Design Therapeutics, Inc.
DSGN- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001807120
No open-market purchases or sales by Design Therapeutics, Inc. insiders were filed in the last 90 days; 136 institutions reported holding it in 13F filings for Q2 2026, worth $626.4M in total; no superinvestor holds it.
13F holders, Q4 2025
Institutional positions in Design Therapeutics, Inc. as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 117
- +23 vs. Q3 2025
- Shares held
- 38.1M
- +3.63M (+10.5%) vs. Q3 2025
- Total value
- $357.6M
- +$97.9M (+37.7%) vs. Q3 2025
- New holders
- 31
- 39 more added
- Sold out
- 8
- 28 more reduced
1 institution that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting DSGN on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 136 | $626.4M |
| Q1 2026 | 125 | $404.1M |
| Q4 2025 | 117 | $357.6M |
| Q3 2025 | 95 | $259.7M |
| Q2 2025 | 93 | $116.4M |
| Q1 2025 | 98 | $133.0M |
| Q4 2024 | 95 | $206.5M |
| Q3 2024 | 100 | $172.3M |
| Q2 2024 | 95 | $107.5M |
| Q1 2024 | 93 | $123.9M |
| Q4 2023 | 88 | $84.0M |
| Q3 2023 | 87 | $77.6M |
| Q2 2023 | 97 | $244.4M |
| Q1 2023 | 96 | $223.3M |
| Q4 2022 | 83 | $414.2M |
| Q3 2022 | 79 | $667.2M |
| Q2 2022 | 74 | $541.7M |
| Q1 2022 | 63 | $613.7M |
| Q4 2021 | 60 | $773.1M |
| Q3 2021 | 52 | $414.8M |
| Q2 2021 | 50 | $546.2M |
| Q1 2021 | 43 | $755.2M |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Design Therapeutics, Inc.; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Capital Advisors, Ltd. LLC | 12 | $0 | 0.00% | 00.0% | Unchanged |
| True Wealth Design, LLC | 1 | $10 | 0.00% | +1 | New |
| EverSource Wealth Advisors, LLC | 3 | $28 | 0.00% | −232−98.7% | Reduced |
| Larson Financial Group LLC | 3 | $28 | 0.00% | 00.0% | Unchanged |
| Advisor Group Holdings, Inc. | 10 | $94 | 0.00% | +10 | New |
| SRS Capital Advisors, Inc. | 47 | $441 | 0.00% | −147−75.8% | Reduced |
| Daiwa Securities Group Inc. | 100 | $1.00K | 0.00% | 00.0% | Unchanged |
| CWM, LLC | 239 | $2.00K | 0.00% | +17+7.7% | Added |
| Massmutual Trust Co FSB | 239 | $2.24K | 0.00% | 00.0% | Unchanged |
| UMA Financial Services, Inc. | 268 | $2.51K | 0.00% | 00.0% | Unchanged |
| Optiver Holding B.V. | 328 | $3.08K | 0.00% | 00.0% | Unchanged |
| UBS Asset Management Americas Inc | 380 | $3.56K | 0.00% | +380 | New |
| Farther Finance Advisors, LLC | 385 | $3.61K | 0.00% | 00.0% | Unchanged |
| Private Wealth Management Group, LLC | 558 | $5.24K | 0.00% | 00.0% | Unchanged |
| Clearstead Advisors, LLC | 610 | $5.72K | 0.00% | 00.0% | Unchanged |
| Royal Bank of Canada | 638 | $6.00K | 0.00% | +193+43.4% | Added |
| Rockefeller Capital Management L.P. | 738 | $6.92K | 0.00% | +738 | New |
| Amalgamated Bank | 751 | $7.00K | 0.00% | −425−36.1% | Reduced |
| GAMMA Investing LLC | 750 | $7.04K | 0.00% | +307+69.3% | Added |
| GF Fund Management Co. Ltd. | 1,118 | $10.5K | 0.00% | −95−7.8% | Reduced |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 1,227 | $11.5K | 0.00% | 00.0% | Unchanged |
| Sterling Capital Management LLC | 1,377 | $12.9K | 0.00% | −271−16.4% | Reduced |
