Opko Health, Inc.
OPK- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0000944809
No open-market purchases or sales by Opko Health, Inc. insiders were filed in the last 90 days; 222 institutions reported holding it in 13F filings for Q2 2026, worth $303.4M in total; no superinvestor holds it.
13F holders, Q4 2025
Institutional positions in Opko Health, Inc. as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 221
- −3 vs. Q3 2025
- Shares held
- 199.6M
- +3.58M (+1.8%) vs. Q3 2025
- Total value
- $251.1M
- −$52.0M (−17.2%) vs. Q3 2025
- New holders
- 30
- 43 more added
- Sold out
- 33
- 77 more reduced
9 institutions that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting OPK on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 222 | $303.4M |
| Q1 2026 | 236 | $229.4M |
| Q4 2025 | 221 | $251.1M |
| Q3 2025 | 233 | $303.6M |
| Q2 2025 | 222 | $270.4M |
| Q1 2025 | 255 | $401.4M |
| Q4 2024 | 235 | $290.3M |
| Q3 2024 | 234 | $278.1M |
| Q2 2024 | 232 | $227.7M |
| Q1 2024 | 224 | $190.7M |
| Q4 2023 | 218 | $256.6M |
| Q3 2023 | 225 | $267.6M |
| Q2 2023 | 230 | $375.6M |
| Q1 2023 | 227 | $259.3M |
| Q4 2022 | 221 | $224.8M |
| Q3 2022 | 221 | $349.6M |
| Q2 2022 | 231 | $479.9M |
| Q1 2022 | 229 | $671.0M |
| Q4 2021 | 236 | $914.8M |
| Q3 2021 | 206 | $668.9M |
| Q2 2021 | 234 | $773.3M |
| Q1 2021 | 239 | $817.1M |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Opko Health, Inc.; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Russell Investments Group, Ltd. | 34,690 | $43.7K | 0.00% | 00.0% | Unchanged |
| Warren Averett Asset Management, LLC | 34,727 | $43.8K | 0.00% | +34,727 | New |
| RSM US Wealth Management LLC | 33,757 | $43.9K | 0.00% | 00.0% | Unchanged |
| The PNC Financial Services Group, Inc. | 37,000 | $46.6K | 0.00% | −20,050−35.1% | Reduced |
| HighTower Advisors, LLC | 37,453 | $47.2K | 0.00% | −2,954−7.3% | Reduced |
| Raymond James Financial Inc | 38,744 | $48.8K | 0.00% | −23,461−37.7% | Reduced |
| Caitong International Asset Management Co., Ltd | 39,232 | $49.4K | 0.01% | +35,841+1,056.9% | Added |
| Hollencrest Capital Management | 40,000 | $50.4K | 0.00% | −50,000−55.6% | Reduced |
| Captrust Financial Advisors | 40,120 | $50.6K | 0.00% | −27,906−41.0% | Reduced |
| RK Asset Management, LLC | 40,485 | $51.0K | 0.05% | 00.0% | Unchanged |
| Mariner, LLC | 42,225 | $53.3K | 0.00% | −26,781−38.8% | Reduced |
| Victory Capital Management Inc | 45,025 | $56.7K | 0.00% | +3,721+9.0% | Added |
| Farmers National Bank | 50,300 | $63.4K | 0.01% | 00.0% | Unchanged |
| Verition Fund Management LLC | 50,650 | $63.8K | 0.00% | −28,884−36.3% | Reduced |
| First Manhattan Co | 51,750 | $65.2K | 0.00% | 00.0% | Unchanged |
| Transcend Wealth Collective, LLC | 52,741 | $66.5K | 0.01% | +176+0.3% | Added |
| Teacher Retirement System of Texas | 52,815 | $66.5K | 0.00% | −28,710−35.2% | Reduced |
| SG Americas Securities, LLC | 54,022 | $68.0K | 0.00% | −32,995−37.9% | Reduced |
| Great West Life Assurance Co | 54,068 | $68.0K | 0.00% | 00.0% | Unchanged |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 55,140 | $69.5K | 0.00% | 00.0% | Unchanged |
| Private Advisor Group, LLC | 55,301 | $69.7K | 0.00% | 00.0% | Unchanged |
