q4 2025 haven't filed for Q1 2026 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q4 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting PRME on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 187 | $393.5M |
| Q1 2026 | 192 | $342.6M |
| Q4 2025 | 183 | $336.5M |
| Q3 2025 | 167 | $511.5M |
| Q2 2025 | 121 | $145.0M |
| Q1 2025 | 125 | $120.4M |
| Q4 2024 | 132 | $188.0M |
| Q3 2024 | 116 | $265.9M |
| Q2 2024 | 122 | $354.0M |
| Q1 2024 | 115 | $466.6M |
| Q4 2023 | 105 | $431.4M |
| Q3 2023 | 83 | $472.3M |
| Q2 2023 | 79 | $675.7M |
| Q1 2023 | 76 | $512.1M |
| Q4 2022 | 66 | $767.8M |
| Q3 2022 | 0 | $0 |
| Q2 2022 | 0 | $0 |
| Q1 2022 | 0 | $0 |
| Q4 2021 | 0 | $0 |
| Q3 2021 | 0 | $0 |
| Q2 2021 | 0 | $0 |
| Q1 2021 | 0 | $0 |
Institutions, Q1 2026
Shares, value and share of portfolio for each institution holding Prime Medicine, Inc.; share changes are against Q4 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| State of New Jersey Common Pension Fund D | 30,845 | $107.3K | 0.00% | +30,845 | New |
| Police & Firemen's Retirement System of New Jersey | 30,751 | $107.0K | 0.00% | +9,585+45.3% | Added |
| Intech Investment Management LLC | 30,538 | $106.3K | 0.00% | −4,498−12.8% | Reduced |
| Transcend Wealth Collective, LLC | 30,070 | $104.6K | 0.01% | +3,570+13.5% | Added |
| SEI Investments Co | 29,183 | $101.6K | 0.00% | +29,183 | New |
| Envestnet Asset Management Inc | 29,040 | $101.1K | 0.00% | −3,536−10.9% | Reduced |
| Manufacturers Life Insurance Company, The | 28,872 | $100.5K | 0.00% | −2,730−8.6% | Reduced |
| Creative Planning | 28,246 | $98.3K | 0.00% | +10,354+57.9% | Added |
| E Fund Management Co., Ltd. | 27,099 | $94.3K | 0.00% | +27,099 | New |
| Blue Bell Private Wealth Management, LLC | 27,015 | $94.0K | 0.01% | +27,015 | New |
| Vanguard Investments Australia, Ltd. | 26,124 | $90.9K | 0.00% | +26,124 | New |
| Abacus Planning Group, Inc. | 25,188 | $87.7K | 0.01% | 00.0% | Unchanged |
| Turtle Creek Wealth Advisors, LLC | 25,000 | $87.0K | 0.01% | +25,000 | New |
| Nomura Holdings Inc | 24,823 | $86.4K | 0.00% | +34+0.1% | Added |
| Arizona State Retirement System | 24,791 | $86.3K | 0.00% | +706+2.9% | Added |
| Group One Trading, L.P. | 24,766 | $86.2K | 0.00% | −78,447−76.0% | Reduced |
| ProShare Advisors LLC | 22,968 | $79.9K | 0.00% | −3,190−12.2% | Reduced |
| JustInvest LLC | 21,954 | $76.4K | 0.00% | −1,697−7.2% | Reduced |
| Tower Research Capital LLC (TRC) | 21,814 | $75.9K | 0.00% | +21,007+2,603.1% | Added |
| Shelton Wealth Management, LLC | 20,066 | $69.8K | 0.03% | 00.0% | Unchanged |
| KLP Kapitalforvaltning AS | 18,500 | $64.4K | 0.00% | 00.0% | Unchanged |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 18,225 | $63.4K | 0.00% | +9,411+106.8% | Added |
| Scientech Research LLC | 17,931 | $62.4K | 0.05% | −4,462−19.9% | Reduced |
| Voya Investment Management LLC | 17,345 | $60.4K | 0.00% | −146−0.8% | Reduced |
