Prime Medicine, Inc.
PRME- Exchange
- Nasdaq
- Industry
- Biological Products, (No Diagnostic Substances)
- SEC CIK
- 0001894562
No open-market purchases or sales by Prime Medicine, Inc. insiders were filed in the last 90 days; 187 institutions reported holding it in 13F filings for Q2 2026, worth $393.5M in total; ARK Invest is the only superinvestor holding it.
13F holders, Q4 2025
Institutional positions in Prime Medicine, Inc. as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 183
- +18 vs. Q3 2025
- Shares held
- 97.0M
- +6.43M (+7.1%) vs. Q3 2025
- Total value
- $336.5M
- −$165.1M (−32.9%) vs. Q3 2025
- New holders
- 44
- 66 more added
- Sold out
- 26
- 40 more reduced
2 institutions that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting PRME on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 187 | $393.5M |
| Q1 2026 | 192 | $342.6M |
| Q4 2025 | 183 | $336.5M |
| Q3 2025 | 167 | $511.5M |
| Q2 2025 | 121 | $145.0M |
| Q1 2025 | 125 | $120.4M |
| Q4 2024 | 132 | $188.0M |
| Q3 2024 | 116 | $265.9M |
| Q2 2024 | 122 | $354.0M |
| Q1 2024 | 115 | $466.6M |
| Q4 2023 | 105 | $431.4M |
| Q3 2023 | 83 | $472.3M |
| Q2 2023 | 79 | $675.7M |
| Q1 2023 | 76 | $512.1M |
| Q4 2022 | 66 | $767.8M |
| Q3 2022 | 0 | $0 |
| Q2 2022 | 0 | $0 |
| Q1 2022 | 0 | $0 |
| Q4 2021 | 0 | $0 |
| Q3 2021 | 0 | $0 |
| Q2 2021 | 0 | $0 |
| Q1 2021 | 0 | $0 |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Prime Medicine, Inc.; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Covestor Ltd | 31 | $0 | 0.00% | 00.0% | Unchanged |
| IFP Advisors, Inc | 10 | $35 | 0.00% | +1+11.1% | Added |
| Farther Finance Advisors, LLC | 71 | $246 | 0.00% | 00.0% | Unchanged |
| Sunbelt Securities, Inc. | 80 | $278 | 0.00% | 00.0% | Unchanged |
| GAMMA Investing LLC | 111 | $385 | 0.00% | +111 | New |
| True Wealth Design, LLC | 115 | $400 | 0.00% | 00.0% | Unchanged |
| Global Retirement Partners, LLC | 146 | $507 | 0.00% | +146 | New |
| Optiver Holding B.V. | 160 | $555 | 0.00% | −738−82.2% | Reduced |
| Essential Partners LLC | 221 | $767 | 0.00% | +11+5.2% | Added |
| CIBC Private Wealth Group, LLC | 267 | $926 | 0.00% | +267 | New |
| MAI Capital Management | 274 | $951 | 0.00% | 00.0% | Unchanged |
| Parkside Financial Bank & Trust | 285 | $989 | 0.00% | 00.0% | Unchanged |
| Basecamp Wealth Advisors LLC | 287 | $996 | 0.00% | +287 | New |
| Daiwa Securities Group Inc. | 398 | $1.00K | 0.00% | 00.0% | Unchanged |
| Fortitude Family Office, LLC | 296 | $1.03K | 0.00% | 00.0% | Unchanged |
| SBI Securities Co., Ltd. | 303 | $1.05K | 0.00% | −697−69.7% | Reduced |
| The PNC Financial Services Group, Inc. | 319 | $1.11K | 0.00% | 00.0% | Unchanged |
| Rothschild Investment LLC | 345 | $1.20K | 0.00% | 00.0% | Unchanged |
| Fairman Group, LLC | 500 | $1.74K | 0.00% | 00.0% | Unchanged |
| Tower Research Capital LLC (TRC) | 807 | $2.80K | 0.00% | −3,085−79.3% | Reduced |
| Leonteq Securities AG | 915 | $3.17K | 0.00% | 00.0% | Unchanged |
| GWM Advisors LLC | 1,000 | $3.47K | 0.00% | 00.0% | Unchanged |
| Corsicana & Co. | 1,000 | $3.47K | 0.00% | 00.0% | Unchanged |
