Krystal Biotech, Inc.
KRYS- Exchange
- Nasdaq
- Industry
- Biological Products, (No Diagnostic Substances)
- SEC CIK
- 0001711279
In the last 90 days, Krystal Biotech, Inc. insiders filed 0 open-market purchases and 3 sales; 422 institutions reported holding it in 13F filings for Q2 2026, worth $11.1B in total; no superinvestor holds it.
13F holders, Q4 2025
Institutional positions in Krystal Biotech, Inc. as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 334
- +55 vs. Q3 2025
- Shares held
- 28.4M
- +470.1K (+1.7%) vs. Q3 2025
- Total value
- $7.01B
- +$2.07B (+42.0%) vs. Q3 2025
- New holders
- 82
- 111 more added
- Sold out
- 27
- 105 more reduced
5 institutions that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting KRYS on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 422 | $11.1B |
| Q1 2026 | 368 | $7.32B |
| Q4 2025 | 334 | $7.01B |
| Q3 2025 | 284 | $4.94B |
| Q2 2025 | 275 | $3.80B |
| Q1 2025 | 299 | $4.98B |
| Q4 2024 | 264 | $4.35B |
| Q3 2024 | 283 | $5.15B |
| Q2 2024 | 245 | $5.24B |
| Q1 2024 | 234 | $4.49B |
| Q4 2023 | 194 | $3.03B |
| Q3 2023 | 188 | $2.76B |
| Q2 2023 | 183 | $2.71B |
| Q1 2023 | 160 | $1.68B |
| Q4 2022 | 154 | $1.66B |
| Q3 2022 | 148 | $1.45B |
| Q2 2022 | 137 | $1.36B |
| Q1 2022 | 135 | $1.37B |
| Q4 2021 | 140 | $1.35B |
| Q3 2021 | 113 | $850.7M |
| Q2 2021 | 113 | $1.12B |
| Q1 2021 | 113 | $1.27B |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Krystal Biotech, Inc.; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Transcend Wealth Collective, LLC | 1,680 | $414.2K | 0.03% | 00.0% | Unchanged |
| Los Angeles Capital Management LLC | 2,171 | $410.5K | 0.00% | −4,586−67.9% | Reduced |
| CIBC World Markets Corp | 1,640 | $404.3K | 0.00% | +1,640 | New |
| City Center Advisors, LLC | 1,628 | $401.4K | 0.37% | −74−4.3% | Reduced |
| Sound View Wealth Advisors Group, LLC | 1,579 | $389.3K | 0.03% | −424−21.2% | Reduced |
| Mackenzie Financial Corp | 1,554 | $384.4K | 0.00% | −43−2.7% | Reduced |
| J. Goldman & Co LP | 1,535 | $378.4K | 0.01% | +1,535 | New |
| CWM, LLC | 1,508 | $372.0K | 0.00% | −28−1.8% | Reduced |
| Royal Bank of Canada | 1,501 | $369.0K | 0.00% | +1,103+277.1% | Added |
| Vident Advisory, LLC | 1,494 | $368.3K | 0.00% | +76+5.4% | Added |
| Stratos Wealth Partners, LTD. | 1,459 | $359.7K | 0.00% | +1,459 | New |
| Vise Technologies, Inc. | 1,424 | $351.1K | 0.01% | +1,424 | New |
| Mirae Asset Global Investments Co., Ltd. | 1,409 | $347.4K | 0.00% | +290+25.9% | Added |
| Tudor Investment Corp Et Al | 1,375 | $339.0K | 0.00% | +1,375 | New |
| Ensign Peak Advisors, Inc | 1,369 | $337.5K | 0.00% | −3,050−69.0% | Reduced |
| Cerity Partners LLC | 1,361 | $335.5K | 0.00% | +1,361 | New |
| Roman Butler Fullerton & Co | 1,125 | $325.3K | 0.09% | +1,125 | New |
| Gotham Asset Management, LLC | 1,303 | $321.2K | 0.00% | −4−0.3% | Reduced |
| Argent Trust Co | 1,261 | $310.9K | 0.01% | −46−3.5% | Reduced |
