Krystal Biotech, Inc.
KRYS- Exchange
- Nasdaq
- Industry
- Biological Products, (No Diagnostic Substances)
- SEC CIK
- 0001711279
In the last 90 days, Krystal Biotech, Inc. insiders filed 0 open-market purchases and 3 sales; 422 institutions reported holding it in 13F filings for Q2 2026, worth $11.1B in total; no superinvestor holds it.
13F holders, Q3 2025
Institutional positions in Krystal Biotech, Inc. as of Sep 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 284
- +15 vs. Q2 2025
- Shares held
- 28.0M
- +649.0K (+2.4%) vs. Q2 2025
- Total value
- $4.94B
- +$1.18B (+31.5%) vs. Q2 2025
- New holders
- 46
- 106 more added
- Sold out
- 31
- 86 more reduced
6 institutions that held it in Q2 2025 haven't filed for Q3 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q2 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting KRYS on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 422 | $11.1B |
| Q1 2026 | 368 | $7.32B |
| Q4 2025 | 334 | $7.01B |
| Q3 2025 | 284 | $4.94B |
| Q2 2025 | 275 | $3.80B |
| Q1 2025 | 299 | $4.98B |
| Q4 2024 | 264 | $4.35B |
| Q3 2024 | 283 | $5.15B |
| Q2 2024 | 245 | $5.24B |
| Q1 2024 | 234 | $4.49B |
| Q4 2023 | 194 | $3.03B |
| Q3 2023 | 188 | $2.76B |
| Q2 2023 | 183 | $2.71B |
| Q1 2023 | 160 | $1.68B |
| Q4 2022 | 154 | $1.66B |
| Q3 2022 | 148 | $1.45B |
| Q2 2022 | 137 | $1.36B |
| Q1 2022 | 135 | $1.37B |
| Q4 2021 | 140 | $1.35B |
| Q3 2021 | 113 | $850.7M |
| Q2 2021 | 113 | $1.12B |
| Q1 2021 | 113 | $1.27B |
Institutions, Q3 2025
Shares, value and share of portfolio for each institution holding Krystal Biotech, Inc.; share changes are against Q2 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| State of Tennessee, Treasury Department | 11,118 | $1.96M | 0.01% | +167+1.5% | Added |
| Wellington Management Group LLP | 10,881 | $1.92M | 0.00% | +728+7.2% | Added |
| Acuta Capital Partners, LLC | 10,573 | $1.87M | 1.93% | +10,573 | New |
| GW&K Investment Management, LLC | 10,492 | $1.85M | 0.02% | −19,683−65.2% | Reduced |
| Schroder Investment Management Group | 10,170 | $1.80M | 0.00% | −58−0.6% | Reduced |
| Main Management ETF Advisors, LLC | 10,075 | $1.78M | 0.07% | +4,944+96.4% | Added |
| Janus Henderson Group PLC | 10,071 | $1.78M | 0.00% | 00.0% | Unchanged |
| Commonwealth Equity Services, LLC | 10,006 | $1.77M | 0.00% | +1,791+21.8% | Added |
| Connor, Clark & Lunn Investment Management Ltd. | 9,778 | $1.73M | 0.01% | +9,778 | New |
| Intech Investment Management LLC | 9,751 | $1.72M | 0.02% | −1,227−11.2% | Reduced |
| Bridgewater Associates, LP | 9,723 | $1.72M | 0.01% | +9,723 | New |
| Citigroup Inc | 9,650 | $1.70M | 0.00% | −42,883−81.6% | Reduced |
| BNP Paribas Arbitrage, SA | 9,179 | $1.62M | 0.00% | +1,996+27.8% | Added |
| Perigon Wealth Management, LLC | 8,929 | $1.58M | 0.03% | +31+0.3% | Added |
| Boothbay Fund Management, LLC | 8,889 | $1.57M | 0.04% | +8,889 | New |
| NFJ Investment Group, LLC | 8,612 | $1.52M | 0.05% | +8,612 | New |
| Profund Advisors LLC | 8,330 | $1.47M | 0.05% | +164+2.0% | Added |
| Yousif Capital Management, LLC | 8,217 | $1.45M | 0.02% | −1,383−14.4% | Reduced |
| Winton Group Ltd | 8,212 | $1.45M | 0.05% | +8,212 | New |
