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Lexicon Pharmaceuticals, Inc.

LXRX
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
SEC CIK
0001062822

No open-market purchases or sales by Lexicon Pharmaceuticals, Inc. insiders were filed in the last 90 days; 149 institutions reported holding it in 13F filings for Q2 2026, worth $875.1M in total; no superinvestor holds it.

13F holders, Q3 2021

Institutional positions in Lexicon Pharmaceuticals, Inc. as of Sep 30, 2021. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
96
−11 vs. Q2 2021
Shares held
121.2M
+3.50M (+3.0%) vs. Q2 2021
Total value
$583.0M
+$42.8M (+7.9%) vs. Q2 2021
New holders
8
33 more added
Sold out
19
35 more reduced

Compare with Q2 2021: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting LXRX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ3 2021: 96 institutions
Q1 2021: 107 institutionsQ2 2021: 107 institutionsQ3 2021: 96 institutionsQ4 2021: 110 institutionsQ1 2022: 101 institutionsQ2 2022: 86 institutionsQ3 2022: 98 institutionsQ4 2022: 105 institutionsQ1 2023: 104 institutionsQ2 2023: 123 institutionsQ3 2023: 112 institutionsQ4 2023: 106 institutionsQ1 2024: 118 institutionsQ2 2024: 127 institutionsQ3 2024: 137 institutionsQ4 2024: 127 institutionsQ1 2025: 127 institutionsQ2 2025: 123 institutionsQ3 2025: 124 institutionsQ4 2025: 126 institutionsQ1 2026: 137 institutionsQ2 2026: 149 institutions
Value heldQ3 2021: $583.0M
Q1 2021: $711.5MQ2 2021: $540.2MQ3 2021: $583.0MQ4 2021: $478.9MQ1 2022: $251.3MQ2 2022: $221.0MQ3 2022: $357.3MQ4 2022: $280.5MQ1 2023: $353.8MQ2 2023: $438.2MQ3 2023: $205.8MQ4 2023: $279.8MQ1 2024: $417.8MQ2 2024: $471.0MQ3 2024: $453.1MQ4 2024: $220.1MQ1 2025: $122.5MQ2 2025: $242.9MQ3 2025: $344.4MQ4 2025: $299.5MQ1 2026: $504.5MQ2 2026: $875.1M
Institutions holding LXRX and their total value by quarter
QuarterHoldersValue
Q2 2026149$875.1M
Q1 2026137$504.5M
Q4 2025126$299.5M
Q3 2025124$344.4M
Q2 2025123$242.9M
Q1 2025127$122.5M
Q4 2024127$220.1M
Q3 2024137$453.1M
Q2 2024127$471.0M
Q1 2024118$417.8M
Q4 2023106$279.8M
Q3 2023112$205.8M
Q2 2023123$438.2M
Q1 2023104$353.8M
Q4 2022105$280.5M
Q3 202298$357.3M
Q2 202286$221.0M
Q1 2022101$251.3M
Q4 2021110$478.9M
Q3 202196$583.0M
Q2 2021107$540.2M
Q1 2021107$711.5M

Institutions, Q3 2021

Shares, value and share of portfolio for each institution holding Lexicon Pharmaceuticals, Inc.; share changes are against Q2 2021.

