Krystal Biotech, Inc.
KRYS- Exchange
- Nasdaq
- Industry
- Biological Products, (No Diagnostic Substances)
- SEC CIK
- 0001711279
In the last 90 days, Krystal Biotech, Inc. insiders filed 0 open-market purchases and 3 sales; 422 institutions reported holding it in 13F filings for Q2 2026, worth $11.1B in total; no superinvestor holds it.
13F holders, Q4 2025
Institutional positions in Krystal Biotech, Inc. as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 334
- +55 vs. Q3 2025
- Shares held
- 28.4M
- +470.1K (+1.7%) vs. Q3 2025
- Total value
- $7.01B
- +$2.07B (+42.0%) vs. Q3 2025
- New holders
- 82
- 111 more added
- Sold out
- 27
- 105 more reduced
5 institutions that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting KRYS on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 422 | $11.1B |
| Q1 2026 | 368 | $7.32B |
| Q4 2025 | 334 | $7.01B |
| Q3 2025 | 284 | $4.94B |
| Q2 2025 | 275 | $3.80B |
| Q1 2025 | 299 | $4.98B |
| Q4 2024 | 264 | $4.35B |
| Q3 2024 | 283 | $5.15B |
| Q2 2024 | 245 | $5.24B |
| Q1 2024 | 234 | $4.49B |
| Q4 2023 | 194 | $3.03B |
| Q3 2023 | 188 | $2.76B |
| Q2 2023 | 183 | $2.71B |
| Q1 2023 | 160 | $1.68B |
| Q4 2022 | 154 | $1.66B |
| Q3 2022 | 148 | $1.45B |
| Q2 2022 | 137 | $1.36B |
| Q1 2022 | 135 | $1.37B |
| Q4 2021 | 140 | $1.35B |
| Q3 2021 | 113 | $850.7M |
| Q2 2021 | 113 | $1.12B |
| Q1 2021 | 113 | $1.27B |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Krystal Biotech, Inc.; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| FMR LLC | 4,349,628 | $1.07B | 0.05% | +8,181+0.2% | Added |
| BlackRock, Inc. | 3,937,817 | $970.8M | 0.02% | +103,689+2.7% | Added |
| Avoro Capital Advisors LLC | 2,888,888 | $712.2M | 7.00% | +111,111+4.0% | Added |
| Vanguard Group Inc | 2,778,845 | $685.1M | 0.01% | −13,363−0.5% | Reduced |
| State Street Corp | 1,342,303 | $330.9M | 0.01% | −53,664−3.8% | Reduced |
| Soleus Capital Management, L.P. | 941,059 | $232.0M | 9.84% | −77,772−7.6% | Reduced |
| Capital World Investors | 809,500 | $199.6M | 0.03% | +2600.0% | Added |
| Redmile Group, LLC | 677,705 | $167.1M | 12.30% | +16,317+2.5% | Added |
| Hood River Capital Management LLC | 613,302 | $151.2M | 1.66% | +6,356+1.0% | Added |
| Geode Capital Management, LLC | 611,878 | $150.9M | 0.01% | +634+0.1% | Added |
| Price T Rowe Associates Inc | 529,955 | $130.7M | 0.01% | +62,897+13.5% | Added |
| Dimensional Fund Advisors LP | 492,968 | $121.5M | 0.03% | −40,996−7.7% | Reduced |
| Frazier Life Sciences Management, L.P. | 488,460 | $120.4M | 3.23% | −200,000−29.1% | Reduced |
| Bellevue Group AG | 410,323 | $101.2M | 1.92% | +409,011+31,174.6% | Added |
| Citadel Advisors LLC | 386,505 | $95.3M | 0.06% | −250,483−39.3% | Reduced |
| William Blair Investment Management, LLC | 376,340 | $92.8M | 0.26% | +227,038+152.1% | Added |
| Goldman Sachs Group Inc | 293,525 | $72.4M | 0.01% | −54,725−15.7% | Reduced |
| Norges Bank | 284,573 | $70.2M | 0.01% | +284,573 | New |
| Northern Trust Corp | 247,443 | $61.0M | 0.01% | −722−0.3% | Reduced |
| First Trust Advisors LP | 245,276 | $60.5M | 0.04% | −3,116−1.3% | Reduced |
| Charles Schwab Investment Management Inc | 242,774 | $59.9M | 0.01% | −890.0% | Reduced |