| Tealwood Asset Management Inc | 7,902 | $1.40M | 0.56% | −281−3.4% | Reduced |
| Amalgamated Bank | 7,416 | $1.31M | 0.01% | +190+2.6% | Added |
| STRS Ohio | 7,400 | $1.31M | 0.00% | 00.0% | Unchanged |
| Teachers Retirement System of the State of Kentucky | 7,220 | $1.27M | 0.01% | −1,109−13.3% | Reduced |
| Quantum Private Wealth, LLC | 7,205 | $1.27M | 0.37% | 00.0% | Unchanged |
| Comerica Bank | 7,151 | $1.26M | 0.00% | −1,557−17.9% | Reduced |
| Police & Firemen's Retirement System of New Jersey | 6,859 | $1.21M | 0.01% | +1,259+22.5% | Added |
| D. E. Shaw & Co., Inc. | 6,814 | $1.20M | 0.00% | −4,913−41.9% | Reduced |
| Los Angeles Capital Management LLC | 6,757 | $1.19M | 0.00% | −19,881−74.6% | Reduced |
| Commonwealth of Pennsylvania Public School Empls Retrmt Sys | 6,560 | $1.16M | 0.01% | +31+0.5% | Added |
| Summit Trail Advisors, LLC | 6,464 | $1.14M | 0.02% | −36−0.6% | Reduced |
| Arizona State Retirement System | 6,397 | $1.13M | 0.01% | +81+1.3% | Added |
| Cynosure Management, LLC | 5,918 | $1.04M | 0.11% | 00.0% | Unchanged |
| Dark Forest Capital Management LP | 5,903 | $1.04M | 0.04% | +399+7.2% | Added |
| Oregon Public Employees Retirement Fund | 5,839 | $1.03M | 0.01% | +37+0.6% | Added |
| State Board of Administration of Florida Retirement System | 5,785 | $1.02M | 0.00% | −22−0.4% | Reduced |
| ProShare Advisors LLC | 5,717 | $1.01M | 0.00% | −908−13.7% | Reduced |
| Cookson Peirce & Co Inc | 5,654 | $998.1K | 0.04% | +5,654 | New |
| Teacher Retirement System of Texas | 5,331 | $941.1K | 0.00% | −510−8.7% | Reduced |
| China Universal Asset Management Co., Ltd. | 5,073 | $895.5K | 0.07% | −731−12.6% | Reduced |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 5,025 | $887.1K | 0.00% | +891+21.6% | Added |
| Polygon Management Ltd. | 4,870 | $859.7K | 0.12% | +4,870 | New |
| Blair William & Co | 4,752 | $838.9K | 0.00% | −100−2.1% | Reduced |
| KLP Kapitalforvaltning AS | 4,700 | $829.7K | 0.00% | +400+9.3% | Added |
| Amundi | 4,561 | $823.6K | 0.00% | +367+8.8% | Added |
| Mariner, LLC | 4,605 | $812.9K | 0.00% | +350+8.2% | Added |
| Martingale Asset Management L P | 4,505 | $795.3K | 0.02% | 00.0% | Unchanged |
| Cetera Investment Advisers | 4,498 | $794.0K | 0.00% | +154+3.5% | Added |
| Ensign Peak Advisors, Inc | 4,419 | $780.1K | 0.00% | −2,150−32.7% | Reduced |
| Pathstone Holdings, LLC | 4,347 | $767.4K | 0.00% | +408+10.4% | Added |
| Regal Investment Advisors LLC | 4,316 | $761.9K | 0.05% | −118−2.7% | Reduced |
| Guggenheim Capital LLC | 4,052 | $715.3K | 0.01% | −2,010−33.2% | Reduced |
| Omers Administration Corp | 4,000 | $706.1K | 0.01% | +4,000 | New |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 3,864 | $682.1K | 0.00% | 00.0% | Unchanged |
| Pier 88 Investment Partners LLC | 3,820 | $674.3K | 0.13% | 00.0% | Unchanged |
| Susquehanna Portfolio Strategies, LLC | 3,779 | $667.1K | 0.01% | +240+6.8% | Added |
| Legato Capital Management LLC | 3,757 | $663.2K | 0.07% | +3,757 | New |
| Maryland State Retirement & Pension System | 3,705 | $654.0K | 0.01% | −3,769−50.4% | Reduced |
| CenterBook Partners LP | 3,429 | $605.3K | 0.03% | −1,622−32.1% | Reduced |
| Jane Street Group, LLC | 3,381 | $596.8K | 0.00% | +3,381 | New |
