Prime Medicine, Inc.
PRME- Exchange
- Nasdaq
- Industry
- Biological Products, (No Diagnostic Substances)
- SEC CIK
- 0001894562
No open-market purchases or sales by Prime Medicine, Inc. insiders were filed in the last 90 days; 187 institutions reported holding it in 13F filings for Q2 2026, worth $393.5M in total; ARK Invest is the only superinvestor holding it.
13F holders, Q4 2024
Institutional positions in Prime Medicine, Inc. as of Dec 31, 2024. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 132
- +18 vs. Q3 2024
- Shares held
- 64.3M
- −4.33M (−6.3%) vs. Q3 2024
- Total value
- $188.0M
- −$77.7M (−29.2%) vs. Q3 2024
- New holders
- 35
- 39 more added
- Sold out
- 17
- 32 more reduced
2 institutions that held it in Q3 2024 haven't filed for Q4 2024 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2024: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting PRME on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 187 | $393.5M |
| Q1 2026 | 192 | $342.6M |
| Q4 2025 | 183 | $336.5M |
| Q3 2025 | 167 | $511.5M |
| Q2 2025 | 121 | $145.0M |
| Q1 2025 | 125 | $120.4M |
| Q4 2024 | 132 | $188.0M |
| Q3 2024 | 116 | $265.9M |
| Q2 2024 | 122 | $354.0M |
| Q1 2024 | 115 | $466.6M |
| Q4 2023 | 105 | $431.4M |
| Q3 2023 | 83 | $472.3M |
| Q2 2023 | 79 | $675.7M |
| Q1 2023 | 76 | $512.1M |
| Q4 2022 | 66 | $767.8M |
| Q3 2022 | 0 | $0 |
| Q2 2022 | 0 | $0 |
| Q1 2022 | 0 | $0 |
| Q4 2021 | 0 | $0 |
| Q3 2021 | 0 | $0 |
| Q2 2021 | 0 | $0 |
| Q1 2021 | 0 | $0 |
Institutions, Q4 2024
Shares, value and share of portfolio for each institution holding Prime Medicine, Inc.; share changes are against Q3 2024.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Lazard Asset Management LLC | 26 | $0 | 0.00% | 00.0% | Unchanged |
| Covestor Ltd | 14 | $0 | 0.00% | +1+7.7% | Added |
| EverSource Wealth Advisors, LLC | 6 | $18 | 0.00% | −100−94.3% | Reduced |
| Federated Hermes, Inc. | 6 | $18 | 0.00% | +2+50.0% | Added |
| IFP Advisors, Inc | 24 | $70 | 0.00% | +24 | New |
| Farther Finance Advisors, LLC | 26 | $76 | 0.00% | 00.0% | Unchanged |
| Sterling Capital Management LLC | 58 | $169 | 0.00% | 00.0% | Unchanged |
| Catherine Avery Investment Management LLC | 67 | $196 | 0.00% | +67 | New |
| Massmutual Trust Co FSB | 104 | $304 | 0.00% | +104 | New |
| The PNC Financial Services Group, Inc. | 146 | $426 | 0.00% | +118+421.4% | Added |
| Allworth Financial LP | 141 | $449 | 0.00% | +141 | New |
| US Bancorp | 202 | $590 | 0.00% | +202 | New |
| Raffa Wealth Management, LLC | 250 | $730 | 0.00% | +250 | New |
| Principal Securities, Inc. | 280 | $818 | 0.00% | 00.0% | Unchanged |
| Rothschild Investment LLC | 280 | $818 | 0.00% | +280 | New |
| Point72 (DIFC) Ltd | 309 | $902 | 0.00% | +309 | New |
| Daiwa Securities Group Inc. | 398 | $1.00K | 0.00% | 00.0% | Unchanged |
| Advisor Group Holdings, Inc. | 388 | $1.13K | 0.00% | −9,513−96.1% | Reduced |
| Russell Investments Group, Ltd. | 388 | $1.13K | 0.00% | +336+646.2% | Added |
| National Bank of Canada | 400 | $1.17K | 0.00% | −4,122−91.2% | Reduced |
