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Krystal Biotech, Inc.

KRYS
Exchange
Nasdaq
Industry
Biological Products, (No Diagnostic Substances)
SEC CIK
0001711279

In the last 90 days, Krystal Biotech, Inc. insiders filed 0 open-market purchases and 3 sales; 422 institutions reported holding it in 13F filings for Q2 2026, worth $11.1B in total; no superinvestor holds it.

13F holders, Q2 2026

Institutional positions in Krystal Biotech, Inc. as of Jun 30, 2026. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
422
+57 vs. Q1 2026
Shares held
30.3M
+2.20M (+7.8%) vs. Q1 2026
Total value
$11.1B
+$3.82B (+52.7%) vs. Q1 2026
New holders
93
178 more added
Sold out
36
109 more reduced

3 institutions that held it in Q1 2026 haven't filed for Q2 2026 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.

Compare with Q1 2026: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting KRYS on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ2 2026: 422 institutions
Q1 2021: 113 institutionsQ2 2021: 113 institutionsQ3 2021: 113 institutionsQ4 2021: 140 institutionsQ1 2022: 135 institutionsQ2 2022: 137 institutionsQ3 2022: 148 institutionsQ4 2022: 154 institutionsQ1 2023: 160 institutionsQ2 2023: 183 institutionsQ3 2023: 188 institutionsQ4 2023: 194 institutionsQ1 2024: 234 institutionsQ2 2024: 245 institutionsQ3 2024: 283 institutionsQ4 2024: 264 institutionsQ1 2025: 299 institutionsQ2 2025: 275 institutionsQ3 2025: 284 institutionsQ4 2025: 334 institutionsQ1 2026: 368 institutionsQ2 2026: 422 institutions
Value heldQ2 2026: $11.1B
Q1 2021: $1.27BQ2 2021: $1.12BQ3 2021: $850.7MQ4 2021: $1.35BQ1 2022: $1.37BQ2 2022: $1.36BQ3 2022: $1.46BQ4 2022: $1.76BQ1 2023: $1.93BQ2 2023: $2.80BQ3 2023: $2.84BQ4 2023: $3.17BQ1 2024: $4.69BQ2 2024: $5.34BQ3 2024: $5.17BQ4 2024: $4.35BQ1 2025: $4.99BQ2 2025: $3.80BQ3 2025: $4.96BQ4 2025: $7.02BQ1 2026: $7.32BQ2 2026: $11.1B
Institutions holding KRYS and their total value by quarter
QuarterHoldersValue
Q2 2026422$11.1B
Q1 2026368$7.32B
Q4 2025334$7.02B
Q3 2025284$4.96B
Q2 2025275$3.80B
Q1 2025299$4.99B
Q4 2024264$4.35B
Q3 2024283$5.17B
Q2 2024245$5.34B
Q1 2024234$4.69B
Q4 2023194$3.17B
Q3 2023188$2.84B
Q2 2023183$2.80B
Q1 2023160$1.93B
Q4 2022154$1.76B
Q3 2022148$1.46B
Q2 2022137$1.36B
Q1 2022135$1.37B
Q4 2021140$1.35B
Q3 2021113$850.7M
Q2 2021113$1.12B
Q1 2021113$1.27B

Institutions, Q2 2026

Shares, value and share of portfolio for each institution holding Krystal Biotech, Inc.; share changes are against Q1 2026.

