Prime Medicine, Inc.
PRME- Exchange
- Nasdaq
- Industry
- Biological Products, (No Diagnostic Substances)
- SEC CIK
- 0001894562
No open-market purchases or sales by Prime Medicine, Inc. insiders were filed in the last 90 days; 187 institutions reported holding it in 13F filings for Q2 2026, worth $393.5M in total; ARK Invest is the only superinvestor holding it.
13F holders, Q3 2025
Institutional positions in Prime Medicine, Inc. as of Sep 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 167
- +46 vs. Q2 2025
- Shares held
- 92.3M
- +33.7M (+57.4%) vs. Q2 2025
- Total value
- $511.5M
- +$366.5M (+252.7%) vs. Q2 2025
- New holders
- 53
- 63 more added
- Sold out
- 7
- 31 more reduced
Compare with Q2 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting PRME on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 187 | $393.5M |
| Q1 2026 | 192 | $342.6M |
| Q4 2025 | 183 | $336.5M |
| Q3 2025 | 167 | $511.5M |
| Q2 2025 | 121 | $145.0M |
| Q1 2025 | 125 | $120.4M |
| Q4 2024 | 132 | $188.0M |
| Q3 2024 | 116 | $265.9M |
| Q2 2024 | 122 | $354.0M |
| Q1 2024 | 115 | $466.6M |
| Q4 2023 | 105 | $431.4M |
| Q3 2023 | 83 | $472.3M |
| Q2 2023 | 79 | $675.7M |
| Q1 2023 | 76 | $512.1M |
| Q4 2022 | 66 | $767.8M |
| Q3 2022 | 0 | $0 |
| Q2 2022 | 0 | $0 |
| Q1 2022 | 0 | $0 |
| Q4 2021 | 0 | $0 |
| Q3 2021 | 0 | $0 |
| Q2 2021 | 0 | $0 |
| Q1 2021 | 0 | $0 |
Institutions, Q3 2025
Shares, value and share of portfolio for each institution holding Prime Medicine, Inc.; share changes are against Q2 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Intech Investment Management LLC | 23,228 | $128.7K | 0.00% | −7,582−24.6% | Reduced |
| Creative Planning | 23,082 | $127.9K | 0.00% | +12,937+127.5% | Added |
| Prelude Capital Management, LLC | 22,483 | $124.6K | 0.01% | −18,805−45.5% | Reduced |
| Police & Firemen's Retirement System of New Jersey | 21,166 | $117.3K | 0.00% | +4,074+23.8% | Added |
| Polymer Capital Management (US) LLC | 20,791 | $115.2K | 0.02% | +20,791 | New |
| BNP Paribas Arbitrage, SA | 19,656 | $108.9K | 0.00% | −7,079−26.5% | Reduced |
| ProShare Advisors LLC | 19,099 | $105.8K | 0.00% | +2,228+13.2% | Added |
| Owen LaRue, LLC | 19,032 | $105.4K | 0.04% | +19,032 | New |
| Mariner, LLC | 18,219 | $100.9K | 0.00% | +18,219 | New |
| Shelton Wealth Management, LLC | 17,332 | $96.0K | 0.04% | +17,332 | New |
| Clarius Group, LLC | 16,080 | $89.1K | 0.01% | 00.0% | Unchanged |
| Federation des caisses Desjardins du Quebec | 15,900 | $88.1K | 0.00% | −5,300−25.0% | Reduced |
| Levin Capital Strategies, L.P. | 15,000 | $83.1K | 0.01% | −125,000−89.3% | Reduced |
| Prime Capital Investment Advisors, LLC | 14,379 | $79.7K | 0.00% | −1,652−10.3% | Reduced |
| Sanctuary Advisors, LLC | 14,323 | $79.3K | 0.00% | +14,323 | New |
| JTC Employer Solutions Trusteee Ltd | 13,249 | $73.0K | 0.01% | 00.0% | Unchanged |
| Hudson Bay Capital Management LP | 13,025 | $72.2K | 0.00% | +13,025 | New |
| Voya Investment Management LLC | 12,849 | $71.2K | 0.00% | −4,373−25.4% | Reduced |
| Wiley Bros.-Aintree Capital, LLC | 11,848 | $70.6K | 0.00% | +11,848 | New |
| Virtu Financial LLC | 11,830 | $66.0K | 0.00% | −715−5.7% | Reduced |
| Victory Capital Management Inc | 10,190 | $56.5K | 0.00% | +10,190 | New |
| Quadrature Capital Ltd | 10,182 | $56.3K | 0.00% | +10,182 | New |
| Sterling Investment Advisors, Ltd. | 10,000 | $55.4K | 0.01% | +10,000 | New |
| Jones Financial Companies LLLP | 9,575 | $49.0K | 0.00% | +9,575 | New |
| New York State Common Retirement Fund | 8,434 | $46.7K | 0.00% | 00.0% | Unchanged |
| NBC Securities, Inc. | 7,500 | $41.5K | 0.00% | +7,500 | New |
