Krystal Biotech, Inc.
KRYS- Exchange
- Nasdaq
- Industry
- Biological Products, (No Diagnostic Substances)
- SEC CIK
- 0001711279
In the last 90 days, Krystal Biotech, Inc. insiders filed 0 open-market purchases and 3 sales; 422 institutions reported holding it in 13F filings for Q2 2026, worth $11.1B in total; no superinvestor holds it.
13F holders, Q3 2025
Institutional positions in Krystal Biotech, Inc. as of Sep 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 284
- +15 vs. Q2 2025
- Shares held
- 28.0M
- +649.0K (+2.4%) vs. Q2 2025
- Total value
- $4.94B
- +$1.18B (+31.5%) vs. Q2 2025
- New holders
- 46
- 106 more added
- Sold out
- 31
- 86 more reduced
6 institutions that held it in Q2 2025 haven't filed for Q3 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q2 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting KRYS on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 422 | $11.1B |
| Q1 2026 | 368 | $7.32B |
| Q4 2025 | 334 | $7.01B |
| Q3 2025 | 284 | $4.94B |
| Q2 2025 | 275 | $3.80B |
| Q1 2025 | 299 | $4.98B |
| Q4 2024 | 264 | $4.35B |
| Q3 2024 | 283 | $5.15B |
| Q2 2024 | 245 | $5.24B |
| Q1 2024 | 234 | $4.49B |
| Q4 2023 | 194 | $3.03B |
| Q3 2023 | 188 | $2.76B |
| Q2 2023 | 183 | $2.71B |
| Q1 2023 | 160 | $1.68B |
| Q4 2022 | 154 | $1.66B |
| Q3 2022 | 148 | $1.45B |
| Q2 2022 | 137 | $1.36B |
| Q1 2022 | 135 | $1.37B |
| Q4 2021 | 140 | $1.35B |
| Q3 2021 | 113 | $850.7M |
| Q2 2021 | 113 | $1.12B |
| Q1 2021 | 113 | $1.27B |
Institutions, Q3 2025
Shares, value and share of portfolio for each institution holding Krystal Biotech, Inc.; share changes are against Q2 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| FMR LLC | 4,341,447 | $766.4M | 0.04% | +6,686+0.2% | Added |
| BlackRock, Inc. | 3,834,128 | $676.8M | 0.01% | −11,027−0.3% | Reduced |
| Vanguard Group Inc | 2,792,208 | $492.9M | 0.01% | −30,680−1.1% | Reduced |
| Avoro Capital Advisors LLC | 2,777,777 | $490.4M | 6.34% | +117,777+4.4% | Added |
| State Street Corp | 1,395,967 | $246.4M | 0.01% | +40,621+3.0% | Added |
| Soleus Capital Management, L.P. | 1,018,831 | $179.9M | 9.61% | +95,873+10.4% | Added |
| Capital World Investors | 809,240 | $142.9M | 0.02% | −133,009−14.1% | Reduced |
| Frazier Life Sciences Management, L.P. | 688,460 | $121.5M | 3.64% | 00.0% | Unchanged |
| Redmile Group, LLC | 661,388 | $116.8M | 11.36% | −2,083−0.3% | Reduced |
| Citadel Advisors LLC | 636,988 | $112.4M | 0.09% | +602,428+1,743.1% | Added |
| Geode Capital Management, LLC | 611,244 | $107.9M | 0.01% | −8,303−1.3% | Reduced |
| Hood River Capital Management LLC | 606,946 | $107.1M | 1.27% | +73,923+13.9% | Added |
| Dimensional Fund Advisors LP | 533,964 | $94.3M | 0.02% | +28,075+5.5% | Added |
| Braidwell LP | 520,401 | $91.9M | 2.73% | −207,410−28.5% | Reduced |
| Price T Rowe Associates Inc | 467,058 | $82.5M | 0.01% | +205,675+78.7% | Added |
| Goldman Sachs Group Inc | 348,250 | $61.5M | 0.01% | −182,111−34.3% | Reduced |
| First Trust Advisors LP | 248,392 | $43.8M | 0.03% | +26,022+11.7% | Added |
| Northern Trust Corp | 248,165 | $43.8M | 0.01% | −3,243−1.3% | Reduced |
| Charles Schwab Investment Management Inc | 242,863 | $42.9M | 0.01% | −3,317−1.3% | Reduced |
| Morgan Stanley | 234,578 | $41.4M | 0.00% | +157+0.1% | Added |
