Prime Medicine, Inc.
PRME- Exchange
- Nasdaq
- Industry
- Biological Products, (No Diagnostic Substances)
- SEC CIK
- 0001894562
No open-market purchases or sales by Prime Medicine, Inc. insiders were filed in the last 90 days; 187 institutions reported holding it in 13F filings for Q2 2026, worth $393.5M in total; ARK Invest is the only superinvestor holding it.
13F holders, Q4 2025
Institutional positions in Prime Medicine, Inc. as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 183
- +18 vs. Q3 2025
- Shares held
- 97.0M
- +6.43M (+7.1%) vs. Q3 2025
- Total value
- $336.5M
- −$165.1M (−32.9%) vs. Q3 2025
- New holders
- 44
- 66 more added
- Sold out
- 26
- 40 more reduced
2 institutions that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting PRME on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 187 | $393.5M |
| Q1 2026 | 192 | $342.6M |
| Q4 2025 | 183 | $336.5M |
| Q3 2025 | 167 | $511.5M |
| Q2 2025 | 121 | $145.0M |
| Q1 2025 | 125 | $120.4M |
| Q4 2024 | 132 | $188.0M |
| Q3 2024 | 116 | $265.9M |
| Q2 2024 | 122 | $354.0M |
| Q1 2024 | 115 | $466.6M |
| Q4 2023 | 105 | $431.4M |
| Q3 2023 | 83 | $472.3M |
| Q2 2023 | 79 | $675.7M |
| Q1 2023 | 76 | $512.1M |
| Q4 2022 | 66 | $767.8M |
| Q3 2022 | 0 | $0 |
| Q2 2022 | 0 | $0 |
| Q1 2022 | 0 | $0 |
| Q4 2021 | 0 | $0 |
| Q3 2021 | 0 | $0 |
| Q2 2021 | 0 | $0 |
| Q1 2021 | 0 | $0 |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Prime Medicine, Inc.; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Toroso Investments, LLC | 50,244 | $174.3K | 0.00% | +50,244 | New |
| Citigroup Inc | 51,229 | $177.8K | 0.00% | +46,078+894.5% | Added |
| Millennium Management LLC | 51,335 | $178.1K | 0.00% | −1,367,128−96.4% | Reduced |
| Quadrature Capital Ltd | 52,866 | $183.4K | 0.00% | +42,684+419.2% | Added |
| Ameriprise Financial Inc | 54,082 | $187.7K | 0.00% | −7,490−12.2% | Reduced |
| Brevan Howard Capital Management LP | 56,088 | $194.6K | 0.00% | −6,154−9.9% | Reduced |
| Invesco Ltd. | 56,779 | $197.0K | 0.00% | −705,299−92.5% | Reduced |
| MetLife Investment Management | 57,570 | $199.8K | 0.00% | +14,573+33.9% | Added |
| Wiley Bros.-Aintree Capital, LLC | 60,352 | $209.4K | 0.00% | +48,504+409.4% | Added |
| Engineers Gate Manager LP | 60,490 | $209.9K | 0.00% | +4,893+8.8% | Added |
| Janus Henderson Group PLC | 60,900 | $210.4K | 0.00% | +60,900 | New |
| Virtus Investment Advisers, Inc. | 64,886 | $225.2K | 0.06% | +64,886 | New |
| Profund Advisors LLC | 69,605 | $241.5K | 0.01% | +69,605 | New |
| XTX Topco Ltd | 72,935 | $253.1K | 0.01% | +24,710+51.2% | Added |
| Legal & General Group Plc | 80,749 | $280.2K | 0.00% | +73,998+1,096.1% | Added |
| Dimensional Fund Advisors LP | 84,054 | $291.7K | 0.00% | +84,054 | New |
| Palumbo Wealth Management LLC | 85,539 | $296.8K | 0.07% | −6,996−7.6% | Reduced |
| California State Teachers Retirement System | 86,929 | $301.6K | 0.00% | +83,275+2,279.0% | Added |
| TD Asset Management Inc | 94,148 | $326.7K | 0.00% | −86,900−48.0% | Reduced |
| Qube Research & Technologies Ltd | 94,670 | $328.5K | 0.00% | +94,670 | New |
| Virtu Financial LLC | 94,778 | $329.0K | 0.01% | +82,948+701.2% | Added |
