Design Therapeutics, Inc.
DSGN- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001807120
No open-market purchases or sales by Design Therapeutics, Inc. insiders were filed in the last 90 days; 136 institutions reported holding it in 13F filings for Q2 2026, worth $626.4M in total; no superinvestor holds it.
13F holders, Q1 2026
Institutional positions in Design Therapeutics, Inc. as of Mar 31, 2026. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 125
- +9 vs. Q4 2025
- Shares held
- 38.0M
- +1.50M (+4.1%) vs. Q4 2025
- Total value
- $404.1M
- +$61.9M (+18.1%) vs. Q4 2025
- New holders
- 22
- 56 more added
- Sold out
- 13
- 28 more reduced
1 institution that held it in Q4 2025 haven't filed for Q1 2026 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q4 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting DSGN on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 136 | $626.4M |
| Q1 2026 | 125 | $404.1M |
| Q4 2025 | 117 | $357.6M |
| Q3 2025 | 95 | $259.7M |
| Q2 2025 | 93 | $116.4M |
| Q1 2025 | 98 | $133.0M |
| Q4 2024 | 95 | $206.5M |
| Q3 2024 | 100 | $172.3M |
| Q2 2024 | 95 | $107.5M |
| Q1 2024 | 93 | $123.9M |
| Q4 2023 | 88 | $84.0M |
| Q3 2023 | 87 | $77.6M |
| Q2 2023 | 97 | $244.4M |
| Q1 2023 | 96 | $223.3M |
| Q4 2022 | 83 | $414.2M |
| Q3 2022 | 79 | $667.2M |
| Q2 2022 | 74 | $541.7M |
| Q1 2022 | 63 | $613.7M |
| Q4 2021 | 60 | $773.1M |
| Q3 2021 | 52 | $414.8M |
| Q2 2021 | 50 | $546.2M |
| Q1 2021 | 43 | $755.2M |
Institutions, Q1 2026
Shares, value and share of portfolio for each institution holding Design Therapeutics, Inc.; share changes are against Q4 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Sr One Capital Management, LP | 6,526,476 | $69.4M | 7.59% | 00.0% | Unchanged |
| Ra Capital Management, L.P. | 2,972,973 | $31.6M | 0.34% | +1,511,592+103.4% | Added |
| Point72 Asset Management, L.P. | 2,722,754 | $29.0M | 0.05% | −2,649,250−49.3% | Reduced |
| Baker Bros. Advisors LP | 2,585,978 | $27.5M | 0.16% | +352,879+15.8% | Added |
| BlackRock, Inc. | 2,133,764 | $22.7M | 0.00% | +16,608+0.8% | Added |
| Logos Global Management LP | 1,950,000 | $20.7M | 1.07% | −550,000−22.0% | Reduced |
| Driehaus Capital Management LLC | 1,744,987 | $18.6M | 0.14% | +565,170+47.9% | Added |
| Vivo Capital, LLC | 1,612,903 | $17.2M | 1.43% | 00.0% | Unchanged |
| Almitas Capital LLC | 1,530,335 | $16.3M | 3.68% | −1000.0% | Reduced |
| Vanguard Capital Management LLC | 1,349,850 | $14.4M | 0.00% | +1,349,850 | New |
| Woodline Partners LP | 961,501 | $10.2M | 0.04% | +17,462+1.8% | Added |
| Trails Edge Capital Partners, LP | 852,013 | $9.07M | 2.13% | +852,013 | New |
| FMR LLC | 798,411 | $8.50M | 0.00% | +27,143+3.5% | Added |
| Kynam Capital Management, LP | 784,606 | $8.35M | 0.53% | 00.0% | Unchanged |
| Geode Capital Management, LLC | 692,518 | $7.37M | 0.00% | +12,928+1.9% | Added |
| State Street Corp | 659,575 | $7.02M | 0.00% | +11,939+1.8% | Added |
| Morgan Stanley | 656,565 | $6.99M | 0.00% | −45,741−6.5% | Reduced |
| Acadian Asset Management LLC | 616,481 | $6.55M | 0.01% | +3,713+0.6% | Added |
| Goldman Sachs Group Inc | 504,718 | $5.37M | 0.00% | +234,064+86.5% | Added |
