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Design Therapeutics, Inc.

DSGN
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
SEC CIK
0001807120

No open-market purchases or sales by Design Therapeutics, Inc. insiders were filed in the last 90 days; 136 institutions reported holding it in 13F filings for Q2 2026, worth $626.4M in total; no superinvestor holds it.

13F holders, Q2 2025

Institutional positions in Design Therapeutics, Inc. as of Jun 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
93
−5 vs. Q1 2025
Shares held
34.5M
+70.8K (+0.2%) vs. Q1 2025
Total value
$116.4M
−$16.6M (−12.5%) vs. Q1 2025
New holders
6
35 more added
Sold out
11
34 more reduced

Compare with Q1 2025: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting DSGN on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ2 2025: 93 institutions
Q1 2021: 43 institutionsQ2 2021: 50 institutionsQ3 2021: 52 institutionsQ4 2021: 60 institutionsQ1 2022: 63 institutionsQ2 2022: 74 institutionsQ3 2022: 79 institutionsQ4 2022: 83 institutionsQ1 2023: 96 institutionsQ2 2023: 97 institutionsQ3 2023: 87 institutionsQ4 2023: 88 institutionsQ1 2024: 93 institutionsQ2 2024: 95 institutionsQ3 2024: 100 institutionsQ4 2024: 95 institutionsQ1 2025: 98 institutionsQ2 2025: 93 institutionsQ3 2025: 95 institutionsQ4 2025: 117 institutionsQ1 2026: 125 institutionsQ2 2026: 136 institutions
Value heldQ2 2025: $116.4M
Q1 2021: $755.2MQ2 2021: $546.2MQ3 2021: $414.8MQ4 2021: $773.1MQ1 2022: $613.7MQ2 2022: $541.7MQ3 2022: $667.2MQ4 2022: $414.2MQ1 2023: $223.3MQ2 2023: $244.4MQ3 2023: $77.6MQ4 2023: $84.0MQ1 2024: $123.9MQ2 2024: $107.5MQ3 2024: $172.3MQ4 2024: $206.5MQ1 2025: $133.0MQ2 2025: $116.4MQ3 2025: $259.7MQ4 2025: $357.6MQ1 2026: $404.1MQ2 2026: $626.4M
Institutions holding DSGN and their total value by quarter
QuarterHoldersValue
Q2 2026136$626.4M
Q1 2026125$404.1M
Q4 2025117$357.6M
Q3 202595$259.7M
Q2 202593$116.4M
Q1 202598$133.0M
Q4 202495$206.5M
Q3 2024100$172.3M
Q2 202495$107.5M
Q1 202493$123.9M
Q4 202388$84.0M
Q3 202387$77.6M
Q2 202397$244.4M
Q1 202396$223.3M
Q4 202283$414.2M
Q3 202279$667.2M
Q2 202274$541.7M
Q1 202263$613.7M
Q4 202160$773.1M
Q3 202152$414.8M
Q2 202150$546.2M
Q1 202143$755.2M

Institutions, Q2 2025

Shares, value and share of portfolio for each institution holding Design Therapeutics, Inc.; share changes are against Q1 2025.

