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Definium Therapeutics, Inc.

DFTX
Exchange
Nasdaq
Industry
Medicinal Chemicals & Botanical Products
SEC CIK
0001813814

In the last 90 days, Definium Therapeutics, Inc. insiders filed 0 open-market purchases and 1 sale; 362 institutions reported holding it in 13F filings for Q2 2026, worth $5.35B in total; Duquesne Family Office is the only superinvestor holding it.

13F holders, Q3 2021

Institutional positions in Definium Therapeutics, Inc. as of Sep 30, 2021. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
175
+22 vs. Q2 2021
Shares held
44.7M
+6.88M (+18.2%) vs. Q2 2021
Total value
$104.8M
−$26.1M (−19.9%) vs. Q2 2021
New holders
40
56 more added
Sold out
18
34 more reduced

3 institutions that held it in Q2 2021 haven't filed for Q3 2021 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.

Compare with Q2 2021: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting DFTX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ3 2021: 175 institutions
Q1 2021: 8 institutionsQ2 2021: 156 institutionsQ3 2021: 175 institutionsQ4 2021: 176 institutionsQ1 2022: 159 institutionsQ2 2022: 156 institutionsQ3 2022: 101 institutionsQ4 2022: 104 institutionsQ1 2023: 89 institutionsQ2 2023: 84 institutionsQ3 2023: 93 institutionsQ4 2023: 104 institutionsQ1 2024: 135 institutionsQ2 2024: 152 institutionsQ3 2024: 158 institutionsQ4 2024: 174 institutionsQ1 2025: 191 institutionsQ2 2025: 183 institutionsQ3 2025: 196 institutionsQ4 2025: 209 institutionsQ1 2026: 248 institutionsQ2 2026: 362 institutions
Value heldQ3 2021: $104.8M
Q1 2021: $932.0KQ2 2021: $131.0MQ3 2021: $104.8MQ4 2021: $72.0MQ1 2022: $53.6MQ2 2022: $15.1MQ3 2022: $20.5MQ4 2022: $11.1MQ1 2023: $12.6MQ2 2023: $13.9MQ3 2023: $12.1MQ4 2023: $17.9MQ1 2024: $327.2MQ2 2024: $299.3MQ3 2024: $281.6MQ4 2024: $288.9MQ1 2025: $240.5MQ2 2025: $271.0MQ3 2025: $468.6MQ4 2025: $908.7MQ1 2026: $1.47BQ2 2026: $5.35B
Institutions holding DFTX and their total value by quarter
QuarterHoldersValue
Q2 2026362$5.35B
Q1 2026248$1.47B
Q4 2025209$908.7M
Q3 2025196$468.6M
Q2 2025183$271.0M
Q1 2025191$240.5M
Q4 2024174$288.9M
Q3 2024158$281.6M
Q2 2024152$299.3M
Q1 2024135$327.2M
Q4 2023104$17.9M
Q3 202393$12.1M
Q2 202384$13.9M
Q1 202389$12.6M
Q4 2022104$11.1M
Q3 2022101$20.5M
Q2 2022156$15.1M
Q1 2022159$53.6M
Q4 2021176$72.0M
Q3 2021175$104.8M
Q2 2021156$131.0M
Q1 20218$932.0K

Institutions, Q3 2021

Shares, value and share of portfolio for each institution holding Definium Therapeutics, Inc.; share changes are against Q2 2021.

