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Livermore
ZHEN

Krystal Biotech, Inc.

KRYS
Exchange
Nasdaq
Industry
Biological Products, (No Diagnostic Substances)
SEC CIK
0001711279

In the last 90 days, Krystal Biotech, Inc. insiders filed 0 open-market purchases and 3 sales; 422 institutions reported holding it in 13F filings for Q2 2026, worth $11.1B in total; no superinvestor holds it.

13F holders, Q4 2025

Institutional positions in Krystal Biotech, Inc. as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
334
+55 vs. Q3 2025
Shares held
28.4M
+470.1K (+1.7%) vs. Q3 2025
Total value
$7.01B
+$2.07B (+42.0%) vs. Q3 2025
New holders
82
111 more added
Sold out
27
105 more reduced

5 institutions that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.

Compare with Q3 2025: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting KRYS on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ4 2025: 334 institutions
Q1 2021: 113 institutionsQ2 2021: 113 institutionsQ3 2021: 113 institutionsQ4 2021: 140 institutionsQ1 2022: 135 institutionsQ2 2022: 137 institutionsQ3 2022: 148 institutionsQ4 2022: 154 institutionsQ1 2023: 160 institutionsQ2 2023: 183 institutionsQ3 2023: 188 institutionsQ4 2023: 194 institutionsQ1 2024: 234 institutionsQ2 2024: 245 institutionsQ3 2024: 283 institutionsQ4 2024: 264 institutionsQ1 2025: 299 institutionsQ2 2025: 275 institutionsQ3 2025: 284 institutionsQ4 2025: 334 institutionsQ1 2026: 368 institutionsQ2 2026: 422 institutions
Value heldQ4 2025: $7.01B
Q1 2021: $1.27BQ2 2021: $1.12BQ3 2021: $850.7MQ4 2021: $1.35BQ1 2022: $1.37BQ2 2022: $1.36BQ3 2022: $1.45BQ4 2022: $1.66BQ1 2023: $1.68BQ2 2023: $2.71BQ3 2023: $2.76BQ4 2023: $3.03BQ1 2024: $4.49BQ2 2024: $5.24BQ3 2024: $5.15BQ4 2024: $4.35BQ1 2025: $4.98BQ2 2025: $3.80BQ3 2025: $4.94BQ4 2025: $7.01BQ1 2026: $7.32BQ2 2026: $11.1B
Institutions holding KRYS and their total value by quarter
QuarterHoldersValue
Q2 2026422$11.1B
Q1 2026368$7.32B
Q4 2025334$7.01B
Q3 2025284$4.94B
Q2 2025275$3.80B
Q1 2025299$4.98B
Q4 2024264$4.35B
Q3 2024283$5.15B
Q2 2024245$5.24B
Q1 2024234$4.49B
Q4 2023194$3.03B
Q3 2023188$2.76B
Q2 2023183$2.71B
Q1 2023160$1.68B
Q4 2022154$1.66B
Q3 2022148$1.45B
Q2 2022137$1.36B
Q1 2022135$1.37B
Q4 2021140$1.35B
Q3 2021113$850.7M
Q2 2021113$1.12B
Q1 2021113$1.27B

Institutions, Q4 2025

Shares, value and share of portfolio for each institution holding Krystal Biotech, Inc.; share changes are against Q3 2025.

