Krystal Biotech, Inc.
KRYS- Exchange
- Nasdaq
- Industry
- Biological Products, (No Diagnostic Substances)
- SEC CIK
- 0001711279
In the last 90 days, Krystal Biotech, Inc. insiders filed 0 open-market purchases and 3 sales; 422 institutions reported holding it in 13F filings for Q2 2026, worth $11.1B in total; no superinvestor holds it.
13F holders, Q4 2025
Institutional positions in Krystal Biotech, Inc. as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 334
- +55 vs. Q3 2025
- Shares held
- 28.4M
- +470.1K (+1.7%) vs. Q3 2025
- Total value
- $7.01B
- +$2.07B (+42.0%) vs. Q3 2025
- New holders
- 82
- 111 more added
- Sold out
- 27
- 105 more reduced
5 institutions that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting KRYS on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 422 | $11.1B |
| Q1 2026 | 368 | $7.32B |
| Q4 2025 | 334 | $7.01B |
| Q3 2025 | 284 | $4.94B |
| Q2 2025 | 275 | $3.80B |
| Q1 2025 | 299 | $4.98B |
| Q4 2024 | 264 | $4.35B |
| Q3 2024 | 283 | $5.15B |
| Q2 2024 | 245 | $5.24B |
| Q1 2024 | 234 | $4.49B |
| Q4 2023 | 194 | $3.03B |
| Q3 2023 | 188 | $2.76B |
| Q2 2023 | 183 | $2.71B |
| Q1 2023 | 160 | $1.68B |
| Q4 2022 | 154 | $1.66B |
| Q3 2022 | 148 | $1.45B |
| Q2 2022 | 137 | $1.36B |
| Q1 2022 | 135 | $1.37B |
| Q4 2021 | 140 | $1.35B |
| Q3 2021 | 113 | $850.7M |
| Q2 2021 | 113 | $1.12B |
| Q1 2021 | 113 | $1.27B |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Krystal Biotech, Inc.; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| MetLife Investment Management | 13,844 | $3.41M | 0.02% | −586−4.1% | Reduced |
| Credit Agricole S A | 12,976 | $3.20M | 0.01% | +12,976 | New |
| Mirae Asset Global ETFs Holdings Ltd. | 12,954 | $3.20M | 0.00% | −336−2.5% | Reduced |
| Illinois Municipal Retirement Fund | 12,699 | $3.13M | 0.04% | −1,546−10.9% | Reduced |
| Privium Fund Management B.V. | 12,170 | $3.00M | 0.55% | 00.0% | Unchanged |
| Bridge City Capital, LLC | 12,135 | $2.99M | 0.88% | −2,019−14.3% | Reduced |
| Torray LLC | 11,985 | $2.95M | 0.42% | +84+0.7% | Added |
| Polygon Management Ltd. | 11,814 | $2.91M | 0.61% | +6,944+142.6% | Added |
| Louisiana State Employees Retirement System | 11,800 | $2.91M | 0.05% | 00.0% | Unchanged |
| Natixis Advisors, L.P. | 11,682 | $2.88M | 0.00% | +11,682 | New |
| State of Tennessee, Treasury Department | 10,193 | $2.85M | 0.01% | −925−8.3% | Reduced |
| DekaBank Deutsche Girozentrale | 15,503 | $2.63M | 0.00% | 00.0% | Unchanged |
| Wellington Management Group LLP | 10,651 | $2.63M | 0.00% | −230−2.1% | Reduced |
| Envestnet Asset Management Inc | 10,577 | $2.61M | 0.00% | −2,531−19.3% | Reduced |
| Main Management ETF Advisors, LLC | 10,179 | $2.51M | 0.09% | +104+1.0% | Added |
| Bridgewater Associates, LP | 10,015 | $2.47M | 0.01% | +292+3.0% | Added |
| Profund Advisors LLC | 9,887 | $2.44M | 0.07% | +1,557+18.7% | Added |
| Commonwealth Equity Services, LLC | 9,887 | $2.44M | 0.00% | −119−1.2% | Reduced |
| Intech Investment Management LLC | 9,751 | $2.40M | 0.02% | 00.0% | Unchanged |
| Nomura Asset Management International Inc. | 9,591 | $2.37M | 0.00% | +9,591 | New |