Institutions holding DFTX in Q3 2021
InstitutionSharesValue% of portfolioChange in sharesAction
Hochman Cole Investment Advisors, Inc.31,760$74.0K0.03%+31,760New
Arete Wealth Advisors, LLC32,052$75.0K0.01%−446−1.4%Reduced
Koshinski Asset Management, Inc.32,272$75.2K0.01%+17,112+112.9%Added
Intersect Capital LLC32,500$76.0K0.01%00.0%Unchanged
Stratos Wealth Partners, LTD.33,604$78.0K0.00%+1,128+3.5%Added
Virtu Financial LLC37,355$87.0K0.01%−195,551−84.0%Reduced
Bank of America Corp37,194$87.0K0.00%−12,615−25.3%Reduced
Jaffetilchin Investment Partners, LLC36,855$89.0K0.01%−725−1.9%Reduced
HSBC Holdings PLC28,115$93.0K0.00%+28,115New
Toronto Dominion Bank39,823$96.0K0.00%−6,400−13.8%Reduced
Citigroup Inc40,527$98.0K0.00%+25,197+164.4%Added
First Republic Investment Management, Inc.42,337$99.0K0.00%+42,337New
LPL Financial LLC43,885$102.0K0.00%−285−0.6%Reduced
Envestnet Asset Management Inc44,030$103.0K0.00%+44,030New
ProShare Advisors LLC44,591$104.0K0.00%−38,965−46.6%Reduced
Stifel Financial Corp44,980$105.0K0.00%+240+0.5%Added
Stokes Family Office, LLC46,095$111.0K0.02%00.0%Unchanged
State Board of Administration of Florida Retirement System48,130$112.0K0.00%+48,130New
Ergoteles LLC48,108$112.0K0.00%+48,108New
Jane Street Group, LLC51,035$123.0K0.00%−571,329−91.8%Reduced
Legal & General Group Plc53,688$129.0K0.00%+2,065+4.0%Added
Huntington National Bank60,000$140.0K0.00%00.0%Unchanged
Private Advisor Group, LLC60,504$140.0K0.00%+19,321+46.9%Added
Metropolitan Life Insurance Co70,945$165.3K0.00%−25,461−26.4%Reduced
Gofen & Glossberg LLC72,500$169.0K0.00%00.0%Unchanged
Principal Financial Group Inc73,001$170.0K0.00%+21,507+41.8%Added
Advisor Group Holdings, Inc.73,292$172.0K0.00%+37,000+102.0%Added
Creative Planning76,232$178.0K0.00%+54,096+244.4%Added
STRS Ohio79,800$185.0K0.00%+5,100+6.8%Added
Scotia Capital Inc.83,147$194.0K0.00%+90.0%Added
MetLife Investment Management92,265$215.0K0.00%−33,654−26.7%Reduced
Royal Bank of Canada96,013$223.0K0.00%−13,256−12.1%Reduced
HighTower Advisors, LLC112,203$264.0K0.00%+54,721+95.2%Added
Parametric Portfolio Associates LLC125,880$293.0K0.00%+77,430+159.8%Added
Voya Investment Management LLC134,392$313.0K0.00%+7,913+6.3%Added
BIT Capital GmbH140,000$326.2K0.02%00.0%Unchanged
Shay Capital LLC141,250$329.0K0.10%−29,200−17.1%Reduced
SG Americas Securities, LLC141,023$329.0K0.00%+123,477+703.7%Added
Group One Trading, L.P.147,657$344.0K0.01%+35,568+31.7%Added
AdvisorShares Investments LLC152,518$355.0K0.06%+72,518+90.6%Added
Commonwealth Equity Services, LLC149,962$361.0K0.00%+29,770+24.8%Added
tru Independence LLC167,293$385.0K0.11%00.0%Unchanged
Belvedere Trading LLC171,274$392.0K0.11%−11,870−6.5%Reduced
D. E. Shaw & Co., Inc.170,522$397.0K0.00%+37,719+28.4%Added
Bank of Montreal169,612$400.0K0.00%+21,119+14.2%Added
California State Teachers Retirement System188,695$440.0K0.00%−255,577−57.5%Reduced