Institutions holding KRYS in Q4 2025
InstitutionSharesValue% of portfolioChange in sharesAction
Rakuten Securities, Inc.1$2470.00%−4−80.0%Reduced
Abound Wealth Management1$2470.00%00.0%Unchanged
Optiver Holding B.V.1$2470.00%+1New
Rialto Wealth Management, LLC1$2470.00%+1New
Kilter Group LLC1$2470.00%+1New
Trust Co2$4930.00%+2New
Flagship Harbor Advisors, LLC2$4930.00%+2New
Signature Equity Partners, LLC2$4930.00%+2New
UMA Financial Services, Inc.2$4940.00%+2New
Gilpin Wealth Management, LLC2$4940.00%+2New
JFS Wealth Advisors, LLC3$7400.00%+1+50.0%Added
SJS Investment Consulting Inc.3$7410.00%+3New
Ronald Blue Trust, Inc.4$9860.00%−2−33.3%Reduced
Hughes Financial Services, LLC4$9860.00%00.0%Unchanged
Essential Partners LLC4$9860.00%00.0%Unchanged
Ankerstar Wealth, LLC4$9860.00%+4New
Avion Wealth6$1.00K0.00%+2+50.0%Added
Glen Eagle Advisors, LLC5$1.23K0.00%00.0%Unchanged
Keating Financial Advisory Services, Inc.5$1.23K0.00%+5New
Fortitude Family Office, LLC7$1.73K0.00%+3+75.0%Added
Retirement Wealth Solutions LLC7$1.73K0.00%+5+250.0%Added
Root Financial Partners, LLC7$1.73K0.00%+7New
CIBC Private Wealth Group, LLC9$2.22K0.00%+9New
Cornerstone Financial Management LLC14$3.45K0.00%+14New
Farmers & Merchants Investments Inc15$3.70K0.00%00.0%Unchanged
Accent Capital Management, LLC15$3.70K0.00%+15New
Bell Investment Advisors, Inc16$3.94K0.00%00.0%Unchanged
Larson Financial Group LLC17$4.19K0.00%00.0%Unchanged
Trust Co of Vermont20$4.93K0.00%00.0%Unchanged
Allworth Financial LP27$6.66K0.00%+7+35.0%Added
Aster Capital Management (DIFC) Ltd27$6.66K0.00%+27New
Rothschild Investment LLC28$6.90K0.00%+2+7.7%Added
Clearstead Advisors, LLC28$6.90K0.00%−5−15.2%Reduced
SRS Capital Advisors, Inc.32$7.89K0.00%−224−87.5%Reduced
Harbour Investments, Inc.33$8.14K0.00%+33New
Parkside Financial Bank & Trust33$8.14K0.00%+8+32.0%Added
Quent Capital, LLC34$8.38K0.00%00.0%Unchanged
Acumen Wealth Advisors, LLC34$8.38K0.00%+34New
Farther Finance Advisors, LLC39$9.62K0.00%+6+18.2%Added
Bare Financial Services, Inc43$10.6K0.00%00.0%Unchanged
Federation des caisses Desjardins du Quebec50$12.3K0.00%00.0%Unchanged
Private Wealth Management Group, LLC55$13.6K0.00%00.0%Unchanged
Rockefeller Capital Management L.P.56$13.8K0.00%−49−46.7%Reduced
SageView Advisory Group, LLC57$14.1K0.00%+57New
Versant Capital Management, Inc71$17.5K0.00%00.0%Unchanged
GWM Advisors LLC72$17.8K0.00%+38+111.8%Added
EverSource Wealth Advisors, LLC75$18.5K0.00%+12+19.0%Added
Advisors Asset Management, Inc.81$20.0K0.00%+81New
Kemnay Advisory Services Inc.84$20.7K0.00%+84New
Massmutual Trust Co FSB85$21.0K0.00%+13+18.1%Added
Daiwa Securities Group Inc.86$21.0K0.00%−5−5.5%Reduced
Quantbot Technologies LP86$21.2K0.00%+86New
Signaturefd, LLC89$21.9K0.00%−1−1.1%Reduced
Basecamp Wealth Advisors LLC94$23.2K0.00%+94New
Reyes Financial Architecture, Inc.100$24.7K0.02%00.0%Unchanged
Greenline Wealth Management LLC136$33.5K0.03%+136New
Umb Bank N A144$35.5K0.00%+37+34.6%Added
Fifth Third Bancorp146$36.0K0.00%+15+11.5%Added
Key Financial Inc151$37.2K0.01%00.0%Unchanged
Quadrant Capital Group LLC156$38.5K0.00%+20+14.7%Added
Sound Income Strategies, LLC137$39.0K0.00%+127+1,270.0%Added
Global Retirement Partners, LLC160$39.4K0.00%+142+788.9%Added
Sterling Capital Management LLC162$39.9K0.00%+102+170.0%Added
Vestor Capital, LLC2,940$42.0K0.00%+2,940New
AdvisorNet Financial, Inc171$42.2K0.00%00.0%Unchanged
Salomon & Ludwin, LLC183$44.8K0.00%+1+0.5%Added
Huntington National Bank188$46.3K0.00%−2−1.1%Reduced
Danske Bank A/S200$49.3K0.00%00.0%Unchanged
SBI Securities Co., Ltd.202$49.8K0.00%+134+197.1%Added
Caldwell Trust Co250$61.6K0.01%00.0%Unchanged
BNP PARIBAS ASSET MANAGEMENT Holding S.A.262$65.0K0.00%+88+50.6%Added
IFP Advisors, Inc265$65.3K0.00%+189+248.7%Added
MAI Capital Management284$70.0K0.00%00.0%Unchanged
Jones Financial Companies LLLP290$71.5K0.00%+253+683.8%Added
Simplex Trading, LLC293$72.2K0.00%+293New
US Bancorp313$77.2K0.00%+3+1.0%Added
Hantz Financial Services, Inc.371$91.0K0.00%+79+27.1%Added
Bryn Mawr Trust Co393$96.9K0.00%00.0%Unchanged
Horizon Investments, LLC412$101.6K0.00%+412New
Eurizon Capital SGR S.p.A.553$136.9K0.00%+553New
Quest Partners LLC565$139.3K0.01%−99−14.9%Reduced
GF Fund Management Co. Ltd.569$140.3K0.00%−54−8.7%Reduced
Canada Pension Plan Investment Board600$147.9K0.00%00.0%Unchanged
Smartleaf Asset Management LLC610$151.2K0.01%+188+44.5%Added
KBC Group NV685$169.0K0.00%00.0%Unchanged
Pinnacle Wealth Planning Services, Inc.759$187.1K0.02%+759New
GAMMA Investing LLC789$194.5K0.01%+292+58.8%Added
Fiduciary Trust Co840$207.1K0.00%+840New
Shelton Capital Management840$207.1K0.00%+840New
Fox Run Management, L.L.C.856$211.0K0.03%+856New
Hidden Cove Wealth Management, LLC859$211.8K0.14%+859New
CIBC Asset Management Inc888$218.9K0.00%+888New
Net Worth Advisory Group923$227.6K0.05%+923New
Coldstream Capital Management Inc923$227.6K0.00%+923New
Exchange Traded Concepts, LLC926$228.3K0.00%+430+86.7%Added
Brinker Capital Investments, LLC927$228.5K0.00%+927New
Nisa Investment Advisors, LLC930$229.3K0.00%+4+0.4%Added
NLB Skladi, upravljanje premozenja, d.o.o.955$235.4K0.01%+955New
Ethic Inc.963$237.4K0.00%+963New
Swiss Life Asset Management Ltd991$244.3K0.00%+991New