Institutions holding DSGN in Q2 2025
InstitutionSharesValue% of portfolioChange in sharesAction
Sr One Capital Management, LP6,526,476$22.0M4.77%00.0%Unchanged
Logos Global Management LP4,217,627$14.2M1.90%00.0%Unchanged
BlackRock, Inc.2,395,743$8.07M0.00%−84,220−3.4%Reduced
Frazier Life Sciences Management, L.P.1,953,547$6.58M0.26%00.0%Unchanged
Point72 Asset Management, L.P.1,807,218$6.09M0.01%−10,640−0.6%Reduced
Tang Capital Management LLC1,780,975$6.00M0.30%+100,000+5.9%Added
Baker Bros. Advisors LP1,712,882$5.77M0.06%−30,843−1.8%Reduced
Almitas Capital LLC1,530,435$5.16M1.30%+77,539+5.3%Added
Vanguard Group Inc1,471,574$4.96M0.00%+44,107+3.1%Added
Driehaus Capital Management LLC1,076,236$3.63M0.03%+162,837+17.8%Added
Kynam Capital Management, LP1,029,579$3.47M0.37%+125,562+13.9%Added
FMR LLC951,198$3.21M0.00%+3,148+0.3%Added
Citadel Advisors LLC840,793$2.83M0.00%−122,667−12.7%Reduced
Geode Capital Management, LLC794,008$2.68M0.00%+18,511+2.4%Added
Woodline Partners LP777,537$2.62M0.01%+131,843+20.4%Added
State Street Corp719,212$2.42M0.00%+5,138+0.7%Added
Acadian Asset Management LLC627,348$2.11M0.00%−3,605−0.6%Reduced
MPM Oncology Impact Management LP555,187$1.87M0.32%−7,756−1.4%Reduced
D. E. Shaw & Co., Inc.390,648$1.32M0.00%−4,603−1.2%Reduced
Northern Trust Corp362,518$1.22M0.00%−11,135−3.0%Reduced
Dimensional Fund Advisors LP313,363$1.06M0.00%+24,761+8.6%Added
Renaissance Technologies LLC267,800$902.5K0.00%+2,800+1.1%Added
Charles Schwab Investment Management Inc250,949$845.7K0.00%−7,426−2.9%Reduced
Goldman Sachs Group Inc239,459$807.0K0.00%−26,557−10.0%Reduced
Morgan Stanley213,550$719.7K0.00%−34,328−13.8%Reduced
Bridgeway Capital Management, LLC188,200$634.2K0.02%+74,400+65.4%Added
Nuveen, LLC133,028$448.3K0.00%−14,200−9.6%Reduced
Barclays PLC109,536$369.1K0.00%+25,530+30.4%Added
Two Sigma Advisers, LP108,500$365.6K0.00%−38,200−26.0%Reduced
Bank of New York Mellon Corp94,603$318.8K0.00%−745−0.8%Reduced
Two Sigma Investments, LP89,311$301.0K0.00%−39,436−30.6%Reduced
Lynx1 Capital Management LP65,954$222.3K0.06%00.0%Unchanged
Palumbo Wealth Management LLC60,555$204.1K0.06%+2,277+3.9%Added
Gsa Capital Partners LLP59,975$202.0K0.01%−12,174−16.9%Reduced
Prudential Financial Inc57,925$195.2K0.00%+1,520+2.7%Added
Rhumbline Advisers48,317$162.8K0.00%+1,948+4.2%Added
American Century Companies Inc46,385$156.3K0.00%+1,970+4.4%Added
Alliancebernstein L.P.45,030$151.8K0.00%+2,940+7.0%Added
ADAR1 Capital Management, LLC42,408$142.9K0.02%+42,408New
Susquehanna International Group, LLP38,170$128.6K0.00%−5,053−11.7%Reduced
Assenagon Asset Management S.A.31,125$104.9K0.00%−5,792−15.7%Reduced
Jane Street Group, LLC31,079$104.7K0.00%+12,954+71.5%Added
AQR Capital Management LLC28,726$96.8K0.00%−3,014−9.5%Reduced
State of Wisconsin Investment Board28,662$96.6K0.00%+6,700+30.5%Added
Deutsche Bank AG28,094$94.7K0.00%−35−0.1%Reduced
UBS Group AG27,342$92.1K0.00%−5,477−16.7%Reduced
CI Private Wealth, LLC26,965$90.9K0.00%00.0%Unchanged
Bank of America Corp24,625$83.0K0.00%+2,459+11.1%Added