| Fairman Group, LLC | 500 | $1.46K | 0.00% | 00.0% | Unchanged |
| Quadrant Capital Group LLC | 833 | $2.43K | 0.00% | −133−13.8% | Reduced |
| Royal Bank of Canada | 1,162 | $3.00K | 0.00% | −9,523−89.1% | Reduced |
| Comerica Bank | 1,073 | $3.13K | 0.00% | +758+240.6% | Added |
| First Horizon Advisors, Inc. | 1,109 | $3.24K | 0.00% | 00.0% | Unchanged |
| SBI Securities Co., Ltd. | 1,205 | $3.52K | 0.00% | +1,205 | New |
| Amalgamated Bank | 1,347 | $4.00K | 0.00% | 00.0% | Unchanged |
| Simplex Trading, LLC | 1,458 | $4.00K | 0.00% | +1,458 | New |
| Tower Research Capital LLC (TRC) | 1,397 | $4.08K | 0.00% | −6,652−82.6% | Reduced |
| Signaturefd, LLC | 1,653 | $4.83K | 0.00% | +243+17.2% | Added |
| Skopos Labs, Inc. | 1,894 | $5.53K | 0.00% | +1,894 | New |
| R Squared Ltd | 2,230 | $6.51K | 0.01% | +2,230 | New |
| CWM, LLC | 2,432 | $7.00K | 0.00% | +2,410+10,954.5% | Added |
| GF Fund Management Co. Ltd. | 2,700 | $7.88K | 0.00% | +2,700 | New |
| Ameritas Investment Partners, Inc. | 3,901 | $11.4K | 0.00% | 00.0% | Unchanged |
| California State Teachers Retirement System | 4,110 | $12.0K | 0.00% | 00.0% | Unchanged |
| Mirae Asset Global Investments Co., Ltd. | 4,371 | $12.7K | 0.00% | +30+0.7% | Added |
| Legal & General Group Plc | 6,279 | $18.4K | 0.00% | 00.0% | Unchanged |
| New York State Common Retirement Fund | 8,434 | $24.6K | 0.00% | 00.0% | Unchanged |
| Pathstone Holdings, LLC | 11,311 | $33.0K | 0.00% | −3,059−21.3% | Reduced |
| State Board of Administration of Florida Retirement System | 11,420 | $33.3K | 0.00% | 00.0% | Unchanged |
| American Century Companies Inc | 11,426 | $33.4K | 0.00% | +11,426 | New |
| Oppenheimer & Co Inc | 12,106 | $35.4K | 0.00% | −5,765−32.3% | Reduced |
| JustInvest LLC | 12,378 | $36.1K | 0.00% | +12,378 | New |
| Nisa Investment Advisors, LLC | 12,616 | $36.8K | 0.00% | +12,507+11,474.3% | Added |
| XTX Topco Ltd | 14,466 | $42.2K | 0.00% | +14,466 | New |
| Invesco Ltd. | 15,071 | $44.0K | 0.00% | +1,048+7.5% | Added |
| Axq Capital, LP | 15,363 | $44.9K | 0.02% | +15,363 | New |
| Gsa Capital Partners LLP | 15,311 | $45.0K | 0.00% | −83,749−84.5% | Reduced |
| AQR Capital Management LLC | 16,046 | $46.9K | 0.00% | +16,046 | New |
| Clarius Group, LLC | 16,080 | $47.0K | 0.00% | 00.0% | Unchanged |
| Balyasny Asset Management LLC | 16,342 | $47.7K | 0.00% | +16,342 | New |
| Police & Firemen's Retirement System of New Jersey | 17,092 | $49.9K | 0.00% | +17,092 | New |
| Impact Partnership Wealth, LLC | 17,274 | $50.4K | 0.01% | +17,274 | New |
| Voya Investment Management LLC | 18,173 | $53.1K | 0.00% | −1,011−5.3% | Reduced |
| CIBC World Markets Inc. | 19,023 | $56.0K | 0.00% | +8,801+86.1% | Added |
| BNP Paribas Arbitrage, SA | 20,096 | $58.7K | 0.00% | +20,096 | New |
| Sherbrooke Park Advisers LLC | 20,441 | $59.7K | 0.02% | +20,441 | New |
| Envestnet Asset Management Inc | 21,557 | $62.9K | 0.00% | −6,798−24.0% | Reduced |
| HRT Financial LP | 21,695 | $63.0K | 0.00% | +21,695 | New |
| HighTower Advisors, LLC | 21,590 | $63.0K | 0.00% | −85−0.4% | Reduced |
