Opko Health, Inc.
OPK- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0000944809
No open-market purchases or sales by Opko Health, Inc. insiders were filed in the last 90 days; 222 institutions reported holding it in 13F filings for Q2 2026, worth $303.4M in total; no superinvestor holds it.
13F holders, Q3 2025
Institutional positions in Opko Health, Inc. as of Sep 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 233
- +16 vs. Q2 2025
- Shares held
- 196.3M
- −8.63M (−4.2%) vs. Q2 2025
- Total value
- $303.6M
- +$33.5M (+12.4%) vs. Q2 2025
- New holders
- 30
- 77 more added
- Sold out
- 14
- 53 more reduced
5 institutions that held it in Q2 2025 haven't filed for Q3 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q2 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting OPK on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 222 | $303.4M |
| Q1 2026 | 236 | $229.4M |
| Q4 2025 | 221 | $251.1M |
| Q3 2025 | 233 | $303.6M |
| Q2 2025 | 222 | $270.4M |
| Q1 2025 | 255 | $401.4M |
| Q4 2024 | 235 | $290.3M |
| Q3 2024 | 234 | $278.1M |
| Q2 2024 | 232 | $227.7M |
| Q1 2024 | 224 | $190.7M |
| Q4 2023 | 218 | $256.6M |
| Q3 2023 | 225 | $267.6M |
| Q2 2023 | 230 | $375.6M |
| Q1 2023 | 227 | $259.3M |
| Q4 2022 | 221 | $224.8M |
| Q3 2022 | 221 | $349.6M |
| Q2 2022 | 231 | $479.9M |
| Q1 2022 | 229 | $671.0M |
| Q4 2021 | 236 | $914.8M |
| Q3 2021 | 206 | $668.9M |
| Q2 2021 | 234 | $773.3M |
| Q1 2021 | 239 | $817.1M |
Institutions, Q3 2025
Shares, value and share of portfolio for each institution holding Opko Health, Inc.; share changes are against Q2 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Principal Financial Group Inc | 28,737 | $44.5K | 0.00% | +3,964+16.0% | Added |
| CIBC World Markets Inc. | 29,928 | $46.4K | 0.00% | 00.0% | Unchanged |
| Fisher Asset Management, LLC | 30,000 | $46.5K | 0.00% | −301−1.0% | Reduced |
| IPG Investment Advisors LLC | 30,000 | $46.5K | 0.01% | 00.0% | Unchanged |
| Brinker Capital Investments, LLC | 30,096 | $46.6K | 0.00% | +96+0.3% | Added |
| LPL Financial LLC | 30,935 | $47.9K | 0.00% | +10,699+52.9% | Added |
| Ameritas Investment Partners, Inc. | 31,889 | $49.4K | 0.00% | 00.0% | Unchanged |
| STRS Ohio | 31,900 | $49.4K | 0.00% | 00.0% | Unchanged |
| Norris Perne & French LLP | 32,000 | $49.6K | 0.00% | 00.0% | Unchanged |
| Operose Advisors LLC | 32,000 | $49.6K | 0.01% | 00.0% | Unchanged |
| Xponance, Inc. | 32,170 | $49.9K | 0.00% | +4,221+15.1% | Added |
| Citigroup Inc | 32,748 | $50.8K | 0.00% | −134,363−80.4% | Reduced |
| RSM US Wealth Management LLC | 33,757 | $52.3K | 0.00% | 00.0% | Unchanged |
| Cerity Partners LLC | 34,566 | $53.6K | 0.00% | +34,566 | New |
| Russell Investments Group, Ltd. | 34,690 | $53.8K | 0.00% | +34,070+5,495.2% | Added |
| Kestra Advisory Services, LLC | 38,807 | $60.2K | 0.00% | 00.0% | Unchanged |
| EntryPoint Capital, LLC | 38,828 | $60.2K | 0.02% | +38,828 | New |
| State of Wisconsin Investment Board | 39,097 | $60.6K | 0.00% | +17,904+84.5% | Added |
| HighTower Advisors, LLC | 40,407 | $62.6K | 0.00% | +1,501+3.9% | Added |
| Pensionmark Financial Group, LLC | 40,618 | $63.0K | 0.00% | 00.0% | Unchanged |
| RK Asset Management, LLC | 40,485 | $63.0K | 0.06% | 00.0% | Unchanged |