| Virginia Retirement Systems Et Al | 9,000 | $2.22M | 0.01% | +7,000+350.0% | Added |
| Perigon Wealth Management, LLC | 8,970 | $2.21M | 0.04% | +41+0.5% | Added |
| NFJ Investment Group, LLC | 8,249 | $2.03M | 0.07% | −363−4.2% | Reduced |
| Yousif Capital Management, LLC | 7,167 | $1.97M | 0.02% | −1,050−12.8% | Reduced |
| Clough Capital Partners L P | 7,806 | $1.92M | 0.17% | +7,806 | New |
| Tealwood Asset Management Inc | 7,713 | $1.90M | 0.85% | −189−2.4% | Reduced |
| Amalgamated Bank | 7,486 | $1.85M | 0.01% | +70+0.9% | Added |
| State of New Jersey Common Pension Fund D | 7,409 | $1.83M | 0.01% | −7,190−49.2% | Reduced |
| Guggenheim Capital LLC | 7,252 | $1.79M | 0.01% | +3,200+79.0% | Added |
| Quantum Private Wealth, LLC | 7,181 | $1.77M | 0.52% | −24−0.3% | Reduced |
| Police & Firemen's Retirement System of New Jersey | 6,747 | $1.66M | 0.01% | −112−1.6% | Reduced |
| Advisor Group Holdings, Inc. | 6,732 | $1.66M | 0.00% | +6,344+1,635.1% | Added |
| STRS Ohio | 6,500 | $1.60M | 0.01% | −900−12.2% | Reduced |
| Teachers Retirement System of the State of Kentucky | 6,458 | $1.59M | 0.01% | −762−10.6% | Reduced |
| Commonwealth of Pennsylvania Public School Empls Retrmt Sys | 6,389 | $1.58M | 0.01% | −171−2.6% | Reduced |
| ProShare Advisors LLC | 6,116 | $1.51M | 0.00% | +399+7.0% | Added |
| Arizona State Retirement System | 6,038 | $1.49M | 0.01% | −359−5.6% | Reduced |
| Cookson Peirce & Co Inc | 5,954 | $1.47M | 0.06% | +300+5.3% | Added |
| Oregon Public Employees Retirement Fund | 5,896 | $1.45M | 0.02% | +57+1.0% | Added |
| Winton Group Ltd | 5,874 | $1.45M | 0.05% | −2,338−28.5% | Reduced |
| Erste Asset Management GmbH | 5,700 | $1.45M | 0.01% | −12,500−68.7% | Reduced |
| Comerica Bank | 5,692 | $1.40M | 0.01% | −1,459−20.4% | Reduced |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 5,086 | $1.25M | 0.00% | +61+1.2% | Added |
| China Universal Asset Management Co., Ltd. | 4,725 | $1.16M | 0.09% | −348−6.9% | Reduced |
| KLP Kapitalforvaltning AS | 4,700 | $1.16M | 0.00% | 00.0% | Unchanged |
| Cetera Investment Advisers | 4,616 | $1.14M | 0.00% | +118+2.6% | Added |
| Martingale Asset Management L P | 4,506 | $1.11M | 0.03% | +10.0% | Added |
| Kennedy Capital Management, Inc. | 4,501 | $1.11M | 0.02% | −34,790−88.5% | Reduced |
| Regal Investment Advisors LLC | 4,360 | $1.07M | 0.06% | +44+1.0% | Added |
| Mariner, LLC | 4,320 | $1.07M | 0.00% | −285−6.2% | Reduced |
| Susquehanna Portfolio Strategies, LLC | 4,104 | $1.01M | 0.02% | +325+8.6% | Added |
| Seven Fleet Capital Management LP | 4,000 | $986.2K | 0.67% | +4,000 | New |
| Pier 88 Investment Partners LLC | 3,970 | $978.8K | 0.22% | +150+3.9% | Added |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 3,864 | $952.6K | 0.00% | 00.0% | Unchanged |
| Fisher Asset Management, LLC | 3,786 | $933.4K | 0.00% | +3,786 | New |
| Maryland State Retirement & Pension System | 3,774 | $930.4K | 0.02% | +69+1.9% | Added |
| Amundi | 3,754 | $925.5K | 0.00% | −807−17.7% | Reduced |
| Boothbay Fund Management, LLC | 3,527 | $869.5K | 0.02% | −5,362−60.3% | Reduced |
| Renaissance Technologies LLC | 3,300 | $813.6K | 0.00% | +3,300 | New |