| California State Teachers Retirement System | 1,471 | $13.8K | 0.00% | −498−25.3% | Reduced |
| The PNC Financial Services Group, Inc. | 1,816 | $17.0K | 0.00% | −7−0.4% | Reduced |
| New York State Common Retirement Fund | 2,026 | $19.0K | 0.00% | 00.0% | Unchanged |
| Legal & General Group Plc | 2,077 | $19.5K | 0.00% | 00.0% | Unchanged |
| Ameritas Investment Partners, Inc. | 2,570 | $24.1K | 0.00% | 00.0% | Unchanged |
| Mirae Asset Global Investments Co., Ltd. | 2,768 | $26.0K | 0.00% | +566+25.7% | Added |
| Torren Management, LLC | 2,820 | $26.5K | 0.01% | +2,820 | New |
| Citigroup Inc | 3,113 | $29.2K | 0.00% | +1,523+95.8% | Added |
| Caz Investments LP | 3,500 | $32.8K | 0.06% | −1,500−30.0% | Reduced |
| Tower Research Capital LLC (TRC) | 4,273 | $40.1K | 0.00% | +2,314+118.1% | Added |
| Police & Firemen's Retirement System of New Jersey | 6,598 | $61.9K | 0.00% | 00.0% | Unchanged |
| Public Employees Retirement System of Ohio | 7,093 | $66.5K | 0.00% | +7,093 | New |
| Mirae Asset Global ETFs Holdings Ltd. | 11,091 | $104.0K | 0.00% | +367+3.4% | Added |
| Two Sigma Securities, LLC | 11,396 | $106.9K | 0.01% | +11,396 | New |
| Axq Capital, LP | 11,728 | $110.0K | 0.02% | +11,728 | New |
| Nisa Investment Advisors, LLC | 11,824 | $110.9K | 0.00% | 00.0% | Unchanged |
| Mariner, LLC | 12,822 | $120.0K | 0.00% | −3,259−20.3% | Reduced |
| AQR Capital Management LLC | 13,730 | $128.8K | 0.00% | +66+0.5% | Added |
| Engineers Gate Manager LP | 14,012 | $131.4K | 0.00% | +14,012 | New |
| JPMorgan Chase & Co | 14,451 | $135.6K | 0.00% | −8,770−37.8% | Reduced |
| MetLife Investment Management | 15,249 | $143.0K | 0.00% | +4,929+47.8% | Added |
| Deutsche Bank AG | 15,541 | $145.8K | 0.00% | +15,541 | New |
| Price T Rowe Associates Inc | 15,711 | $148.0K | 0.00% | −603−3.7% | Reduced |
| 9823 Capital, L.P. | 19,197 | $180.1K | 0.12% | +19,197 | New |
| Velan Capital Investment Management LP | 20,000 | $187.6K | 0.11% | 00.0% | Unchanged |
| Baader Bank INC | 20,000 | $187.6K | 0.02% | +20,000 | New |
| AlphaCentric Advisors LLC | 20,262 | $190.1K | 0.19% | +20,262 | New |
| Virtu Financial LLC | 22,651 | $212.0K | 0.01% | +22,651 | New |
| STRS Ohio | 25,200 | $236.4K | 0.00% | +2,600+11.5% | Added |
| Russell Investments Group, Ltd. | 25,234 | $236.7K | 0.00% | +18,857+295.7% | Added |
| Two Sigma Advisers, LP | 25,300 | $237.3K | 0.00% | −15,200−37.5% | Reduced |
| UBS Group AG | 25,537 | $239.5K | 0.00% | +2,844+12.5% | Added |
| Wells Fargo & Company | 26,786 | $251.3K | 0.00% | +8,469+46.2% | Added |
| CI Private Wealth, LLC | 26,965 | $252.9K | 0.00% | +26,965 | New |
| Bank of America Corp | 27,446 | $257.4K | 0.00% | +3,539+14.8% | Added |
| China Universal Asset Management Co., Ltd. | 34,282 | $321.6K | 0.02% | −700−2.0% | Reduced |
| Rhumbline Advisers | 34,778 | $326.2K | 0.00% | −11,556−24.9% | Reduced |
| Persistent Asset Partners Ltd | 34,989 | $328.2K | 0.16% | +34,989 | New |
| XTX Topco Ltd | 35,284 | $331.0K | 0.01% | +23,416+197.3% | Added |