Institutions holding LXRX in Q3 2021
InstitutionSharesValue% of portfolioChange in sharesAction
Northwestern Mutual Wealth Management Co500$2.00K0.00%00.0%Unchanged
Avion Wealth407$2.00K0.00%00.0%Unchanged
First Manhattan Co1,079$5.00K0.00%00.0%Unchanged
Farmers & Merchants Investments Inc1,000$5.00K0.00%+1,000New
O'Shaughnessy Asset Management, LLC1,415$7.00K0.00%−5,132−78.4%Reduced
Meeder Asset Management Inc1,535$7.00K0.00%00.0%Unchanged
Advisor Group Holdings, Inc.1,524$7.00K0.00%+200+15.1%Added
Hall Laurie J Trustee1,650$8.00K0.00%−1,230−42.7%Reduced
Tarbox Family Office, Inc.3,000$14.0K0.00%00.0%Unchanged
Quantbot Technologies LP3,625$17.0K0.00%00.0%Unchanged
Compagnie Lombard Odier SCmA4,000$19.0K0.00%00.0%Unchanged
UBS Group AG3,974$19.0K0.00%+1,983+99.6%Added
Ameritas Investment Partners, Inc.5,367$26.0K0.00%00.0%Unchanged
Royal Bank of Canada6,677$31.0K0.00%+1,492+28.8%Added
Citigroup Inc8,935$43.0K0.00%−2,660−22.9%Reduced
Pegasus Asset Management, Inc.10,000$48.0K0.02%00.0%Unchanged
Amalgamated Bank10,453$50.0K0.00%−415−3.8%Reduced
Klingenstein Fields & Co LP10,618$51.0K0.00%00.0%Unchanged
Squarepoint Ops LLC12,314$59.0K0.00%−438−3.4%Reduced
Wolverine Trading, LLC13,652$67.0K0.00%−25−0.2%Reduced
Commonwealth Equity Services, LLC14,276$68.0K0.00%+107+0.8%Added
Tower Research Capital LLC (TRC)15,000$73.0K0.00%+11,143+288.9%Added
BNP Paribas Arbitrage, SA15,241$73.3K0.00%+12,484+452.8%Added
Arizona State Retirement System15,732$76.0K0.00%+36+0.2%Added
Group One Trading, L.P.16,373$79.0K0.00%−20,210−55.2%Reduced
Legal & General Group Plc17,566$84.0K0.00%+11,412+185.4%Added
Bank of America Corp19,008$91.0K0.00%−14,238−42.8%Reduced
Metropolitan Life Insurance Co19,371$93.2K0.00%+19,371New
Victory Capital Management Inc20,965$101.0K0.00%+10,272+96.1%Added
ExodusPoint Capital Management, LP24,201$116.0K0.00%−7,637−24.0%Reduced
MetLife Investment Management25,604$123.2K0.00%+25,604New
Voya Investment Management LLC26,907$129.0K0.00%00.0%Unchanged
Invesco Ltd.27,753$133.0K0.00%+4,568+19.7%Added
Barclays PLC27,747$134.0K0.00%+14,497+109.4%Added
HighVista Strategies LLC27,978$135.0K0.09%+11,935+74.4%Added
State Board of Administration of Florida Retirement System29,214$141.0K0.00%00.0%Unchanged
Campbell & CO Investment Adviser LLC31,400$151.0K0.05%+31,400New
New York State Common Retirement Fund33,596$162.0K0.00%−24,926−42.6%Reduced
University of Texas/Texas Am Investment Managment Co35,714$172.0K0.10%00.0%Unchanged
American International Group, Inc.37,155$179.0K0.00%−883−2.3%Reduced
Manufacturers Life Insurance Company, The39,070$188.0K0.00%−2,455−5.9%Reduced
Jane Street Group, LLC39,720$191.0K0.00%+24,509+161.1%Added
Deutsche Bank AG40,253$194.0K0.00%−126,028−75.8%Reduced
Virtus ETF Advisers LLC44,378$213.0K0.09%−2,321−5.0%Reduced
Cubist Systematic Strategies, LLC44,604$215.0K0.00%+44,604New
Credit Suisse AG45,008$216.0K0.00%+13,446+42.6%Added
Ergoteles LLC46,300$223.0K0.01%+46,300New
Citadel Advisors LLC46,856$225.0K0.00%+35,223+302.8%Added
Alliancebernstein L.P.50,111$241.0K0.00%−6,000−10.7%Reduced
Simplex Trading, LLC59,274$258.0K0.01%−11,139−15.8%Reduced