Institutions holding KRYS in Q2 2026
InstitutionSharesValue% of portfolioChange in sharesAction
FMR LLC4,418,197$1.64B0.07%+44,210+1.0%Added
BlackRock, Inc.4,181,432$1.55B0.02%+240,976+6.1%Added
Avoro Capital Advisors LLC2,888,888$1.07B9.64%00.0%Unchanged
Vanguard Portfolio Management LLC1,574,905$585.3M0.03%+118,178+8.1%Added
State Street Corp1,351,158$502.2M0.01%+36,724+2.8%Added
Vanguard Capital Management LLC1,240,567$461.1M0.01%+75,243+6.5%Added
Soleus Capital Management, L.P.939,254$349.1M12.03%−213,833−18.5%Reduced
Capital World Investors777,843$289.1M0.03%−46,877−5.7%Reduced
Geode Capital Management, LLC698,993$259.8M0.01%+55,018+8.5%Added
Price T Rowe Associates Inc687,400$255.5M0.03%+202,326+41.7%Added
Hood River Capital Management LLC663,375$246.6M1.79%+43,789+7.1%Added
Redmile Group, LLC632,005$234.9M15.77%−41,500−6.2%Reduced
William Blair Investment Management, LLC570,153$211.9M0.64%+162,975+40.0%Added
Frazier Life Sciences Management, L.P.481,307$178.9M3.90%00.0%Unchanged
Dimensional Fund Advisors LP476,038$176.9M0.03%+7,048+1.5%Added
First Trust Advisors LP324,900$120.8M0.07%−25,621−7.3%Reduced
Invesco Ltd.324,755$120.7M0.01%+73,382+29.2%Added
Goldman Sachs Group Inc298,841$111.1M0.01%+83,892+39.0%Added
Northern Trust Corp283,784$105.5M0.01%+31,321+12.4%Added
Franklin Resources Inc261,917$97.3M0.02%+82,652+46.1%Added
Norges Bank259,030$96.3M0.01%+259,030New
Jupiter Topco LLC256,665$95.4M0.04%+256,665New
Bank of America Corp256,431$95.3M0.01%−4,216−1.6%Reduced
Charles Schwab Investment Management Inc254,828$94.7M0.01%+12,842+5.3%Added
Morgan Stanley235,491$87.5M0.00%+26,409+12.6%Added
Vestor Capital, LLC700,914$78.2M4.91%+700,714+350,357.0%Added
Vanguard Fiduciary Trust Co189,528$70.4M0.02%+10,367+5.8%Added
Principal Financial Group Inc169,550$63.0M0.03%+7,480+4.6%Added
Bank of New York Mellon Corp163,610$60.8M0.01%+14,303+9.6%Added
Raymond James Financial Inc158,675$59.0M0.02%+2,611+1.7%Added
Woodline Partners LP150,616$56.0M0.17%00.0%Unchanged
UBS Group AG148,316$55.1M0.01%+4,791+3.3%Added
Nuveen, LLC146,520$54.5M0.01%+3,152+2.2%Added
Braidwell LP128,975$47.9M1.77%−53,450−29.3%Reduced
Voya Investment Management LLC124,442$46.3M0.04%+16,045+14.8%Added
TimesSquare Capital Management, LLC111,545$41.5M0.61%−797−0.7%Reduced
Pictet Asset Management Holding SA107,798$40.1M0.04%−2,867−2.6%Reduced
Public Sector Pension Investment Board105,515$39.2M0.10%+13,229+14.3%Added
1832 Asset Management L.P.99,300$36.9M0.05%+56,700+133.1%Added
Westfield Capital Management Co LP98,707$36.7M0.12%+98,707New
BNP Paribas Arbitrage, SA92,234$34.3M0.02%−797−0.9%Reduced
Handelsbanken Fonder AB90,407$33.6M0.10%−993−1.1%Reduced
JPMorgan Chase & Co87,342$33.5M0.00%−11,763−11.9%Reduced
OrbiMed Advisors LLC83,200$30.9M0.59%+14,100+20.4%Added
S Squared Technology, LLC77,545$28.8M8.94%−8,670−10.1%Reduced
Bellevue Group AG77,530$28.8M0.61%−404,255−83.9%Reduced
Biondo Investment Advisors, LLC70,945$26.4M3.23%−1,100−1.5%Reduced
Segall Bryant & Hamill, LLC65,211$24.2M0.29%−14,286−18.0%Reduced
Rhumbline Advisers61,236$22.8M0.02%−6,863−10.1%Reduced
Renaissance Technologies LLC59,680$22.2M0.03%+50,080+521.7%Added
