Design Therapeutics, Inc.
DSGN- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001807120
No open-market purchases or sales by Design Therapeutics, Inc. insiders were filed in the last 90 days; 136 institutions reported holding it in 13F filings for Q2 2026, worth $626.4M in total; no superinvestor holds it.
13F holders, Q4 2025
Institutional positions in Design Therapeutics, Inc. as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 117
- +23 vs. Q3 2025
- Shares held
- 38.1M
- +3.63M (+10.5%) vs. Q3 2025
- Total value
- $357.6M
- +$97.9M (+37.7%) vs. Q3 2025
- New holders
- 31
- 39 more added
- Sold out
- 8
- 28 more reduced
1 institution that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting DSGN on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 136 | $626.4M |
| Q1 2026 | 125 | $404.1M |
| Q4 2025 | 117 | $357.6M |
| Q3 2025 | 95 | $259.7M |
| Q2 2025 | 93 | $116.4M |
| Q1 2025 | 98 | $133.0M |
| Q4 2024 | 95 | $206.5M |
| Q3 2024 | 100 | $172.3M |
| Q2 2024 | 95 | $107.5M |
| Q1 2024 | 93 | $123.9M |
| Q4 2023 | 88 | $84.0M |
| Q3 2023 | 87 | $77.6M |
| Q2 2023 | 97 | $244.4M |
| Q1 2023 | 96 | $223.3M |
| Q4 2022 | 83 | $414.2M |
| Q3 2022 | 79 | $667.2M |
| Q2 2022 | 74 | $541.7M |
| Q1 2022 | 63 | $613.7M |
| Q4 2021 | 60 | $773.1M |
| Q3 2021 | 52 | $414.8M |
| Q2 2021 | 50 | $546.2M |
| Q1 2021 | 43 | $755.2M |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Design Therapeutics, Inc.; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Sr One Capital Management, LP | 6,526,476 | $61.2M | 8.67% | 00.0% | Unchanged |
| Point72 Asset Management, L.P. | 5,372,004 | $50.4M | 0.08% | +2,031,452+60.8% | Added |
| Logos Global Management LP | 2,500,000 | $23.4M | 1.56% | −1,155,000−31.6% | Reduced |
| Baker Bros. Advisors LP | 2,233,099 | $20.9M | 0.12% | +520,217+30.4% | Added |
| BlackRock, Inc. | 2,117,156 | $19.9M | 0.00% | +72,768+3.6% | Added |
| Vanguard Group Inc | 1,630,910 | $15.3M | 0.00% | +187,209+13.0% | Added |
| Vivo Capital, LLC | 1,612,903 | $15.1M | 0.98% | +1,612,903 | New |
| Almitas Capital LLC | 1,530,435 | $14.4M | 3.16% | 00.0% | Unchanged |
| Ra Capital Management, L.P. | 1,461,381 | $13.7M | 0.14% | +985,682+207.2% | Added |
| Driehaus Capital Management LLC | 1,179,817 | $11.1M | 0.08% | +103,581+9.6% | Added |
| Woodline Partners LP | 944,039 | $8.86M | 0.03% | +331,327+54.1% | Added |
| Kynam Capital Management, LP | 784,606 | $7.36M | 0.48% | −244,973−23.8% | Reduced |
| FMR LLC | 771,268 | $7.23M | 0.00% | +30,419+4.1% | Added |
| Morgan Stanley | 702,306 | $6.59M | 0.00% | +526,315+299.1% | Added |
| Geode Capital Management, LLC | 679,590 | $6.38M | 0.00% | −16,023−2.3% | Reduced |
| State Street Corp | 647,636 | $6.07M | 0.00% | +13,239+2.1% | Added |
| Acadian Asset Management LLC | 612,768 | $5.74M | 0.01% | −4,721−0.8% | Reduced |
| Frazier Life Sciences Management, L.P. | 521,000 | $4.89M | 0.13% | −1,432,547−73.3% | Reduced |
| Citadel Advisors LLC | 459,874 | $4.31M | 0.00% | −94,146−17.0% | Reduced |
| D. E. Shaw & Co., Inc. | 438,894 | $4.12M | 0.00% | +65,618+17.6% | Added |