SG Americas Securities, LLC59,992$289.0K0.00%−23,961−28.5%Reduced
Salem Investment Counselors Inc73,000$351.0K0.02%00.0%Unchanged
Millennium Management LLC78,037$375.0K0.00%−101,818−56.6%Reduced
Parametric Portfolio Associates LLC78,798$379.0K0.00%−7,048−8.2%Reduced
Vontobel Holding Ltd.80,000$385.0K0.00%00.0%Unchanged
UBS Asset Management Americas Inc83,874$403.4K0.00%+7,499+9.8%Added
California State Teachers Retirement System83,888$404.0K0.00%−9,946−10.6%Reduced
Rhumbline Advisers83,991$404.0K0.00%+2,199+2.7%Added
Goldman Sachs Group Inc89,913$432.0K0.00%+18,925+26.7%Added
Susquehanna Fundamental Investments, LLC94,222$453.0K0.01%+78,422+496.3%Added
Natixis Advisors, L.P.94,537$455.0K0.00%−208−0.2%Reduced
Morgan Stanley99,575$479.0K0.00%−35,186−26.1%Reduced
Tudor Investment Corp Et Al108,541$522.0K0.01%+93,480+620.7%Added
Winton Group Ltd112,120$539.0K0.03%−36,182−24.4%Reduced
Stifel Financial Corp115,914$558.0K0.00%+34,325+42.1%Added
Los Angeles Capital Management LLC119,199$573.0K0.00%+60,950+104.6%Added
DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main126,917$610.5K0.00%+126,917New
Swiss National Bank127,300$612.0K0.00%00.0%Unchanged
Price T Rowe Associates Inc129,568$623.0K0.00%00.0%Unchanged
Susquehanna International Group, LLP131,349$632.0K0.00%+91,773+231.9%Added
State of Wisconsin Investment Board159,200$766.0K0.00%+5,500+3.6%Added
Principal Financial Group Inc193,412$930.0K0.00%−5,870−2.9%Reduced
AQR Capital Management LLC203,359$978.0K0.00%−121,645−37.4%Reduced
Russell Investments Group, Ltd.242,187$1.16M0.00%00.0%Unchanged
Bank of New York Mellon Corp260,990$1.25M0.00%+19,655+8.1%Added
Panagora Asset Management Inc289,154$1.39M0.01%+15,420+5.6%Added
Integral Health Asset Management, LLC350,000$1.68M0.48%+350,000New
Bridgeway Capital Management, LLC380,092$1.83M0.03%−20,000−5.0%Reduced
Charles Schwab Investment Management Inc475,794$2.29M0.00%+6,090+1.3%Added
Dimensional Fund Advisors LP495,438$2.38M0.00%−46,217−8.5%Reduced
Wells Fargo & Company552,963$2.66M0.00%+259,555+88.5%Added
Nuveen Asset Management, LLC583,300$2.83M0.00%−85,183−12.7%Reduced
Nomura Holdings Inc665,746$3.21M0.02%−253,021−27.5%Reduced
Northern Trust Corp688,078$3.31M0.00%−39,918−5.5%Reduced
Eversept Partners, LP872,694$4.20M0.34%+643,405+280.6%Added
State Street Corp1,101,753$5.30M0.00%+64,106+6.2%Added
JPMorgan Chase & Co1,157,703$5.57M0.00%−155,458−11.8%Reduced
Geode Capital Management, LLC1,193,922$5.74M0.00%−86,732−6.8%Reduced
Pinnacle Associates Ltd2,097,647$10.1M0.19%−93,135−4.3%Reduced
NEA Management Company, LLC2,382,286$11.5M0.14%00.0%Unchanged
D. E. Shaw & Co., Inc.3,216,048$15.5M0.02%−186,377−5.5%Reduced
Vanguard Group Inc3,985,180$19.2M0.00%+15,191+0.4%Added
BlackRock Inc.4,650,670$22.4M0.00%+3,811+0.1%Added
FMR LLC6,461,356$31.1M0.00%−975,157−13.1%Reduced
BVF Inc14,360,000$69.1M2.69%+5,966,000+71.1%Added
Artal Group S.A.71,178,364$342.4M8.42%00.0%Unchanged
Boothe Investment Group, Inc.0$00.00%−467,919−100.0%Sold out
Two Sigma Advisers, LP0$00.00%−359,316−100.0%Sold out
Norges Bank0$00.00%−344,600−100.0%Sold out
Two Sigma Investments, LP0$00.00%−292,896−100.0%Sold out