Legal & General Group Plc58,580$21.8M0.00%−470−0.8%Reduced
C WorldWide Group Holding A/S57,809$21.5M0.52%−10,000−14.7%Reduced
Citigroup Inc56,016$20.8M0.01%+24,844+79.7%Added
Bridgewater Associates, LP54,489$20.3M0.08%+8,122+17.5%Added
SEI Investments Co54,040$20.1M0.02%+7,470+16.0%Added
Russell Investments Group, Ltd.52,621$19.6M0.02%+26,411+100.8%Added
Allspring Global Investments Holdings, LLC52,407$19.5M0.03%+49,932+2,017.5%Added
Neuberger Berman Group LLC51,876$19.3M0.01%+18,792+56.8%Added
Ameriprise Financial Inc48,790$18.1M0.00%−1,047−2.1%Reduced
Palisades Investment Partners, LLC47,801$17.8M5.05%+2,396+5.3%Added
ACT Capital Management, LLC45,000$16.7M10.93%−15,477−25.6%Reduced
Victory Capital Management Inc44,935$16.7M0.01%+4,220+10.4%Added
Federated Hermes, Inc.43,848$16.3M0.02%+8,353+23.5%Added
Swiss National Bank41,360$15.4M0.01%−1,640−3.8%Reduced
Gilder Gagnon Howe & Co LLC40,296$15.0M0.15%+168+0.4%Added
Congress Asset Management Co40,134$14.9M0.09%+40,134New
UBS Asset Management Americas Inc38,697$14.4M0.00%+1,760+4.8%Added
SEB Asset Management AB37,731$14.0M0.05%−8,612−18.6%Reduced
Wellington Management Group LLP36,936$13.7M0.00%+26,709+261.2%Added
Life Cycle Investment Partners Ltd35,124$13.1M0.06%+35,124New
Wells Fargo & Company34,502$12.8M0.00%+19,514+130.2%Added
New York State Common Retirement Fund34,033$12.6M0.02%+2,691+8.6%Added
Granite Investment Partners, LLC32,837$12.2M0.63%+8,553+35.2%Added
Prudential Financial Inc32,662$12.1M0.01%+3,024+10.2%Added
Mutual of America Capital Management LLC31,998$11.9M0.12%−3,861−10.8%Reduced
Deutsche Bank AG31,836$11.8M0.00%+7,005+28.2%Added
CI Private Wealth, LLC30,558$11.4M0.02%+27,035+767.4%Added
Fisher Asset Management, LLC27,676$10.3M0.00%−108−0.4%Reduced
Manufacturers Life Insurance Company, The25,867$9.61M0.01%−10,202−28.3%Reduced
Standard Life Aberdeen plc25,141$9.34M0.01%−5,014−16.6%Reduced
HealthInvest Partners AB24,019$8.93M2.40%−13,560−36.1%Reduced
California State Teachers Retirement System23,692$8.81M0.01%−2,494−9.5%Reduced
Alliancebernstein L.P.34,039$8.79M0.00%+2,110+6.6%Added
TD Asset Management Inc22,712$8.44M0.01%−20,606−47.6%Reduced
Elmind Capital, LP22,000$8.18M2.05%00.0%Unchanged
Great West Life Assurance Co21,711$8.06M0.01%+298+1.4%Added
Vanguard Asset Management, Ltd21,390$7.95M0.01%+784+3.8%Added
Creative Planning20,318$7.55M0.00%+4,381+27.5%Added
Bessemer Group Inc20,285$7.54M0.01%00.0%Unchanged
Pinnacle Financial Partners, Inc.20,243$7.52M0.05%+63+0.3%Added
Polygon Management Ltd.19,668$7.31M1.19%00.0%Unchanged
Lisanti Capital Growth, LLC19,050$7.08M1.56%+535+2.9%Added
GW&K Investment Management, LLC18,295$6.80M0.05%−950−4.9%Reduced
Thrivent Financial for Lutherans17,229$6.40M0.01%+30.0%Added
Van Eck Associates Corp17,071$6.34M0.00%+17,071New
New York State Teachers Retirement System16,801$6.24M0.01%+1,164+7.4%Added
ADAR1 Capital Management, LLC16,420$6.10M0.29%−3,594−18.0%Reduced
Cinctive Capital Management LP16,367$6.08M0.24%+13,493+469.5%Added
Rhenman & Partners Asset Management AB16,325$6.07M0.57%−350−2.1%Reduced
EAM Investors, LLC16,227$6.03M0.54%−256−1.6%Reduced