STRS Ohio22,600$76.2K0.00%00.0%Unchanged
Wells Fargo & Company20,284$68.4K0.00%+1,438+7.6%Added
Velan Capital Investment Management LP20,000$67.4K0.07%+6,000+42.9%Added
Intech Investment Management LLC19,668$66.3K0.00%−882−4.3%Reduced
JPMorgan Chase & Co18,325$61.8K0.00%−952−4.9%Reduced
Mirae Asset Global ETFs Holdings Ltd.17,957$60.5K0.00%−780−4.2%Reduced
Price T Rowe Associates Inc16,314$55.0K0.00%+3,245+24.8%Added
Mariner, LLC15,740$53.0K0.00%+269+1.7%Added
Kennedy Capital Management, Inc.15,010$50.6K0.00%+627+4.4%Added
Invesco Ltd.14,364$48.4K0.00%+3,033+26.8%Added
Citigroup Inc13,648$46.0K0.00%−9,231−40.3%Reduced
Jacobs Levy Equity Management, Inc13,501$45.5K0.00%−3,981−22.8%Reduced
Los Angeles Capital Management LLC12,735$42.9K0.00%+12,735New
Manufacturers Life Insurance Company, The11,955$40.3K0.00%−1,002−7.7%Reduced
Nisa Investment Advisors, LLC11,824$39.8K0.00%−92−0.8%Reduced
China Universal Asset Management Co., Ltd.11,402$38.4K0.00%+45+0.4%Added
Tower Research Capital LLC (TRC)9,698$32.7K0.00%+1,796+22.7%Added
Caz Investments LP7,500$25.3K0.14%−7,500−50.0%Reduced
Police & Firemen's Retirement System of New Jersey6,598$22.2K0.00%00.0%Unchanged
Royal Bank of Canada3,812$13.0K0.00%+1,006+35.9%Added
BNP Paribas Arbitrage, SA3,823$12.9K0.00%−49,049−92.8%Reduced
Russell Investments Group, Ltd.3,759$12.7K0.00%−181−4.6%Reduced
Legal & General Group Plc3,078$10.4K0.00%+513+20.0%Added
Ameritas Investment Partners, Inc.2,570$8.66K0.00%00.0%Unchanged
Mirae Asset Global Investments Co., Ltd.2,193$7.39K0.00%+298+15.7%Added
New York State Common Retirement Fund2,026$6.83K0.00%00.0%Unchanged
Zurcher Kantonalbank (Zurich Cantonalbank)1,817$6.12K0.00%−348−16.1%Reduced
The PNC Financial Services Group, Inc.1,671$5.63K0.00%−7,580−81.9%Reduced
GF Fund Management Co. Ltd.1,449$4.88K0.00%00.0%Unchanged
Amalgamated Bank1,176$4.00K0.00%00.0%Unchanged
Sterling Capital Management LLC841$2.83K0.00%+299+55.2%Added
Clearstead Advisors, LLC610$2.06K0.00%00.0%Unchanged
Private Wealth Management Group, LLC558$1.88K0.00%00.0%Unchanged
Daiwa Securities Group Inc.350$1.00K0.00%00.0%Unchanged
CWM, LLC271$1.00K0.00%+160+144.1%Added
UMA Financial Services, Inc.268$9040.00%+268New
Massmutual Trust Co FSB239$8050.00%00.0%Unchanged
EverSource Wealth Advisors, LLC235$7920.00%+204+658.1%Added
Rise Advisors, LLC130$4380.00%+130New
IFP Advisors, Inc0$1550.00%0New
Point72 (DIFC) Ltd20$660.00%+20New
Skopos Labs, Inc.19$650.00%00.0%Unchanged
Farther Finance Advisors, LLC19$640.00%00.0%Unchanged
Advisor Group Holdings, Inc.10$340.00%−39−79.6%Reduced
Capital Advisors, Ltd. LLC12$00.00%00.0%Unchanged
Wellington Management Group LLP0$00.00%−141,519−100.0%Sold out
Millennium Management LLC0$00.00%−87,988−100.0%Sold out
MetLife Investment Management0$00.00%−18,962−100.0%Sold out
Corebridge Financial, Inc.0$00.00%−15,383−100.0%Sold out
SG Americas Securities, LLC0$00.00%−12,980−100.0%Sold out
CoreCap Advisors, LLC0$00.00%−2,879−100.0%Sold out
California State Teachers Retirement System0$00.00%−2,275−100.0%Sold out