| Covestor Ltd | 1,241 | $306.0K | 0.16% | −537−30.2% | Reduced |
| New Age Alpha Advisors, LLC | 1,220 | $300.8K | 0.01% | +1,220 | New |
| Hohimer Wealth Management, LLC | 1,214 | $299.3K | 0.04% | −1−0.1% | Reduced |
| Mitsubishi UFJ Kokusai Asset Management Co., Ltd. | 1,175 | $290.1K | 0.00% | −623−34.6% | Reduced |
| Captrust Financial Advisors | 1,175 | $289.7K | 0.00% | +1,175 | New |
| LPL Financial LLC | 1,154 | $284.5K | 0.00% | +1,154 | New |
| HighTower Advisors, LLC | 1,112 | $274.2K | 0.00% | +1,112 | New |
| Evergreen Capital Management LLC | 1,086 | $267.7K | 0.01% | +1,086 | New |
| Sequoia Financial Advisors, LLC | 1,083 | $267.0K | 0.00% | +1,083 | New |
| Truist Financial Corp | 1,080 | $266.3K | 0.00% | +1,080 | New |
| Lazard Asset Management LLC | 1,058 | $260.8K | 0.00% | +1,058 | New |
| Oppenheimer Asset Management Inc. | 1,044 | $257.4K | 0.00% | −219−17.3% | Reduced |
| Neuberger Berman Group LLC | 1,033 | $254.7K | 0.00% | +1,033 | New |
| Prelude Capital Management, LLC | 1,032 | $254.4K | 0.02% | +1,032 | New |
| Avanza Fonder AB | 996 | $245.6K | 0.01% | −422−29.8% | Reduced |
| Swiss Life Asset Management Ltd | 991 | $244.3K | 0.00% | +991 | New |
| Ethic Inc. | 963 | $237.4K | 0.00% | +963 | New |
| NLB Skladi, upravljanje premozenja, d.o.o. | 955 | $235.4K | 0.01% | +955 | New |
| Nisa Investment Advisors, LLC | 930 | $229.3K | 0.00% | +4+0.4% | Added |
| Brinker Capital Investments, LLC | 927 | $228.5K | 0.00% | +927 | New |
| Exchange Traded Concepts, LLC | 926 | $228.3K | 0.00% | +430+86.7% | Added |
| Coldstream Capital Management Inc | 923 | $227.6K | 0.00% | +923 | New |
| Net Worth Advisory Group | 923 | $227.6K | 0.05% | +923 | New |
| CIBC Asset Management Inc | 888 | $218.9K | 0.00% | +888 | New |
| Hidden Cove Wealth Management, LLC | 859 | $211.8K | 0.14% | +859 | New |
| Fox Run Management, L.L.C. | 856 | $211.0K | 0.03% | +856 | New |
| Fiduciary Trust Co | 840 | $207.1K | 0.00% | +840 | New |
| Shelton Capital Management | 840 | $207.1K | 0.00% | +840 | New |
| GAMMA Investing LLC | 789 | $194.5K | 0.01% | +292+58.8% | Added |
| Pinnacle Wealth Planning Services, Inc. | 759 | $187.1K | 0.02% | +759 | New |
| KBC Group NV | 685 | $169.0K | 0.00% | 00.0% | Unchanged |
| Smartleaf Asset Management LLC | 610 | $151.2K | 0.01% | +188+44.5% | Added |
| Canada Pension Plan Investment Board | 600 | $147.9K | 0.00% | 00.0% | Unchanged |
| GF Fund Management Co. Ltd. | 569 | $140.3K | 0.00% | −54−8.7% | Reduced |
| Quest Partners LLC | 565 | $139.3K | 0.01% | −99−14.9% | Reduced |
| Eurizon Capital SGR S.p.A. | 553 | $136.9K | 0.00% | +553 | New |
| Horizon Investments, LLC | 412 | $101.6K | 0.00% | +412 | New |
| Bryn Mawr Trust Co | 393 | $96.9K | 0.00% | 00.0% | Unchanged |
| Hantz Financial Services, Inc. | 371 | $91.0K | 0.00% | +79+27.1% | Added |
| US Bancorp | 313 | $77.2K | 0.00% | +3+1.0% | Added |