| Creative Planning | 58,061 | $73.2K | 0.00% | −22,735−28.1% | Reduced |
| Kestra Private Wealth Services, LLC | 58,450 | $73.6K | 0.00% | 00.0% | Unchanged |
| Mercer Global Advisors Inc | 59,026 | $74.4K | 0.00% | −18,860−24.2% | Reduced |
| Cetera Investment Advisers | 59,163 | $74.5K | 0.00% | +112+0.2% | Added |
| Wellington Grp LLC | 60,000 | $75.6K | 0.03% | +60,000 | New |
| Wealth Enhancement Advisory Services, LLC | 57,529 | $75.9K | 0.00% | −18,220−24.1% | Reduced |
| Public Employees Retirement Association of Colorado | 61,502 | $77.0K | 0.00% | 00.0% | Unchanged |
| Pictet Asset Management Holding SA | 65,495 | $82.5K | 0.00% | 00.0% | Unchanged |
| Cascade Financial Partners, LLC | 66,490 | $83.8K | 0.01% | 00.0% | Unchanged |
| Pensionmark Financial Group, LLC | 66,520 | $83.8K | 0.00% | +25,902+63.8% | Added |
| CWM, LLC | 69,147 | $87.0K | 0.00% | −55,627−44.6% | Reduced |
| Advisor Group Holdings, Inc. | 75,315 | $94.9K | 0.00% | −11,460−13.2% | Reduced |
| Brevan Howard Capital Management LP | 85,348 | $107.5K | 0.00% | +85,348 | New |
| 360 Financial, Inc. | 87,300 | $110.0K | 0.03% | −4,000−4.4% | Reduced |
| Headlands Technologies LLC | 88,962 | $112.1K | 0.01% | +43,722+96.6% | Added |
| Cambridge Investment Research Advisors, Inc. | 89,721 | $113.0K | 0.00% | −6,790−7.0% | Reduced |
| BNP Paribas Arbitrage, SA | 90,433 | $113.9K | 0.00% | −27,876−23.6% | Reduced |
| KLP Kapitalforvaltning AS | 90,700 | $114.3K | 0.00% | +16,700+22.6% | Added |
| Quadrature Capital Ltd | 91,702 | $115.5K | 0.00% | +91,702 | New |
| Simplex Trading, LLC | 93,881 | $118.3K | 0.00% | −56,685−37.6% | Reduced |
| Ameriprise Financial Inc | 96,242 | $121.3K | 0.00% | +1,001+1.1% | Added |
| RPg Family Wealth Advisory, LLC | 98,990 | $124.7K | 0.03% | 00.0% | Unchanged |
| Police & Firemen's Retirement System of New Jersey | 102,397 | $129.0K | 0.00% | 00.0% | Unchanged |
| Qube Research & Technologies Ltd | 102,763 | $129.5K | 0.00% | +102,763 | New |
| SIH Partners, LLLP | 104,334 | $131.5K | 0.01% | −45,791−30.5% | Reduced |
| Y-Intercept (Hong Kong) Ltd | 112,930 | $142.3K | 0.00% | +112,930 | New |
| Glenmede Trust Co NA | 113,483 | $143.0K | 0.00% | +113,483 | New |
| Arizona State Retirement System | 113,834 | $143.4K | 0.00% | −14,774−11.5% | Reduced |
| New York State Common Retirement Fund | 114,301 | $144.0K | 0.00% | −16,600−12.7% | Reduced |
| Virtu Financial LLC | 115,298 | $145.0K | 0.01% | +115,298 | New |
| Highline Wealth Partners LLC | 116,681 | $147.0K | 0.04% | 00.0% | Unchanged |
| Graham Capital Management, L.P. | 119,654 | $150.8K | 0.01% | +21,286+21.6% | Added |
| Comerica Bank | 120,000 | $151.2K | 0.00% | +8,000+7.1% | Added |
| Quantbot Technologies LP | 122,747 | $154.7K | 0.01% | +122,747 | New |
| Van Eck Associates Corp | 137,019 | $173.0K | 0.00% | +25,193+22.5% | Added |
| Teton Advisors, LLC | 140,000 | $176.4K | 0.12% | −2,000−1.4% | Reduced |
| Zazove Associates LLC | 150,000 | $189.0K | 0.02% | −57,600−27.7% | Reduced |
| ProShare Advisors LLC | 156,354 | $197.0K | 0.00% | +85,985+122.2% | Added |
| Ieq Capital, LLC | 157,779 | $198.8K | 0.00% | −119,815−43.2% | Reduced |