| Invesco Ltd. | 305,757 | $2.87M | 0.00% | +291,168+1,995.8% | Added |
| Dimensional Fund Advisors LP | 297,921 | $2.80M | 0.00% | +18,104+6.5% | Added |
| Renaissance Technologies LLC | 287,100 | $2.69M | 0.00% | +12,800+4.7% | Added |
| Northern Trust Corp | 286,572 | $2.69M | 0.00% | −9,957−3.4% | Reduced |
| Goldman Sachs Group Inc | 270,654 | $2.54M | 0.00% | +9,209+3.5% | Added |
| Charles Schwab Investment Management Inc | 236,863 | $2.22M | 0.00% | −11,071−4.5% | Reduced |
| Jane Street Group, LLC | 226,512 | $2.12M | 0.00% | +108,679+92.2% | Added |
| Marshall Wace, LLP | 225,528 | $2.12M | 0.00% | +225,528 | New |
| Elmind Capital, LP | 207,900 | $1.95M | 0.58% | +207,900 | New |
| Jacobs Levy Equity Management, Inc | 194,611 | $1.83M | 0.01% | +194,611 | New |
| Algert Global LLC | 187,769 | $1.76M | 0.03% | +187,769 | New |
| Millennium Management LLC | 180,866 | $1.70M | 0.00% | +112,043+162.8% | Added |
| Ameriprise Financial Inc | 158,383 | $1.49M | 0.00% | +158,383 | New |
| Acuta Capital Partners, LLC | 150,906 | $1.42M | 0.96% | +150,906 | New |
| Nuveen, LLC | 125,260 | $1.17M | 0.00% | −7,768−5.8% | Reduced |
| Raymond James Financial Inc | 109,763 | $1.03M | 0.00% | +109,763 | New |
| Diadema Partners LP | 100,320 | $941.0K | 0.56% | +100,320 | New |
| Trexquant Investment LP | 99,967 | $937.7K | 0.01% | +99,967 | New |
| BNP Paribas Arbitrage, SA | 94,828 | $889.5K | 0.00% | +89,695+1,747.4% | Added |
| Barclays PLC | 87,060 | $816.6K | 0.00% | −1,116−1.3% | Reduced |
| Bank of New York Mellon Corp | 84,975 | $797.1K | 0.00% | −2,500−2.9% | Reduced |
| EAM Investors, LLC | 78,949 | $740.5K | 0.08% | +78,949 | New |
| Bridgeway Capital Management, LLC | 78,500 | $736.3K | 0.02% | −109,700−58.3% | Reduced |
| Lynx1 Capital Management LP | 69,516 | $652.1K | 0.13% | +3,562+5.4% | Added |
| Palumbo Wealth Management LLC | 69,377 | $650.8K | 0.16% | +17,296+33.2% | Added |
| Susquehanna International Group, LLP | 61,852 | $580.2K | 0.00% | +47,829+341.1% | Added |
| American Century Companies Inc | 57,798 | $542.1K | 0.00% | +6,946+13.7% | Added |
| Canada Pension Plan Investment Board | 54,600 | $512.1K | 0.00% | +54,600 | New |
| SEI Investments Co | 52,730 | $494.6K | 0.00% | +52,730 | New |
| State of Wisconsin Investment Board | 50,657 | $475.2K | 0.00% | +23,595+87.2% | Added |
| Kennedy Capital Management, Inc. | 50,023 | $469.2K | 0.01% | +20,612+70.1% | Added |
| Alps Advisors Inc | 46,771 | $438.7K | 0.00% | +46,771 | New |
| Two Sigma Investments, LP | 46,237 | $433.7K | 0.00% | −13,000−21.9% | Reduced |
| Squarepoint Ops LLC | 46,142 | $432.8K | 0.00% | +46,142 | New |
| Alliancebernstein L.P. | 46,120 | $432.6K | 0.00% | 00.0% | Unchanged |
| Prudential Financial Inc | 42,710 | $400.6K | 0.00% | −2,115−4.7% | Reduced |
| XTX Topco Ltd | 35,284 | $331.0K | 0.01% | +23,416+197.3% | Added |
| Persistent Asset Partners Ltd | 34,989 | $328.2K | 0.16% | +34,989 | New |
| Rhumbline Advisers | 34,778 | $326.2K | 0.00% | −11,556−24.9% | Reduced |
| China Universal Asset Management Co., Ltd. | 34,282 | $321.6K | 0.02% | −700−2.0% | Reduced |