| Scarborough Advisors, LLC | 1,257 | $4.36K | 0.00% | +752+148.9% | Added |
| EverSource Wealth Advisors, LLC | 1,762 | $6.11K | 0.00% | 00.0% | Unchanged |
| MTM Investment Management, LLC | 3,090 | $10.7K | 0.00% | +3,090 | New |
| Allworth Financial LP | 3,115 | $10.8K | 0.00% | +2,109+209.6% | Added |
| Amalgamated Bank | 3,126 | $11.0K | 0.00% | +1,169+59.7% | Added |
| Financial Connections Group, Inc. | 3,712 | $12.0K | 0.00% | 00.0% | Unchanged |
| GF Fund Management Co. Ltd. | 3,547 | $12.3K | 0.00% | −215−5.7% | Reduced |
| Nisa Investment Advisors, LLC | 4,546 | $15.8K | 0.00% | −55,900−92.5% | Reduced |
| Royal Bank of Canada | 4,889 | $17.0K | 0.00% | +3,046+165.3% | Added |
| NBC Securities, Inc. | 5,000 | $17.4K | 0.00% | −2,500−33.3% | Reduced |
| Signaturefd, LLC | 5,000 | $17.4K | 0.00% | 00.0% | Unchanged |
| Sterling Capital Management LLC | 5,736 | $19.9K | 0.00% | +542+10.4% | Added |
| Ameritas Investment Partners, Inc. | 5,901 | $20.5K | 0.00% | 00.0% | Unchanged |
| Russell Investments Group, Ltd. | 6,827 | $23.7K | 0.00% | 00.0% | Unchanged |
| Advisor Group Holdings, Inc. | 8,428 | $29.2K | 0.00% | +1,478+21.3% | Added |
| New York State Common Retirement Fund | 8,434 | $29.3K | 0.00% | 00.0% | Unchanged |
| Mirae Asset Global Investments Co., Ltd. | 8,772 | $30.4K | 0.00% | +2,012+29.8% | Added |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 8,814 | $30.6K | 0.00% | +8,814 | New |
| BNP Paribas Arbitrage, SA | 9,823 | $34.1K | 0.00% | −9,833−50.0% | Reduced |
| Forum Financial Management, LP | 10,000 | $34.7K | 0.00% | +10,000 | New |
| Glen Eagle Advisors, LLC | 10,000 | $34.7K | 0.00% | +10,000 | New |
| Prelude Capital Management, LLC | 10,200 | $35.4K | 0.00% | −12,283−54.6% | Reduced |
| Rhodes Investment Advisors Inc | 10,750 | $37.3K | 0.03% | +10,750 | New |
| Victory Capital Management Inc | 10,801 | $37.5K | 0.00% | +611+6.0% | Added |
| Lazard Asset Management LLC | 10,844 | $37.6K | 0.00% | +10,844 | New |
| Neuberger Berman Group LLC | 10,915 | $37.9K | 0.00% | +10,915 | New |
| Callan Family Office, LLC | 11,292 | $39.2K | 0.00% | +11,292 | New |
| Integrity Advisory Solutions, LLC | 11,689 | $40.6K | 0.01% | +11,689 | New |
| Federation des caisses Desjardins du Quebec | 12,000 | $41.6K | 0.00% | −3,900−24.5% | Reduced |
| Teacher Retirement System of Texas | 12,235 | $42.5K | 0.00% | +12,235 | New |
| Oppenheimer & Co Inc | 12,433 | $43.1K | 0.00% | +12,433 | New |
| JTC Employer Solutions Trusteee Ltd | 13,249 | $46.0K | 0.00% | 00.0% | Unchanged |
| Sterling Investment Advisors, Ltd. | 13,400 | $46.5K | 0.01% | +3,400+34.0% | Added |
| Prime Capital Investment Advisors, LLC | 14,055 | $48.8K | 0.00% | −324−2.3% | Reduced |
| Sanctuary Advisors, LLC | 14,659 | $50.9K | 0.00% | +336+2.3% | Added |
| Martingale Asset Management L P | 14,808 | $51.4K | 0.00% | +14,808 | New |
| Kingsview Wealth Management, LLC | 15,000 | $52.0K | 0.00% | −9,750−39.4% | Reduced |
| Levin Capital Strategies, L.P. | 15,000 | $52.0K | 0.00% | 00.0% | Unchanged |