| Prudential Financial Inc | 42,710 | $400.6K | 0.00% | −2,115−4.7% | Reduced |
| Alliancebernstein L.P. | 46,120 | $432.6K | 0.00% | 00.0% | Unchanged |
| Squarepoint Ops LLC | 46,142 | $432.8K | 0.00% | +46,142 | New |
| Two Sigma Investments, LP | 46,237 | $433.7K | 0.00% | −13,000−21.9% | Reduced |
| Alps Advisors Inc | 46,771 | $438.7K | 0.00% | +46,771 | New |
| Kennedy Capital Management, Inc. | 50,023 | $469.2K | 0.01% | +20,612+70.1% | Added |
| State of Wisconsin Investment Board | 50,657 | $475.2K | 0.00% | +23,595+87.2% | Added |
| SEI Investments Co | 52,730 | $494.6K | 0.00% | +52,730 | New |
| Canada Pension Plan Investment Board | 54,600 | $512.1K | 0.00% | +54,600 | New |
| American Century Companies Inc | 57,798 | $542.1K | 0.00% | +6,946+13.7% | Added |
| Susquehanna International Group, LLP | 61,852 | $580.2K | 0.00% | +47,829+341.1% | Added |
| Palumbo Wealth Management LLC | 69,377 | $650.8K | 0.16% | +17,296+33.2% | Added |
| Lynx1 Capital Management LP | 69,516 | $652.1K | 0.13% | +3,562+5.4% | Added |
| Bridgeway Capital Management, LLC | 78,500 | $736.3K | 0.02% | −109,700−58.3% | Reduced |
| EAM Investors, LLC | 78,949 | $740.5K | 0.08% | +78,949 | New |
| Bank of New York Mellon Corp | 84,975 | $797.1K | 0.00% | −2,500−2.9% | Reduced |
| Barclays PLC | 87,060 | $816.6K | 0.00% | −1,116−1.3% | Reduced |
| BNP Paribas Arbitrage, SA | 94,828 | $889.5K | 0.00% | +89,695+1,747.4% | Added |
| Trexquant Investment LP | 99,967 | $937.7K | 0.01% | +99,967 | New |
| Diadema Partners LP | 100,320 | $941.0K | 0.56% | +100,320 | New |
| Raymond James Financial Inc | 109,763 | $1.03M | 0.00% | +109,763 | New |
| Nuveen, LLC | 125,260 | $1.17M | 0.00% | −7,768−5.8% | Reduced |
| Acuta Capital Partners, LLC | 150,906 | $1.42M | 0.96% | +150,906 | New |
| Ameriprise Financial Inc | 158,383 | $1.49M | 0.00% | +158,383 | New |
| Millennium Management LLC | 180,866 | $1.70M | 0.00% | +112,043+162.8% | Added |
| Algert Global LLC | 187,769 | $1.76M | 0.03% | +187,769 | New |
| Jacobs Levy Equity Management, Inc | 194,611 | $1.83M | 0.01% | +194,611 | New |
| Elmind Capital, LP | 207,900 | $1.95M | 0.58% | +207,900 | New |
| Marshall Wace, LLP | 225,528 | $2.12M | 0.00% | +225,528 | New |
| Jane Street Group, LLC | 226,512 | $2.12M | 0.00% | +108,679+92.2% | Added |
| Charles Schwab Investment Management Inc | 236,863 | $2.22M | 0.00% | −11,071−4.5% | Reduced |
| Goldman Sachs Group Inc | 270,654 | $2.54M | 0.00% | +9,209+3.5% | Added |
| Northern Trust Corp | 286,572 | $2.69M | 0.00% | −9,957−3.4% | Reduced |
| Renaissance Technologies LLC | 287,100 | $2.69M | 0.00% | +12,800+4.7% | Added |
| Dimensional Fund Advisors LP | 297,921 | $2.80M | 0.00% | +18,104+6.5% | Added |
| Invesco Ltd. | 305,757 | $2.87M | 0.00% | +291,168+1,995.8% | Added |
| D. E. Shaw & Co., Inc. | 438,894 | $4.12M | 0.00% | +65,618+17.6% | Added |
| Citadel Advisors LLC | 459,874 | $4.31M | 0.00% | −94,146−17.0% | Reduced |
| Frazier Life Sciences Management, L.P. | 521,000 | $4.89M | 0.13% | −1,432,547−73.3% | Reduced |