American International Group, Inc.190,445$444.0K0.00%+9,975+5.5%Added
Morgan Stanley194,828$453.0K0.00%+22,894+13.3%Added
Penserra Capital Management LLC196,020$456.0K0.01%+72,611+58.8%Added
Invesco Ltd.199,632$465.0K0.00%+46,695+30.5%Added
New York State Common Retirement Fund206,923$482.0K0.00%−68,977−25.0%Reduced
Manufacturers Life Insurance Company, The176,046$537.0K0.00%+248+0.1%Added
Credit Suisse AG237,331$553.0K0.00%−703−0.3%Reduced
JPMorgan Chase & Co128,678$603.0K0.00%−184,601−58.9%Reduced
Citadel Advisors LLC270,095$629.0K0.00%−50,168−15.7%Reduced
Simplex Trading, LLC198,466$680.0K0.02%−5,805−2.8%Reduced
Rhumbline Advisers307,204$716.0K0.00%+14,880+5.1%Added
Deutsche Bank AG314,629$732.0K0.00%+25,705+8.9%Added
MMCAP International Inc. SPC325,804$759.0K0.05%+325,804New
Two Sigma Investments, LP332,906$776.0K0.00%+332,906New
Alliancebernstein L.P.335,900$783.0K0.00%00.0%Unchanged
Swiss National Bank716,500$1.72M0.00%00.0%Unchanged
Charles Schwab Investment Management Inc737,060$1.72M0.00%+54,260+7.9%Added
Busey Wealth Management816,934$1.90M0.08%+816,934New
Bank of New York Mellon Corp885,835$2.06M0.00%+134,482+17.9%Added
Goldman Sachs Group Inc1,016,014$2.37M0.00%+742,184+271.0%Added
Susquehanna International Group, LLP1,061,186$2.47M0.00%−177,056−14.3%Reduced
Millennium Management LLC1,392,359$3.24M0.00%+350,178+33.6%Added
Vanguard Group Inc1,875,408$4.37M0.00%+207,346+12.4%Added
Northern Trust Corp2,589,317$6.03M0.00%+2,370,459+1,083.1%Added
Geode Capital Management, LLC2,913,033$6.79M0.00%+200,941+7.4%Added
State Street Corp5,634,088$13.1M0.00%+1,159,118+25.9%Added
BlackRock Inc.16,681,997$38.9M0.00%+997,490+6.4%Added
Gerber Kawasaki Wealth & Investment Management9––−17,003−99.9%Reduced
Activest Wealth Management44––+44New
UBS Asset Management Americas Inc0$00.00%−163,000−100.0%Sold out
HAP Trading, LLC0$00.00%−68,055−100.0%Sold out
Two Sigma Advisers, LP0$00.00%−43,500−100.0%Sold out
MYDA Advisors LLC0$00.00%−30,000−100.0%Sold out
Engineers Gate Manager LP0$00.00%−17,144−100.0%Sold out
Point72 Hong Kong Ltd0$00.00%−16,821−100.0%Sold out
EP Wealth Advisors, LLC0$00.00%−12,292−100.0%Sold out
Resources Investment Advisors, LLC.0$00.00%−11,675−100.0%Sold out
Raymond James Financial Services Advisors, Inc.0$00.00%−10,541−100.0%Sold out
Clear Street Markets LLC0$00.00%−10,000−100.0%Sold out
Optimum Investment Advisors0$00.00%−8,000−100.0%Sold out
Pinz Capital Management, LP0$00.00%−6,200−100.0%Sold out
Bank Julius Baer & Co. Ltd, Zurich0$00.00%−5,171−100.0%Sold out
HHM Wealth Advisors, LLC0$00.00%−725−100.0%Sold out
Anfield Capital Management, LLC0$00.00%−550−100.0%Sold out
Glen Eagle Advisors, LLC0$00.00%−433−100.0%Sold out
FMR LLC0$00.00%−1−100.0%Sold out
Ford Financial Group, LLC0$00.00%−200−100.0%Sold out
CWM, LLC––––Not filed
Pictet Asset Management Ltd––––Not filed
Hoover Financial Advisors, Inc.––––Not filed