| UBS Asset Management Americas Inc | 202,589 | $35.8M | 0.01% | −31,731−13.5% | Reduced |
| Nuveen, LLC | 197,378 | $34.8M | 0.01% | +9,359+5.0% | Added |
| Pictet Asset Management Holding SA | 196,904 | $34.8M | 0.03% | +66,367+50.8% | Added |
| Bank of New York Mellon Corp | 155,553 | $27.5M | 0.00% | −4,964−3.1% | Reduced |
| Woodline Partners LP | 150,616 | $26.6M | 0.13% | 00.0% | Unchanged |
| William Blair Investment Management, LLC | 149,302 | $26.4M | 0.07% | +58,203+63.9% | Added |
| Millennium Management LLC | 148,713 | $26.3M | 0.02% | +136,151+1,083.8% | Added |
| JPMorgan Chase & Co | 146,354 | $25.8M | 0.00% | +55,201+60.6% | Added |
| Principal Financial Group Inc | 142,843 | $25.2M | 0.01% | +1,960+1.4% | Added |
| Bank of America Corp | 137,995 | $24.4M | 0.00% | +16,183+13.3% | Added |
| UBS Group AG | 130,173 | $23.0M | 0.00% | +32,933+33.9% | Added |
| Marshall Wace, LLP | 128,960 | $22.8M | 0.03% | +16,578+14.8% | Added |
| TimesSquare Capital Management, LLC | 118,514 | $20.9M | 0.30% | +4,310+3.8% | Added |
| S Squared Technology, LLC | 109,215 | $19.3M | 7.33% | 00.0% | Unchanged |
| OrbiMed Advisors LLC | 102,745 | $18.1M | 0.43% | +93,545+1,016.8% | Added |
| Public Sector Pension Investment Board | 100,431 | $17.7M | 0.07% | +13,743+15.9% | Added |
| Voya Investment Management LLC | 93,908 | $16.6M | 0.02% | +29,915+46.7% | Added |
| C WorldWide Group Holding A/S | 85,809 | $15.1M | 0.23% | 00.0% | Unchanged |
| Segall Bryant & Hamill, LLC | 85,263 | $15.1M | 0.20% | −63,351−42.6% | Reduced |
| Barclays PLC | 75,896 | $13.4M | 0.00% | −16,975−18.3% | Reduced |
| Rhumbline Advisers | 70,552 | $12.5M | 0.01% | −201−0.3% | Reduced |
| Readystate Asset Management LP | 70,349 | $12.4M | 0.60% | −77,631−52.5% | Reduced |
| Invesco Ltd. | 66,880 | $11.8M | 0.00% | −4,008−5.7% | Reduced |
| Handelsbanken Fonder AB | 66,800 | $11.8M | 0.04% | 00.0% | Unchanged |
| Legal & General Group Plc | 65,815 | $11.6M | 0.00% | −2,578−3.8% | Reduced |
| Raymond James Financial Inc | 64,363 | $11.4M | 0.00% | −4,372−6.4% | Reduced |
| Skandinaviska Enskilda Banken AB (publ) | 59,978 | $10.6M | 0.04% | 00.0% | Unchanged |
| Standard Life Aberdeen plc | 59,372 | $10.5M | 0.02% | −49,146−45.3% | Reduced |
| Ameriprise Financial Inc | 55,792 | $9.85M | 0.00% | −7,043−11.2% | Reduced |
| Victory Capital Management Inc | 54,816 | $9.68M | 0.01% | −25,307−31.6% | Reduced |
| Biondo Investment Advisors, LLC | 51,885 | $9.16M | 1.15% | +30,645+144.3% | Added |
| TD Asset Management Inc | 45,080 | $7.96M | 0.01% | +25,000+124.5% | Added |
| HealthInvest Partners AB | 42,191 | $7.91M | 2.93% | +22,033+109.3% | Added |
| Swiss National Bank | 42,000 | $7.41M | 0.00% | +600+1.4% | Added |
| Palisades Investment Partners, LLC | 41,389 | $7.31M | 2.87% | +1,186+3.0% | Added |
| Kennedy Capital Management, Inc. | 39,291 | $6.94M | 0.15% | +1,145+3.0% | Added |
| CI Private Wealth, LLC | 39,130 | $6.92M | 0.01% | −1,408−3.5% | Reduced |
| Mutual of America Capital Management LLC | 37,934 | $6.70M | 0.07% | −423−1.1% | Reduced |
| Perceptive Advisors LLC | 35,000 | $6.18M | 0.18% | +35,000 | New |
| Rafferty Asset Management, LLC | 34,640 | $6.11M | 0.02% | −25−0.1% | Reduced |