| Clarius Group, LLC | 16,080 | $55.8K | 0.00% | 00.0% | Unchanged |
| Voya Investment Management LLC | 17,491 | $60.7K | 0.00% | +4,642+36.1% | Added |
| Creative Planning | 17,892 | $62.1K | 0.00% | −5,190−22.5% | Reduced |
| KLP Kapitalforvaltning AS | 18,500 | $64.2K | 0.00% | +18,500 | New |
| Shelton Wealth Management, LLC | 20,066 | $69.6K | 0.03% | +2,734+15.8% | Added |
| Police & Firemen's Retirement System of New Jersey | 21,166 | $73.4K | 0.00% | 00.0% | Unchanged |
| Scientech Research LLC | 22,393 | $77.7K | 0.05% | +22,393 | New |
| Thompson Davis & Co., Inc. | 22,740 | $78.9K | 0.05% | −4,833−17.5% | Reduced |
| Voloridge Investment Management, LLC | 23,121 | $80.2K | 0.00% | −146,900−86.4% | Reduced |
| JustInvest LLC | 23,651 | $82.1K | 0.00% | −333−1.4% | Reduced |
| Arizona State Retirement System | 24,085 | $83.6K | 0.00% | +24,085 | New |
| Nomura Holdings Inc | 24,789 | $86.0K | 0.00% | −126−0.5% | Reduced |
| Abacus Planning Group, Inc. | 25,188 | $87.4K | 0.01% | 00.0% | Unchanged |
| CWM, LLC | 25,427 | $88.0K | 0.00% | +75+0.3% | Added |
| ProShare Advisors LLC | 26,158 | $90.8K | 0.00% | +7,059+37.0% | Added |
| Transcend Wealth Collective, LLC | 26,500 | $92.0K | 0.01% | +26,500 | New |
| Raymond James Financial Inc | 27,044 | $93.8K | 0.00% | −4,763−15.0% | Reduced |
| Wealth Enhancement Advisory Services, LLC | 26,098 | $96.6K | 0.00% | −680−2.5% | Reduced |
| China Universal Asset Management Co., Ltd. | 29,414 | $102.1K | 0.01% | −1,236−4.0% | Reduced |
| SG Americas Securities, LLC | 30,954 | $107.0K | 0.00% | +30,954 | New |
| Manufacturers Life Insurance Company, The | 31,602 | $109.7K | 0.00% | +4,470+16.5% | Added |
| Crestwood Advisors Group LLC | 31,973 | $110.9K | 0.00% | +286+0.9% | Added |
| Envestnet Asset Management Inc | 32,576 | $113.0K | 0.00% | +32,576 | New |
| LPL Financial LLC | 32,924 | $114.2K | 0.00% | +1,885+6.1% | Added |
| Axq Capital, LP | 33,405 | $115.9K | 0.03% | −11,413−25.5% | Reduced |
| Commonwealth Equity Services, LLC | 34,399 | $119.4K | 0.00% | −28,769−45.5% | Reduced |
| Central Trust Co | 34,995 | $121.4K | 0.00% | +34,995 | New |
| Intech Investment Management LLC | 35,036 | $121.6K | 0.00% | +11,808+50.8% | Added |
| Polymer Capital Management (US) LLC | 35,981 | $124.9K | 0.02% | +15,190+73.1% | Added |
| Mariner, LLC | 36,290 | $125.9K | 0.00% | +18,071+99.2% | Added |
| Ieq Capital, LLC | 37,136 | $128.9K | 0.00% | +469+1.3% | Added |
| Gsa Capital Partners LLP | 38,510 | $134.0K | 0.01% | +38,510 | New |
| Caitong International Asset Management Co., Ltd | 38,696 | $134.3K | 0.03% | +38,696 | New |
| CI Private Wealth, LLC | 38,777 | $134.6K | 0.00% | 00.0% | Unchanged |
| Jones Financial Companies LLLP | 40,403 | $140.2K | 0.00% | +30,828+322.0% | Added |
| IvyRock Asset Management (HK) Ltd | 41,800 | $145.0K | 0.08% | 00.0% | Unchanged |
| Elevate Capital Advisors, LLC | 42,666 | $148.1K | 0.10% | +42,666 | New |
| Mutual Advisors, LLC | 45,200 | $156.8K | 0.00% | 00.0% | Unchanged |
| Walleye Capital LLC | 46,139 | $160.1K | 0.00% | +46,139 | New |