| Teacher Retirement System of Texas | 3,222 | $794.4K | 0.00% | −2,109−39.6% | Reduced |
| Blair William & Co | 3,177 | $783.3K | 0.00% | −1,575−33.1% | Reduced |
| Baader Bank INC | 3,163 | $769.1K | 0.06% | +3,163 | New |
| DnB Asset Management AS | 3,093 | $762.5K | 0.00% | +737+31.3% | Added |
| Resona Asset Management Co.,Ltd. | 3,057 | $753.7K | 0.00% | 00.0% | Unchanged |
| Odyssean, LLC | 3,014 | $743.1K | 0.53% | +3,014 | New |
| Confluence Wealth Services, Inc. | 2,922 | $720.4K | 0.03% | 00.0% | Unchanged |
| Natixis | 2,920 | $719.9K | 0.00% | +2,798+2,293.4% | Added |
| Quantinno Capital Management LP | 2,904 | $716.0K | 0.00% | +742+34.3% | Added |
| Brevan Howard Capital Management LP | 2,902 | $715.5K | 0.01% | +2,902 | New |
| Optimize Financial Inc | 2,855 | $703.9K | 0.35% | +40+1.4% | Added |
| Virtus Investment Advisers, Inc. | 2,792 | $688.3K | 0.19% | −375−11.8% | Reduced |
| Entropy Technologies, LP | 2,503 | $617.1K | 0.03% | +2,503 | New |
| O'Shaughnessy Asset Management, LLC | 2,423 | $597.4K | 0.00% | +938+63.2% | Added |
| Cynosure Management, LLC | 2,406 | $593.2K | 0.06% | −3,512−59.3% | Reduced |
| Janney Montgomery Scott LLC | 2,398 | $591.0K | 0.00% | −182−7.1% | Reduced |
| Public Employees Retirement Association of Colorado | 2,363 | $583.0K | 0.00% | 00.0% | Unchanged |
| Pathstone Holdings, LLC | 2,281 | $562.4K | 0.00% | −2,066−47.5% | Reduced |
| Allspring Global Investments Holdings, LLC | 2,234 | $551.6K | 0.00% | +185+9.0% | Added |
| Bank of Montreal | 2,231 | $550.0K | 0.00% | −98−4.2% | Reduced |
| Aviva PLC | 2,228 | $549.3K | 0.00% | −1,003−31.0% | Reduced |
| Vontobel Holding Ltd. | 2,155 | $531.3K | 0.00% | −1,023−32.2% | Reduced |
| JustInvest LLC | 2,127 | $524.4K | 0.01% | +116+5.8% | Added |
| Crossmark Global Holdings, Inc. | 2,124 | $523.6K | 0.01% | +55+2.7% | Added |
| FORA Capital, LLC | 2,112 | $520.7K | 0.06% | +2,112 | New |
| Ballentine Partners, LLC | 2,108 | $519.7K | 0.01% | −7−0.3% | Reduced |
| D. E. Shaw & Co., Inc. | 2,108 | $519.7K | 0.00% | −4,706−69.1% | Reduced |
| Ameritas Investment Partners, Inc. | 2,013 | $496.3K | 0.02% | −59−2.8% | Reduced |
| Farallon Capital Management, L.L.C. | 2,000 | $493.1K | 0.00% | 00.0% | Unchanged |
| Yorktown Management & Research Co Inc | 2,000 | $493.1K | 0.39% | 00.0% | Unchanged |
| Xponance, Inc. | 1,959 | $483.0K | 0.00% | +8+0.4% | Added |
| Legato Capital Management LLC | 1,913 | $471.6K | 0.04% | −1,844−49.1% | Reduced |
| Allianz Asset Management GmbH | 1,900 | $468.4K | 0.00% | +1,900 | New |
| Susquehanna International Group, LLP | 1,867 | $460.3K | 0.00% | +1,867 | New |
| EP Wealth Advisors, LLC | 1,846 | $455.1K | 0.00% | +1,846 | New |
| AlphaCentric Advisors LLC | 1,813 | $447.0K | 0.45% | +1,813 | New |
| Mindset Wealth Management, LLC | 1,793 | $442.0K | 0.12% | +323+22.0% | Added |
| Pacer Advisors, Inc. | 1,712 | $422.1K | 0.00% | +1,105+182.0% | Added |
| The PNC Financial Services Group, Inc. | 1,696 | $418.1K | 0.00% | +2+0.1% | Added |
| Tower Research Capital LLC (TRC) | 1,686 | $415.7K | 0.01% | +693+69.8% | Added |
| Parallel Advisors, LLC | 1,680 | $414.2K | 0.01% | −183−9.8% | Reduced |