| Manufacturers Life Insurance Company, The | 34,455 | $6.08M | 0.01% | +9,775+39.6% | Added |
| Decheng Capital LLC | 32,300 | $5.70M | 0.99% | −33,700−51.1% | Reduced |
| Verition Fund Management LLC | 31,333 | $5.53M | 0.03% | +4,819+18.2% | Added |
| Alliancebernstein L.P. | 29,920 | $5.28M | 0.00% | −1,200−3.9% | Reduced |
| State of Wisconsin Investment Board | 29,340 | $5.18M | 0.01% | −6,749−18.7% | Reduced |
| EFG Asset Management (North America) Corp. | 27,095 | $4.78M | 0.62% | +4,217+18.4% | Added |
| New York State Common Retirement Fund | 26,994 | $4.77M | 0.01% | +3,612+15.4% | Added |
| Russell Investments Group, Ltd. | 26,549 | $4.69M | 0.01% | +16,191+156.3% | Added |
| Prudential Financial Inc | 25,496 | $4.50M | 0.01% | −655−2.5% | Reduced |
| Ikarian Capital, LLC | 24,421 | $4.31M | 0.98% | +24,421 | New |
| Federated Hermes, Inc. | 23,981 | $4.23M | 0.01% | −18,762−43.9% | Reduced |
| SEI Investments Co | 23,393 | $4.13M | 0.00% | +4,093+21.2% | Added |
| Great West Life Assurance Co | 21,398 | $3.78M | 0.01% | +551+2.6% | Added |
| Deutsche Bank AG | 21,379 | $3.77M | 0.00% | +2,244+11.7% | Added |
| California State Teachers Retirement System | 20,882 | $3.69M | 0.00% | +756+3.8% | Added |
| Synovus Financial Corp | 20,516 | $3.62M | 0.04% | −127−0.6% | Reduced |
| AQR Capital Management LLC | 20,133 | $3.55M | 0.00% | +8,165+68.2% | Added |
| Franklin Resources Inc | 19,850 | $3.50M | 0.00% | +1,425+7.7% | Added |
| Wells Fargo & Company | 19,653 | $3.47M | 0.00% | +3,106+18.8% | Added |
| Thrivent Financial for Lutherans | 18,584 | $3.28M | 0.01% | −116−0.6% | Reduced |
| ADAR1 Capital Management, LLC | 18,523 | $3.27M | 0.32% | +18,523 | New |
| Erste Asset Management GmbH | 18,200 | $3.22M | 0.03% | 00.0% | Unchanged |
| New York State Teachers Retirement System | 15,550 | $2.75M | 0.01% | −100−0.6% | Reduced |
| DekaBank Deutsche Girozentrale | 15,503 | $2.72M | 0.00% | 00.0% | Unchanged |
| Fiera Capital Corp | 15,063 | $2.66M | 0.01% | −448−2.9% | Reduced |
| Fieldview Capital Management, LLC | 14,705 | $2.60M | 0.42% | +159+1.1% | Added |
| State of New Jersey Common Pension Fund D | 14,599 | $2.58M | 0.01% | −434−2.9% | Reduced |
| MetLife Investment Management | 14,430 | $2.55M | 0.01% | −316−2.1% | Reduced |
| State of Alaska, Department of Revenue | 14,274 | $2.52M | 0.03% | −856−5.7% | Reduced |
| Illinois Municipal Retirement Fund | 14,245 | $2.51M | 0.03% | +1,934+15.7% | Added |
| Bridge City Capital, LLC | 14,154 | $2.50M | 0.67% | +14,154 | New |
| Alps Advisors Inc | 13,367 | $2.36M | 0.01% | −4,095−23.5% | Reduced |
| Mirae Asset Global ETFs Holdings Ltd. | 13,290 | $2.35M | 0.00% | −1,993−13.0% | Reduced |
| Envestnet Asset Management Inc | 13,108 | $2.31M | 0.00% | −2,008−13.3% | Reduced |
| Evolutionary Tree Capital Management, LLC | 12,461 | $2.20M | 2.40% | +165+1.3% | Added |
| Privium Fund Management B.V. | 12,170 | $2.15M | 0.39% | +2,850+30.6% | Added |
| Torray LLC | 11,901 | $2.10M | 0.29% | +327+2.8% | Added |
| Louisiana State Employees Retirement System | 11,800 | $2.08M | 0.03% | −100−0.8% | Reduced |
| Rhenman & Partners Asset Management AB | 11,750 | $2.07M | 0.23% | −1,000−7.8% | Reduced |
| Creative Planning | 11,609 | $2.05M | 0.00% | +3,253+38.9% | Added |