Taysha Gene Therapies, Inc.
TSHA- Exchange
- Nasdaq
- Industry
- Biological Products, (No Diagnostic Substances)
- SEC CIK
- 0001806310
In the last 90 days, Taysha Gene Therapies, Inc. insiders filed 0 open-market purchases and 1 sale; 208 institutions reported holding it in 13F filings for Q2 2026, worth $2.03B in total; no superinvestor holds it.
13F holders, Q4 2025
Institutional positions in Taysha Gene Therapies, Inc. as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 195
- +42 vs. Q3 2025
- Shares held
- 269.0M
- +8.09M (+3.1%) vs. Q3 2025
- Total value
- $1.48B
- +$625.8M (+73.3%) vs. Q3 2025
- New holders
- 64
- 62 more added
- Sold out
- 22
- 46 more reduced
2 institutions that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting TSHA on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 208 | $2.03B |
| Q1 2026 | 191 | $1.18B |
| Q4 2025 | 195 | $1.48B |
| Q3 2025 | 155 | $865.6M |
| Q2 2025 | 150 | $595.4M |
| Q1 2025 | 127 | $232.0M |
| Q4 2024 | 131 | $289.8M |
| Q3 2024 | 119 | $315.5M |
| Q2 2024 | 107 | $354.3M |
| Q1 2024 | 109 | $402.2M |
| Q4 2023 | 87 | $230.3M |
| Q3 2023 | 63 | $410.6M |
| Q2 2023 | 39 | $9.05M |
| Q1 2023 | 44 | $13.3M |
| Q4 2022 | 52 | $43.8M |
| Q3 2022 | 54 | $27.0M |
| Q2 2022 | 59 | $54.7M |
| Q1 2022 | 71 | $110.9M |
| Q4 2021 | 65 | $215.6M |
| Q3 2021 | 48 | $361.9M |
| Q2 2021 | 49 | $388.6M |
| Q1 2021 | 46 | $358.5M |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Taysha Gene Therapies, Inc.; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| State of Wisconsin Investment Board | 113,178 | $622.5K | 0.00% | +70,229+163.5% | Added |
| MetLife Investment Management | 113,266 | $623.0K | 0.00% | −13,778−10.8% | Reduced |
| Price T Rowe Associates Inc | 121,814 | $670.0K | 0.00% | +7,979+7.0% | Added |
| Mirae Asset Global ETFs Holdings Ltd. | 122,639 | $677.7K | 0.00% | +11,615+10.5% | Added |
| Susquehanna International Group, LLP | 124,975 | $687.4K | 0.00% | +103,233+474.8% | Added |
| Profund Advisors LLC | 128,590 | $707.2K | 0.02% | +75,224+141.0% | Added |
| Legal & General Group Plc | 133,146 | $732.3K | 0.00% | +109,997+475.2% | Added |
| California State Teachers Retirement System | 138,580 | $762.2K | 0.00% | +128,207+1,236.0% | Added |
| Two Sigma Advisers, LP | 139,581 | $767.7K | 0.00% | +139,581 | New |
| Chicago Partners Investment Group LLC | 166,541 | $776.1K | 0.02% | +2,504+1.5% | Added |
| Polen Capital Management LLC | 156,586 | $861.2K | 0.00% | +156,586 | New |
| Deutsche Bank AG | 160,779 | $884.3K | 0.00% | +37,980+30.9% | Added |
| Jane Street Group, LLC | 163,146 | $897.3K | 0.00% | −393,639−70.7% | Reduced |
| Privium Fund Management B.V. | 164,900 | $907.0K | 0.17% | +30,000+22.2% | Added |
| Seven Fleet Capital Management LP | 167,223 | $919.7K | 0.62% | +167,223 | New |
| UBS Asset Management Americas Inc | 167,500 | $921.3K | 0.00% | +167,500 | New |
| AQR Capital Management LLC | 168,862 | $928.7K | 0.00% | +17,862+11.8% | Added |
| Renaissance Technologies LLC | 171,100 | $941.0K | 0.00% | +171,100 | New |
| BNP Paribas Arbitrage, SA | 172,482 | $948.7K | 0.00% | +126,448+274.7% | Added |
| Palumbo Wealth Management LLC | 178,007 | $979.0K | 0.24% | +20,654+13.1% | Added |