| Russell Investments Group, Ltd. | 6,827 | $37.8K | 0.00% | +6,345+1,316.4% | Added |
| Mirae Asset Global Investments Co., Ltd. | 6,760 | $37.5K | 0.00% | +1,688+33.3% | Added |
| Legal & General Group Plc | 6,751 | $37.4K | 0.00% | +1,852+37.8% | Added |
| Advisor Group Holdings, Inc. | 6,950 | $37.4K | 0.00% | +6,822+5,329.7% | Added |
| Ameritas Investment Partners, Inc. | 5,901 | $32.7K | 0.00% | +2,000+51.3% | Added |
| SRS Capital Advisors, Inc. | 5,406 | $29.9K | 0.00% | +5,406 | New |
| Sterling Capital Management LLC | 5,194 | $28.8K | 0.00% | +3,618+229.6% | Added |
| Citigroup Inc | 5,151 | $28.5K | 0.00% | −29,608−85.2% | Reduced |
| Signaturefd, LLC | 5,000 | $27.7K | 0.00% | +4,000+400.0% | Added |
| National Bank of Canada | 4,500 | $24.9K | 0.00% | −94,307−95.4% | Reduced |
| Tower Research Capital LLC (TRC) | 3,892 | $21.6K | 0.00% | −8,354−68.2% | Reduced |
| GF Fund Management Co. Ltd. | 3,762 | $20.8K | 0.00% | +404+12.0% | Added |
| California State Teachers Retirement System | 3,654 | $20.2K | 0.00% | +3,654 | New |
| Financial Connections Group, Inc. | 3,712 | $20.0K | 0.01% | +3,712 | New |
| Royal Bank of Canada | 1,843 | $11.0K | 0.00% | −3,302−64.2% | Reduced |
| Amalgamated Bank | 1,957 | $11.0K | 0.00% | 00.0% | Unchanged |
| EverSource Wealth Advisors, LLC | 1,762 | $9.76K | 0.00% | +400+29.4% | Added |
| FSA Wealth Management LLC | 1,500 | $8.31K | 0.00% | +1,500 | New |
| Rockefeller Capital Management L.P. | 1,139 | $6.31K | 0.00% | +1,139 | New |
| Allworth Financial LP | 1,006 | $5.57K | 0.00% | +1,006 | New |
| SBI Securities Co., Ltd. | 1,000 | $5.54K | 0.00% | +273+37.6% | Added |
| GWM Advisors LLC | 1,000 | $5.54K | 0.00% | +1,000 | New |
| Corsicana & Co. | 1,000 | $5.54K | 0.00% | +1,000 | New |
| Leonteq Securities AG | 915 | $5.07K | 0.00% | 00.0% | Unchanged |
| Optiver Holding B.V. | 898 | $4.97K | 0.00% | +898 | New |
| Scarborough Advisors, LLC | 505 | $2.80K | 0.00% | +505 | New |
| Fairman Group, LLC | 500 | $2.77K | 0.00% | 00.0% | Unchanged |
| Daiwa Securities Group Inc. | 398 | $2.00K | 0.00% | 00.0% | Unchanged |
| Rothschild Investment LLC | 345 | $1.91K | 0.00% | 00.0% | Unchanged |
| The PNC Financial Services Group, Inc. | 319 | $1.77K | 0.00% | 00.0% | Unchanged |
| Fortitude Family Office, LLC | 296 | $1.64K | 0.00% | 00.0% | Unchanged |
| Parkside Financial Bank & Trust | 285 | $1.58K | 0.00% | 00.0% | Unchanged |
| MAI Capital Management | 274 | $1.52K | 0.00% | −341−55.4% | Reduced |
| Essential Partners LLC | 210 | $1.16K | 0.00% | 00.0% | Unchanged |
| Principal Securities, Inc. | 200 | $1.11K | 0.00% | −80−28.6% | Reduced |
| True Wealth Design, LLC | 115 | $638 | 0.00% | 00.0% | Unchanged |
| Sunbelt Securities, Inc. | 80 | $443 | 0.00% | +80 | New |
| Farther Finance Advisors, LLC | 71 | $393 | 0.00% | +45+173.1% | Added |
| IFP Advisors, Inc | 9 | $50 | 0.00% | +1+12.5% | Added |
| Larson Financial Group LLC | 6 | $33 | 0.00% | −194−97.0% | Reduced |
| Covestor Ltd | 31 | $0 | 0.00% | 00.0% | Unchanged |
| Jaffetilchin Investment Partners, LLC | 0 | $0 | 0.00% | −37,744−100.0% | Sold out |
| SG Americas Securities, LLC | 0 | $0 | 0.00% | −27,919−100.0% | Sold out |
| CIBC World Markets Inc. | 0 | $0 | 0.00% | −14,326−100.0% | Sold out |
| R Squared Ltd | 0 | $0 | 0.00% | −12,519−100.0% | Sold out |
| State Board of Administration of Florida Retirement System | 0 | $0 | 0.00% | −11,420−100.0% | Sold out |
| Eqis Capital Management, Inc. | 0 | $0 | 0.00% | −10,432−100.0% | Sold out |
| Fogel Capital Management, Inc. | 0 | $0 | 0.00% | −10,000−100.0% | Sold out |