| Morgan Stanley | 221,481 | $54.6M | 0.00% | −13,097−5.6% | Reduced |
| Janus Henderson Group PLC | 219,440 | $54.1M | 0.02% | +209,369+2,078.9% | Added |
| Braidwell LP | 202,101 | $49.8M | 1.59% | −318,300−61.2% | Reduced |
| Bank of America Corp | 190,807 | $47.0M | 0.00% | +52,812+38.3% | Added |
| Nuveen, LLC | 189,094 | $46.6M | 0.01% | −8,284−4.2% | Reduced |
| Marshall Wace, LLP | 183,754 | $45.3M | 0.04% | +54,794+42.5% | Added |
| Principal Financial Group Inc | 165,074 | $40.7M | 0.02% | +22,231+15.6% | Added |
| UBS Group AG | 159,595 | $39.3M | 0.01% | +29,422+22.6% | Added |
| Pictet Asset Management Holding SA | 156,568 | $38.6M | 0.04% | −40,336−20.5% | Reduced |
| Bank of New York Mellon Corp | 151,313 | $37.3M | 0.01% | −4,240−2.7% | Reduced |
| Woodline Partners LP | 150,616 | $37.1M | 0.14% | 00.0% | Unchanged |
| JPMorgan Chase & Co | 134,624 | $33.2M | 0.00% | −11,730−8.0% | Reduced |
| Franklin Resources Inc | 125,675 | $31.0M | 0.01% | +105,825+533.1% | Added |
| OrbiMed Advisors LLC | 119,800 | $29.5M | 0.60% | +17,055+16.6% | Added |
| Handelsbanken Fonder AB | 105,800 | $26.1M | 0.08% | +39,000+58.4% | Added |
| Voya Investment Management LLC | 103,261 | $25.5M | 0.03% | +9,353+10.0% | Added |
| TimesSquare Capital Management, LLC | 97,400 | $24.0M | 0.36% | −21,114−17.8% | Reduced |
| S Squared Technology, LLC | 96,215 | $23.7M | 9.19% | −13,000−11.9% | Reduced |
| Public Sector Pension Investment Board | 89,362 | $22.0M | 0.07% | −11,069−11.0% | Reduced |
| C WorldWide Group Holding A/S | 85,809 | $21.2M | 0.37% | 00.0% | Unchanged |
| Segall Bryant & Hamill, LLC | 83,246 | $20.5M | 0.28% | −2,017−2.4% | Reduced |
| Raymond James Financial Inc | 76,538 | $19.0M | 0.01% | +12,175+18.9% | Added |
| Biondo Investment Advisors, LLC | 68,130 | $16.8M | 2.03% | +16,245+31.3% | Added |
| Rhumbline Advisers | 66,436 | $16.4M | 0.01% | −4,116−5.8% | Reduced |
| Legal & General Group Plc | 63,361 | $15.6M | 0.00% | −2,454−3.7% | Reduced |
| ACT Capital Management, LLC | 60,500 | $14.9M | 12.06% | +60,500 | New |
| Barclays PLC | 60,062 | $14.8M | 0.01% | −15,834−20.9% | Reduced |
| Invesco Ltd. | 60,008 | $14.8M | 0.00% | −6,872−10.3% | Reduced |
| TD Asset Management Inc | 54,142 | $13.3M | 0.01% | +9,062+20.1% | Added |
| BNP Paribas Arbitrage, SA | 53,911 | $13.3M | 0.01% | +44,732+487.3% | Added |
| Ameriprise Financial Inc | 52,345 | $12.9M | 0.00% | −3,447−6.2% | Reduced |
| Skandinaviska Enskilda Banken AB (publ) | 46,732 | $11.5M | 0.05% | −13,246−22.1% | Reduced |
| Swiss National Bank | 42,900 | $10.6M | 0.01% | +900+2.1% | Added |
| Palisades Investment Partners, LLC | 42,765 | $10.5M | 3.98% | +1,376+3.3% | Added |
| Manufacturers Life Insurance Company, The | 40,629 | $10.1M | 0.01% | +6,174+17.9% | Added |
| Standard Life Aberdeen plc | 39,360 | $9.70M | 0.02% | −20,012−33.7% | Reduced |
| CI Private Wealth, LLC | 38,346 | $9.50M | 0.01% | −784−2.0% | Reduced |
| Mutual of America Capital Management LLC | 37,269 | $9.19M | 0.10% | −665−1.8% | Reduced |
| Federated Hermes, Inc. | 34,541 | $8.52M | 0.01% | +10,560+44.0% | Added |
| HealthInvest Partners AB | 33,853 | $8.35M | 2.66% | −8,338−19.8% | Reduced |
