Prime Medicine, Inc.
PRME- Exchange
- Nasdaq
- Industry
- Biological Products, (No Diagnostic Substances)
- SEC CIK
- 0001894562
No open-market purchases or sales by Prime Medicine, Inc. insiders were filed in the last 90 days; 187 institutions reported holding it in 13F filings for Q2 2026, worth $393.5M in total; ARK Invest is the only superinvestor holding it.
13F holders, Q3 2025
Institutional positions in Prime Medicine, Inc. as of Sep 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 167
- +46 vs. Q2 2025
- Shares held
- 92.3M
- +33.7M (+57.4%) vs. Q2 2025
- Total value
- $511.5M
- +$366.5M (+252.7%) vs. Q2 2025
- New holders
- 53
- 63 more added
- Sold out
- 7
- 31 more reduced
Compare with Q2 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting PRME on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 187 | $393.5M |
| Q1 2026 | 192 | $342.6M |
| Q4 2025 | 183 | $336.5M |
| Q3 2025 | 167 | $511.5M |
| Q2 2025 | 121 | $145.0M |
| Q1 2025 | 125 | $120.4M |
| Q4 2024 | 132 | $188.0M |
| Q3 2024 | 116 | $265.9M |
| Q2 2024 | 122 | $354.0M |
| Q1 2024 | 115 | $466.6M |
| Q4 2023 | 105 | $431.4M |
| Q3 2023 | 83 | $472.3M |
| Q2 2023 | 79 | $675.7M |
| Q1 2023 | 76 | $512.1M |
| Q4 2022 | 66 | $767.8M |
| Q3 2022 | 0 | $0 |
| Q2 2022 | 0 | $0 |
| Q1 2022 | 0 | $0 |
| Q4 2021 | 0 | $0 |
| Q3 2021 | 0 | $0 |
| Q2 2021 | 0 | $0 |
| Q1 2021 | 0 | $0 |
Institutions, Q3 2025
Shares, value and share of portfolio for each institution holding Prime Medicine, Inc.; share changes are against Q2 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Covestor Ltd | 31 | $0 | 0.00% | 00.0% | Unchanged |
| Larson Financial Group LLC | 6 | $33 | 0.00% | −194−97.0% | Reduced |
| IFP Advisors, Inc | 9 | $50 | 0.00% | +1+12.5% | Added |
| Farther Finance Advisors, LLC | 71 | $393 | 0.00% | +45+173.1% | Added |
| Sunbelt Securities, Inc. | 80 | $443 | 0.00% | +80 | New |
| True Wealth Design, LLC | 115 | $638 | 0.00% | 00.0% | Unchanged |
| Principal Securities, Inc. | 200 | $1.11K | 0.00% | −80−28.6% | Reduced |
| Essential Partners LLC | 210 | $1.16K | 0.00% | 00.0% | Unchanged |
| MAI Capital Management | 274 | $1.52K | 0.00% | −341−55.4% | Reduced |
| Parkside Financial Bank & Trust | 285 | $1.58K | 0.00% | 00.0% | Unchanged |
| Fortitude Family Office, LLC | 296 | $1.64K | 0.00% | 00.0% | Unchanged |
| The PNC Financial Services Group, Inc. | 319 | $1.77K | 0.00% | 00.0% | Unchanged |
| Rothschild Investment LLC | 345 | $1.91K | 0.00% | 00.0% | Unchanged |
| Daiwa Securities Group Inc. | 398 | $2.00K | 0.00% | 00.0% | Unchanged |
| Fairman Group, LLC | 500 | $2.77K | 0.00% | 00.0% | Unchanged |
| Scarborough Advisors, LLC | 505 | $2.80K | 0.00% | +505 | New |
| Optiver Holding B.V. | 898 | $4.97K | 0.00% | +898 | New |
| Leonteq Securities AG | 915 | $5.07K | 0.00% | 00.0% | Unchanged |
| SBI Securities Co., Ltd. | 1,000 | $5.54K | 0.00% | +273+37.6% | Added |
| GWM Advisors LLC | 1,000 | $5.54K | 0.00% | +1,000 | New |
| Corsicana & Co. | 1,000 | $5.54K | 0.00% | +1,000 | New |
