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Definium Therapeutics, Inc.

DFTX
Exchange
Nasdaq
Industry
Medicinal Chemicals & Botanical Products
SEC CIK
0001813814

In the last 90 days, Definium Therapeutics, Inc. insiders filed 0 open-market purchases and 1 sale; 362 institutions reported holding it in 13F filings for Q2 2026, worth $5.35B in total; Duquesne Family Office is the only superinvestor holding it.

13F holders, Q3 2025

Institutional positions in Definium Therapeutics, Inc. as of Sep 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
196
+15 vs. Q2 2025
Shares held
39.7M
−2.05M (−4.9%) vs. Q2 2025
Total value
$468.6M
+$197.6M (+72.9%) vs. Q2 2025
New holders
39
56 more added
Sold out
24
48 more reduced

2 institutions that held it in Q2 2025 haven't filed for Q3 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.

Compare with Q2 2025: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting DFTX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ3 2025: 196 institutions
Q1 2021: 8 institutionsQ2 2021: 156 institutionsQ3 2021: 175 institutionsQ4 2021: 176 institutionsQ1 2022: 159 institutionsQ2 2022: 156 institutionsQ3 2022: 101 institutionsQ4 2022: 104 institutionsQ1 2023: 89 institutionsQ2 2023: 84 institutionsQ3 2023: 93 institutionsQ4 2023: 104 institutionsQ1 2024: 135 institutionsQ2 2024: 152 institutionsQ3 2024: 158 institutionsQ4 2024: 174 institutionsQ1 2025: 191 institutionsQ2 2025: 183 institutionsQ3 2025: 196 institutionsQ4 2025: 209 institutionsQ1 2026: 248 institutionsQ2 2026: 362 institutions
Value heldQ3 2025: $468.6M
Q1 2021: $932.0KQ2 2021: $131.0MQ3 2021: $104.8MQ4 2021: $72.0MQ1 2022: $53.6MQ2 2022: $15.1MQ3 2022: $20.5MQ4 2022: $11.1MQ1 2023: $12.6MQ2 2023: $13.9MQ3 2023: $12.1MQ4 2023: $17.9MQ1 2024: $327.2MQ2 2024: $299.3MQ3 2024: $281.6MQ4 2024: $288.9MQ1 2025: $240.5MQ2 2025: $271.0MQ3 2025: $468.6MQ4 2025: $908.7MQ1 2026: $1.47BQ2 2026: $5.35B
Institutions holding DFTX and their total value by quarter
QuarterHoldersValue
Q2 2026362$5.35B
Q1 2026248$1.47B
Q4 2025209$908.7M
Q3 2025196$468.6M
Q2 2025183$271.0M
Q1 2025191$240.5M
Q4 2024174$288.9M
Q3 2024158$281.6M
Q2 2024152$299.3M
Q1 2024135$327.2M
Q4 2023104$17.9M
Q3 202393$12.1M
Q2 202384$13.9M
Q1 202389$12.6M
Q4 2022104$11.1M
Q3 2022101$20.5M
Q2 2022156$15.1M
Q1 2022159$53.6M
Q4 2021176$72.0M
Q3 2021175$104.8M
Q2 2021156$131.0M
Q1 20218$932.0K

Institutions, Q3 2025

Shares, value and share of portfolio for each institution holding Definium Therapeutics, Inc.; share changes are against Q2 2025.

Institutions holding DFTX in Q3 2025
InstitutionSharesValue% of portfolioChange in sharesAction
Polar Asset Management Partners Inc.0$00.00%−29,300−100.0%Sold out
Mitchell McLeod Pugh & Williams Inc0$00.00%−20,000−100.0%Sold out
Squarepoint Ops LLC0$00.00%−19,684−100.0%Sold out
ExodusPoint Capital Management, LP0$00.00%−17,877−100.0%Sold out
Bailard, Inc.0$00.00%−14,600−100.0%Sold out
Diametric Capital, LP0$00.00%−12,433−100.0%Sold out
PEAK6 LLC0$00.00%−10,915−100.0%Sold out
Sharpepoint LLC0$00.00%−10,165−100.0%Sold out
Capital Advisors Inc0$00.00%−50,000−100.0%Sold out
Clear Street Markets LLC0$00.00%−3,096−100.0%Sold out
Larson Financial Group LLC0$00.00%−2,932−100.0%Sold out
Skopos Labs, Inc.0$00.00%−519−100.0%Sold out
SRS Capital Advisors, Inc.0$00.00%−501−100.0%Sold out
IFP Advisors, Inc0$00.00%0Sold out
Caitong International Asset Management Co., Ltd0$00.00%−341−100.0%Sold out
CarsonAllaria Wealth Management, Ltd.0$00.00%−325−100.0%Sold out
Pandora Wealth, Inc.0$00.00%−131−100.0%Sold out
First Pacific Financial0$00.00%−102−100.0%Sold out
TruNorth Capital Management, LLC0$00.00%−33−100.0%Sold out
Total Investment Management Inc0$00.00%−20−100.0%Sold out
Avantax Advisory Services, Inc.––––Not filed
Belmont Capital, LLC––––Not filed