| SG Americas Securities, LLC | 3,318 | $586.0K | 0.00% | −9,289−73.7% | Reduced |
| Aviva PLC | 3,231 | $570.4K | 0.00% | −344−9.6% | Reduced |
| Vontobel Holding Ltd. | 3,178 | $561.0K | 0.00% | +103+3.3% | Added |
| Virtus Investment Advisers, Inc. | 3,167 | $559.1K | 0.16% | 00.0% | Unchanged |
| Resona Asset Management Co.,Ltd. | 3,057 | $539.7K | 0.00% | +140+4.8% | Added |
| Confluence Wealth Services, Inc. | 2,922 | $515.8K | 0.03% | 00.0% | Unchanged |
| Sig Brokerage, LP | 2,849 | $502.9K | 0.13% | +2,849 | New |
| Optimize Financial Inc | 2,815 | $496.9K | 0.26% | +2,815 | New |
| CIBC Bancorp USA Inc. | 2,643 | $466.6K | 0.00% | +2,643 | New |
| Janney Montgomery Scott LLC | 2,580 | $455.0K | 0.00% | +240+10.3% | Added |
| Advantage Alpha Capital Partners LP | 2,387 | $421.4K | 0.13% | −507−17.5% | Reduced |
| Public Employees Retirement Association of Colorado | 2,363 | $417.0K | 0.00% | 00.0% | Unchanged |
| DnB Asset Management AS | 2,356 | $415.9K | 0.00% | +625+36.1% | Added |
| Bank of Montreal | 2,329 | $411.1K | 0.00% | −2,078−47.2% | Reduced |
| Quantinno Capital Management LP | 2,162 | $381.7K | 0.00% | +2,162 | New |
| Wolverine Trading, LLC | 2,154 | $380.7K | 0.01% | +2,154 | New |
| Ballentine Partners, LLC | 2,115 | $373.4K | 0.01% | 00.0% | Unchanged |
| Man Group plc | 2,088 | $368.6K | 0.00% | −28,393−93.1% | Reduced |
| Allspring Global Investments Holdings, LLC | 2,049 | $368.0K | 0.00% | −19−0.9% | Reduced |
| Ameritas Investment Partners, Inc. | 2,072 | $365.8K | 0.01% | −437−17.4% | Reduced |
| Crossmark Global Holdings, Inc. | 2,069 | $365.2K | 0.01% | −388−15.8% | Reduced |
| Freestone Grove Partners LP | 2,031 | $358.5K | 0.00% | +136+7.2% | Added |
| JustInvest LLC | 2,011 | $355.0K | 0.00% | +316+18.6% | Added |
| Sound View Wealth Advisors Group, LLC | 2,003 | $353.6K | 0.02% | +56+2.9% | Added |
| Virginia Retirement Systems Et Al | 2,000 | $353.1K | 0.00% | −5,800−74.4% | Reduced |
| Farallon Capital Management, L.L.C. | 2,000 | $353.1K | 0.00% | 00.0% | Unchanged |
| Yorktown Management & Research Co Inc | 2,000 | $353.1K | 0.28% | +2,000 | New |
| Xponance, Inc. | 1,951 | $344.4K | 0.00% | +22+1.1% | Added |
| Altfest L J & Co Inc | 1,870 | $330.1K | 0.04% | +1,870 | New |
| Parallel Advisors, LLC | 1,863 | $328.9K | 0.01% | 00.0% | Unchanged |
| Mitsubishi UFJ Kokusai Asset Management Co., Ltd. | 1,798 | $317.4K | 0.00% | +3+0.2% | Added |
| Covestor Ltd | 1,778 | $314.0K | 0.17% | +405+29.5% | Added |
| Campbell & CO Investment Adviser LLC | 1,721 | $303.8K | 0.02% | −270−13.6% | Reduced |
| City Center Advisors, LLC | 1,702 | $300.5K | 0.29% | +1,702 | New |
| The PNC Financial Services Group, Inc. | 1,694 | $299.0K | 0.00% | +272+19.1% | Added |
| Transcend Wealth Collective, LLC | 1,680 | $296.6K | 0.02% | +1,680 | New |
| Mackenzie Financial Corp | 1,597 | $281.9K | 0.00% | 00.0% | Unchanged |
| CWM, LLC | 1,536 | $271.0K | 0.00% | −47−3.0% | Reduced |
| O'Shaughnessy Asset Management, LLC | 1,485 | $262.1K | 0.00% | +1,485 | New |
| Mindset Wealth Management, LLC | 1,470 | $259.5K | 0.07% | +1,470 | New |
| Vident Advisory, LLC | 1,418 | $250.3K | 0.00% | −564−28.5% | Reduced |