| Simplex Trading, LLC | 293 | $72.2K | 0.00% | +293 | New |
| Jones Financial Companies LLLP | 290 | $71.5K | 0.00% | +253+683.8% | Added |
| MAI Capital Management | 284 | $70.0K | 0.00% | 00.0% | Unchanged |
| IFP Advisors, Inc | 265 | $65.3K | 0.00% | +189+248.7% | Added |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 262 | $65.0K | 0.00% | +88+50.6% | Added |
| Caldwell Trust Co | 250 | $61.6K | 0.01% | 00.0% | Unchanged |
| SBI Securities Co., Ltd. | 202 | $49.8K | 0.00% | +134+197.1% | Added |
| Danske Bank A/S | 200 | $49.3K | 0.00% | 00.0% | Unchanged |
| Huntington National Bank | 188 | $46.3K | 0.00% | −2−1.1% | Reduced |
| Salomon & Ludwin, LLC | 183 | $44.8K | 0.00% | +1+0.5% | Added |
| AdvisorNet Financial, Inc | 171 | $42.2K | 0.00% | 00.0% | Unchanged |
| Vestor Capital, LLC | 2,940 | $42.0K | 0.00% | +2,940 | New |
| Sterling Capital Management LLC | 162 | $39.9K | 0.00% | +102+170.0% | Added |
| Global Retirement Partners, LLC | 160 | $39.4K | 0.00% | +142+788.9% | Added |
| Sound Income Strategies, LLC | 137 | $39.0K | 0.00% | +127+1,270.0% | Added |
| Quadrant Capital Group LLC | 156 | $38.5K | 0.00% | +20+14.7% | Added |
| Key Financial Inc | 151 | $37.2K | 0.01% | 00.0% | Unchanged |
| Fifth Third Bancorp | 146 | $36.0K | 0.00% | +15+11.5% | Added |
| Umb Bank N A | 144 | $35.5K | 0.00% | +37+34.6% | Added |
| Greenline Wealth Management LLC | 136 | $33.5K | 0.03% | +136 | New |
| Reyes Financial Architecture, Inc. | 100 | $24.7K | 0.02% | 00.0% | Unchanged |
| Basecamp Wealth Advisors LLC | 94 | $23.2K | 0.00% | +94 | New |
| Signaturefd, LLC | 89 | $21.9K | 0.00% | −1−1.1% | Reduced |
| Quantbot Technologies LP | 86 | $21.2K | 0.00% | +86 | New |
| Daiwa Securities Group Inc. | 86 | $21.0K | 0.00% | −5−5.5% | Reduced |
| Massmutual Trust Co FSB | 85 | $21.0K | 0.00% | +13+18.1% | Added |
| Kemnay Advisory Services Inc. | 84 | $20.7K | 0.00% | +84 | New |
| Advisors Asset Management, Inc. | 81 | $20.0K | 0.00% | +81 | New |
| EverSource Wealth Advisors, LLC | 75 | $18.5K | 0.00% | +12+19.0% | Added |
| GWM Advisors LLC | 72 | $17.8K | 0.00% | +38+111.8% | Added |
| Versant Capital Management, Inc | 71 | $17.5K | 0.00% | 00.0% | Unchanged |
| SageView Advisory Group, LLC | 57 | $14.1K | 0.00% | +57 | New |
| Rockefeller Capital Management L.P. | 56 | $13.8K | 0.00% | −49−46.7% | Reduced |
| Private Wealth Management Group, LLC | 55 | $13.6K | 0.00% | 00.0% | Unchanged |
| Federation des caisses Desjardins du Quebec | 50 | $12.3K | 0.00% | 00.0% | Unchanged |
| Bare Financial Services, Inc | 43 | $10.6K | 0.00% | 00.0% | Unchanged |
| Farther Finance Advisors, LLC | 39 | $9.62K | 0.00% | +6+18.2% | Added |
| Acumen Wealth Advisors, LLC | 34 | $8.38K | 0.00% | +34 | New |
| Quent Capital, LLC | 34 | $8.38K | 0.00% | 00.0% | Unchanged |
| Parkside Financial Bank & Trust | 33 | $8.14K | 0.00% | +8+32.0% | Added |
| Harbour Investments, Inc. | 33 | $8.14K | 0.00% | +33 | New |