| Bank of America Corp | 27,446 | $257.4K | 0.00% | +3,539+14.8% | Added |
| CI Private Wealth, LLC | 26,965 | $252.9K | 0.00% | +26,965 | New |
| Wells Fargo & Company | 26,786 | $251.3K | 0.00% | +8,469+46.2% | Added |
| UBS Group AG | 25,537 | $239.5K | 0.00% | +2,844+12.5% | Added |
| Two Sigma Advisers, LP | 25,300 | $237.3K | 0.00% | −15,200−37.5% | Reduced |
| Russell Investments Group, Ltd. | 25,234 | $236.7K | 0.00% | +18,857+295.7% | Added |
| STRS Ohio | 25,200 | $236.4K | 0.00% | +2,600+11.5% | Added |
| Virtu Financial LLC | 22,651 | $212.0K | 0.01% | +22,651 | New |
| AlphaCentric Advisors LLC | 20,262 | $190.1K | 0.19% | +20,262 | New |
| Velan Capital Investment Management LP | 20,000 | $187.6K | 0.11% | 00.0% | Unchanged |
| Baader Bank INC | 20,000 | $187.6K | 0.02% | +20,000 | New |
| 9823 Capital, L.P. | 19,197 | $180.1K | 0.12% | +19,197 | New |
| Price T Rowe Associates Inc | 15,711 | $148.0K | 0.00% | −603−3.7% | Reduced |
| Deutsche Bank AG | 15,541 | $145.8K | 0.00% | +15,541 | New |
| MetLife Investment Management | 15,249 | $143.0K | 0.00% | +4,929+47.8% | Added |
| JPMorgan Chase & Co | 14,451 | $135.6K | 0.00% | −8,770−37.8% | Reduced |
| Engineers Gate Manager LP | 14,012 | $131.4K | 0.00% | +14,012 | New |
| AQR Capital Management LLC | 13,730 | $128.8K | 0.00% | +66+0.5% | Added |
| Mariner, LLC | 12,822 | $120.0K | 0.00% | −3,259−20.3% | Reduced |
| Nisa Investment Advisors, LLC | 11,824 | $110.9K | 0.00% | 00.0% | Unchanged |
| Axq Capital, LP | 11,728 | $110.0K | 0.02% | +11,728 | New |
| Two Sigma Securities, LLC | 11,396 | $106.9K | 0.01% | +11,396 | New |
| Mirae Asset Global ETFs Holdings Ltd. | 11,091 | $104.0K | 0.00% | +367+3.4% | Added |
| Public Employees Retirement System of Ohio | 7,093 | $66.5K | 0.00% | +7,093 | New |
| Police & Firemen's Retirement System of New Jersey | 6,598 | $61.9K | 0.00% | 00.0% | Unchanged |
| Tower Research Capital LLC (TRC) | 4,273 | $40.1K | 0.00% | +2,314+118.1% | Added |
| Caz Investments LP | 3,500 | $32.8K | 0.06% | −1,500−30.0% | Reduced |
| Citigroup Inc | 3,113 | $29.2K | 0.00% | +1,523+95.8% | Added |
| Torren Management, LLC | 2,820 | $26.5K | 0.01% | +2,820 | New |
| Mirae Asset Global Investments Co., Ltd. | 2,768 | $26.0K | 0.00% | +566+25.7% | Added |
| Ameritas Investment Partners, Inc. | 2,570 | $24.1K | 0.00% | 00.0% | Unchanged |
| Legal & General Group Plc | 2,077 | $19.5K | 0.00% | 00.0% | Unchanged |
| New York State Common Retirement Fund | 2,026 | $19.0K | 0.00% | 00.0% | Unchanged |
| The PNC Financial Services Group, Inc. | 1,816 | $17.0K | 0.00% | −7−0.4% | Reduced |
| California State Teachers Retirement System | 1,471 | $13.8K | 0.00% | −498−25.3% | Reduced |
| Sterling Capital Management LLC | 1,377 | $12.9K | 0.00% | −271−16.4% | Reduced |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 1,227 | $11.5K | 0.00% | 00.0% | Unchanged |
| GF Fund Management Co. Ltd. | 1,118 | $10.5K | 0.00% | −95−7.8% | Reduced |
| GAMMA Investing LLC | 750 | $7.04K | 0.00% | +307+69.3% | Added |
| Amalgamated Bank | 751 | $7.00K | 0.00% | −425−36.1% | Reduced |