| Intech Investment Management LLC | 159,652 | $201.2K | 0.00% | +16,329+11.4% | Added |
| Gabelli Funds LLC | 170,000 | $214.2K | 0.00% | 00.0% | Unchanged |
| Gamco Investors, Inc. Et Al | 175,000 | $220.5K | 0.00% | 00.0% | Unchanged |
| MetLife Investment Management | 175,676 | $221.4K | 0.00% | −31,499−15.2% | Reduced |
| State Board of Administration of Florida Retirement System | 176,260 | $222.1K | 0.00% | 00.0% | Unchanged |
| Mirae Asset Global ETFs Holdings Ltd. | 191,104 | $240.8K | 0.00% | −820.0% | Reduced |
| Two Sigma Advisers, LP | 191,201 | $240.9K | 0.00% | −152,896−44.4% | Reduced |
| Mirabella Financial Services LLP | 193,722 | $244.1K | 0.02% | +193,722 | New |
| Balyasny Asset Management LLC | 198,821 | $250.5K | 0.00% | +198,821 | New |
| Janus Henderson Group PLC | 206,314 | $258.9K | 0.00% | 00.0% | Unchanged |
| Manufacturers Life Insurance Company, The | 229,590 | $289.3K | 0.00% | −7,132−3.0% | Reduced |
| Tudor Investment Corp Et Al | 244,821 | $308.5K | 0.00% | 00.0% | Unchanged |
| Royal Bank of Canada | 261,020 | $329.0K | 0.00% | −11,846−4.3% | Reduced |
| Millennium Management LLC | 265,268 | $334.2K | 0.00% | +265,268 | New |
| EntryPoint Capital, LLC | 309,024 | $389.4K | 0.15% | +270,196+695.9% | Added |
| Deutsche Bank AG | 325,889 | $410.6K | 0.00% | +50,701+18.4% | Added |
| XTX Topco Ltd | 342,757 | $431.9K | 0.01% | +342,757 | New |
| Price T Rowe Associates Inc | 367,191 | $463.0K | 0.00% | +23,905+7.0% | Added |
| Two Sigma Securities, LLC | 374,468 | $471.8K | 0.06% | +253,374+209.2% | Added |
| California State Teachers Retirement System | 417,088 | $525.5K | 0.00% | +1,702+0.4% | Added |
| Connor, Clark & Lunn Investment Management Ltd. | 430,630 | $542.6K | 0.00% | +37,869+9.6% | Added |
| Susquehanna International Group, LLP | 437,287 | $551.0K | 0.00% | +139,452+46.8% | Added |
| Alliancebernstein L.P. | 448,190 | $564.7K | 0.00% | −27,000−5.7% | Reduced |
| Legal & General Group Plc | 453,265 | $571.1K | 0.00% | +66,428+17.2% | Added |
| Wells Fargo & Company | 468,518 | $590.3K | 0.00% | +126,032+36.8% | Added |
| Rhumbline Advisers | 511,479 | $644.5K | 0.00% | −43,903−7.9% | Reduced |
| JPMorgan Chase & Co | 579,778 | $730.5K | 0.00% | +52,367+9.9% | Added |
| Bank of America Corp | 618,259 | $779.0K | 0.00% | −695,623−52.9% | Reduced |
| Gsa Capital Partners LLP | 621,328 | $783.0K | 0.07% | +621,328 | New |
| Commonwealth Equity Services, LLC | 641,456 | $808.2K | 0.00% | +49,126+8.3% | Added |
| Assenagon Asset Management S.A. | 652,066 | $834.7K | 0.00% | −38,134−5.5% | Reduced |
| Barclays PLC | 663,236 | $835.7K | 0.00% | +75,483+12.8% | Added |
| UBS Asset Management Americas Inc | 673,565 | $848.7K | 0.00% | 00.0% | Unchanged |
| HRT Financial LP | 675,483 | $851.0K | 0.00% | +675,483 | New |
| Two Sigma Investments, LP | 734,747 | $925.8K | 0.00% | −520,900−41.5% | Reduced |
| Invesco Ltd. | 781,672 | $984.9K | 0.00% | −235,889−23.2% | Reduced |
| Nuveen, LLC | 841,836 | $1.06M | 0.00% | 00.0% | Unchanged |
| Swiss National Bank | 845,755 | $1.07M | 0.00% | 00.0% | Unchanged |
| Tejara Capital Ltd | 877,941 | $1.11M | 0.46% | 00.0% | Unchanged |
| Clearstead Advisors, LLC | 882,367 | $1.11M | 0.01% | +882,367 | New |