| UBS Asset Management Americas Inc | 33,617 | $8.29M | 0.00% | −168,972−83.4% | Reduced |
| SEI Investments Co | 32,310 | $7.97M | 0.01% | +8,917+38.1% | Added |
| Wells Fargo & Company | 31,572 | $7.78M | 0.00% | +11,919+60.6% | Added |
| Alliancebernstein L.P. | 31,529 | $7.77M | 0.00% | +1,609+5.4% | Added |
| New York State Common Retirement Fund | 31,342 | $7.73M | 0.01% | +4,348+16.1% | Added |
| Citigroup Inc | 29,943 | $7.38M | 0.01% | +20,293+210.3% | Added |
| Castleark Management LLC | 29,260 | $7.21M | 0.21% | +29,260 | New |
| Russell Investments Group, Ltd. | 28,954 | $7.14M | 0.01% | +2,405+9.1% | Added |
| Prudential Financial Inc | 27,015 | $6.66M | 0.01% | +1,519+6.0% | Added |
| Victory Capital Management Inc | 26,461 | $6.52M | 0.00% | −28,355−51.7% | Reduced |
| Granite Investment Partners, LLC | 25,760 | $6.35M | 0.38% | +25,760 | New |
| Rhenman & Partners Asset Management AB | 25,000 | $6.16M | 0.58% | +13,250+112.8% | Added |
| EAM Investors, LLC | 24,667 | $6.08M | 0.68% | +24,667 | New |
| Rafferty Asset Management, LLC | 24,268 | $5.98M | 0.02% | −10,372−29.9% | Reduced |
| EFG International AG | 23,569 | $5.82M | 0.11% | +23,569 | New |
| Deutsche Bank AG | 22,450 | $5.53M | 0.00% | +1,071+5.0% | Added |
| Great West Life Assurance Co | 22,087 | $5.45M | 0.01% | +689+3.2% | Added |
| Elmind Capital, LP | 22,000 | $5.42M | 1.60% | +22,000 | New |
| California State Teachers Retirement System | 20,583 | $5.07M | 0.01% | −299−1.4% | Reduced |
| Bessemer Group Inc | 20,260 | $5.00M | 0.01% | +20,111+13,497.3% | Added |
| ADAR1 Capital Management, LLC | 20,014 | $4.93M | 0.37% | +1,491+8.0% | Added |
| GW&K Investment Management, LLC | 19,581 | $4.83M | 0.04% | +9,089+86.6% | Added |
| SG Americas Securities, LLC | 18,909 | $4.66M | 0.01% | +15,591+469.9% | Added |
| Fiera Capital Corp | 18,857 | $4.65M | 0.01% | +3,794+25.2% | Added |
| State of Alaska, Department of Revenue | 17,902 | $4.41M | 0.05% | +3,628+25.4% | Added |
| Thrivent Financial for Lutherans | 17,734 | $4.37M | 0.01% | −850−4.6% | Reduced |
| 1832 Asset Management L.P. | 17,600 | $4.34M | 0.01% | +17,600 | New |
| Perceptive Advisors LLC | 17,500 | $4.31M | 0.08% | −17,500−50.0% | Reduced |
| Decheng Capital LLC | 17,300 | $4.27M | 0.57% | −15,000−46.4% | Reduced |
| Pinnacle Financial Partners, Inc. | 16,983 | $4.19M | 0.03% | +16,983 | New |
| Verition Fund Management LLC | 16,969 | $4.18M | 0.02% | −14,364−45.8% | Reduced |
| Evolutionary Tree Capital Management, LLC | 16,811 | $4.14M | 4.81% | +4,350+34.9% | Added |
| State Board of Administration of Florida Retirement System | 15,756 | $3.88M | 0.01% | +9,971+172.4% | Added |
| New York State Teachers Retirement System | 15,650 | $3.86M | 0.01% | +100+0.6% | Added |
| Ikarian Capital, LLC | 14,814 | $3.65M | 0.47% | −9,607−39.3% | Reduced |
| Millennium Management LLC | 14,658 | $3.61M | 0.00% | −134,055−90.1% | Reduced |
| State of Wisconsin Investment Board | 14,466 | $3.57M | 0.01% | −14,874−50.7% | Reduced |
| AQR Capital Management LLC | 14,157 | $3.49M | 0.00% | −5,976−29.7% | Reduced |
| Creative Planning | 13,881 | $3.42M | 0.00% | +2,272+19.6% | Added |