| Allworth Financial LP | 1,006 | $5.57K | 0.00% | +1,006 | New |
| Rockefeller Capital Management L.P. | 1,139 | $6.31K | 0.00% | +1,139 | New |
| FSA Wealth Management LLC | 1,500 | $8.31K | 0.00% | +1,500 | New |
| EverSource Wealth Advisors, LLC | 1,762 | $9.76K | 0.00% | +400+29.4% | Added |
| Royal Bank of Canada | 1,843 | $11.0K | 0.00% | −3,302−64.2% | Reduced |
| Amalgamated Bank | 1,957 | $11.0K | 0.00% | 00.0% | Unchanged |
| Financial Connections Group, Inc. | 3,712 | $20.0K | 0.01% | +3,712 | New |
| California State Teachers Retirement System | 3,654 | $20.2K | 0.00% | +3,654 | New |
| GF Fund Management Co. Ltd. | 3,762 | $20.8K | 0.00% | +404+12.0% | Added |
| Tower Research Capital LLC (TRC) | 3,892 | $21.6K | 0.00% | −8,354−68.2% | Reduced |
| National Bank of Canada | 4,500 | $24.9K | 0.00% | −94,307−95.4% | Reduced |
| Signaturefd, LLC | 5,000 | $27.7K | 0.00% | +4,000+400.0% | Added |
| Citigroup Inc | 5,151 | $28.5K | 0.00% | −29,608−85.2% | Reduced |
| Sterling Capital Management LLC | 5,194 | $28.8K | 0.00% | +3,618+229.6% | Added |
| SRS Capital Advisors, Inc. | 5,406 | $29.9K | 0.00% | +5,406 | New |
| Ameritas Investment Partners, Inc. | 5,901 | $32.7K | 0.00% | +2,000+51.3% | Added |
| Advisor Group Holdings, Inc. | 6,950 | $37.4K | 0.00% | +6,822+5,329.7% | Added |
| Legal & General Group Plc | 6,751 | $37.4K | 0.00% | +1,852+37.8% | Added |
| Mirae Asset Global Investments Co., Ltd. | 6,760 | $37.5K | 0.00% | +1,688+33.3% | Added |
| Russell Investments Group, Ltd. | 6,827 | $37.8K | 0.00% | +6,345+1,316.4% | Added |
| NBC Securities, Inc. | 7,500 | $41.5K | 0.00% | +7,500 | New |
| New York State Common Retirement Fund | 8,434 | $46.7K | 0.00% | 00.0% | Unchanged |
| Jones Financial Companies LLLP | 9,575 | $49.0K | 0.00% | +9,575 | New |
| Sterling Investment Advisors, Ltd. | 10,000 | $55.4K | 0.01% | +10,000 | New |
| Quadrature Capital Ltd | 10,182 | $56.3K | 0.00% | +10,182 | New |
| Victory Capital Management Inc | 10,190 | $56.5K | 0.00% | +10,190 | New |
| Virtu Financial LLC | 11,830 | $66.0K | 0.00% | −715−5.7% | Reduced |
| Wiley Bros.-Aintree Capital, LLC | 11,848 | $70.6K | 0.00% | +11,848 | New |
| Voya Investment Management LLC | 12,849 | $71.2K | 0.00% | −4,373−25.4% | Reduced |
| Hudson Bay Capital Management LP | 13,025 | $72.2K | 0.00% | +13,025 | New |
| JTC Employer Solutions Trusteee Ltd | 13,249 | $73.0K | 0.01% | 00.0% | Unchanged |
| Sanctuary Advisors, LLC | 14,323 | $79.3K | 0.00% | +14,323 | New |
| Prime Capital Investment Advisors, LLC | 14,379 | $79.7K | 0.00% | −1,652−10.3% | Reduced |
| Levin Capital Strategies, L.P. | 15,000 | $83.1K | 0.01% | −125,000−89.3% | Reduced |
| Federation des caisses Desjardins du Quebec | 15,900 | $88.1K | 0.00% | −5,300−25.0% | Reduced |
| Clarius Group, LLC | 16,080 | $89.1K | 0.01% | 00.0% | Unchanged |
| Shelton Wealth Management, LLC | 17,332 | $96.0K | 0.04% | +17,332 | New |
| Mariner, LLC | 18,219 | $100.9K | 0.00% | +18,219 | New |
| Owen LaRue, LLC | 19,032 | $105.4K | 0.04% | +19,032 | New |
| ProShare Advisors LLC | 19,099 | $105.8K | 0.00% | +2,228+13.2% | Added |