| Victory Capital Management Inc | 41,304 | $64.0K | 0.00% | −457−1.1% | Reduced |
| Atom Investors LP | 41,872 | $64.9K | 0.00% | −1,410−3.3% | Reduced |
| Squarepoint Ops LLC | 42,519 | $65.9K | 0.00% | −49,915−54.0% | Reduced |
| CIBC Bancorp USA Inc. | 43,868 | $68.0K | 0.00% | +43,868 | New |
| Headlands Technologies LLC | 45,240 | $70.1K | 0.01% | −12,484−21.6% | Reduced |
| Farmers National Bank | 50,300 | $78.0K | 0.02% | 00.0% | Unchanged |
| Great West Life Assurance Co | 54,068 | $79.0K | 0.00% | 00.0% | Unchanged |
| First Manhattan Co | 51,750 | $80.2K | 0.00% | 00.0% | Unchanged |
| Transcend Wealth Collective, LLC | 52,565 | $81.5K | 0.01% | +1,714+3.4% | Added |
| Prudential Financial Inc | 54,772 | $84.9K | 0.00% | +7,930+16.9% | Added |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 55,140 | $85.5K | 0.00% | 00.0% | Unchanged |
| Private Advisor Group, LLC | 55,301 | $85.7K | 0.00% | 00.0% | Unchanged |
| The PNC Financial Services Group, Inc. | 57,050 | $88.4K | 0.00% | +250+0.4% | Added |
| Kestra Private Wealth Services, LLC | 58,450 | $90.6K | 0.00% | 00.0% | Unchanged |
| Cetera Investment Advisers | 59,051 | $91.5K | 0.00% | −1,506−2.5% | Reduced |
| Brighton Jones LLC | 59,426 | $92.1K | 0.00% | +20,510+52.7% | Added |
| Renaissance Technologies LLC | 59,700 | $92.5K | 0.00% | +21,600+56.7% | Added |
| Public Employees Retirement Association of Colorado | 61,502 | $95.0K | 0.00% | 00.0% | Unchanged |
| Raymond James Financial Inc | 62,205 | $96.4K | 0.00% | −3,965−6.0% | Reduced |
| SRS Capital Advisors, Inc. | 63,780 | $98.9K | 0.00% | +63,780 | New |
| Pictet Asset Management Holding SA | 65,495 | $101.5K | 0.00% | 00.0% | Unchanged |
| Cascade Financial Partners, LLC | 66,490 | $103.1K | 0.01% | 00.0% | Unchanged |
| Captrust Financial Advisors | 68,026 | $105.4K | 0.00% | +26,099+62.2% | Added |
| Mariner, LLC | 69,006 | $107.0K | 0.00% | +44,914+186.4% | Added |
| ProShare Advisors LLC | 70,369 | $109.1K | 0.00% | −3,815−5.1% | Reduced |
| Cubist Systematic Strategies, LLC | 72,127 | $111.8K | 0.00% | −61,532−46.0% | Reduced |
| KLP Kapitalforvaltning AS | 74,000 | $114.7K | 0.00% | 00.0% | Unchanged |
| Wealth Enhancement Advisory Services, LLC | 75,749 | $116.7K | 0.00% | +38,755+104.8% | Added |
| Mercer Global Advisors Inc | 77,886 | $120.7K | 0.00% | +38,352+97.0% | Added |
| Verition Fund Management LLC | 79,534 | $123.3K | 0.00% | +28,884+57.0% | Added |
| Advisor Group Holdings, Inc. | 86,775 | $123.6K | 0.00% | −7,701−8.2% | Reduced |
| Creative Planning | 80,796 | $125.2K | 0.00% | +56,304+229.9% | Added |
| Teacher Retirement System of Texas | 81,525 | $126.4K | 0.00% | +30,248+59.0% | Added |
| SG Americas Securities, LLC | 87,017 | $135.0K | 0.00% | −119,358−57.8% | Reduced |
| Hollencrest Capital Management | 90,000 | $139.5K | 0.01% | 00.0% | Unchanged |
| 360 Financial, Inc. | 91,300 | $141.5K | 0.05% | +2,500+2.8% | Added |
| Ameriprise Financial Inc | 95,241 | $147.6K | 0.00% | +481+0.5% | Added |
| Cambridge Investment Research Advisors, Inc. | 96,511 | $150.0K | 0.00% | −6,600−6.4% | Reduced |
| Graham Capital Management, L.P. | 98,368 | $152.5K | 0.01% | −1,812,763−94.9% | Reduced |