| Thompson Davis & Co., Inc. | 17,240 | $60.0K | 0.04% | −5,500−24.2% | Reduced |
| Commonwealth Equity Services, LLC | 16,437 | $57.2K | 0.00% | −17,962−52.2% | Reduced |
| Graham Capital Management, L.P. | 16,015 | $55.7K | 0.00% | −98,665−86.0% | Reduced |
| Magnetar Financial LLC | 15,784 | $54.9K | 0.00% | +15,784 | New |
| Levin Capital Strategies, L.P. | 15,000 | $52.2K | 0.00% | 00.0% | Unchanged |
| Martingale Asset Management L P | 14,848 | $51.7K | 0.00% | +40+0.3% | Added |
| Prudential Financial Inc | 14,755 | $51.3K | 0.00% | +14,755 | New |
| Sanctuary Advisors, LLC | 13,894 | $48.4K | 0.00% | −765−5.2% | Reduced |
| Benjamin Edwards Inc | 13,852 | $48.2K | 0.00% | +13,852 | New |
| Sterling Investment Advisors, Ltd. | 13,400 | $46.6K | 0.01% | 00.0% | Unchanged |
| JTC Employer Solutions Trusteee Ltd | 13,249 | $46.0K | 0.00% | 00.0% | Unchanged |
| Prime Capital Investment Advisors, LLC | 12,945 | $45.0K | 0.00% | −1,110−7.9% | Reduced |
| Cambridge Investment Research Advisors, Inc. | 12,337 | $43.0K | 0.00% | +12,337 | New |
| Mercer Global Advisors Inc | 12,305 | $42.8K | 0.00% | +12,305 | New |
| Pictet Asset Management Holding SA | 12,107 | $42.1K | 0.00% | +12,107 | New |
| Raymond James Financial Inc | 12,044 | $41.9K | 0.00% | −15,000−55.5% | Reduced |
| Sequoia Financial Advisors, LLC | 11,673 | $40.6K | 0.00% | +11,673 | New |
| Teacher Retirement System of Texas | 11,058 | $38.5K | 0.00% | −1,177−9.6% | Reduced |
| Victory Capital Management Inc | 10,817 | $37.6K | 0.00% | +16+0.1% | Added |
| Wealthfront Advisers LLC | 10,379 | $36.1K | 0.00% | +10,379 | New |
| Polymer Capital Management (US) LLC | 10,317 | $35.9K | 0.01% | −25,664−71.3% | Reduced |
| Forum Financial Management, LP | 10,000 | $34.8K | 0.00% | 00.0% | Unchanged |
| Glen Eagle Advisors, LLC | 10,000 | $34.8K | 0.00% | 00.0% | Unchanged |
| Federation des caisses Desjardins du Quebec | 9,500 | $33.1K | 0.00% | −2,500−20.8% | Reduced |
| Mirae Asset Global Investments Co., Ltd. | 9,415 | $32.8K | 0.00% | +643+7.3% | Added |
| Nisa Investment Advisors, LLC | 9,346 | $32.5K | 0.00% | +4,800+105.6% | Added |
| Royal Bank of Canada | 9,254 | $32.0K | 0.00% | +4,365+89.3% | Added |
| New York State Common Retirement Fund | 8,434 | $29.4K | 0.00% | 00.0% | Unchanged |
| Ameritas Investment Partners, Inc. | 8,407 | $29.3K | 0.00% | +2,506+42.5% | Added |
| NBC Securities, Inc. | 5,000 | $17.4K | 0.00% | 00.0% | Unchanged |
| Signaturefd, LLC | 5,000 | $17.4K | 0.00% | 00.0% | Unchanged |
| Allworth Financial LP | 4,405 | $15.3K | 0.00% | +1,290+41.4% | Added |
| Advisor Group Holdings, Inc. | 4,097 | $14.3K | 0.00% | −4,331−51.4% | Reduced |
| GF Fund Management Co. Ltd. | 4,036 | $14.0K | 0.00% | +489+13.8% | Added |
| Sterling Capital Management LLC | 3,462 | $12.0K | 0.00% | −2,274−39.6% | Reduced |
| Financial Connections Group, Inc. | 3,712 | $12.0K | 0.00% | 00.0% | Unchanged |