| BNP Paribas Arbitrage, SA | 19,656 | $108.9K | 0.00% | −7,079−26.5% | Reduced |
| Polymer Capital Management (US) LLC | 20,791 | $115.2K | 0.02% | +20,791 | New |
| Police & Firemen's Retirement System of New Jersey | 21,166 | $117.3K | 0.00% | +4,074+23.8% | Added |
| Prelude Capital Management, LLC | 22,483 | $124.6K | 0.01% | −18,805−45.5% | Reduced |
| Creative Planning | 23,082 | $127.9K | 0.00% | +12,937+127.5% | Added |
| Intech Investment Management LLC | 23,228 | $128.7K | 0.00% | −7,582−24.6% | Reduced |
| JustInvest LLC | 23,984 | $132.9K | 0.00% | +793+3.4% | Added |
| Kingsview Wealth Management, LLC | 24,750 | $137.1K | 0.00% | −250−1.0% | Reduced |
| Nomura Holdings Inc | 24,915 | $138.0K | 0.00% | +24,915 | New |
| Turtle Creek Wealth Advisors, LLC | 25,000 | $138.5K | 0.01% | +25,000 | New |
| Abacus Planning Group, Inc. | 25,188 | $139.5K | 0.02% | +25,188 | New |
| CWM, LLC | 25,352 | $140.0K | 0.00% | −10,409−29.1% | Reduced |
| Bank of Nova Scotia | 25,500 | $141.3K | 0.00% | +25,500 | New |
| Manufacturers Life Insurance Company, The | 27,132 | $150.3K | 0.00% | +6,153+29.3% | Added |
| Thompson Davis & Co., Inc. | 27,573 | $152.8K | 0.09% | +27,573 | New |
| Wealth Enhancement Advisory Services, LLC | 26,778 | $157.2K | 0.00% | +771+3.0% | Added |
| China Universal Asset Management Co., Ltd. | 30,650 | $169.8K | 0.01% | +4,280+16.2% | Added |
| LPL Financial LLC | 31,039 | $172.0K | 0.00% | +31,039 | New |
| Crestwood Advisors Group LLC | 31,687 | $175.5K | 0.00% | 00.0% | Unchanged |
| Raymond James Financial Inc | 31,807 | $176.2K | 0.00% | +30,243+1,933.7% | Added |
| ExodusPoint Capital Management, LP | 33,494 | $185.6K | 0.00% | +33,494 | New |
| PEAK6 LLC | 35,063 | $194.2K | 0.00% | +35,063 | New |
| Ieq Capital, LLC | 36,667 | $203.1K | 0.00% | +837+2.3% | Added |
| CI Private Wealth, LLC | 38,777 | $214.8K | 0.00% | +38,777 | New |
| Squarepoint Ops LLC | 39,601 | $219.4K | 0.00% | +3,775+10.5% | Added |
| IvyRock Asset Management (HK) Ltd | 41,800 | $231.6K | 0.10% | +41,800 | New |
| MetLife Investment Management | 42,997 | $238.2K | 0.00% | +3,983+10.2% | Added |
| JPMorgan Chase & Co | 43,389 | $240.4K | 0.00% | +10,354+31.3% | Added |
| Mutual Advisors, LLC | 45,200 | $243.2K | 0.01% | 00.0% | Unchanged |
| Axq Capital, LP | 44,818 | $248.3K | 0.10% | +7,231+19.2% | Added |
| Jain Global LLC | 44,849 | $248.5K | 0.00% | +44,849 | New |
| Balyasny Asset Management LLC | 47,873 | $265.2K | 0.00% | +47,873 | New |
| XTX Topco Ltd | 48,225 | $267.2K | 0.01% | −85,265−63.9% | Reduced |
| Boothbay Fund Management, LLC | 55,050 | $305.0K | 0.01% | +55,050 | New |
| Engineers Gate Manager LP | 55,597 | $308.0K | 0.00% | +55,597 | New |
| Nisa Investment Advisors, LLC | 60,446 | $334.9K | 0.00% | +56,210+1,327.0% | Added |
| Ameriprise Financial Inc | 61,572 | $341.1K | 0.00% | +61,572 | New |
| Brevan Howard Capital Management LP | 62,242 | $344.8K | 0.00% | +62,242 | New |
| Tudor Investment Corp Et Al | 62,981 | $348.9K | 0.00% | +62,981 | New |