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Rhythm Pharmaceuticals, Inc.

RYTM
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
SEC CIK
0001649904

In the last 90 days, Rhythm Pharmaceuticals, Inc. insiders filed 0 open-market purchases and 6 sales; 304 institutions reported holding it in 13F filings for Q2 2026, worth $8.55B in total; Duquesne Family Office is the only superinvestor holding it.

13F holders, Q2 2026

Institutional positions in Rhythm Pharmaceuticals, Inc. as of Jun 30, 2026. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
304
+23 vs. Q1 2026
Shares held
77.2M
+4.58M (+6.3%) vs. Q1 2026
Total value
$8.55B
+$2.21B (+34.8%) vs. Q1 2026
New holders
64
105 more added
Sold out
41
101 more reduced

4 institutions that held it in Q1 2026 haven't filed for Q2 2026 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.

Compare with Q1 2026: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting RYTM on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ2 2026: 304 institutions
Q1 2021: 124 institutionsQ2 2021: 105 institutionsQ3 2021: 97 institutionsQ4 2021: 98 institutionsQ1 2022: 111 institutionsQ2 2022: 90 institutionsQ3 2022: 101 institutionsQ4 2022: 115 institutionsQ1 2023: 126 institutionsQ2 2023: 116 institutionsQ3 2023: 144 institutionsQ4 2023: 169 institutionsQ1 2024: 167 institutionsQ2 2024: 165 institutionsQ3 2024: 176 institutionsQ4 2024: 203 institutionsQ1 2025: 228 institutionsQ2 2025: 227 institutionsQ3 2025: 264 institutionsQ4 2025: 281 institutionsQ1 2026: 285 institutionsQ2 2026: 304 institutions
Value heldQ2 2026: $8.55B
Q1 2021: $1.01BQ2 2021: $905.6MQ3 2021: $626.3MQ4 2021: $483.6MQ1 2022: $562.7MQ2 2022: $190.8MQ3 2022: $1.45BQ4 2022: $1.81BQ1 2023: $1.08BQ2 2023: $1.09BQ3 2023: $1.56BQ4 2023: $3.07BQ1 2024: $2.95BQ2 2024: $2.85BQ3 2024: $3.55BQ4 2024: $3.63BQ1 2025: $3.44BQ2 2025: $4.20BQ3 2025: $7.20BQ4 2025: $7.80BQ1 2026: $6.42BQ2 2026: $8.55B
Institutions holding RYTM and their total value by quarter
QuarterHoldersValue
Q2 2026304$8.55B
Q1 2026285$6.42B
Q4 2025281$7.80B
Q3 2025264$7.20B
Q2 2025227$4.20B
Q1 2025228$3.44B
Q4 2024203$3.63B
Q3 2024176$3.55B
Q2 2024165$2.85B
Q1 2024167$2.95B
Q4 2023169$3.07B
Q3 2023144$1.56B
Q2 2023116$1.09B
Q1 2023126$1.08B
Q4 2022115$1.81B
Q3 2022101$1.45B
Q2 202290$190.8M
Q1 2022111$562.7M
Q4 202198$483.6M
Q3 202197$626.3M
Q2 2021105$905.6M
Q1 2021124$1.01B

Institutions, Q2 2026

Shares, value and share of portfolio for each institution holding Rhythm Pharmaceuticals, Inc.; share changes are against Q1 2026.

Institutions holding RYTM in Q2 2026
InstitutionSharesValue% of portfolioChange in sharesAction
Primecap Management Co3,168,853$351.8M0.21%−248,656−7.3%Reduced
Baker Bros. Advisors LP5,604,483$622.3M3.12%00.0%Unchanged
BlackRock, Inc.6,156,902$683.6M0.01%−80,249−1.3%Reduced
Ra Capital Management, L.P.6,666,837$740.2M6.43%00.0%Unchanged
Lord, Abbett & Co. LLC0$00.00%−348,953−100.0%Sold out
Hood River Capital Management LLC0$00.00%−239,912−100.0%Sold out
M&G Plc0$00.00%−138,567−100.0%Sold out
Balyasny Asset Management LLC0$00.00%−52,967−100.0%Sold out
Castleark Management LLC0$00.00%−52,279−100.0%Sold out
Harvest Investment Services, LLC0$00.00%−48,468−100.0%Sold out
Utah Retirement Systems0$00.00%−42,177−100.0%Sold out
Alyeska Investment Group, L.P.0$00.00%−32,589−100.0%Sold out
Harbor Capital Advisors, Inc.0$00.00%−30,353−100.0%Sold out
PDT Partners, LLC0$00.00%−27,232−100.0%Sold out
HSBC Holdings PLC0$00.00%−14,307−100.0%Sold out
Hudson Bay Capital Management LP0$00.00%−9,120−100.0%Sold out
HighTower Advisors, LLC0$00.00%−9,058−100.0%Sold out
Prelude Capital Management, LLC0$00.00%−8,372−100.0%Sold out
IMC-Chicago, LLC0$00.00%−6,697−100.0%Sold out
Texas Treasury Safekeeping Trust Co0$00.00%−6,154−100.0%Sold out
Campbell & CO Investment Adviser LLC0$00.00%−5,958−100.0%Sold out
Blueshift Asset Management, LLC0$00.00%−5,787−100.0%Sold out
Centiva Capital, LP0$00.00%−4,000−100.0%Sold out
Fox Run Management, L.L.C.0$00.00%−4,499−100.0%Sold out
Bank of Montreal0$00.00%−3,801−100.0%Sold out
Brevan Howard Capital Management LP0$00.00%−3,777−100.0%Sold out
Chicago Partners Investment Group LLC0$00.00%−3,125−100.0%Sold out
Ethic Inc.0$00.00%−3,003−100.0%Sold out
MAI Capital Management0$00.00%−2,710−100.0%Sold out
Blackstone Group Inc.0$00.00%−2,600−100.0%Sold out
DRW Securities, LLC0$00.00%−2,562−100.0%Sold out
Two Sigma Securities, LLC0$00.00%−2,545−100.0%Sold out
Cornerstone Partners Capital Management, LLC0$00.00%−2,462−100.0%Sold out
Verdad Advisers, LP0$00.00%−2,445−100.0%Sold out
Quantbot Technologies LP0$00.00%−1,363−100.0%Sold out
Sound Income Strategies, LLC0$00.00%−114−100.0%Sold out
Eastern Bank0$00.00%−59−100.0%Sold out
Advisory Services Network, LLC0$00.00%−37−100.0%Sold out
Golden State Equity Partners0$00.00%−37−100.0%Sold out
Root Financial Partners, LLC0$00.00%−31−100.0%Sold out
JFS Wealth Advisors, LLC0$00.00%−10−100.0%Sold out
Toronto Dominion Bank0$00.00%−6−100.0%Sold out
Twin Peaks Wealth Advisors, LLC0$00.00%−6−100.0%Sold out
HFM Investment Advisors, LLC0$00.00%−1−100.0%Sold out
Bay Harbor Wealth Management, LLC0$00.00%−1−100.0%Sold out
Janus Henderson Group PLC––––Not filed
Leo Wealth, LLC––––Not filed
Cim Investment Mangement Inc––––Not filed
CWM, LLC––––Not filed