| D. E. Shaw & Co., Inc. | 470,270 | $5.00M | 0.00% | +31,376+7.1% | Added |
| Dimensional Fund Advisors LP | 431,840 | $4.59M | 0.00% | +133,919+45.0% | Added |
| Renaissance Technologies LLC | 408,200 | $4.34M | 0.01% | +121,100+42.2% | Added |
| Northern Trust Corp | 300,279 | $3.19M | 0.00% | +13,707+4.8% | Added |
| Jacobs Levy Equity Management, Inc | 289,385 | $3.08M | 0.01% | +94,774+48.7% | Added |
| Kennedy Capital Management, Inc. | 271,554 | $2.89M | 0.06% | +221,531+442.9% | Added |
| Charles Schwab Investment Management Inc | 241,485 | $2.57M | 0.00% | +4,622+2.0% | Added |
| Citadel Advisors LLC | 231,513 | $2.46M | 0.00% | −228,361−49.7% | Reduced |
| Elmind Capital, LP | 207,900 | $2.21M | 0.63% | 00.0% | Unchanged |
| Algert Global LLC | 204,739 | $2.18M | 0.03% | +16,970+9.0% | Added |
| Vanguard Fiduciary Trust Co | 195,658 | $2.08M | 0.00% | +195,658 | New |
| Marshall Wace, LLP | 151,008 | $1.61M | 0.00% | −74,520−33.0% | Reduced |
| Acuta Capital Partners, LLC | 145,900 | $1.55M | 1.10% | −5,006−3.3% | Reduced |
| Invesco Ltd. | 141,920 | $1.51M | 0.00% | −163,837−53.6% | Reduced |
| Vanguard Portfolio Management LLC | 138,565 | $1.47M | 0.00% | +138,565 | New |
| SEI Investments Co | 133,203 | $1.42M | 0.00% | +80,473+152.6% | Added |
| Nuveen, LLC | 126,815 | $1.35M | 0.00% | +1,555+1.2% | Added |
| Lynx1 Capital Management LP | 119,516 | $1.27M | 0.20% | +50,000+71.9% | Added |
| Trexquant Investment LP | 117,111 | $1.25M | 0.01% | +17,144+17.1% | Added |
| Millennium Management LLC | 108,928 | $1.16M | 0.00% | −71,938−39.8% | Reduced |
| Raymond James Financial Inc | 108,449 | $1.15M | 0.00% | −1,314−1.2% | Reduced |
| Jane Street Group, LLC | 103,902 | $1.11M | 0.00% | −122,610−54.1% | Reduced |
| Verdad Advisers, LP | 92,310 | $982.2K | 1.11% | +92,310 | New |
| Caption Management, LLC | 86,708 | $922.6K | 0.04% | +86,708 | New |
| Squarepoint Ops LLC | 86,117 | $916.3K | 0.00% | +39,975+86.6% | Added |
| Bank of New York Mellon Corp | 79,645 | $847.4K | 0.00% | −5,330−6.3% | Reduced |
| EAM Investors, LLC | 78,949 | $840.0K | 0.10% | 00.0% | Unchanged |
| Palumbo Wealth Management LLC | 71,408 | $759.8K | 0.19% | +2,031+2.9% | Added |
| American Century Companies Inc | 65,638 | $698.4K | 0.00% | +7,840+13.6% | Added |
| XTX Topco Ltd | 60,939 | $648.4K | 0.01% | +25,655+72.7% | Added |
| Canada Pension Plan Investment Board | 60,400 | $642.7K | 0.00% | +5,800+10.6% | Added |
| Barclays PLC | 55,790 | $593.6K | 0.00% | −31,270−35.9% | Reduced |
| Bridgeway Capital Management, LLC | 52,000 | $553.3K | 0.01% | −26,500−33.8% | Reduced |
| BNP Paribas Arbitrage, SA | 50,272 | $534.9K | 0.00% | −44,556−47.0% | Reduced |
| Alps Advisors Inc | 50,209 | $534.2K | 0.00% | +3,438+7.4% | Added |
| State of Wisconsin Investment Board | 49,214 | $523.6K | 0.00% | −1,443−2.8% | Reduced |
| Prudential Financial Inc | 45,810 | $487.4K | 0.00% | +3,100+7.3% | Added |
| STRS Ohio | 44,700 | $475.6K | 0.00% | +19,500+77.4% | Added |
| Alliancebernstein L.P. | 46,120 | $432.6K | 0.00% | 00.0% | Unchanged |
| China Universal Asset Management Co., Ltd. | 35,109 | $373.6K | 0.03% | +827+2.4% | Added |
| Ameriprise Financial Inc | 34,990 | $372.3K | 0.00% | −123,393−77.9% | Reduced |