| Alliancebernstein L.P. | 179,640 | $988.0K | 0.00% | 00.0% | Unchanged |
| Wexford Capital LP | 180,853 | $994.7K | 0.26% | +177,353+5,067.2% | Added |
| StemPoint Capital LP | 182,130 | $1.00M | 0.17% | −657,539−78.3% | Reduced |
| Victory Capital Management Inc | 195,764 | $1.08M | 0.00% | +170,164+664.7% | Added |
| Gsa Capital Partners LLP | 208,016 | $1.14M | 0.10% | −269,733−56.5% | Reduced |
| Voya Investment Management LLC | 218,185 | $1.20M | 0.00% | +181,685+497.8% | Added |
| Alps Advisors Inc | 224,920 | $1.24M | 0.01% | +224,920 | New |
| Rhumbline Advisers | 257,440 | $1.42M | 0.00% | −31,419−10.9% | Reduced |
| Nomura Holdings Inc | 259,339 | $1.43M | 0.00% | +259,339 | New |
| Oracle Investment Management Inc | 265,000 | $1.46M | 0.96% | +265,000 | New |
| Swiss National Bank | 268,800 | $1.48M | 0.00% | +268,800 | New |
| Ensign Peak Advisors, Inc | 275,111 | $1.51M | 0.00% | +275,111 | New |
| American Century Companies Inc | 288,535 | $1.59M | 0.00% | +249,979+648.4% | Added |
| Colony Group, LLC | 295,516 | $1.63M | 0.00% | +295,516 | New |
| Capricorn Fund Managers Ltd | 300,000 | $1.65M | 0.40% | +300,000 | New |
| Wells Fargo & Company | 305,086 | $1.68M | 0.00% | +159,988+110.3% | Added |
| Hennion & Walsh Asset Management, Inc. | 308,457 | $1.70M | 0.06% | +308,457 | New |
| Boothbay Fund Management, LLC | 309,481 | $1.70M | 0.04% | −106,126−25.5% | Reduced |
| Rafferty Asset Management, LLC | 344,784 | $1.90M | 0.01% | +104,999+43.8% | Added |
| Two Sigma Investments, LP | 351,126 | $1.93M | 0.00% | +285,021+431.2% | Added |
| Sphera Funds Management Ltd. | 368,146 | $2.02M | 0.42% | −40,000−9.8% | Reduced |
| UBS Group AG | 383,043 | $2.11M | 0.00% | −256,313−40.1% | Reduced |
| HRT Financial LP | 409,254 | $2.25M | 0.01% | +409,254 | New |
| Acuta Capital Partners, LLC | 454,827 | $2.50M | 1.70% | 00.0% | Unchanged |
| Ally Bridge Group (NY) LLC | 457,132 | $2.51M | 3.99% | −1,440,980−75.9% | Reduced |
| Squarepoint Ops LLC | 471,577 | $2.59M | 0.01% | +273,225+137.7% | Added |
| Dimensional Fund Advisors LP | 490,472 | $2.70M | 0.00% | +145,309+42.1% | Added |
| Woodline Partners LP | 500,000 | $2.75M | 0.01% | 00.0% | Unchanged |
| Nuveen, LLC | 545,286 | $3.00M | 0.00% | +38,076+7.5% | Added |
| Bank of New York Mellon Corp | 624,367 | $3.43M | 0.00% | −472−0.1% | Reduced |
| Granahan Investment Management Inc | 703,971 | $3.87M | 0.17% | −412,658−37.0% | Reduced |
| Wellington Management Group LLP | 711,235 | $3.91M | 0.00% | +143,229+25.2% | Added |
| Sands Capital Ventures, LLC | 724,873 | $3.99M | 0.77% | 00.0% | Unchanged |
| JPMorgan Chase & Co | 774,412 | $4.26M | 0.00% | +478,168+161.4% | Added |
| SG Americas Securities, LLC | 781,474 | $4.30M | 0.01% | +748,525+2,271.8% | Added |
| Quantum Private Wealth, LLC | 819,715 | $4.51M | 1.32% | −2,361−0.3% | Reduced |
| EAM Investors, LLC | 823,758 | $4.53M | 0.50% | +823,758 | New |
| Superstring Capital Management LP | 980,768 | $5.39M | 2.89% | +980,768 | New |
| Standard Life Aberdeen plc | 1,021,063 | $5.62M | 0.01% | +1,021,063 | New |
| Bank of America Corp | 1,152,680 | $6.34M | 0.00% | −154,607−11.8% | Reduced |