| UBS Asset Management Americas Inc | 99,100 | $343.9K | 0.00% | +99,100 | New |
| Group One Trading, L.P. | 103,213 | $358.1K | 0.01% | +103,213 | New |
| Price T Rowe Associates Inc | 104,553 | $363.0K | 0.00% | +30,051+40.3% | Added |
| Rhumbline Advisers | 108,409 | $376.2K | 0.00% | −1,378−1.3% | Reduced |
| Alliancebernstein L.P. | 108,690 | $377.2K | 0.00% | 00.0% | Unchanged |
| Citadel Advisors LLC | 112,870 | $391.7K | 0.00% | −787,272−87.5% | Reduced |
| Graham Capital Management, L.P. | 114,680 | $397.9K | 0.01% | +114,680 | New |
| Mirae Asset Global ETFs Holdings Ltd. | 115,060 | $398.9K | 0.00% | −5,363−4.5% | Reduced |
| FIL Ltd | 115,602 | $401.1K | 0.00% | −727−0.6% | Reduced |
| Steward Partners Investment Advisory, LLC | 118,406 | $410.9K | 0.00% | −7,981−6.3% | Reduced |
| Rockefeller Capital Management L.P. | 121,391 | $421.2K | 0.00% | +120,252+10,557.7% | Added |
| Keystone Financial Group | 129,665 | $449.9K | 0.03% | +58,810+83.0% | Added |
| Bridgeway Capital Management, LLC | 134,800 | $467.8K | 0.01% | −30,000−18.2% | Reduced |
| Deutsche Bank AG | 147,943 | $513.4K | 0.00% | +15,174+11.4% | Added |
| Swiss National Bank | 170,100 | $590.2K | 0.00% | +170,100 | New |
| Jump Financial, LLC | 171,931 | $596.6K | 0.01% | +171,931 | New |
| Davy Global Fund Management Ltd | 178,519 | $619.5K | 0.04% | +57,746+47.8% | Added |
| Rafferty Asset Management, LLC | 187,711 | $651.4K | 0.00% | +187,711 | New |
| Green Alpha Advisors, LLC | 190,883 | $662.4K | 0.61% | +530+0.3% | Added |
| Squarepoint Ops LLC | 218,042 | $756.6K | 0.00% | +178,441+450.6% | Added |
| Dark Forest Capital Management LP | 225,859 | $783.7K | 0.04% | +225,859 | New |
| Chelsea Counsel Co | 227,000 | $787.7K | 0.34% | +18,790+9.0% | Added |
| Bank of New York Mellon Corp | 246,770 | $856.3K | 0.00% | +49,041+24.8% | Added |
| Wellington Management Group LLP | 248,227 | $861.3K | 0.00% | +42,902+20.9% | Added |
| Nuveen, LLC | 251,636 | $873.2K | 0.00% | +25,793+11.4% | Added |
| Verition Fund Management LLC | 290,983 | $1.01M | 0.01% | +290,983 | New |
| Wells Fargo & Company | 294,496 | $1.02M | 0.00% | +97,482+49.5% | Added |
| Bollard Group LLC | 361,136 | $1.25M | 0.03% | 00.0% | Unchanged |
| Barclays PLC | 363,826 | $1.26M | 0.00% | +247,926+213.9% | Added |
| Two Sigma Advisers, LP | 383,500 | $1.33M | 0.00% | +383,500 | New |
| HighTower Advisors, LLC | 400,110 | $1.39M | 0.00% | +66,355+19.9% | Added |
| AQR Capital Management LLC | 415,821 | $1.44M | 0.00% | +1,610+0.4% | Added |
| JPMorgan Chase & Co | 435,710 | $1.51M | 0.00% | +392,321+904.2% | Added |
| Moore Capital Management, LP | 500,000 | $1.74M | 0.04% | 00.0% | Unchanged |
| Point72 Asset Management, L.P. | 551,030 | $1.91M | 0.00% | +551,030 | New |
| Bank of America Corp | 648,012 | $2.25M | 0.00% | +537,170+484.6% | Added |
| HRT Financial LP | 655,351 | $2.27M | 0.01% | +433,887+195.9% | Added |
| Greenwich Wealth Management LLC | 740,001 | $2.57M | 0.11% | +20,000+2.8% | Added |
| Northern Trust Corp | 842,153 | $2.92M | 0.00% | +234,164+38.5% | Added |