| RPg Family Wealth Advisory, LLC | 98,990 | $153.4K | 0.03% | +98,990 | New |
| Phoenix Holdings Ltd. | 100,000 | $155.9K | 0.00% | 00.0% | Unchanged |
| Police & Firemen's Retirement System of New Jersey | 102,397 | $158.7K | 0.00% | +24,948+32.2% | Added |
| Van Eck Associates Corp | 111,826 | $173.0K | 0.00% | −7,215−6.1% | Reduced |
| Comerica Bank | 112,000 | $173.6K | 0.00% | 00.0% | Unchanged |
| Glenmede Investment Management, LP | 113,413 | $175.8K | 0.00% | +663+0.6% | Added |
| Humankind Investments LLC | 114,644 | $177.7K | 0.04% | +5,345+4.9% | Added |
| Highline Wealth Partners LLC | 116,681 | $180.9K | 0.05% | +10.0% | Added |
| Csenge Advisory Group | 117,001 | $181.4K | 0.01% | +10.0% | Added |
| BNP Paribas Arbitrage, SA | 118,309 | $183.4K | 0.00% | −463,362−79.7% | Reduced |
| Two Sigma Securities, LLC | 121,094 | $187.7K | 0.03% | +121,094 | New |
| CWM, LLC | 124,774 | $193.0K | 0.00% | +102,184+452.3% | Added |
| Arizona State Retirement System | 128,608 | $199.3K | 0.00% | +40,414+45.8% | Added |
| New York State Common Retirement Fund | 130,901 | $202.9K | 0.00% | +70,100+115.3% | Added |
| State of Wyoming | 135,954 | $210.7K | 0.02% | +53,947+65.8% | Added |
| Teton Advisors, LLC | 142,000 | $220.1K | 0.14% | +142,000 | New |
| Intech Investment Management LLC | 143,323 | $222.2K | 0.00% | +1,699+1.2% | Added |
| SIH Partners, LLLP | 150,125 | $232.7K | 0.02% | +80,706+116.3% | Added |
| Simplex Trading, LLC | 150,566 | $233.0K | 0.01% | +150,566 | New |
| Gabelli Funds LLC | 170,000 | $263.5K | 0.00% | 00.0% | Unchanged |
| Gamco Investors, Inc. Et Al | 175,000 | $271.3K | 0.00% | 00.0% | Unchanged |
| State Board of Administration of Florida Retirement System | 176,260 | $273.2K | 0.00% | 00.0% | Unchanged |
| Mirae Asset Global ETFs Holdings Ltd. | 191,186 | $296.3K | 0.00% | −6,962−3.5% | Reduced |
| Janus Henderson Group PLC | 206,314 | $318.8K | 0.00% | 00.0% | Unchanged |
| MetLife Investment Management | 207,175 | $321.1K | 0.00% | −11,097−5.1% | Reduced |
| Zazove Associates LLC | 207,600 | $321.8K | 0.03% | 00.0% | Unchanged |
| Manufacturers Life Insurance Company, The | 236,722 | $366.9K | 0.00% | +98,079+70.7% | Added |
| Tudor Investment Corp Et Al | 244,821 | $379.5K | 0.00% | 00.0% | Unchanged |
| Jane Street Group, LLC | 262,838 | $407.4K | 0.00% | −1,121,714−81.0% | Reduced |
| Royal Bank of Canada | 272,866 | $423.0K | 0.00% | +5,418+2.0% | Added |
| Deutsche Bank AG | 275,188 | $426.5K | 0.00% | +36,170+15.1% | Added |
| Ieq Capital, LLC | 277,594 | $430.3K | 0.00% | +168,375+154.2% | Added |
| Citadel Advisors LLC | 279,875 | $433.8K | 0.00% | +62,480+28.7% | Added |
| Susquehanna International Group, LLP | 297,835 | $461.6K | 0.00% | −346,835−53.8% | Reduced |
| Wells Fargo & Company | 342,486 | $530.9K | 0.00% | +71,392+26.3% | Added |
| Price T Rowe Associates Inc | 343,286 | $533.0K | 0.00% | −94,220−21.5% | Reduced |
| Two Sigma Advisers, LP | 344,097 | $533.4K | 0.00% | −304,200−46.9% | Reduced |
| Legal & General Group Plc | 386,837 | $598.2K | 0.00% | +31,155+8.8% | Added |
| Connor, Clark & Lunn Investment Management Ltd. | 392,761 | $608.8K | 0.00% | +1,097+0.3% | Added |
| California State Teachers Retirement System | 415,386 | $643.8K | 0.00% | +91,269+28.2% | Added |