| Benjamin Edwards Inc | 21,921 | $63.9K | 0.00% | −1,275−5.5% | Reduced |
| ProShare Advisors LLC | 22,186 | $64.8K | 0.00% | +4,375+24.6% | Added |
| Avanza Fonder AB | 22,480 | $65.6K | 0.00% | +22,480 | New |
| Manufacturers Life Insurance Company, The | 23,592 | $68.9K | 0.00% | +197+0.8% | Added |
| Virtus ETF Advisers LLC | 23,618 | $69.0K | 0.03% | +11,948+102.4% | Added |
| Prime Capital Investment Advisors, LLC | 23,955 | $69.9K | 0.00% | +23,955 | New |
| MetLife Investment Management | 25,031 | $73.1K | 0.00% | −9,097−26.7% | Reduced |
| Creative Planning | 27,623 | $80.7K | 0.00% | +27,623 | New |
| China Universal Asset Management Co., Ltd. | 27,811 | $81.2K | 0.01% | +4,725+20.5% | Added |
| Corebridge Financial, Inc. | 28,197 | $82.3K | 0.00% | −2,128−7.0% | Reduced |
| PEAK6 LLC | 30,013 | $87.6K | 0.00% | +30,013 | New |
| Intech Investment Management LLC | 30,404 | $88.8K | 0.00% | +16,302+115.6% | Added |
| Crestwood Advisors Group LLC | 31,687 | $92.5K | 0.00% | +31,687 | New |
| Mirae Asset Global ETFs Holdings Ltd. | 32,499 | $94.9K | 0.00% | +1,372+4.4% | Added |
| JPMorgan Chase & Co | 35,640 | $104.1K | 0.00% | −1,742−4.7% | Reduced |
| Susquehanna International Group, LLP | 37,052 | $108.2K | 0.00% | −78,002−67.8% | Reduced |
| Two Sigma Advisers, LP | 43,200 | $126.1K | 0.00% | −76,700−64.0% | Reduced |
| TD Asset Management Inc | 46,434 | $135.6K | 0.00% | 00.0% | Unchanged |
| Citigroup Inc | 47,431 | $138.5K | 0.00% | −640−1.3% | Reduced |
| Sculptor Capital LP | 50,700 | $148.0K | 0.00% | +50,700 | New |
| SG Americas Securities, LLC | 60,229 | $176.0K | 0.00% | +13,247+28.2% | Added |
| Davy Global Fund Management Ltd | 60,685 | $177.2K | 0.02% | +32,572+115.9% | Added |
| Green Alpha Advisors, LLC | 64,406 | $188.1K | 0.15% | +64,406 | New |
| Point72 Asset Management, L.P. | 68,528 | $200.1K | 0.00% | +68,528 | New |
| Aristides Capital LLC | 70,500 | $205.9K | 0.06% | +70,500 | New |
| Rhumbline Advisers | 71,956 | $210.1K | 0.00% | +1,909+2.7% | Added |
| Levin Capital Strategies, L.P. | 75,000 | $219.0K | 0.02% | +45,000+150.0% | Added |
| Alliancebernstein L.P. | 76,000 | $221.9K | 0.00% | 00.0% | Unchanged |
| Deutsche Bank AG | 80,835 | $236.0K | 0.00% | −34,072−29.7% | Reduced |
| Wells Fargo & Company | 96,181 | $280.8K | 0.00% | −75,287−43.9% | Reduced |
| Barclays PLC | 97,621 | $285.1K | 0.00% | +12,924+15.3% | Added |
| Jane Street Group, LLC | 101,758 | $297.1K | 0.00% | +44,210+76.8% | Added |
| Verition Fund Management LLC | 103,545 | $302.4K | 0.00% | +65,000+168.6% | Added |
| FIL Ltd | 121,017 | $353.4K | 0.00% | −8,844−6.8% | Reduced |
| Bank of New York Mellon Corp | 129,514 | $378.2K | 0.00% | −200−0.2% | Reduced |
| ExodusPoint Capital Management, LP | 131,732 | $385.0K | 0.00% | +131,732 | New |
| Susquehanna Fundamental Investments, LLC | 144,719 | $422.6K | 0.01% | +144,719 | New |
| Vestmark Advisory Solutions, Inc. | 111,465 | $459.7K | 0.02% | +21,429+23.8% | Added |
| Two Sigma Investments, LP | 166,199 | $485.3K | 0.00% | −152,374−47.8% | Reduced |