| Charles Schwab Investment Management Inc | 936,815 | $3.25M | 0.00% | +363,657+63.4% | Added |
| Renaissance Technologies LLC | 1,149,159 | $3.99M | 0.01% | +14,489+1.3% | Added |
| Morgan Stanley | 1,169,898 | $4.06M | 0.00% | +438,894+60.0% | Added |
| Susquehanna International Group, LLP | 1,176,727 | $4.08M | 0.01% | +592,303+101.3% | Added |
| Farallon Capital Management, L.L.C. | 1,240,843 | $4.31M | 0.02% | −3,509,157−73.9% | Reduced |
| D. E. Shaw & Co., Inc. | 1,551,369 | $5.38M | 0.00% | −664,483−30.0% | Reduced |
| Two Sigma Investments, LP | 1,629,324 | $5.65M | 0.01% | +1,181,657+264.0% | Added |
| Goldman Sachs Group Inc | 1,755,768 | $6.09M | 0.00% | +1,345,032+327.5% | Added |
| MWG Caph Ltd | 1,792,210 | $6.22M | 8.59% | +1,792,210 | New |
| FMR LLC | 2,176,646 | $7.55M | 0.00% | −636,429−22.6% | Reduced |
| UBS Group AG | 2,440,583 | $8.47M | 0.00% | +2,135,810+700.8% | Added |
| Geode Capital Management, LLC | 2,628,429 | $9.12M | 0.00% | +861,533+48.8% | Added |
| Woodline Partners LP | 3,002,844 | $10.4M | 0.04% | +3620.0% | Added |
| Balyasny Asset Management LLC | 3,124,362 | $10.8M | 0.02% | +3,076,489+6,426.4% | Added |
| Casdin Capital, LLC | 3,167,175 | $11.0M | 0.68% | 00.0% | Unchanged |
| Nikko Asset Management Americas, Inc. | 3,245,506 | $11.2M | 0.13% | −384,418−10.6% | Reduced |
| Sumitomo Mitsui Trust Holdings, Inc. | 3,245,506 | $11.3M | 0.01% | −384,418−10.6% | Reduced |
| State Street Corp | 5,095,510 | $17.7M | 0.00% | +3,798,884+293.0% | Added |
| ARK Investment Management LLCSuperinvestorARK Invest | 5,368,526 | $18.6M | 0.12% | −109,325−2.0% | Reduced |
| T. Rowe Price Investment Management, Inc. | 5,995,183 | $20.8M | 0.01% | −3,221,914−35.0% | Reduced |
| Vanguard Group Inc | 6,467,872 | $22.4M | 0.00% | +1,546,007+31.4% | Added |
| BlackRock, Inc. | 8,268,843 | $28.7M | 0.00% | +2,617,984+46.3% | Added |
| Alphabet Inc. | 16,562,498 | $57.5M | 2.23% | 00.0% | Unchanged |
| Ra Capital Management, L.P. | 0 | $0 | 0.00% | −3,000,000−100.0% | Sold out |
| EcoR1 Capital, LLC | 0 | $0 | 0.00% | −1,543,326−100.0% | Sold out |
| Adage Capital Partners GP, L.L.C. | 0 | $0 | 0.00% | −771,361−100.0% | Sold out |
| Schonfeld Strategic Advisors LLC | 0 | $0 | 0.00% | −593,039−100.0% | Sold out |
| Man Group plc | 0 | $0 | 0.00% | −189,588−100.0% | Sold out |
| JBF Capital, Inc. | 0 | $0 | 0.00% | −188,900−100.0% | Sold out |
| DnB Asset Management AS | 0 | $0 | 0.00% | −182,133−100.0% | Sold out |
| Simplex Trading, LLC | 0 | $0 | 0.00% | −157,897−100.0% | Sold out |
| Ikarian Capital, LLC | 0 | $0 | 0.00% | −150,000−100.0% | Sold out |
| Fred Alger Management, LLC | 0 | $0 | 0.00% | −122,654−100.0% | Sold out |
| Redmile Group, LLC | 0 | $0 | 0.00% | −87,118−100.0% | Sold out |
| Jane Street Group, LLC | 0 | $0 | 0.00% | −85,892−100.0% | Sold out |
| Diametric Capital, LP | 0 | $0 | 0.00% | −81,271−100.0% | Sold out |
| Tudor Investment Corp Et Al | 0 | $0 | 0.00% | −62,981−100.0% | Sold out |
| Boothbay Fund Management, LLC | 0 | $0 | 0.00% | −55,050−100.0% | Sold out |
| Jain Global LLC | 0 | $0 | 0.00% | −44,849−100.0% | Sold out |
| PEAK6 LLC | 0 | $0 | 0.00% | −35,063−100.0% | Sold out |