| Rhumbline Advisers | 34,860 | $370.9K | 0.00% | +82+0.2% | Added |
| Qube Research & Technologies Ltd | 34,183 | $363.7K | 0.00% | +34,183 | New |
| CI Private Wealth, LLC | 27,169 | $289.1K | 0.00% | +204+0.8% | Added |
| AQR Capital Management LLC | 25,957 | $276.2K | 0.00% | +12,227+89.1% | Added |
| Russell Investments Group, Ltd. | 25,437 | $270.6K | 0.00% | +203+0.8% | Added |
| Bank of America Corp | 23,264 | $247.5K | 0.00% | −4,182−15.2% | Reduced |
| AlphaCentric Advisors LLC | 21,231 | $225.9K | 0.23% | +969+4.8% | Added |
| Deutsche Bank AG | 20,644 | $219.7K | 0.00% | +5,103+32.8% | Added |
| Velan Capital Investment Management LP | 20,000 | $212.8K | 0.13% | 00.0% | Unchanged |
| UBS Group AG | 17,091 | $181.8K | 0.00% | −8,446−33.1% | Reduced |
| Price T Rowe Associates Inc | 16,370 | $175.0K | 0.00% | +659+4.2% | Added |
| Two Sigma Investments, LP | 16,300 | $173.4K | 0.00% | −29,937−64.7% | Reduced |
| Engineers Gate Manager LP | 16,090 | $171.2K | 0.00% | +2,078+14.8% | Added |
| Brevan Howard Capital Management LP | 15,294 | $162.7K | 0.00% | +15,294 | New |
| MetLife Investment Management | 15,249 | $162.2K | 0.00% | 00.0% | Unchanged |
| Public Employees Retirement System of Ohio | 15,193 | $161.7K | 0.00% | +8,100+114.2% | Added |
| Nisa Investment Advisors, LLC | 14,824 | $157.7K | 0.00% | +3,000+25.4% | Added |
| Dynamic Technology Lab Private Ltd | 14,749 | $156.9K | 0.03% | +14,749 | New |
| Quantinno Capital Management LP | 14,128 | $150.3K | 0.00% | +14,128 | New |
| JPMorgan Chase & Co | 14,134 | $146.6K | 0.00% | −317−2.2% | Reduced |
| Mariner, LLC | 13,066 | $138.9K | 0.00% | +244+1.9% | Added |
| Baader Bank INC | 12,792 | $136.1K | 0.01% | −7,208−36.0% | Reduced |
| Vanguard Global Advisers, LLC | 11,839 | $126.0K | 0.00% | +11,839 | New |
| Mirabella Financial Services LLP | 11,814 | $125.7K | 0.01% | +11,814 | New |
| Royal Bank of Canada | 11,366 | $121.0K | 0.00% | +10,728+1,681.5% | Added |
| Mirae Asset Global ETFs Holdings Ltd. | 11,363 | $120.9K | 0.00% | +272+2.5% | Added |
| ADAR1 Capital Management, LLC | 10,000 | $106.4K | 0.01% | +10,000 | New |
| Wells Fargo & Company | 9,027 | $96.0K | 0.00% | −17,759−66.3% | Reduced |
| Police & Firemen's Retirement System of New Jersey | 6,598 | $70.2K | 0.00% | 00.0% | Unchanged |
| Citigroup Inc | 4,263 | $45.4K | 0.00% | +1,150+36.9% | Added |
| Rockefeller Capital Management L.P. | 3,684 | $39.2K | 0.00% | +2,946+399.2% | Added |
| Caz Investments LP | 3,500 | $37.2K | 0.04% | 00.0% | Unchanged |
| Mirae Asset Global Investments Co., Ltd. | 2,971 | $31.6K | 0.00% | +203+7.3% | Added |
| Ameritas Investment Partners, Inc. | 2,570 | $27.3K | 0.00% | 00.0% | Unchanged |
| Legal & General Group Plc | 2,077 | $22.1K | 0.00% | 00.0% | Unchanged |
| New York State Common Retirement Fund | 2,026 | $21.6K | 0.00% | 00.0% | Unchanged |
| The PNC Financial Services Group, Inc. | 1,816 | $19.3K | 0.00% | 00.0% | Unchanged |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 1,594 | $17.0K | 0.00% | +367+29.9% | Added |
| Tower Research Capital LLC (TRC) | 1,545 | $16.4K | 0.00% | −2,728−63.8% | Reduced |
| GAMMA Investing LLC | 1,472 | $15.7K | 0.00% | +722+96.3% | Added |