| MTM Investment Management, LLC | 3,090 | $10.8K | 0.00% | 00.0% | Unchanged |
| Owl Creek Wealth Partners LLC | 2,615 | $9.10K | 0.00% | +2,615 | New |
| CI Private Wealth, LLC | 41,221 | $8.64K | 0.00% | +2,444+6.3% | Added |
| EverSource Wealth Advisors, LLC | 2,000 | $6.96K | 0.00% | +238+13.5% | Added |
| Scarborough Advisors, LLC | 1,258 | $4.38K | 0.00% | +1+0.1% | Added |
| Essential Partners LLC | 1,008 | $3.51K | 0.00% | +787+356.1% | Added |
| GWM Advisors LLC | 1,000 | $3.48K | 0.00% | 00.0% | Unchanged |
| Optiver Holding B.V. | 892 | $3.10K | 0.00% | +732+457.5% | Added |
| GAMMA Investing LLC | 647 | $2.25K | 0.00% | +536+482.9% | Added |
| Fairman Group, LLC | 500 | $1.74K | 0.00% | 00.0% | Unchanged |
| Fortitude Family Office, LLC | 436 | $1.52K | 0.00% | +140+47.3% | Added |
| SBI Securities Co., Ltd. | 391 | $1.36K | 0.00% | +88+29.0% | Added |
| MAI Capital Management | 386 | $1.34K | 0.00% | +112+40.9% | Added |
| Caitong International Asset Management Co., Ltd | 383 | $1.33K | 0.00% | −38,313−99.0% | Reduced |
| Rothschild Investment LLC | 382 | $1.33K | 0.00% | +37+10.7% | Added |
| Vanguard National Trust Co | 334 | $1.16K | 0.00% | +334 | New |
| The PNC Financial Services Group, Inc. | 319 | $1.11K | 0.00% | 00.0% | Unchanged |
| Basecamp Wealth Advisors LLC | 287 | $999 | 0.00% | 00.0% | Unchanged |
| Parkside Financial Bank & Trust | 285 | $992 | 0.00% | 00.0% | Unchanged |
| SRS Capital Advisors, Inc. | 230 | $800 | 0.00% | +230 | New |
| True Wealth Design, LLC | 152 | $529 | 0.00% | +37+32.2% | Added |
| Farther Finance Advisors, LLC | 154 | $522 | 0.00% | +83+116.9% | Added |
| Sunbelt Securities, Inc. | 80 | $278 | 0.00% | 00.0% | Unchanged |
| Harbour Investments, Inc. | 74 | $258 | 0.00% | +74 | New |
| Keating Financial Advisory Services, Inc. | 59 | $205 | 0.00% | +59 | New |
| Newbridge Financial Services Group, Inc. | 45 | $157 | 0.00% | +45 | New |
| US Bancorp | 33 | $115 | 0.00% | +33 | New |
| National Bank of Canada | 10 | $35 | 0.00% | +10 | New |
| SJS Investment Consulting Inc. | 10 | $35 | 0.00% | +10 | New |
| Twin Peaks Wealth Advisors, LLC | 3 | $10 | 0.00% | +3 | New |
| IFP Advisors, Inc | 2 | $7 | 0.00% | −8−80.0% | Reduced |
| Covestor Ltd | 31 | $0 | 0.00% | 00.0% | Unchanged |
| Point72 Asset Management, L.P. | 0 | $0 | 0.00% | −551,030−100.0% | Sold out |
| Two Sigma Advisers, LP | 0 | $0 | 0.00% | −383,500−100.0% | Sold out |
| Verition Fund Management LLC | 0 | $0 | 0.00% | −290,983−100.0% | Sold out |
| Dark Forest Capital Management LP | 0 | $0 | 0.00% | −225,859−100.0% | Sold out |
| Jump Financial, LLC | 0 | $0 | 0.00% | −171,931−100.0% | Sold out |
| Virtu Financial LLC | 0 | $0 | 0.00% | −94,778−100.0% | Sold out |
| Qube Research & Technologies Ltd | 0 | $0 | 0.00% | −94,670−100.0% | Sold out |
| Brevan Howard Capital Management LP | 0 | $0 | 0.00% | −56,088−100.0% | Sold out |