| Palo Alto Investors LP | 1,183,195 | $6.51M | 0.91% | −62,838−5.0% | Reduced |
| Northern Trust Corp | 1,237,987 | $6.81M | 0.00% | −479,191−27.9% | Reduced |
| Rice Hall James & Associates, LLC | 1,270,645 | $6.99M | 0.38% | +692,527+119.8% | Added |
| Adage Capital Partners GP, L.L.C. | 1,328,000 | $7.30M | 0.01% | −2,000,000−60.1% | Reduced |
| GordonMD Global Investments LP | 1,330,901 | $7.32M | 5.25% | +1,330,901 | New |
| Invesco Ltd. | 1,332,780 | $7.33M | 0.00% | +1,052,987+376.3% | Added |
| Casdin Capital, LLC | 1,500,000 | $8.25M | 0.51% | +1,500,000 | New |
| B Group, Inc. | 1,800,556 | $9.90M | 7.34% | 00.0% | Unchanged |
| Norges Bank | 1,837,800 | $10.1M | 0.00% | +1,837,800 | New |
| Citadel Advisors LLC | 1,854,855 | $10.2M | 0.01% | +1,487,546+405.0% | Added |
| Charles Schwab Investment Management Inc | 1,902,978 | $10.5M | 0.00% | +56,468+3.1% | Added |
| ADAR1 Capital Management, LLC | 2,495,809 | $13.7M | 1.03% | −339,871−12.0% | Reduced |
| Deerfield Management Company, L.P. (Series C) | 2,722,165 | $15.0M | 0.19% | −2,663,835−49.5% | Reduced |
| Millennium Management LLC | 3,178,863 | $17.5M | 0.01% | −847,259−21.0% | Reduced |
| Affinity Asset Advisors, LLC | 3,300,000 | $18.1M | 1.30% | +300,000+10.0% | Added |
| Healthcare of Ontario Pension Plan Trust Fund | 3,722,000 | $20.5M | 0.03% | +3,722,000 | New |
| Point72 Asset Management, L.P. | 3,868,682 | $21.3M | 0.03% | −3,462,788−47.2% | Reduced |
| Baker Bros. Advisors LP | 4,004,756 | $22.0M | 0.13% | 00.0% | Unchanged |
| D. E. Shaw & Co., Inc. | 4,013,635 | $22.1M | 0.02% | +1,307,201+48.3% | Added |
| Geode Capital Management, LLC | 5,387,026 | $29.6M | 0.00% | +212,510+4.1% | Added |
| Barclays PLC | 5,539,001 | $30.5M | 0.01% | +390,889+7.6% | Added |
| Polar Capital Holdings Plc | 7,931,403 | $43.6M | 0.20% | +2,637,524+49.8% | Added |
| Octagon Capital Advisors LP | 8,859,911 | $48.7M | 6.10% | −207,589−2.3% | Reduced |
| Siren, L.L.C. | 10,129,913 | $55.7M | 1.66% | −884,824−8.0% | Reduced |
| State Street Corp | 10,790,084 | $59.3M | 0.00% | +3,553,619+49.1% | Added |
| Vanguard Group Inc | 13,267,805 | $73.0M | 0.00% | +418,192+3.3% | Added |
| FMR LLC | 13,528,366 | $74.4M | 0.00% | −1,065,046−7.3% | Reduced |
| Goldman Sachs Group Inc | 13,692,739 | $75.3M | 0.01% | +309,031+2.3% | Added |
| Vestal Point Capital, LP | 13,750,000 | $75.6M | 2.77% | +8,250,000+150.0% | Added |
| RTW Investments, LP | 16,398,297 | $90.2M | 0.90% | −7,955,994−32.7% | Reduced |
| Morgan Stanley | 18,078,518 | $99.4M | 0.01% | −1,229,085−6.4% | Reduced |
| BlackRock, Inc. | 18,643,129 | $102.5M | 0.00% | +2,278,268+13.9% | Added |
| Avoro Capital Advisors LLC | 21,700,000 | $119.3M | 1.17% | 00.0% | Unchanged |
| Ra Capital Management, L.P. | 23,555,648 | $129.6M | 1.33% | 00.0% | Unchanged |
| Capital Advisors, Ltd. LLC | 77 | – | – | −2−2.5% | Reduced |
| Toronto Dominion Bank | 0 | $0 | 0.00% | −1,923,962−100.0% | Sold out |
| Great Point Partners LLC | 0 | $0 | 0.00% | −1,500,000−100.0% | Sold out |
| Tang Capital Management LLC | 0 | $0 | 0.00% | −900,000−100.0% | Sold out |
| Alphabet Inc. | 0 | $0 | 0.00% | −640,882−100.0% | Sold out |
| Anson Funds Management LP | 0 | $0 | 0.00% | −603,500−100.0% | Sold out |